D:Skeletal Muscle Toxicity

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Disease Term
Synonyms SKELETAL MUSCLE DISEASE, TYPE 1 MUSCLE TOXICITIES, TYPE 1 MUSCLE TOXICITY
Documents 15
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skeletal Muscle Toxicity. They are ordered first by their relevance to Skeletal Muscle Toxicity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT211308 Binding of Cd4 and Cd8a 3 0.19 0.3 0.31 5.00
2 INT329850 APOA5 Negative_regulation of Transcription of APOC3 1 0.24 0.85 0.15 5.00
3 INT329847 PPARA Regulation of Gene_expression of CREB3L3 1 0.17 0.84 0.13 5.00
4 INT329897 PPARA Regulation of Cpt2 1 0.09 0.05 0.07 5.00
5 INT329849 PPARA Regulation of AGXT 1 0.03 0.06 0.04 5.00
6 INT329848 PPARA Regulation of Localization of AGXT 1 0.03 0.06 0.04 5.00
7 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
8 INT329898 MIRLET7C Regulation of Myc 1 0.49 0.62 0 5.00
9 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0 5.00
10 INT265501 Binding of SGCB and SGCD 1 0.00 1.41 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skeletal Muscle Toxicity. They are ordered first by their pain relevance and then by number of times they were reported in Skeletal Muscle Toxicity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT114495 Gene_expression of SGCD 9 0.62 3.64 0.98 89.60
2 INT305646 Protein_catabolism of Lmna 1 0.57 0.2 0 86.00
3 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 84.56
4 INT57763 Gene_expression of Lmna 25 0.78 7.11 4.6 81.80
5 INT282620 Positive_regulation of Gene_expression of Lmna 2 0.61 1.08 0.41 81.80
6 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 80.36
7 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 75.00
8 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 75.00
9 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 74.64
10 INT173159 Localization of PPARA 96 0.74 64.55 10.26 66.48
11 INT186727 Negative_regulation of Localization of PPARA 4 0.35 4.56 0.69 66.48
12 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 60.96
13 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 60.44
14 INT216110 Binding of AAVS1 13 0.36 3.24 0.3 51.60
15 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 44.52
16 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 34.32
17 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 29.52
18 INT151441 Positive_regulation of Gene_expression of Trav6-3 22 0.65 10.21 3.05 28.32
19 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 24.00
20 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
21 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
22 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
23 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
24 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
25 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
26 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
27 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
28 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
29 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
30 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
31 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
32 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
33 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
34 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
35 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
36 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
37 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
38 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
39 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 5.00
40 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35 5.00
41 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02 5.00
42 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 5.00
43 INT66925 Positive_regulation of Gene_expression of Ik 22 0.15 10.47 6.4 5.00
44 INT3645 Positive_regulation of Grhpr 17 0.42 3.64 6.06 5.00
45 INT181194 Regulation of Gene_expression of PPARA 31 0.44 21.27 5.96 5.00
46 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
47 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82 5.00
48 INT86025 Positive_regulation of Positive_regulation of PPARA 34 0.52 22.89 5.74 5.00
49 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
50 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 5.00
51 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
52 INT36892 Positive_regulation of Trav6-3 57 0.68 12.15 3.8 5.00
53 INT114957 Positive_regulation of Transcription of PPARA 18 0.62 10.36 3.65 5.00
54 INT2936 Gene_expression of AGL 36 0.49 9.55 3.63 5.00
55 INT103926 Gene_expression of Cd69 37 0.68 16.76 3.58 5.00
56 INT73463 Positive_regulation of Gene_expression of TSC1 20 0.38 14.59 3.53 5.00
57 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33 5.00
58 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68 5.00
59 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61 5.00
60 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 5.00
61 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 5.00
62 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 5.00
63 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
64 INT105669 Positive_regulation of Gene_expression of AAVS1 20 0.49 9.02 2.06 5.00
65 INT35745 Negative_regulation of AGL 29 0.50 9.16 2.03 5.00
66 INT45723 Gene_expression of Grhpr 5 0.52 1.04 1.96 5.00
67 INT173180 Positive_regulation of Binding of PPARA 14 0.49 3.66 1.88 5.00
68 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
69 INT173198 Regulation of Binding of PPARA 17 0.43 9.58 1.47 5.00
70 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 5.00
71 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 5.00
72 INT92245 Negative_regulation of Fgg 13 0.06 9.68 1.35 5.00
73 INT33520 Negative_regulation of CYC1 11 0.57 5.36 1.26 5.00
74 INT135527 Negative_regulation of Gene_expression of Cd4 17 0.43 6.72 1.09 5.00
75 INT20470 Positive_regulation of Acsl1 5 0.40 3.76 1.03 5.00
76 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 5.00
77 INT182852 Regulation of AAVS1 4 0.12 4.6 1.03 5.00
78 INT231266 Gene_expression of Prh1 13 0.08 3.95 1.02 5.00
79 INT190418 Positive_regulation of AAVS1 15 0.49 4.71 0.98 5.00
80 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 5.00
81 INT122652 Regulation of B4GALNT1 5 0.11 1.76 0.88 5.00
82 INT190361 Protein_catabolism of PPARA 12 0.97 3.01 0.87 5.00
83 INT178183 Binding of Cd8a 16 0.32 7.8 0.85 5.00
84 INT173422 Gene_expression of ETFDH 11 0.45 5.78 0.78 5.00
85 INT204842 Positive_regulation of Cd44 9 0.49 6.6 0.77 5.00
86 INT128078 Gene_expression of Acaa1a 4 0.58 1.48 0.77 5.00
87 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 5.00
88 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7 5.00
89 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7 5.00
90 INT76902 Binding of AGL 3 0.02 2.23 0.64 5.00
91 INT3491 Negative_regulation of CPT2 8 0.57 4.32 0.62 5.00
92 INT5261 Localization of AGL 10 0.36 3.17 0.61 5.00
93 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 5.00
94 INT189574 Positive_regulation of PDK4 9 0.66 3.11 0.55 5.00
95 INT227274 Transcription of Ucp2 10 0.67 9.79 0.54 5.00
96 INT74630 Negative_regulation of ACADVL 8 0.58 2.49 0.53 5.00
97 INT239303 Positive_regulation of Gene_expression of Hdl1 8 0.36 12.46 0.53 5.00
98 INT96769 Positive_regulation of Gene_expression of Cpt1a 5 0.57 2.63 0.51 5.00
99 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51 5.00
100 INT181522 Positive_regulation of Gene_expression of Cd69 7 0.48 4.01 0.51 5.00
101 INT96768 Gene_expression of Cpt1a 8 0.64 3.73 0.48 5.00
102 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48 5.00
103 INT100822 Localization of Fas 8 0.74 6.13 0.48 5.00
104 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46 5.00
105 INT114494 Negative_regulation of Gene_expression of SGCD 2 0.32 0.22 0.44 5.00
106 INT211306 Localization of Trav6-3 6 0.21 1.79 0.43 5.00
107 INT329881 Positive_regulation of Transcription of Ucp2 6 0.57 4.49 0.41 5.00
108 INT329889 Positive_regulation of CYP8B1 1 0.41 0.47 0.37 5.00
109 INT252220 Positive_regulation of Cpt1a 2 0.34 0.43 0.25 5.00
110 INT151978 Negative_regulation of Positive_regulation of Cys1 3 0.41 4.15 0.24 5.00
111 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23 5.00
112 INT124714 Localization of PFKM 2 0.37 1.45 0.21 5.00
113 INT220112 Gene_expression of CREB3L3 2 0.26 1.89 0.21 5.00
114 INT256251 Regulation of Gene_expression of Hdl1 4 0.33 7.35 0.21 5.00
115 INT131864 Negative_regulation of Saa2 2 0.57 1.42 0.19 5.00
116 INT291123 Regulation of PDK4 4 0.43 0.3 0.18 5.00
117 INT312973 Binding of ACADVL 1 0.23 2.35 0.17 5.00
118 INT329893 Regulation of Positive_regulation of CYP8B1 1 0.37 0.18 0.16 5.00
119 INT171595 Negative_regulation of APOC3 3 0.43 1.99 0.15 5.00
120 INT171589 Transcription of APOC3 2 0.71 1.25 0.15 5.00
121 INT218167 Positive_regulation of Gene_expression of ETFDH 1 0.33 1.19 0.15 5.00
122 INT329882 Transcription of CREB3L3 1 0.23 0.81 0.13 5.00
123 INT170472 Negative_regulation of Gene_expression of THY1 4 0.41 0.26 0.1 5.00
124 INT161127 Localization of SLC22A16 2 0.73 1.34 0.1 5.00
125 INT112328 Negative_regulation of PHKG1 2 0.46 0.83 0.1 5.00
126 INT305648 Regulation of Lmna 1 0.39 0.16 0.09 5.00
127 INT305643 Positive_regulation of Negative_regulation of Sell 1 0.33 0.32 0.08 5.00
128 INT3492 Negative_regulation of CPT1A 2 0.39 0.24 0.08 5.00
129 INT305650 Positive_regulation of Gene_expression of Prh1 1 0.05 0 0.08 5.00
130 INT80667 Gene_expression of PFKM 4 0.57 2.13 0.07 5.00
131 INT153679 Regulation of AGL 4 0.04 1.49 0.07 5.00
132 INT329879 Gene_expression of Cpt2 1 0.27 0.05 0.07 5.00
133 INT329876 Localization of Cpt1a 1 0.48 0.06 0.07 5.00
134 INT329875 Positive_regulation of Gene_expression of Cpt2 1 0.20 0.05 0.07 5.00
135 INT305644 Negative_regulation of Gene_expression of Lmna 1 0.43 0.27 0.07 5.00
136 INT329890 Localization of ATE1 1 0.01 0.06 0.07 5.00
137 INT265505 Positive_regulation of Gene_expression of SGCD 1 0.13 0.86 0.05 5.00
138 INT329870 Gene_expression of Acaa2 1 0.25 0 0.04 5.00
139 INT329873 Gene_expression of Asl 1 0.26 0 0.04 5.00
140 INT329892 Positive_regulation of ACAA2 1 0.14 0 0.04 5.00
141 INT329885 Positive_regulation of Localization of AGXT 1 0.05 0.06 0.04 5.00
142 INT329891 Localization of AGXT 1 0.07 0.06 0.04 5.00
143 INT329884 Gene_expression of ACAA2 1 0.19 0 0.04 5.00
144 INT329880 Positive_regulation of Acaa2 1 0.18 0 0.04 5.00
145 INT329877 Gene_expression of Slc22a5 1 0.34 0 0.03 5.00
146 INT329871 Negative_regulation of Gene_expression of Grhpr 1 0.29 0.07 0.03 5.00
147 INT329872 Negative_regulation of Gene_expression of Bbox1 1 0.23 0 0.03 5.00
148 INT329878 Gene_expression of Bbox1 1 0.36 0 0.03 5.00
149 INT329874 Negative_regulation of Gene_expression of Slc22a5 1 0.21 0 0.03 5.00
150 INT265507 Negative_regulation of SGCD 1 0.12 0.68 0 5.00
151 INT312971 Negative_regulation of MLYCD 1 0.05 0 0 5.00
152 INT213647 Gene_expression of F9 10 0.65 6.48 0 5.00
153 INT312967 Positive_regulation of Binding of AGL 1 0.03 0.55 0 5.00
154 INT312966 Regulation of Gene_expression of AGL 1 0.03 0.27 0 5.00
155 INT312969 Negative_regulation of HLA-V 2 0.02 1.01 0 5.00
156 INT238840 Gene_expression of Pygm 2 0.65 1.9 0 5.00
157 INT298759 Regulation of ATP5A1 4 0.60 0.25 0 5.00
158 INT312970 Negative_regulation of ACSL1 1 0.01 0.56 0 5.00
159 INT312977 Positive_regulation of Negative_regulation of HLA-V 1 0.02 0.17 0 5.00
160 INT312974 Gene_expression of CPT2 1 0.47 0.94 0 5.00
161 INT312972 Regulation of HLA-V 1 0.01 0.14 0 5.00
162 INT240052 Negative_regulation of Gene_expression of F9 2 0.04 1.32 0 5.00
163 INT305649 Negative_regulation of Localization of Trav6-3 1 0.12 0.16 0 5.00
164 INT298758 Negative_regulation of ATP5A1 2 0.57 0.12 0 5.00
165 INT312976 Protein_catabolism of ACAT1 1 0.02 0.46 0 5.00
166 INT265506 Binding of F9 1 0.03 0.38 0 5.00
167 INT305647 Negative_regulation of Lmna 1 0.37 0.16 0 5.00
168 INT329894 Protein_catabolism of UBXN11 1 0.64 0 0 5.00
169 INT81028 Negative_regulation of F9 3 0.49 2.14 0 5.00
170 INT312975 Negative_regulation of MSMO1 1 0.01 0 0 5.00
171 INT312968 Gene_expression of ACADVL 1 0.36 0.45 0 5.00
172 INT312978 Negative_regulation of Pygm 1 0.42 0.95 0 5.00
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