D:Skin Abnormalities

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Disease Term
Synonyms Abnormalities Skin, Abnormality Skin, Skin Abnormality
Documents 41
Hot Single Events 14
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skin Abnormalities. They are ordered first by their relevance to Skin Abnormalities and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT352392 Binding of ENOSF1 and Recql4 1 0.02 6.62 0 87.44
2 INT220817 Tert Regulation of hl 1 0.01 0.96 0 72.08
3 INT220816 Tert Regulation of Myc 1 0.44 0.1 0 7.84
4 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0 7.12
5 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0 7.12
6 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
7 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 5.00
8 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 5.00
9 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
10 INT310412 Binding of CP and TF 1 0.14 1.66 0.13 5.00
11 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
12 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
13 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
14 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07 5.00
15 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07 5.00
16 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07 5.00
17 INT220812 Tert Positive_regulation of Gene_expression of hl 1 0.01 0.14 0.04 5.00
18 INT220811 Tert Positive_regulation of Gene_expression of Krt36 1 0.41 0.14 0.04 5.00
19 INT220808 Tert Positive_regulation of Gene_expression of Krt31 1 0.43 0.14 0.04 5.00
20 INT303557 Binding of Dysf and Fgf22 1 0.01 0.45 0.03 5.00
21 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
22 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03 5.00
23 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03 5.00
24 INT282503 Binding of ocd and Dlgap3 1 0.28 1.58 0.03 5.00
25 INT303559 Binding of Fgf7 and Dysf 1 0.01 0.44 0.03 5.00
26 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
27 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0 5.00
28 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
29 INT282507 Binding of Grik3 and ocd 1 0.25 0.61 0 5.00
30 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
31 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
32 INT215470 Binding of HLA-B and CRAMP1L 1 0.05 0.94 0 5.00
33 INT220819 Myc Regulation of Transcription of Tert 1 0.44 0.1 0 5.00
34 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
35 INT220813 Tert Positive_regulation of Terc 1 0.51 0.17 0 5.00
36 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
37 INT282502 Negative_regulation of Binding of ocd and Slc1a1 1 0.30 0.48 0 5.00
38 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0 5.00
39 INT220809 Tert Regulation of Regulation of Myc 1 0.32 0.25 0 5.00
40 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0 5.00
41 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0 5.00
42 INT220820 Binding of Myc and Tert 1 0.26 0.19 0 5.00
43 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skin Abnormalities. They are ordered first by their pain relevance and then by number of times they were reported in Skin Abnormalities. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66 94.96
2 INT149715 Negative_regulation of Amy1a 1 0.11 0.86 0.12 94.22
3 INT193156 Gene_expression of CRAMP1L 17 0.42 10.96 0.18 94.00
4 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 93.92
5 INT269961 Gene_expression of Hoxb8 3 0.69 14.28 3.91 92.92
6 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06 91.84
7 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03 91.84
8 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 91.20
9 INT303539 Binding of Fgfr1 3 0.45 0.96 0.2 90.72
10 INT303536 Localization of Fgfr1 1 0.70 0.28 0.03 90.72
11 INT282488 Negative_regulation of ocd 1 0.43 2.38 0.49 90.00
12 INT220767 Regulation of Tert 1 0.53 1 0.16 89.20
13 INT269960 Negative_regulation of Hoxb8 2 0.38 1.03 0.24 87.32
14 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 83.80
15 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75 79.92
16 INT199647 Regulation of Phyh 1 0.27 2.71 0 78.96
17 INT303538 Positive_regulation of Fgfr1 3 0.65 0.92 0.03 73.72
18 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0 73.72
19 INT193154 Regulation of CRAMP1L 5 0.28 3.04 0.34 69.84
20 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 69.76
21 INT303543 Gene_expression of Il1f8 1 0.42 3.28 1.43 69.76
22 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 68.24
23 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22 68.04
24 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33 68.04
25 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 65.92
26 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 65.92
27 INT77586 Positive_regulation of Gene_expression of HTR1A 6 0.46 3.54 1.51 65.92
28 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 65.80
29 INT148968 Gene_expression of Gpbar1 29 0.56 11.9 5.66 64.80
30 INT85677 Positive_regulation of Gpbar1 24 0.68 8.41 4.09 64.80
31 INT282485 Positive_regulation of Gene_expression of Gpbar1 1 0.17 0.94 0.24 64.80
32 INT181032 Gene_expression of Fgf7 8 0.61 5.96 1.41 64.40
33 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57 64.40
34 INT285494 Positive_regulation of Gene_expression of Fgf7 2 0.40 1.48 0.13 64.40
35 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03 64.40
36 INT178396 Positive_regulation of Fgf7 2 0.55 0.98 0.03 63.84
37 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03 63.48
38 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 60.88
39 INT303526 Gene_expression of Fgf22 1 0.47 1.2 0.04 60.88
40 INT220786 Negative_regulation of Tert 8 0.43 2.55 0.03 60.44
41 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 53.84
42 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 53.36
43 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 50.16
44 INT220785 Positive_regulation of Tert 15 0.68 6.9 0.25 33.60
45 INT181214 Negative_regulation of HLA-DQA2 4 0.03 1.46 0.08 29.04
46 INT15584 Binding of S100A12 14 0.48 15.14 3 27.60
47 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08 25.64
48 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42 25.60
49 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24 25.60
50 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08 24.64
51 INT76857 Transcription of HSPG2 6 0.60 5.07 0.23 22.68
52 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 18.64
53 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 13.44
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
55 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
56 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
57 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
58 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
59 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
60 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
61 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
62 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
63 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
64 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
65 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
66 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
67 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
68 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
69 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
70 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
71 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
72 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
73 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
74 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
75 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
76 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
77 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
78 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
79 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
80 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
81 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
82 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 5.00
83 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
84 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 5.00
85 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
86 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 5.00
87 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02 5.00
88 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
89 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
90 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
91 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
92 INT75742 Binding of RLS 86 0.42 95.27 19.04 5.00
93 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
94 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
95 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
96 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
97 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
98 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 5.00
99 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 5.00
100 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
101 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
102 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
103 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 5.00
104 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
105 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
106 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 5.00
107 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
108 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
109 INT152729 Negative_regulation of Gene_expression of S100a8 33 0.42 32.25 13.64 5.00
110 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
111 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
112 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
113 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
114 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
115 INT142735 Regulation of RLS 33 0.53 45.83 11.35 5.00
116 INT145875 Gene_expression of Grm2 28 0.58 6.81 10.19 5.00
117 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
118 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
119 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 5.00
120 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
121 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
122 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
123 INT146343 Regulation of Slc6a3 17 0.60 7.33 8.27 5.00
124 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
125 INT69460 Positive_regulation of Grm2 12 0.49 6.54 8.18 5.00
126 INT112104 Binding of Grin2b 21 0.44 6.78 8.16 5.00
127 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
128 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 5.00
129 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
130 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
131 INT132246 Negative_regulation of S100a8 19 0.43 22 7.25 5.00
132 INT101121 Regulation of Comt 19 0.53 10.66 7.22 5.00
133 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
134 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
135 INT3309 Binding of CP 25 0.47 17.87 6.62 5.00
136 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
137 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
138 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
139 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
140 INT53196 Binding of Cd4 44 0.47 27.28 5.85 5.00
141 INT65150 Gene_expression of Drb1 10 0.44 12.97 5.82 5.00
142 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 5.00
143 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
144 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
145 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
146 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
147 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
148 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
149 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 5.00
150 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76 5.00
151 INT181054 Positive_regulation of S100a9 14 0.56 9.83 4.6 5.00
152 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6 5.00
153 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
154 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
155 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16 5.00
156 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06 5.00
157 INT120810 Binding of Dlg4 38 0.41 3.55 4.03 5.00
158 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
159 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
160 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 5.00
161 INT185246 Gene_expression of Psmd1 26 0.50 8.89 3.73 5.00
162 INT172198 Protein_catabolism of Comt 7 0.88 2.78 3.6 5.00
163 INT206598 Regulation of Gene_expression of Comt 9 0.60 6 3.56 5.00
164 INT193281 Binding of CAP1 7 0.07 4.57 3.53 5.00
165 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 5.00
166 INT124579 Localization of BAX 35 0.78 30.31 3.43 5.00
167 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
168 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
169 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
170 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
171 INT198076 Gene_expression of Slc1a1 13 0.73 2.41 3.07 5.00
172 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
173 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91 5.00
174 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84 5.00
175 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
176 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
177 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
178 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
179 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
180 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
181 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
182 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
183 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
184 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
185 INT125771 Localization of CP 9 0.73 6.14 1.84 5.00
186 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 5.00
187 INT152894 Regulation of Positive_regulation of Mapk14 9 0.45 6.01 1.74 5.00
188 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
189 INT218827 Negative_regulation of Phosphorylation of Gria1 6 0.36 3.61 1.67 5.00
190 INT121513 Positive_regulation of A4GALT 21 0.63 16.06 1.59 5.00
191 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
192 INT82866 Localization of Atp9a 13 0.78 6.95 1.56 5.00
193 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
194 INT220783 Gene_expression of Tert 39 0.77 12.55 1.49 5.00
195 INT65515 Binding of ocd 7 0.36 6.62 1.48 5.00
196 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 5.00
197 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34 5.00
198 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
199 INT145874 Positive_regulation of Positive_regulation of Grm2 2 0.12 1.24 1.32 5.00
200 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3 5.00
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