D:Sialadenitis

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Disease Term
Synonyms Sialadenitides, Sialitides, SIALITIS
Documents 69
Hot Single Events 31
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sialadenitis. They are ordered first by their relevance to Sialadenitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 99.24
2 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 93.96
3 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
4 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
5 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
6 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
7 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
8 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 5.00
9 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
10 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
11 INT236955 Binding of Cxcr5 and Cxcl13 1 0.28 2.26 0.34 5.00
12 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15 5.00
13 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 5.00
14 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 5.00
15 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
16 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
17 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
18 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
19 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
20 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
21 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
22 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
23 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
24 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
25 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
26 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
27 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
28 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
29 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
30 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
31 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
32 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
33 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
34 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 5.00
35 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 5.00
36 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 5.00
37 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
38 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
39 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
40 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 5.00
41 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 5.00
42 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 5.00
43 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 5.00
44 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 5.00
45 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 5.00
46 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 5.00
47 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 5.00
48 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 5.00
49 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 5.00
50 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
51 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 5.00
52 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sialadenitis. They are ordered first by their pain relevance and then by number of times they were reported in Sialadenitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT88138 Regulation of Ssial1 1 0.00 0.74 0.14 100.00
2 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 99.84
3 INT108479 Positive_regulation of CCL21 18 0.67 19.93 10.76 99.84
4 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 99.70
5 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 99.64
6 INT120062 Binding of AIP 4 0.42 28.86 3.91 99.38
7 INT1129 Binding of Car2 69 0.35 14.01 9.2 99.30
8 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 99.24
9 INT121801 Binding of Aip 18 0.36 24.1 5.26 99.24
10 INT182224 Binding of CCL21 6 0.34 5.91 2.54 99.02
11 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 98.70
12 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 97.88
13 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 96.86
14 INT158410 Negative_regulation of Pdcd1 2 0.37 3.73 0.33 96.86
15 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06 96.56
16 INT354867 Positive_regulation of Gene_expression of Klk13 1 0.38 1.72 0.07 94.20
17 INT354869 Gene_expression of Klk13 1 0.42 1.72 0.07 94.20
18 INT287797 Phosphorylation of AIP 1 0.78 2.04 0.16 93.52
19 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 91.44
20 INT158409 Gene_expression of T2DM 3 0.65 9.58 0.56 91.32
21 INT158408 Gene_expression of Idd3 1 0.60 2.68 0.28 91.32
22 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 90.44
23 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 90.24
24 INT287795 Localization of FAM190B 1 0.05 2.71 0.33 87.52
25 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23 86.36
26 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 86.32
27 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 86.00
28 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 84.08
29 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 82.80
30 INT272794 Positive_regulation of Positive_regulation of IGHG3 3 0.04 2.84 0.17 82.08
31 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 81.20
32 INT354868 Regulation of Cacna1s 1 0.03 2.02 0.37 78.04
33 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 77.68
34 INT49985 Transcription of Il6 62 0.72 40.13 20.29 77.68
35 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 77.68
36 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 75.92
37 INT239218 Positive_regulation of Cacna1s 2 0.04 2.21 0.1 71.56
38 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 71.48
39 INT62872 Gene_expression of Igh 2 0.14 4.05 0.4 70.12
40 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19 63.04
41 INT287798 Localization of AIP 1 0.63 5.96 1.31 62.40
42 INT121422 Gene_expression of BIRC3 7 0.75 6.24 0.96 60.16
43 INT44600 Gene_expression of MALT1 6 0.75 6.14 0.42 58.72
44 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 50.32
45 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 50.32
46 INT287796 Regulation of Positive_regulation of IGHG3 1 0.02 1.19 0.03 50.32
47 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97 48.96
48 INT287800 Positive_regulation of Positive_regulation of AIP 1 0.42 2.15 0.3 48.96
49 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 48.80
50 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 47.92
51 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 47.16
52 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 46.88
53 INT22075 Positive_regulation of Gene_expression of IFNA2 7 0.64 4.7 1.45 46.88
54 INT239221 Negative_regulation of Cacna1s 4 0.04 2.24 0.07 46.00
55 INT354866 Regulation of Xltr1 1 0.02 1.75 0.16 37.76
56 INT236956 Gene_expression of PDZD2 6 0.53 6.13 1.8 36.88
57 INT276323 Binding of Igh 1 0.07 0.84 0 35.04
58 INT276324 Binding of Zap70 1 0.06 0.85 0 35.04
59 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 34.72
60 INT135729 Gene_expression of Zap70 5 0.75 6.86 0.75 33.72
61 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 29.80
62 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46 21.60
63 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 21.52
64 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31 18.72
65 INT354861 Negative_regulation of Gene_expression of Trove2 1 0.41 1.4 0.04 18.72
66 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96 17.52
67 INT226028 Gene_expression of Trove2 4 0.65 9.97 0.54 16.16
68 INT276311 Gene_expression of Irf4 6 0.64 4.95 0.37 14.88
69 INT326369 Gene_expression of Cntn2 2 0.25 1.34 0.2 10.72
70 INT315025 Gene_expression of Cacna1s 3 0.48 2.3 0.18 10.32
71 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54 6.96
72 INT169765 Gene_expression of Mir16-1 6 0.63 3.21 2.47 6.92
73 INT217168 Gene_expression of MIR21 30 0.55 30.86 0.62 6.60
74 INT276358 Gene_expression of MIR150 42 0.74 38.44 7.82 6.12
75 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
76 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
77 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
78 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
79 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
80 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
81 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
82 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
83 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
84 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
85 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
86 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
87 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
88 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
89 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
90 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
91 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
92 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
93 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
94 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
95 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
96 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
97 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
98 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 5.00
99 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
100 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
101 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
102 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
103 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
104 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
105 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
106 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
107 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
108 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
109 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
110 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
111 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
112 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
113 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
114 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
115 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
116 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
117 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
118 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
119 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
120 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
121 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
122 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
123 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
124 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
125 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
126 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
127 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
128 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
129 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
130 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
131 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
132 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
133 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 5.00
134 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 5.00
135 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
136 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
137 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
138 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
139 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
140 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
141 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 5.00
142 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
143 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
144 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
145 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
146 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 5.00
147 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 5.00
148 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
149 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 5.00
150 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
151 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
152 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
153 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
154 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
155 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 5.00
156 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
157 INT34358 Binding of MME 13 0.37 7.25 5.14 5.00
158 INT2065 Binding of BTG3 15 0.36 10.9 4.65 5.00
159 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6 5.00
160 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39 5.00
161 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
162 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
163 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
164 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 5.00
165 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
166 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
167 INT181347 Gene_expression of Cxcl13 9 0.63 9.08 3.75 5.00
168 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
169 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 5.00
170 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62 5.00
171 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62 5.00
172 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 5.00
173 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
174 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
175 INT78190 Gene_expression of Tnc 10 0.75 21.23 2.91 5.00
176 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
177 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
178 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51 5.00
179 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46 5.00
180 INT100399 Gene_expression of CCL17 22 0.77 9.38 2.43 5.00
181 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32 5.00
182 INT26434 Localization of MME 17 0.81 8.67 2.3 5.00
183 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
184 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 5.00
185 INT175388 Localization of Ugcg 22 0.37 13.84 2.24 5.00
186 INT220178 Positive_regulation of Cxcl13 5 0.42 5.98 2.21 5.00
187 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
188 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18 5.00
189 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
190 INT236959 Localization of PDZD2 7 0.16 5.77 2.1 5.00
191 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 5.00
192 INT236951 Gene_expression of Cxcr5 5 0.66 6.2 2.04 5.00
193 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 5.00
194 INT106604 Protein_catabolism of CIB1 4 0.90 1.24 1.98 5.00
195 INT119018 Gene_expression of TREH 22 0.65 12.44 1.95 5.00
196 INT101432 Positive_regulation of Gene_expression of Atp9a 13 0.10 7.86 1.95 5.00
197 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 5.00
198 INT46142 Gene_expression of Chka 18 0.19 16.4 1.84 5.00
199 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 5.00
200 INT99234 Binding of FCGR2A 1 0.01 1.77 1.68 5.00
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