D:Shoulder Pain

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Disease Term
Synonyms Pain Shoulder, PAINS SHOULDER, SHOULDER PAINS
Documents 2442
Hot Single Events 95
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Shoulder Pain. They are ordered first by their relevance to Shoulder Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78 100.00
2 INT245572 Binding of AVPR2 and SPECC1 1 0.10 0.75 0.75 100.00
3 INT330514 Vegfa Positive_regulation of VEGFA 1 0.18 0.5 0.18 88.08
4 INT66590 Gnrhr Regulation of Ldlr 1 0.02 0.4 0.06 58.56
5 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91 58.44
6 INT198729 Binding of Exa and Femwf1 1 0.05 0.37 0 33.72
7 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41 10.08
8 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5 5.00
9 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 5.00
10 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 5.00
11 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
12 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26 5.00
13 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21 5.00
14 INT245118 RBM45 Negative_regulation of CDKN2B 1 0.01 1.41 0.08 5.00
15 INT245119 Negative_regulation of RBM45 Negative_regulation of CDKN2B 1 0.01 1.43 0.08 5.00
16 INT345350 Casp3 Positive_regulation of Prkcd 1 0.05 0.79 0.03 5.00
17 INT198730 Femwf1 Positive_regulation of Exa 1 0.06 0 0 5.00
18 INT198727 Exa Regulation of Femwf1 1 0.06 0.07 0 5.00
19 INT196074 Mtnr1a Positive_regulation of Tmtr 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Shoulder Pain. They are ordered first by their pain relevance and then by number of times they were reported in Shoulder Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91648 Binding of SPECC1 7 0.48 22.42 19.36 100.00
2 INT134106 Positive_regulation of SPECC1 14 0.68 9.44 8.09 100.00
3 INT245574 Regulation of SPECC1 5 0.44 6.03 5 100.00
4 INT245573 Negative_regulation of Binding of SPECC1 1 0.43 2.15 1.8 100.00
5 INT152616 Gene_expression of SPECC1 8 0.66 8.43 4.32 100.00
6 INT1026 Binding of Lbp 207 0.48 150.96 119.16 100.00
7 INT139107 Localization of SPECC1 3 0.71 1.45 1.35 100.00
8 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 100.00
9 INT156696 Positive_regulation of Pain1 10 0.23 10.92 12.42 100.00
10 INT29568 Negative_regulation of Bpifa2 6 0.50 1.83 1.77 100.00
11 INT142550 Binding of Sis 3 0.31 1.98 0.47 99.98
12 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 99.90
13 INT1143 Positive_regulation of OTOR 7 0.67 5.38 1 99.90
14 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 99.70
15 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 99.50
16 INT154018 Binding of Lhb 5 0.31 1.39 1.13 99.36
17 INT37380 Negative_regulation of Sis 31 0.55 19.89 3.92 99.30
18 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.22
19 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 99.20
20 INT121106 Binding of Slmap 10 0.37 5.19 3.71 99.12
21 INT60860 Gene_expression of Slmap 32 0.66 8.55 1.34 99.10
22 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 98.84
23 INT164082 Protein_catabolism of Omd 2 0.76 0.89 0.69 98.76
24 INT164083 Positive_regulation of Protein_catabolism of Omd 1 0.43 0.89 0.39 98.76
25 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 98.60
26 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 98.24
27 INT9730 Binding of LHB 4 0.35 2.38 1.19 98.20
28 INT72565 Localization of IL1RN 45 0.80 23.59 13.17 98.08
29 INT73905 Transcription of IL1RN 10 0.71 9.16 5.04 98.08
30 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 98.04
31 INT111613 Regulation of PTGDS 6 0.52 3.29 0.93 98.04
32 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.96
33 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 97.72
34 INT56406 Regulation of Gene_expression of PROC 4 0.05 1.52 0.79 97.72
35 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 97.24
36 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 97.12
37 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 97.12
38 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69 97.12
39 INT27710 Binding of B2m 5 0.36 3.54 0.53 96.88
40 INT80071 Binding of SLMAP 1 0.37 0.29 0.29 96.60
41 INT121677 Gene_expression of Srms 6 0.59 3.15 1.61 96.16
42 INT6507 Binding of C5 23 0.48 15.35 3.91 96.08
43 INT131066 Binding of C6 4 0.31 1.81 0.86 96.08
44 INT79140 Binding of HCC 36 0.31 46.96 1.87 96.04
45 INT112010 Localization of Sla 1 0.59 0.1 0.1 95.84
46 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 95.76
47 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 95.76
48 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 95.76
49 INT221764 Regulation of TSKU 1 0.14 0.51 0.24 95.68
50 INT178903 Gene_expression of SNRPF 1 0.42 6.73 3.94 95.48
51 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26 95.28
52 INT66926 Transcription of Il1b 15 0.69 13.16 7.81 95.28
53 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 94.48
54 INT9950 Gene_expression of OTOR 11 0.65 10.05 2.23 94.24
55 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 94.08
56 INT10357 Binding of Syncrip 8 0.37 8.95 8.07 94.00
57 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 93.84
58 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 93.84
59 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 93.56
60 INT673 Positive_regulation of B2m 24 0.68 24.24 4.82 93.52
61 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86 93.44
62 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 92.84
63 INT58904 Localization of TH1L 40 0.68 27.11 10.52 91.76
64 INT28097 Negative_regulation of Wbc1 8 0.11 4.07 0.53 91.16
65 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 91.12
66 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 90.76
67 INT136415 Localization of GHS 6 0.70 3.83 0.49 90.76
68 INT146917 Localization of Slmap 4 0.80 1.56 0.42 90.56
69 INT38066 Binding of MSC 14 0.41 5.28 4.12 90.40
70 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 90.12
71 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 89.88
72 INT9440 Binding of MSMB 4 0.38 3.66 2.61 89.68
73 INT195616 Binding of ROM1 4 0.23 1.61 0.9 89.56
74 INT140175 Regulation of Kit 23 0.62 8.59 1.79 88.32
75 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 88.00
76 INT35743 Regulation of tk 4 0.25 2.39 1.39 87.96
77 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09 87.48
78 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 86.56
79 INT272612 Negative_regulation of Gene_expression of Sis 1 0.24 0.62 0.17 86.56
80 INT58160 Positive_regulation of TRIM27 1 0.45 0.98 0.09 86.48
81 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 85.96
82 INT25962 Gene_expression of COX8A 25 0.75 20.04 2.62 85.96
83 INT272613 Gene_expression of Sis 7 0.58 3.48 1.36 84.76
84 INT84799 Binding of Mskt1 1 0.00 1.41 1.21 84.16
85 INT106227 Binding of STK11 3 0.42 3.13 0.13 83.40
86 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 83.32
87 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 83.08
88 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 83.04
89 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 82.96
90 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 81.28
91 INT172109 Gene_expression of SLC26A3 4 0.53 2.28 0.23 81.20
92 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 81.16
93 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 81.16
94 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11 80.72
95 INT144356 Gene_expression of GHS 4 0.57 10.76 2.21 80.56
96 INT2544 Localization of PTH 39 0.81 30.55 2.22 79.84
97 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 77.52
98 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 77.52
99 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 77.44
100 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 77.44
101 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 77.32
102 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 77.04
103 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 76.96
104 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 75.80
105 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 75.80
106 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 75.80
107 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 75.80
108 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 75.80
109 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 75.80
110 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 75.60
111 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 75.00
112 INT44619 Negative_regulation of Msln 1 0.14 1.09 0.71 75.00
113 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 74.32
114 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 73.64
115 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 73.60
116 INT76612 Binding of Srms 3 0.42 1.1 1.87 73.12
117 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 72.80
118 INT2774 Binding of Crp 241 0.48 195.89 44.39 71.96
119 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 71.60
120 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 70.20
121 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 68.76
122 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 68.64
123 INT293883 Positive_regulation of SLA 1 0.25 0.34 0.07 68.64
124 INT167150 Binding of Eri1 2 0.45 0.16 0 67.28
125 INT135382 Transcription of CHGA 1 0.67 1.11 0.07 66.76
126 INT135381 Transcription of NCAM1 1 0.25 1.11 0.07 66.76
127 INT135380 Transcription of SYP 1 0.67 1.11 0.07 66.76
128 INT15044 Localization of Nts 30 0.75 4.58 13.72 66.56
129 INT38561 Regulation of SEMG1 19 0.51 3.75 3.66 66.56
130 INT41727 Negative_regulation of Localization of Nts 3 0.39 1.48 3.15 66.56
131 INT55801 Regulation of Positive_regulation of Got1 3 0.08 2.08 0.33 66.40
132 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 66.32
133 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 66.24
134 INT31340 Positive_regulation of Gene_expression of Got1 20 0.46 10.5 3.17 66.24
135 INT55802 Regulation of Gene_expression of Got1 2 0.14 1.23 0.22 66.24
136 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 66.20
137 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64 65.84
138 INT92398 Negative_regulation of Localization of Nfkb1 17 0.42 11.24 5.4 65.84
139 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 65.76
140 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 65.60
141 INT14572 Binding of INS 205 0.48 175.43 13.38 65.48
142 INT7909 Positive_regulation of Positive_regulation of Got1 8 0.49 6.44 3.06 64.96
143 INT162666 Gene_expression of ST3 5 0.67 5.66 1.73 64.88
144 INT165840 Gene_expression of GSTZ1 3 0.37 2.71 0.41 64.44
145 INT23105 Gene_expression of MS4A1 5 0.75 5.17 0.95 64.32
146 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 64.24
147 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 63.00
148 INT425 Localization of PRL 455 0.81 189.64 144.8 62.96
149 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 62.16
150 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 62.16
151 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 62.16
152 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 62.16
153 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 62.16
154 INT70297 Gene_expression of NEFH 12 0.75 4.85 2.33 62.16
155 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 62.16
156 INT36200 Gene_expression of S100A1 9 0.77 9.56 0.75 62.16
157 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 61.44
158 INT110810 Positive_regulation of Gene_expression of Mmp1 9 0.52 4.2 5.11 61.44
159 INT110076 Regulation of C6 2 0.22 1.14 0.96 61.24
160 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 60.96
161 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 59.52
162 INT162726 Localization of RCT 12 0.58 4.53 1.66 59.12
163 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 59.00
164 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 57.40
165 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 57.00
166 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08 57.00
167 INT219079 Gene_expression of WBP1L 2 0.04 1.93 0.68 56.96
168 INT196064 Binding of Mtnr1a 1 0.03 0.06 0.09 56.48
169 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 55.88
170 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 55.44
171 INT10694 Binding of Bche 19 0.48 8.03 4.85 55.44
172 INT250980 Negative_regulation of FMOD 2 0.14 2.67 2.31 55.12
173 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 54.88
174 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 54.72
175 INT196060 Positive_regulation of Muted 2 0.07 0.85 0.83 53.84
176 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 53.68
177 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 53.12
178 INT154821 Negative_regulation of MOS 1 0.41 1.29 0.28 53.12
179 INT39415 Gene_expression of HBN1 33 0.43 19.31 0.93 50.80
180 INT139812 Gene_expression of Sh3gl3 1 0.09 0.05 0 50.72
181 INT1120 Gene_expression of C3 33 0.67 22.86 7.56 50.36
182 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 50.00
183 INT10706 Regulation of Il6 150 0.62 93.23 62.34 50.00
184 INT1030 Localization of Lbp 52 0.74 38.92 24.91 50.00
185 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 50.00
186 INT71603 Regulation of Srms 7 0.24 0.93 2.34 50.00
187 INT93944 Regulation of FCER2 3 0.40 0.8 0.36 50.00
188 INT240681 Positive_regulation of AVPR2 3 0.41 0.87 0.29 50.00
189 INT260093 Gene_expression of Prom1 1 0.25 0.05 0.05 50.00
190 INT260092 Positive_regulation of Srm 1 0.18 0 0 50.00
191 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 49.64
192 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 49.32
193 INT45448 Gene_expression of Vom1r68 9 0.03 1.94 1.5 48.88
194 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 48.16
195 INT253864 Negative_regulation of PNP 13 0.26 6.84 6.67 47.04
196 INT214530 Positive_regulation of Mup1 7 0.58 5.5 3.74 46.92
197 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 46.00
198 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 45.60
199 INT333441 Binding of Amt 1 0.24 0 0 45.12
200 INT266250 Gene_expression of Lhb 28 0.64 10.75 4.66 44.64
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