D:Sialorrhea

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Disease Term
Synonyms DROOLING, Hypersalivation
Documents 190
Hot Single Events 16
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sialorrhea. They are ordered first by their relevance to Sialorrhea and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT318920 Binding of XIAP and COMMD1 1 0.12 0.78 0 11.48
2 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 5.00
3 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
4 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 5.00
5 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
6 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
7 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
8 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
9 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
10 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 5.00
11 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
12 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 5.00
13 INT307627 Binding of BMP1 and CSF2 1 0.01 0.33 0.12 5.00
14 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09 5.00
15 INT325295 Binding of SGCA and C14orf166 1 0.04 0.54 0.08 5.00
16 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07 5.00
17 INT218240 Binding of SAE1 and Dync1h1 1 0.00 0.17 0 5.00
18 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 5.00
19 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 5.00
20 INT318922 XIAP Regulation of COMMD1 1 0.09 0.37 0 5.00
21 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
22 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 5.00
23 INT318919 Binding of ATP7B and COMMD1 1 0.37 0.76 0 5.00
24 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sialorrhea. They are ordered first by their pain relevance and then by number of times they were reported in Sialorrhea. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34707 Binding of Nkx6-2 2 0.42 0.45 0.5 97.08
2 INT21932 Negative_regulation of NMS 2 0.37 1.96 0.4 97.08
3 INT2513 Binding of Napa 80 0.42 4.29 6.51 96.12
4 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 95.28
5 INT264637 Localization of CLDN4 3 0.73 0.85 0.29 94.28
6 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 93.52
7 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 93.52
8 INT264629 Localization of Rac1 8 0.72 5.7 0.79 93.40
9 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 93.16
10 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 91.56
11 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 89.68
12 INT23724 Regulation of Nkx6-2 3 0.45 0.48 0.41 85.96
13 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 84.56
14 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 83.52
15 INT398 Localization of AGT 45 0.78 16.97 11.54 81.36
16 INT218247 Gene_expression of Cardf1 3 0.65 2.37 0.24 80.16
17 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 79.76
18 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 79.76
19 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 78.24
20 INT232667 Binding of Pd 17 0.16 20.76 3.58 78.00
21 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 77.04
22 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 77.04
23 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 76.64
24 INT27627 Binding of Rac1 41 0.41 22.88 13.68 73.04
25 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 72.56
26 INT38285 Positive_regulation of SCLY 8 0.36 3.32 3.96 71.12
27 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 69.12
28 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 68.88
29 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 68.88
30 INT72218 Regulation of METTL3 5 0.08 1.62 1.14 68.56
31 INT14091 Binding of Vsig2 8 0.42 3.21 3.91 68.08
32 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 67.12
33 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 66.60
34 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 64.08
35 INT19071 Localization of Ache 66 0.81 5.1 16.27 58.96
36 INT38201 Negative_regulation of Localization of Ache 8 0.59 2.35 1.82 58.96
37 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73 58.96
38 INT181636 Positive_regulation of Gene_expression of BMP1 2 0.44 4.46 0.68 58.24
39 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 54.32
40 INT301479 Positive_regulation of Gene_expression of Vsig2 2 0.32 2.78 0.08 54.04
41 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 53.56
42 INT307632 Regulation of Binding of BMP1 1 0.34 1.53 0.12 52.16
43 INT307631 Positive_regulation of Binding of BMP1 1 0.38 2.99 0.24 51.84
44 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 51.44
45 INT307634 Binding of BMP1 1 0.36 3.12 3.26 51.44
46 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 50.16
47 INT264580 Binding of Grhl2 1 0.05 0.35 0.08 49.52
48 INT72219 Gene_expression of METTL3 45 0.24 9.58 7.61 48.24
49 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 47.84
50 INT3578 Negative_regulation of TPR 7 0.42 4.18 2.41 46.96
51 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 45.52
52 INT177632 Regulation of P4hb 1 0.01 0.14 0 44.92
53 INT177631 Regulation of Ppl 1 0.11 0.33 0 44.92
54 INT307630 Negative_regulation of Localization of BMP1 1 0.32 1.41 0.21 44.48
55 INT307635 Positive_regulation of Localization of BMP1 1 0.38 1.35 0.36 43.60
56 INT282596 Localization of BMP1 2 0.61 4.04 1.97 43.36
57 INT165328 Positive_regulation of Nkx6-2 1 0.21 0.09 0.31 41.48
58 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 41.44
59 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73 40.40
60 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 39.84
61 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 39.20
62 INT18390 Positive_regulation of Positive_regulation of GYPA 2 0.40 1.42 0.39 39.20
63 INT3364 Binding of SGCG 87 0.47 31.93 17.24 31.92
64 INT115329 Gene_expression of HM13 1 0.38 0.67 0.16 29.20
65 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 28.92
66 INT148266 Positive_regulation of SNCA 5 0.67 3.17 1.74 17.76
67 INT318926 Protein_catabolism of XIAP 1 0.19 1.58 0 13.64
68 INT47615 Negative_regulation of DNASE1 9 0.58 3.62 1.74 9.76
69 INT268410 Positive_regulation of MKS1 1 0.03 0 0 9.60
70 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
71 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
72 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
73 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
74 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
75 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
76 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
77 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
78 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
79 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
80 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
81 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
82 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
83 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
84 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
85 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
86 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
87 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
88 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
89 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
90 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
91 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
92 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
93 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
94 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
95 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
96 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
97 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
98 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
99 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
100 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
101 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
102 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
103 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
104 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
105 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
106 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
107 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
108 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
109 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
110 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
111 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
112 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
113 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
114 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
115 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
116 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
117 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
118 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 5.00
119 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
120 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
121 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
122 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
123 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
124 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
125 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
126 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
127 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
128 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
129 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
130 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
131 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
132 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
133 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
134 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
135 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
136 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 5.00
137 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
138 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
139 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
140 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
141 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
142 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
143 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
144 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
145 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
146 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
147 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
148 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
149 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
150 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
151 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
152 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
153 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
154 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
155 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 5.00
156 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
157 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
158 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
159 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
160 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
161 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
162 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
163 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
164 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
165 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
166 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
167 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
168 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
169 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
170 INT49774 Binding of DRD2 48 0.48 17.42 20.73 5.00
171 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
172 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
173 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
174 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
175 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
176 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
177 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
178 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
179 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
180 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
181 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
182 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
183 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
184 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
185 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
186 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
187 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 5.00
188 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
189 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
190 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
191 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
192 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
193 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
194 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 5.00
195 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
196 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
197 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
198 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
199 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
200 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
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