D:Sideroblastic Anemia

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Disease Term
Synonyms ANEMIAS SIDEROBLASTIC, SIDEROBLASTIC ANEMIAS
Documents 15
Hot Single Events 26
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sideroblastic Anemia. They are ordered first by their relevance to Sideroblastic Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0 96.04
2 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0 60.24
3 INT315538 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.14 0 51.52
4 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0 44.72
5 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0 38.64
6 INT315534 Binding of ACO1 and ERN1 1 0.01 0.18 0 38.64
7 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 5.00
8 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
9 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
10 INT187897 Pgp Positive_regulation of Mod2 1 0.11 0.51 0.04 5.00
11 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
12 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
13 INT187899 Binding of Pgp and Mir486 1 0.00 0.25 0 5.00
14 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0 5.00
15 INT187898 Negative_regulation of Binding of Pgp and Mir486 1 0.01 0.25 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sideroblastic Anemia. They are ordered first by their pain relevance and then by number of times they were reported in Sideroblastic Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21 100.00
2 INT4436 Gene_expression of ABCB7 7 0.65 9.26 0.93 100.00
3 INT315560 Gene_expression of SLC19A2 1 0.55 1.32 0 100.00
4 INT315586 Gene_expression of SLC25A38 1 0.52 0.51 0 100.00
5 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0 99.98
6 INT315603 Positive_regulation of Gene_expression of SLC19A2 1 0.41 0.48 0 99.56
7 INT174848 Gene_expression of ISCU 2 0.59 2.79 0.08 99.24
8 INT94423 Binding of ALAS2 4 0.32 2.1 0.61 99.20
9 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32 99.20
10 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 98.58
11 INT115264 Binding of FECH 9 0.41 7.93 1.1 96.04
12 INT315605 Binding of ABCB7 1 0.33 1.84 0 96.04
13 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 95.20
14 INT315552 Negative_regulation of GLRX5 1 0.38 2.17 0 92.36
15 INT315553 Positive_regulation of GLRX5 1 0.44 0.68 0 89.96
16 INT315562 Gene_expression of GLRX5 1 0.69 4.92 0 89.44
17 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 89.36
18 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0 87.12
19 INT315556 Positive_regulation of Binding of ALAS2 1 0.43 1.05 0 86.84
20 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05 86.16
21 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 85.44
22 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 85.44
23 INT315621 Gene_expression of CIAO1 1 0.34 4.11 0 85.28
24 INT315587 Positive_regulation of Gene_expression of CIAO1 1 0.22 1.6 0 85.28
25 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 84.04
26 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26 83.08
27 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 78.92
28 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 78.00
29 INT315550 Transcription of GLRX5 1 0.53 0.66 0 75.32
30 INT192918 Negative_regulation of HAMP 3 0.57 2.29 0.09 74.72
31 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 74.04
32 INT115663 Regulation of Gene_expression of ABCB6 1 0.44 1.2 0.21 72.56
33 INT310513 Gene_expression of Twsg1 1 0.17 3.97 0.28 72.20
34 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 72.04
35 INT187894 Positive_regulation of Gene_expression of ABCB6 5 0.19 1.97 0.03 72.04
36 INT243268 Gene_expression of SLC40A1 6 0.60 4.18 0.13 70.88
37 INT315617 Positive_regulation of Gene_expression of SLC25A37 1 0.10 0.39 0 70.80
38 INT315607 Positive_regulation of Gene_expression of GLRX5 1 0.61 2.28 0 70.56
39 INT315618 Gene_expression of SLC25A37 1 0.14 0.38 0 69.68
40 INT315559 Negative_regulation of CIAO1 1 0.19 2.53 0 68.32
41 INT315572 Positive_regulation of ACO1 1 0.20 0.94 0 66.80
42 INT187880 Binding of Abcg1 3 0.33 2.07 0.1 65.44
43 INT315561 Regulation of ISCU 2 0.35 1.1 0 62.08
44 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74 61.80
45 INT315576 Positive_regulation of Binding of CIAO1 1 0.22 0.67 0 61.24
46 INT315589 Binding of CIAO1 1 0.16 0.67 0 60.72
47 INT315567 Positive_regulation of Negative_regulation of CIAO1 1 0.22 1.29 0 60.64
48 INT279349 Localization of IDUA 7 0.76 4.97 0.07 60.20
49 INT315613 Positive_regulation of WNT2 1 0.09 0.41 0 58.76
50 INT315604 Negative_regulation of Positive_regulation of WNT2 1 0.08 0.41 0 58.76
51 INT315592 Positive_regulation of Gene_expression of SLC40A1 1 0.41 3.52 0 58.56
52 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 57.72
53 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08 56.36
54 INT315565 Negative_regulation of Gene_expression of SLC40A1 1 0.25 1.73 0 51.52
55 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0 50.16
56 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 49.92
57 INT310522 Regulation of Transcription of HAMP 1 0.60 1.36 0.05 49.92
58 INT310527 Gene_expression of MDFIC 1 0.05 1.87 0.29 48.40
59 INT315588 Regulation of ACO1 1 0.18 0.57 0 47.60
60 INT125586 Gene_expression of Stmn1 13 0.75 8.28 0.42 44.00
61 INT235362 Gene_expression of SNORA73A 8 0.75 4.09 0 44.00
62 INT170629 Negative_regulation of Gene_expression of ABCB7 2 0.37 1.32 0.17 41.56
63 INT315636 Negative_regulation of ABCB7 1 0.38 0.17 0 41.56
64 INT315581 Positive_regulation of Phosphorylation of ISCU 1 0.44 0.33 0 41.20
65 INT315629 Phosphorylation of ISCU 1 0.71 0.33 0 41.20
66 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 39.52
67 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 39.52
68 INT74442 Binding of ATRX 2 0.41 3.2 0.09 39.52
69 INT315644 Negative_regulation of Transcription of DLEU1 1 0.21 0.64 0 39.24
70 INT315590 Negative_regulation of Transcription of CIAO1 1 0.19 0.33 0 39.24
71 INT315610 Transcription of DLEU1 1 0.25 0.64 0 38.88
72 INT315569 Transcription of CIAO1 1 0.30 0.33 0 38.88
73 INT315634 Negative_regulation of Binding of ISCU 1 0.33 0.28 0 38.64
74 INT174850 Binding of ISCU 2 0.33 0.51 0 38.64
75 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0 36.96
76 INT315637 Transcription of FXN 1 0.40 1.44 0 36.96
77 INT166958 Gene_expression of LYRM4 4 0.18 2.9 0.27 33.12
78 INT315549 Negative_regulation of Binding of WNT2 1 0.08 0.65 0 32.64
79 INT315579 Binding of WNT2 1 0.07 0.65 0 32.64
80 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 32.60
81 INT315591 Negative_regulation of Positive_regulation of SLC40A1 1 0.25 0.46 0 32.08
82 INT220783 Gene_expression of Tert 39 0.77 12.55 1.49 31.84
83 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04 30.32
84 INT199648 Regulation of Fxn 1 0.29 2.14 0.04 30.32
85 INT199646 Transcription of Fxn 2 0.67 4.78 0.08 29.64
86 INT315580 Negative_regulation of Localization of SLC40A1 1 0.25 0.64 0 28.80
87 INT315558 Negative_regulation of SLC40A1 1 0.25 0.63 0 28.80
88 INT315575 Transcription of SLC40A1 1 0.40 0.85 0 28.40
89 INT315593 Regulation of Transcription of SLC40A1 1 0.26 1.7 0 28.40
90 INT315620 Regulation of Gene_expression of GLRX5 1 0.40 0.5 0 28.04
91 INT315623 Positive_regulation of Localization of ACO1 1 0.20 0.79 0 27.84
92 INT315616 Positive_regulation of Gene_expression of ACO1 1 0.20 0.79 0 27.84
93 INT95756 Gene_expression of ACO1 3 0.27 2.49 0.1 27.44
94 INT315574 Localization of ACO1 1 0.30 0.79 0 27.44
95 INT296387 Localization of SLC40A1 2 0.44 0.94 0 27.28
96 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 26.48
97 INT302084 Negative_regulation of WNT2 2 0.09 0.83 1.26 25.84
98 INT302086 Gene_expression of WNT2 3 0.14 0.97 0.38 25.84
99 INT315606 Regulation of Gene_expression of WNT2 1 0.08 0.84 0 25.84
100 INT315585 Localization of SLC25A37 1 0.13 0.47 0 24.64
101 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 17.76
102 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 17.36
103 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 17.24
104 INT315631 Protein_catabolism of IREB2 1 0.44 0.4 0 15.68
105 INT315632 Positive_regulation of Protein_catabolism of IREB2 1 0.22 0.4 0 15.68
106 INT315568 Regulation of Gene_expression of CIAO1 1 0.20 0.15 0 14.80
107 INT187883 Gene_expression of Mod2 8 0.18 4.59 0.15 13.60
108 INT187884 Positive_regulation of Gene_expression of Mod2 3 0.12 1.31 0 13.60
109 INT252722 Binding of IREB2 2 0.16 1.31 0 11.92
110 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 10.00
111 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 8.08
112 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 7.68
113 INT131139 Binding of ACO1 3 0.27 1.81 0.1 6.56
114 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
115 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
116 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
117 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
118 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
119 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 5.00
120 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
121 INT1556 Regulation of Dnahc8 20 0.61 3.23 14.44 5.00
122 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
123 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
124 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
125 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 5.00
126 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
127 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
128 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
129 INT3915 Gene_expression of SCD 25 0.57 13.94 6 5.00
130 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 5.00
131 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
132 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 5.00
133 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
134 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
135 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 5.00
136 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
137 INT10146 Negative_regulation of Vwf 27 0.40 17.11 3.69 5.00
138 INT137702 Binding of TTN 7 0.35 4.48 3.62 5.00
139 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
140 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
141 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
142 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 5.00
143 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 5.00
144 INT93936 Gene_expression of Pgp 10 0.59 3.43 3.04 5.00
145 INT45503 Binding of EPO 42 0.48 24.85 2.88 5.00
146 INT81578 Gene_expression of TRAP 25 0.72 9.75 2.82 5.00
147 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
148 INT40315 Gene_expression of Abcc1 10 0.76 5.66 2.53 5.00
149 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39 5.00
150 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34 5.00
151 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
152 INT9188 Localization of HBG1 12 0.75 8.14 2.24 5.00
153 INT67139 Negative_regulation of Mod2 7 0.34 3.17 1.98 5.00
154 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
155 INT187888 Binding of Pgp 5 0.32 0.4 1.35 5.00
156 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 5.00
157 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
158 INT164325 Negative_regulation of Abcg2 6 0.39 1.88 1.2 5.00
159 INT76890 Gene_expression of FGFR2 42 0.65 13.91 1.08 5.00
160 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 5.00
161 INT15310 Gene_expression of DLEU1 8 0.67 20.57 0.96 5.00
162 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 5.00
163 INT296385 Binding of IDUA 12 0.39 20.73 0.93 5.00
164 INT135261 Positive_regulation of Pgp 2 0.68 0.18 0.89 5.00
165 INT94563 Gene_expression of H2-Q10 7 0.42 7 0.88 5.00
166 INT19950 Gene_expression of Abo 13 0.16 4.72 0.84 5.00
167 INT133323 Positive_regulation of Mod2 8 0.13 5.55 0.72 5.00
168 INT158136 Binding of FGFR2 9 0.26 4.5 0.63 5.00
169 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 5.00
170 INT194794 Binding of TTPA 7 0.08 2.56 0.57 5.00
171 INT84826 Negative_regulation of ACD 6 0.50 4.02 0.55 5.00
172 INT310529 Positive_regulation of MDFIC 1 0.05 6.21 0.52 5.00
173 INT4597 Regulation of SCD 5 0.39 2.25 0.5 5.00
174 INT220787 Localization of Tert 5 0.69 0.87 0.49 5.00
175 INT82177 Negative_regulation of H2-Q10 5 0.58 5.83 0.45 5.00
176 INT139827 Negative_regulation of ABCB6 5 0.57 2.91 0.43 5.00
177 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 5.00
178 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41 5.00
179 INT50530 Binding of MDFIC 2 0.17 1.88 0.38 5.00
180 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 5.00
181 INT187889 Positive_regulation of Gene_expression of Pgp 1 0.52 0.83 0.35 5.00
182 INT247999 Negative_regulation of FXYD1 2 0.06 1.75 0.35 5.00
183 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31 5.00
184 INT310530 Positive_regulation of Gene_expression of HAMP 3 0.49 4.16 0.28 5.00
185 INT220770 Binding of Tert 7 0.37 1.09 0.27 5.00
186 INT220785 Positive_regulation of Tert 15 0.68 6.9 0.25 5.00
187 INT187887 Regulation of Pgp 1 0.30 0.33 0.24 5.00
188 INT221496 Localization of ISCA1 4 0.73 2.12 0.23 5.00
189 INT187885 Regulation of Gm2677 1 0.00 0.38 0.21 5.00
190 INT84244 Positive_regulation of Gene_expression of IDUA 5 0.70 3.75 0.19 5.00
191 INT236980 Gene_expression of ISCA1 9 0.53 2.43 0.19 5.00
192 INT310528 Negative_regulation of Positive_regulation of HRASLS 1 0.01 1.6 0.18 5.00
193 INT308962 Regulation of SLC7A7 3 0.16 1.2 0.18 5.00
194 INT199644 Positive_regulation of Gene_expression of H2-Q10 3 0.37 2.6 0.15 5.00
195 INT156610 Negative_regulation of HBB 2 0.37 1.25 0.15 5.00
196 INT310523 Localization of MDFIC 1 0.05 0.83 0.14 5.00
197 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14 5.00
198 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14 5.00
199 INT205991 Negative_regulation of SLC7A7 9 0.41 1.81 0.12 5.00
200 INT247998 Negative_regulation of SNORA73A 2 0.41 0.85 0.12 5.00
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