D:Sicca Syndrome

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Disease Term
Synonyms Keratoconjunctivitis Sicca, Rose Bengal Solution, SCHIRMER TEST, SICCA COMPLEX, Sjogren S Syndrome, Sjogren Syndrome, Sjogrens Syndrome, SYNDROME SICCA, Syndrome Sjogren S
Documents 61
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sicca Syndrome. They are ordered first by their relevance to Sicca Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215461 Binding of MLL and TNFSF13B 1 0.01 1.62 0.1 47.28
2 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43 31.08
3 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43 31.08
4 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43 31.08
5 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43 29.52
6 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
7 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
8 INT273774 Binding of GPER and RB1 1 0.01 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sicca Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Sicca Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 100.00
2 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.84
3 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 99.84
4 INT205189 Gene_expression of TBCE 12 0.25 9.67 1.19 99.80
5 INT12339 Localization of IL8 437 0.81 251.87 117.39 99.76
6 INT12082 Localization of IL6 365 0.81 241.78 105.78 99.76
7 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 99.76
8 INT72565 Localization of IL1RN 45 0.80 23.59 13.17 99.76
9 INT311593 Localization of Cx3cl1 3 0.49 1.99 1.69 99.76
10 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 99.64
11 INT36386 Positive_regulation of Gene_expression of FUT4 3 0.45 2.32 0.38 99.32
12 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 99.28
13 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 98.72
14 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 98.72
15 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.72
16 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.72
17 INT24278 Gene_expression of FUT4 33 0.75 26.7 4.29 98.40
18 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 98.04
19 INT10834 Binding of IL8 65 0.48 41.66 16.53 97.72
20 INT315710 Localization of lg 7 0.32 1.72 0.6 96.60
21 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 96.56
22 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 96.56
23 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 95.12
24 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 95.00
25 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 92.64
26 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 91.72
27 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 91.04
28 INT11506 Binding of MUC16 20 0.48 22.89 1.03 87.64
29 INT347547 Negative_regulation of SCNN1A 1 0.48 0.38 0.35 87.56
30 INT756 Gene_expression of C3 138 0.75 100.6 19.2 85.12
31 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 84.44
32 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 82.96
33 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 82.24
34 INT219482 Negative_regulation of WARS 7 0.35 6.92 0 78.32
35 INT315708 Positive_regulation of lg 1 0.10 0.91 0.3 77.32
36 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 77.20
37 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 76.60
38 INT35541 Transcription of MUC16 3 0.69 6.44 0.65 74.12
39 INT347544 Phosphorylation of SCNN1A 1 0.76 0.16 1.54 68.64
40 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 65.44
41 INT215469 Positive_regulation of TNFSF13B 9 0.43 7.14 0.7 64.16
42 INT238522 Localization of ATG9A 1 0.54 3.68 0.27 63.92
43 INT238521 Positive_regulation of Localization of ATG9A 1 0.34 1.91 0.16 63.92
44 INT259507 Regulation of Bcr 1 0.26 0.38 0 63.52
45 INT45209 Positive_regulation of PLA2G2A 37 0.69 33.21 9.02 63.40
46 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 62.20
47 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 62.04
48 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 60.88
49 INT340828 Regulation of ADCY10 1 0.06 5.17 0.11 60.44
50 INT262352 Localization of Lgsn 3 0.60 1.49 0.6 58.88
51 INT278547 Gene_expression of SCNN1A 2 0.73 0.14 2.41 58.00
52 INT347549 Negative_regulation of Gene_expression of SCNN1A 1 0.40 0.14 1.07 58.00
53 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96 57.72
54 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 56.88
55 INT6852 Localization of TNF 883 0.81 705.95 270.84 56.40
56 INT9660 Regulation of TNF 363 0.62 312.94 139.99 56.40
57 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 55.76
58 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 55.28
59 INT95550 Negative_regulation of Positive_regulation of ALB 4 0.42 1.16 0.57 55.28
60 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 55.00
61 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 55.00
62 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 55.00
63 INT238524 Localization of MGS 1 0.44 1.59 0.05 54.64
64 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83 53.88
65 INT94190 Positive_regulation of ADCY10 5 0.49 3.17 0.58 46.60
66 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 46.56
67 INT347546 Binding of SCNN1A 1 0.30 0.07 2.94 45.68
68 INT7127 Positive_regulation of Gene_expression of PLA2G2A 16 0.69 17.11 2.63 41.76
69 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 34.32
70 INT3414 Positive_regulation of Negative_regulation of Alb 4 0.44 1.91 1.09 33.68
71 INT238525 Binding of ATG9A 1 0.33 1.51 0.12 33.24
72 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 32.88
73 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 32.88
74 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 32.88
75 INT161960 Regulation of lg 5 0.26 1.18 2.84 32.20
76 INT315711 Regulation of Localization of lg 1 0.11 0.25 0.04 32.20
77 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 31.76
78 INT315705 Transcription of lg 1 0.14 0.25 0 31.36
79 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 27.80
80 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 27.80
81 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 27.80
82 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 27.80
83 INT311592 Positive_regulation of Cx3cl1 2 0.67 1.93 1.01 27.80
84 INT49802 Localization of MUC1 75 0.81 44.74 8.87 24.48
85 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 24.48
86 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 24.48
87 INT257448 Negative_regulation of Localization of MUC5AC 2 0.35 2.57 0 24.48
88 INT158601 Negative_regulation of lg 2 0.12 0.37 0.12 24.20
89 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81 22.52
90 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 21.84
91 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21 21.68
92 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 21.20
93 INT311604 Gene_expression of AATF 3 0.06 2.9 0.55 19.04
94 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 13.04
95 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87 12.68
96 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 10.80
97 INT125821 Regulation of Positive_regulation of IGHE 6 0.40 5.38 0.53 10.24
98 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 10.04
99 INT15852 Positive_regulation of PSS 7 0.40 4.6 0.67 6.60
100 INT227699 Gene_expression of ATG9A 3 0.46 1.95 0.25 5.76
101 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
102 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
103 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
104 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
105 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
106 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
107 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
108 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
109 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
110 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
111 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
112 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
113 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
114 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
115 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
116 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
117 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
118 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
119 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
120 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
121 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
122 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
123 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
124 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
125 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
126 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
127 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
128 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 5.00
129 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
130 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
131 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 5.00
132 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
133 INT5904 Localization of MPO 62 0.81 36.37 14.64 5.00
134 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
135 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 5.00
136 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
137 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
138 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
139 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 5.00
140 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 5.00
141 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
142 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
143 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
144 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 5.00
145 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
146 INT37227 Regulation of EGF 19 0.45 11.16 5.17 5.00
147 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 5.00
148 INT92234 Regulation of CXCL10 15 0.42 8.37 5.09 5.00
149 INT7130 Localization of PLA2G2A 32 0.80 20.4 5.05 5.00
150 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44 5.00
151 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
152 INT11230 Regulation of MUC16 23 0.60 19.54 3.93 5.00
153 INT148085 Binding of CXCL10 14 0.32 10.22 3.81 5.00
154 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 5.00
155 INT4907 Gene_expression of MUC7 10 0.67 1.69 3.55 5.00
156 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 5.00
157 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
158 INT84020 Positive_regulation of RNASE3 17 0.47 11.92 2.92 5.00
159 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
160 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 5.00
161 INT157461 Binding of CX3CR1 3 0.36 6.72 2.67 5.00
162 INT144168 Gene_expression of CCL1 7 0.13 5.69 2.45 5.00
163 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
164 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
165 INT54615 Gene_expression of GPER 25 0.75 8.23 2.27 5.00
166 INT98132 Regulation of FAS 16 0.42 20.57 2.06 5.00
167 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 5.00
168 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91 5.00
169 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 5.00
170 INT190480 Positive_regulation of Localization of Ros1 11 0.34 8.29 1.81 5.00
171 INT33845 Binding of GPER 20 0.36 5.61 1.81 5.00
172 INT150223 Regulation of Gene_expression of TNFSF13B 2 0.21 3.44 1.8 5.00
173 INT184241 Regulation of Localization of Il4 4 0.15 3.89 1.58 5.00
174 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 5.00
175 INT63905 Regulation of RB1 13 0.62 12.67 1.28 5.00
176 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 5.00
177 INT11887 Localization of MUC16 16 0.80 10.66 1.26 5.00
178 INT184239 Regulation of Localization of Il13 2 0.14 3.24 1.2 5.00
179 INT291359 Binding of Cx3cl1 2 0.36 2.31 1.13 5.00
180 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08 5.00
181 INT311605 Positive_regulation of AATF 5 0.06 6.72 1.05 5.00
182 INT347548 Transcription of SCNN1A 1 0.67 0.13 0.97 5.00
183 INT149687 Positive_regulation of PRG2 3 0.39 2.19 0.87 5.00
184 INT19637 Localization of TF 14 0.73 5.74 0.86 5.00
185 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 5.00
186 INT46295 Regulation of Negative_regulation of ELANE 4 0.39 2.34 0.76 5.00
187 INT205188 Positive_regulation of Gene_expression of TBCE 5 0.19 2.14 0.74 5.00
188 INT87199 Negative_regulation of PSS 9 0.50 5.66 0.68 5.00
189 INT257447 Binding of TBCE 4 0.08 4.68 0.66 5.00
190 INT11889 Regulation of Gene_expression of MUC16 5 0.62 3.24 0.63 5.00
191 INT36313 Localization of ADCY10 3 0.73 1.74 0.62 5.00
192 INT20557 Localization of MUC7 6 0.42 0.43 0.59 5.00
193 INT290711 Binding of Sp3 1 0.05 0.1 0.58 5.00
194 INT311602 Positive_regulation of Binding of CXCL10 1 0.38 2.79 0.57 5.00
195 INT290710 Positive_regulation of Sp3 1 0.07 0.44 0.54 5.00
196 INT347545 Localization of SCNN1A 1 0.61 0 0.44 5.00
197 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 5.00
198 INT311594 Regulation of Cx3cl1 1 0.19 0.3 0.43 5.00
199 INT172996 Gene_expression of MUC2 14 0.69 11.01 0.42 5.00
200 INT347536 Regulation of Localization of Il5 1 0.22 1.44 0.42 5.00
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