D:Sickle Cell Trait

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pChart

Disease Term
Synonyms CELL TRAIT SICKLE, Cell Traits Sickle, Sickle Cell Traits, Trait Sickle Cell, Traits Sickle Cell
Documents 88
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sickle Cell Trait. They are ordered first by their relevance to Sickle Cell Trait and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215432 Binding of IGHG3 and MSMB 1 0.01 0.96 0 25.00
2 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
3 INT318329 Binding of HBA1 and HBB 1 0.02 1 0 5.00
4 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sickle Cell Trait. They are ordered first by their pain relevance and then by number of times they were reported in Sickle Cell Trait. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2367 Binding of Sct 34 0.42 8.46 8.62 100.00
2 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 99.80
3 INT156307 Gene_expression of Xpr1 2 0.23 1.28 0.22 98.52
4 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 97.36
5 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 97.08
6 INT352039 Regulation of Gene_expression of HBS1L 1 0.13 0.94 0 96.32
7 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 95.16
8 INT3915 Gene_expression of SCD 25 0.57 13.94 6 94.00
9 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 93.68
10 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 85.52
11 INT26464 Localization of DNAH8 15 0.80 4.3 1.33 76.60
12 INT189272 Binding of KRT122P 3 0.36 1.77 0.16 73.92
13 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 73.12
14 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 70.68
15 INT121335 Localization of SCD 10 0.68 6.81 1.51 68.96
16 INT206698 Regulation of HBS1L 4 0.09 3.06 0 67.16
17 INT40084 Binding of HBS1L 8 0.36 9.15 0.69 65.92
18 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 64.08
19 INT189275 Transcription of G6PD 1 0.68 0.06 0 60.88
20 INT240787 Positive_regulation of Bcl2a1c 12 0.22 9.79 0.06 59.56
21 INT43385 Gene_expression of C6 5 0.58 2.49 0.15 41.84
22 INT105131 Gene_expression of KRT122P 8 0.58 9.1 0.7 40.40
23 INT69485 Regulation of Bcl2a1c 14 0.34 9.99 0.13 34.20
24 INT179997 Transcription of CANT1 1 0.29 0 0 29.52
25 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 26.88
26 INT179996 Binding of CANT1 1 0.36 0 0 26.16
27 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 25.00
28 INT4103 Regulation of G6PD 6 0.60 0.78 0.82 21.48
29 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
30 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
31 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
32 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
33 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
34 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
35 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
36 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
37 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
38 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
39 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
40 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
41 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
42 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
43 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
44 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
45 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
46 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
47 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
48 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
49 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
50 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
51 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
52 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
53 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
54 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
55 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
56 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
57 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
58 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
59 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
60 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 5.00
61 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
62 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
63 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
64 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
65 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 5.00
66 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
67 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
68 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 5.00
69 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
70 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
71 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
72 INT1539 Positive_regulation of MSMB 22 0.69 9.42 4.62 5.00
73 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
74 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
75 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
76 INT3854 Binding of SCD 16 0.41 11.14 3.7 5.00
77 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3 5.00
78 INT156522 Gene_expression of NAPEPLD 11 0.75 4.25 2.87 5.00
79 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
80 INT142626 Negative_regulation of Localization of ALB 9 0.55 6.63 2.24 5.00
81 INT191534 Negative_regulation of EGFL7 10 0.06 7.52 1.98 5.00
82 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85 5.00
83 INT39513 Positive_regulation of TRAP 14 0.48 5.11 1.67 5.00
84 INT133885 Binding of SCN2A 7 0.47 1.27 1.54 5.00
85 INT93350 Binding of Lepr 17 0.05 27.21 1.5 5.00
86 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 5.00
87 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 5.00
88 INT41893 Negative_regulation of HBS1L 16 0.23 8.98 1.19 5.00
89 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 5.00
90 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05 5.00
91 INT152503 Binding of CR1 3 0.45 8.64 1.03 5.00
92 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 5.00
93 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 5.00
94 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 5.00
95 INT49846 Localization of HBS1L 4 0.24 1.31 0.86 5.00
96 INT207421 Positive_regulation of Gene_expression of GPT 9 0.49 5.62 0.83 5.00
97 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8 5.00
98 INT93559 Gene_expression of Thbd 13 0.75 6.58 0.8 5.00
99 INT44079 Regulation of HBA1 3 0.12 0.98 0.62 5.00
100 INT94826 Positive_regulation of HBS1L 13 0.40 4.62 0.61 5.00
101 INT69486 Negative_regulation of Bcl2a1c 34 0.10 19.03 0.6 5.00
102 INT47030 Negative_regulation of ARMC9 22 0.38 13.08 0.47 5.00
103 INT11118 Gene_expression of RAPGEF5 13 0.65 9.35 0.43 5.00
104 INT184203 Regulation of SPAM1 2 0.17 1.43 0.39 5.00
105 INT214119 Regulation of Lepr 2 0.23 3.17 0.23 5.00
106 INT118575 Positive_regulation of G6PD 9 0.50 3.35 0.18 5.00
107 INT310071 Gene_expression of PMCH 2 0.53 0.51 0.17 5.00
108 INT195213 Positive_regulation of Gene_expression of HBS1L 4 0.15 3.5 0.16 5.00
109 INT240786 Binding of Bcl2a1c 10 0.18 9.47 0.12 5.00
110 INT206658 Negative_regulation of NAPEPLD 2 0.04 2.18 0.1 5.00
111 INT213406 Positive_regulation of XPO1 5 0.27 1.19 0.08 5.00
112 INT242910 Positive_regulation of Positive_regulation of Bcl2a1c 2 0.05 2.24 0.06 5.00
113 INT206657 Positive_regulation of NAPEPLD 4 0.07 1.05 0.05 5.00
114 INT245877 Binding of HBA1 2 0.11 2.59 0.04 5.00
115 INT176521 Positive_regulation of Lepr 8 0.07 6.6 0.03 5.00
116 INT352042 Negative_regulation of Gene_expression of HBS1L 1 0.13 0.76 0 5.00
117 INT191729 Negative_regulation of Gene_expression of CR1 2 0.40 2.26 0 5.00
118 INT290862 Regulation of Regulation of Lepr 1 0.00 1 0 5.00
119 INT352041 Regulation of HBA2 1 0.37 0.8 0 5.00
120 INT298220 Negative_regulation of Negative_regulation of SUGT1 1 0.01 0.94 0 5.00
121 INT189276 Positive_regulation of HBB 1 0.42 0 0 5.00
122 INT290870 Negative_regulation of MNT 1 0.05 1.61 0 5.00
123 INT215433 Gene_expression of Fcgr2b 1 0.58 0 0 5.00
124 INT290871 Positive_regulation of MNT 1 0.06 1.05 0 5.00
125 INT207238 Binding of HBB 4 0.36 1.13 0 5.00
126 INT318334 Localization of HBA1 1 0.23 0.21 0 5.00
127 INT124988 Regulation of Gene_expression of Thbd 2 0.26 0.55 0 5.00
128 INT352038 Regulation of Gene_expression of SCN2A 1 0.19 1.39 0 5.00
129 INT207245 Regulation of Gene_expression of HBM 3 0.36 0.86 0 5.00
130 INT124987 Regulation of Thbd 2 0.38 1.29 0 5.00
131 INT290869 Gene_expression of MNT 1 0.10 3.16 0 5.00
132 INT352040 Transcription of SCN2A 1 0.29 1.31 0 5.00
133 INT290866 Localization of MNT 1 0.11 0.6 0 5.00
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