D:Sjoegrens Syndrome

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Disease Term
Synonyms Dacryosialoadenopathy Syndrome, GOUGEROUT SJOEGREN SYNDROME, Sicca, Sicca Syndrome, Sjoegren S Syndrome, Sjoegrens, Sjogren S, Sjogren S Disease, Sjogren S Syndrome, Sjogren Syndrome, Sjogrens Syndrome
Documents 165
Hot Single Events 75
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sjoegrens Syndrome. They are ordered first by their relevance to Sjoegrens Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT328626 Binding of TBCE and MUC16 1 0.15 0.79 0 100.00
2 INT328627 Binding of LGALS3 and MUC16 1 0.04 0.73 0 92.08
3 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 85.32
4 INT61824 Binding of SERPINH1 and CRP 1 0.24 0.63 0.08 35.20
5 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 31.20
6 INT181994 Binding of Mmp9 and ELOVL1 1 0.00 0.57 0 28.64
7 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
8 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
9 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
10 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
11 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
12 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
13 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7 5.00
14 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
15 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 5.00
16 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 5.00
17 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
18 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 5.00
19 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 5.00
20 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
21 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12 5.00
22 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 5.00
23 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
24 INT215461 Binding of MLL and TNFSF13B 1 0.01 1.62 0.1 5.00
25 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 5.00
26 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
27 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09 5.00
28 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08 5.00
29 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
30 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
31 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
32 INT315945 IgG Positive_regulation of Gene_expression of Ighm 1 0.13 0.56 0.04 5.00
33 INT315943 Ighm Positive_regulation of Gene_expression of IgG 1 0.13 0.56 0.04 5.00
34 INT345281 Binding of CASP1 and Nlrp3 1 0.02 0.31 0.03 5.00
35 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
36 INT345282 Binding of CASP1 and Pycard 1 0.01 0.3 0.03 5.00
37 INT260127 Binding of CD4 and Trav6-3 1 0.03 0 0 5.00
38 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 5.00
39 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0 5.00
40 INT345283 Binding of Ads1 and BDNF-AS 1 0.00 0.26 0 5.00
41 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 5.00
42 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
43 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0 5.00
44 INT260128 Binding of ISG20 and Trav6-3 1 0.01 0 0 5.00
45 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0 5.00
46 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 5.00
47 INT315942 Binding of Tlr4 and Lvs 1 0.08 0.78 0 5.00
48 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
49 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 5.00
50 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 5.00
51 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sjoegrens Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Sjoegrens Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205189 Gene_expression of TBCE 12 0.25 9.67 1.19 100.00
2 INT205188 Positive_regulation of Gene_expression of TBCE 5 0.19 2.14 0.74 100.00
3 INT257447 Binding of TBCE 4 0.08 4.68 0.66 100.00
4 INT328633 Transcription of GPER 2 0.06 2.57 0.54 100.00
5 INT328631 Transcription of TBCE 1 0.20 0.81 0 100.00
6 INT157772 Gene_expression of ASF1B 3 0.07 2.78 0.49 100.00
7 INT257449 Regulation of Gene_expression of TBCE 1 0.09 0.85 0 100.00
8 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 99.88
9 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 99.86
10 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 99.68
11 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 99.64
12 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 99.56
13 INT238521 Positive_regulation of Localization of ATG9A 1 0.34 1.91 0.16 99.54
14 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 99.48
15 INT35541 Transcription of MUC16 3 0.69 6.44 0.65 99.48
16 INT11889 Regulation of Gene_expression of MUC16 5 0.62 3.24 0.63 99.48
17 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 99.36
18 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 99.32
19 INT328632 Regulation of Gene_expression of MUC5AC 1 0.25 2.46 0 99.32
20 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 99.16
21 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 99.16
22 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 99.08
23 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 99.08
24 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 99.06
25 INT129756 Regulation of MUC5AC 7 0.34 6.45 0.7 99.04
26 INT11506 Binding of MUC16 20 0.48 22.89 1.03 98.96
27 INT232067 Gene_expression of RNPC3 6 0.65 0.95 0.2 98.76
28 INT296947 Binding of ISM1 1 0.15 4.54 0.46 98.68
29 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 98.62
30 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 98.56
31 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 98.54
32 INT260114 Regulation of ISG20 5 0.37 4.98 1.27 98.52
33 INT9473 Binding of MUC1 66 0.48 46.77 2.36 98.36
34 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 98.36
35 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 97.80
36 INT182667 Binding of DLAT 11 0.31 40.75 2.8 96.96
37 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 96.92
38 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.30
39 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 95.88
40 INT121800 Positive_regulation of Gene_expression of Arigg4 7 0.31 10.86 2.02 95.88
41 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 95.60
42 INT238522 Localization of ATG9A 1 0.54 3.68 0.27 95.00
43 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 94.84
44 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 94.84
45 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69 94.84
46 INT15799 Positive_regulation of ISG20 18 0.38 9.78 2.01 94.68
47 INT210199 Negative_regulation of Positive_regulation of ISG20 2 0.15 2.52 0.2 94.68
48 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 94.48
49 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 94.20
50 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 93.64
51 INT49802 Localization of MUC1 75 0.81 44.74 8.87 93.32
52 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 93.20
53 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 92.32
54 INT207475 Binding of LGALS3 6 0.34 2.48 0.57 92.08
55 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 91.68
56 INT257448 Negative_regulation of Localization of MUC5AC 2 0.35 2.57 0 91.04
57 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 91.04
58 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61 90.68
59 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 90.24
60 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 90.08
61 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 88.16
62 INT52227 Gene_expression of CD9 11 0.75 6.23 3.71 88.16
63 INT14026 Positive_regulation of Igh-6 24 0.68 10.84 4.32 87.32
64 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 86.64
65 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48 86.12
66 INT64982 Positive_regulation of Ifnb1 10 0.48 6.16 2.35 86.00
67 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 85.76
68 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 85.28
69 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 85.28
70 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 85.12
71 INT15802 Positive_regulation of Gene_expression of ISG20 16 0.42 8.16 4.03 85.12
72 INT2774 Binding of Crp 241 0.48 195.89 44.39 83.52
73 INT227699 Gene_expression of ATG9A 3 0.46 1.95 0.25 82.12
74 INT15870 Regulation of PSS 6 0.25 3.22 0.85 81.48
75 INT24741 Positive_regulation of Rf 16 0.17 18.23 4.75 80.56
76 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 80.00
77 INT121801 Binding of Aip 18 0.36 24.1 5.26 79.96
78 INT571 Negative_regulation of C2 9 0.43 3.93 1.54 79.00
79 INT283509 Regulation of Binding of DLAT 1 0.29 1.99 0.23 78.88
80 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 78.32
81 INT168599 Phosphorylation of Mmp9 2 0.71 1.09 1.73 76.88
82 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 74.40
83 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 73.24
84 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 72.36
85 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 72.24
86 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 71.60
87 INT144179 Localization of Aip 4 0.61 2.59 0.33 70.96
88 INT356136 Negative_regulation of Localization of Aip 1 0.08 0.88 0.23 70.96
89 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 70.44
90 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 70.24
91 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 70.12
92 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 70.00
93 INT146622 Binding of Snrpg 1 0.18 0.07 0 69.12
94 INT149838 Binding of TSHB 5 0.14 3.27 1.1 68.28
95 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 68.24
96 INT135273 Negative_regulation of Tcrb 3 0.05 2.71 0.14 67.96
97 INT227402 Positive_regulation of Negative_regulation of Trbv26 1 0.49 2.04 0.11 67.96
98 INT227404 Negative_regulation of Trbv26 1 0.41 2.03 0.11 67.96
99 INT227403 Positive_regulation of Negative_regulation of Tcrb 1 0.06 2.04 0.11 67.96
100 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 66.44
101 INT146623 Positive_regulation of Snrpg 2 0.24 0.37 0.03 65.80
102 INT260120 Regulation of Gene_expression of FOXP3 4 0.31 2.74 0.29 64.72
103 INT16404 Regulation of CD4 54 0.61 33.05 10.29 64.72
104 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 64.64
105 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 64.56
106 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 64.28
107 INT18680 Positive_regulation of Gene_expression of Sst 4 0.45 1.94 1.41 64.28
108 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 64.00
109 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71 64.00
110 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 63.60
111 INT215464 Positive_regulation of Transcription of Aqp5 1 0.45 0.42 0.13 62.44
112 INT215463 Regulation of Aqp5 1 0.44 0.42 0.13 62.44
113 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 62.32
114 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 61.92
115 INT215465 Transcription of Aqp5 1 0.52 0.42 0.13 61.88
116 INT11230 Regulation of MUC16 23 0.60 19.54 3.93 61.76
117 INT219108 Negative_regulation of Gene_expression of MUC5AC 11 0.31 9.74 1.08 61.04
118 INT158829 Negative_regulation of FAS 5 0.41 4.12 0.48 60.24
119 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 59.72
120 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 59.44
121 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 58.32
122 INT356135 Positive_regulation of Binding of Aip 1 0.09 0.81 0.24 57.20
123 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 57.16
124 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 57.00
125 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 56.44
126 INT114157 Positive_regulation of CTD 7 0.24 6.94 1.82 54.16
127 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 54.00
128 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 53.64
129 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72 52.32
130 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 52.08
131 INT154449 Positive_regulation of Gene_expression of Aip 2 0.43 2.88 0.52 52.08
132 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 49.20
133 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 49.20
134 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 46.24
135 INT227417 Protein_catabolism of DLAT 1 0.44 1.51 0.27 46.16
136 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 33.20
137 INT36569 Positive_regulation of IGSF11 1 0.03 0.6 0 31.44
138 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 31.28
139 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 31.24
140 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 30.96
141 INT309245 Binding of SETX 1 0.08 1.98 0.06 30.68
142 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 30.64
143 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54 27.20
144 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 25.76
145 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 25.32
146 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 23.76
147 INT15852 Positive_regulation of PSS 7 0.40 4.6 0.67 22.92
148 INT148087 Positive_regulation of RTEL1 9 0.17 5.13 0.41 21.24
149 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 21.16
150 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06 19.56
151 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 18.88
152 INT226818 Negative_regulation of RTEL1 1 0.06 1.17 0.41 18.40
153 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 18.16
154 INT16287 Positive_regulation of NOVA2 25 0.49 6.62 3.01 14.56
155 INT89290 Regulation of MUC1 19 0.45 10.4 0.81 12.64
156 INT67133 Gene_expression of Gusb 14 0.75 18.57 1.37 12.16
157 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 10.80
158 INT204175 Localization of Mri1 12 0.60 2.73 2.35 9.20
159 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 5.96
160 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
161 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
162 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
163 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
164 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
165 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
166 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
167 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
168 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
169 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
170 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
171 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
172 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
173 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
174 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
175 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
176 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
177 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
178 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
179 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
180 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
181 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
182 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
183 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
184 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
185 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
186 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
187 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
188 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
189 INT2463 Localization of CCK 101 0.81 37.54 47.59 5.00
190 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
191 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
192 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
193 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
194 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
195 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
196 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
197 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
198 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
199 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
200 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
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