D:Shigella Infection

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Disease Term
Synonyms Bacillary Dysentary, Bacillary Dysentery, Boydii Dysenteries Shigella, Boydii Dysentery Shigella, Dysenteriae Dysenteries Shigella, Dysenteriae Dysentery Shigella, Dysenteries Shigella, Dysenteries Shigella Boydii, Dysenteries Shigella Dysenteriae, Dysenteries Shigella Flexneri, Dysenteries Shigella Sonnei
Documents 84
Hot Single Events 29
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Shigella Infection. They are ordered first by their relevance to Shigella Infection and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT348530 CASP10 Positive_regulation of CASP9 1 0.02 0.3 0 83.12
2 INT348535 CASP10 Positive_regulation of CASP3 1 0.03 0.3 0 83.12
3 INT348537 TNF Positive_regulation of Gene_expression of BIRC2 1 0.03 0.23 0 36.76
4 INT348529 TNF Positive_regulation of Gene_expression of IKBKG 1 0.01 0.23 0 36.52
5 INT323386 Negative_regulation of Binding of Lta and Coq10a 1 0.10 0.57 0 21.24
6 INT323385 Binding of Lta and Coq10a 1 0.09 0.56 0 20.84
7 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13 5.00
8 INT220916 Positive_regulation of Binding of JUN and JUND 2 0.18 0.53 0.07 5.00
9 INT220911 Binding of JUN and JUND 2 0.14 1.08 0.07 5.00
10 INT348523 BCL2L1 Negative_regulation of NLRP1 1 0.01 0.63 0.05 5.00
11 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03 5.00
12 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03 5.00
13 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0 5.00
14 INT348533 Positive_regulation of Binding of FOSL2 and JUN 1 0.09 0.32 0 5.00
15 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0 5.00
16 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0 5.00
17 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0 5.00
18 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0 5.00
19 INT348525 MAPK8 Positive_regulation of Gene_expression of JUND 1 0.01 0.28 0 5.00
20 INT348524 Binding of FOSL2 and JUN 1 0.07 0.59 0 5.00
21 INT348536 Positive_regulation of TP63 Positive_regulation of Gene_expression of CASP9 1 0.02 0.55 0 5.00
22 INT348534 ELMO1 Positive_regulation of RAC1 1 0.02 0.7 0 5.00
23 INT348527 Binding of JUN and Regulation of Gene_expression of GADD45A 1 0.11 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Shigella Infection. They are ordered first by their pain relevance and then by number of times they were reported in Shigella Infection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 99.28
2 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 98.32
3 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 95.76
4 INT49653 Gene_expression of NFKB2 12 0.61 9.51 2.73 95.28
5 INT348458 Regulation of Gene_expression of NFKB2 1 0.19 0.87 0 95.28
6 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61 94.48
7 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0 94.48
8 INT117915 Gene_expression of BIRC2 8 0.63 6.74 1.59 93.92
9 INT348460 Regulation of Gene_expression of BIRC2 1 0.24 0.82 0 93.92
10 INT20212 Binding of Cd79a 10 0.23 3.96 0.17 93.64
11 INT125874 Negative_regulation of CASP10 3 0.41 1.84 0.07 93.32
12 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 92.88
13 INT75503 Regulation of Gene_expression of JUN 6 0.21 2.87 1.11 92.88
14 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 92.28
15 INT214845 Positive_regulation of CASP10 3 0.45 1.97 0 91.00
16 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14 90.64
17 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 90.32
18 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94 89.56
19 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 89.24
20 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 88.08
21 INT214844 Positive_regulation of Gene_expression of CASP10 2 0.45 1.15 0 86.08
22 INT125866 Gene_expression of CASP10 6 0.58 4.01 0.13 85.76
23 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 85.44
24 INT47662 Localization of CHKB 34 0.81 22.63 5.14 85.28
25 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 84.60
26 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 82.44
27 INT97797 Localization of TLR4 18 0.77 13.78 6 80.92
28 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 80.64
29 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 80.08
30 INT348496 Negative_regulation of Positive_regulation of CASP10 1 0.22 0.34 0 77.68
31 INT348465 Localization of MXI1 1 0.73 1.04 0.15 76.56
32 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41 72.00
33 INT149999 Negative_regulation of Gene_expression of BAD 4 0.13 5.46 0.45 72.00
34 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95 71.88
35 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 71.16
36 INT38828 Negative_regulation of STS 14 0.44 7.27 0.68 69.28
37 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94 69.04
38 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 69.04
39 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 68.40
40 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 68.40
41 INT27325 Positive_regulation of Pyy 15 0.62 13.69 6.54 68.12
42 INT99289 Localization of STS 8 0.79 6.5 0.92 65.68
43 INT348479 Localization of CASP10 1 0.13 0.32 0 65.68
44 INT99290 Positive_regulation of STS 16 0.43 6.96 0.75 62.52
45 INT219192 Positive_regulation of Regulation of CD40LG 2 0.43 2.9 0.17 60.72
46 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 59.92
47 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 59.92
48 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02 51.88
49 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71 51.88
50 INT147552 Positive_regulation of Birc2 7 0.68 8.29 0.87 48.32
51 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42 48.12
52 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 47.44
53 INT56803 Positive_regulation of Bcl2a1a 12 0.47 7.29 5.65 46.32
54 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 44.44
55 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 44.44
56 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 44.44
57 INT191018 Positive_regulation of Gene_expression of Cd79a 12 0.26 8.01 1.05 41.60
58 INT12823 Positive_regulation of FAIM3 9 0.64 3.23 4.76 31.40
59 INT155093 Positive_regulation of CFLAR 6 0.67 5.02 0.88 31.40
60 INT106410 Positive_regulation of Positive_regulation of FAIM3 3 0.21 1.25 0.63 31.40
61 INT348499 Positive_regulation of Positive_regulation of CFLAR 1 0.16 1.06 0 31.40
62 INT348459 Positive_regulation of TNFAIP8 1 0.27 1.04 0 31.40
63 INT348453 Positive_regulation of Positive_regulation of TNFAIP3 1 0.17 1.06 0 31.40
64 INT348491 Positive_regulation of Positive_regulation of TNFRSF12A 1 0.06 1.06 0 31.40
65 INT348492 Positive_regulation of TNFRSF12A 1 0.08 1.04 0 31.40
66 INT217333 Positive_regulation of TNFAIP3 3 0.23 2.65 0 31.40
67 INT348462 Positive_regulation of Positive_regulation of TNFAIP8 1 0.27 1.06 0 31.40
68 INT20228 Negative_regulation of Gene_expression of Lta 8 0.22 3.81 1.03 28.56
69 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 28.24
70 INT234430 Negative_regulation of Gene_expression of CASP8 4 0.06 3.79 0 28.24
71 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61 27.92
72 INT60554 Binding of Coq10a 30 0.40 7.99 3.02 25.68
73 INT263932 Positive_regulation of PROCR 6 0.67 2.43 0.46 20.28
74 INT80033 Binding of FAS 37 0.48 41.19 5.67 17.76
75 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 15.52
76 INT191017 Localization of Cd79a 28 0.56 13.94 2.55 13.52
77 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
78 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
79 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
80 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
81 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
82 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
83 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
84 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
85 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
86 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
87 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
88 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
89 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
90 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
91 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
92 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
93 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
94 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
95 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
96 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
97 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
98 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
99 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
100 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
101 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
102 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
103 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
104 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
105 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09 5.00
106 INT5045 Regulation of VIP 26 0.62 7.15 11.61 5.00
107 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
108 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
109 INT60198 Binding of JUN 54 0.48 11.56 10.27 5.00
110 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
111 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
112 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 5.00
113 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
114 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76 5.00
115 INT75497 Regulation of JUN 28 0.61 11.04 7.09 5.00
116 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
117 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93 5.00
118 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56 5.00
119 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
120 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63 5.00
121 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59 5.00
122 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47 5.00
123 INT196782 Positive_regulation of Ppp2ca 32 0.61 1.89 4.33 5.00
124 INT26239 Positive_regulation of Gene_expression of Lta 12 0.36 8.86 4.22 5.00
125 INT67936 Transcription of JUN 18 0.52 9.52 4.13 5.00
126 INT97128 Localization of SPP1 32 0.80 21.75 4.02 5.00
127 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83 5.00
128 INT157664 Positive_regulation of DEFB4A 15 0.56 10.87 3.8 5.00
129 INT170899 Negative_regulation of Positive_regulation of Gopc 16 0.19 5.46 3.71 5.00
130 INT133169 Positive_regulation of Il12b 25 0.49 13 3.64 5.00
131 INT33661 Regulation of Tbpl1 7 0.44 5.36 3.26 5.00
132 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 5.00
133 INT103910 Binding of NOD2 19 0.47 12.24 2.93 5.00
134 INT11920 Regulation of ENO2 18 0.55 11.51 2.89 5.00
135 INT15757 Gene_expression of JUND 11 0.75 2.47 2.86 5.00
136 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69 5.00
137 INT49808 Localization of tryptase 11 0.78 8.74 2.67 5.00
138 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45 5.00
139 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 5.00
140 INT130961 Gene_expression of MADCAM1 4 0.33 5.03 2.28 5.00
141 INT24740 Positive_regulation of Cd79a 36 0.48 14.71 2.17 5.00
142 INT102268 Gene_expression of H2-S 20 0.75 10.77 2.03 5.00
143 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02 5.00
144 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 5.00
145 INT64538 Binding of TNNI3 17 0.48 11.65 1.83 5.00
146 INT68767 Positive_regulation of IER3 6 0.28 2.59 1.8 5.00
147 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78 5.00
148 INT223746 Binding of Il10 12 0.36 9.49 1.73 5.00
149 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69 5.00
150 INT62046 Negative_regulation of Lta 8 0.43 4.42 1.67 5.00
151 INT91664 Positive_regulation of Negative_regulation of IL8 5 0.40 3.28 1.62 5.00
152 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 5.00
153 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62 5.00
154 INT95253 Regulation of IER3 4 0.23 1.89 1.6 5.00
155 INT73330 Positive_regulation of SERPINB2 6 0.47 5.33 1.57 5.00
156 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 5.00
157 INT15758 Positive_regulation of Gene_expression of JUND 5 0.23 0.99 1.53 5.00
158 INT171029 Positive_regulation of Transcription of JUN 4 0.14 2.87 1.48 5.00
159 INT105086 Positive_regulation of CYCS 9 0.49 5.82 1.45 5.00
160 INT43899 Positive_regulation of Positive_regulation of VIP 4 0.57 1.71 1.42 5.00
161 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31 5.00
162 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26 5.00
163 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 5.00
164 INT260285 Gene_expression of E2F3 6 0.54 2.51 1.13 5.00
165 INT7817 Binding of CASP1 7 0.19 1.26 1.13 5.00
166 INT62044 Binding of Lta 16 0.30 7.49 1.01 5.00
167 INT277920 Binding of MADCAM1 4 0.14 3.11 0.96 5.00
168 INT108341 Positive_regulation of BAD 8 0.42 8.75 0.85 5.00
169 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84 5.00
170 INT306834 Positive_regulation of Gene_expression of E2F3 2 0.29 1 0.82 5.00
171 INT101722 Binding of JUND 12 0.31 2.21 0.73 5.00
172 INT147554 Gene_expression of Birc2 11 0.75 10.93 0.6 5.00
173 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58 5.00
174 INT191671 Positive_regulation of Xiap 5 0.67 4.63 0.49 5.00
175 INT204781 Positive_regulation of Nod2 6 0.45 2.79 0.46 5.00
176 INT183682 Positive_regulation of Positive_regulation of Cxcl2 3 0.40 0.86 0.45 5.00
177 INT194993 Binding of RB1 15 0.37 10.96 0.4 5.00
178 INT294539 Binding of BAD 3 0.36 2.35 0.37 5.00
179 INT312037 Gene_expression of BECN1 2 0.33 1.5 0.37 5.00
180 INT188074 Gene_expression of GADD45A 12 0.65 5.11 0.28 5.00
181 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28 5.00
182 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 5.00
183 INT75822 Gene_expression of TRA@ 2 0.65 0.34 0.24 5.00
184 INT101620 Gene_expression of TCHP 4 0.02 2.18 0.21 5.00
185 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2 5.00
186 INT329188 Positive_regulation of FOSL2 2 0.29 1.34 0.19 5.00
187 INT184993 Negative_regulation of NLRP1 7 0.41 2.1 0.17 5.00
188 INT125101 Gene_expression of CASP9 24 0.35 16.54 0.17 5.00
189 INT178607 Binding of CASP3 5 0.19 1.06 0.16 5.00
190 INT169172 Positive_regulation of XIAP 3 0.49 2.54 0.12 5.00
191 INT183671 Localization of EPAS1 5 0.16 5.41 0.09 5.00
192 INT165362 Gene_expression of APAF1 5 0.50 4.37 0.08 5.00
193 INT348468 Regulation of RASGRF1 1 0.02 0.53 0.06 5.00
194 INT125103 Positive_regulation of Gene_expression of CASP9 5 0.31 2.52 0.06 5.00
195 INT194773 Regulation of Gene_expression of GADD45A 2 0.16 0.28 0.04 5.00
196 INT193685 Positive_regulation of GLRX2 2 0.24 1.11 0.04 5.00
197 INT348454 Transcription of STS 1 0.05 0.73 0.03 5.00
198 INT348488 Positive_regulation of EDARADD 1 0.33 0.52 0.03 5.00
199 INT348473 Positive_regulation of Positive_regulation of EDARADD 1 0.24 0.52 0.03 5.00
200 INT348497 Negative_regulation of EDARADD 1 0.24 0.58 0.03 5.00
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