D:Skin Allergy

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pChart

Disease Term
Synonyms ALLERGIC SKIN RASH, Atopic Dermatitides, Atopic Dermatitis, Atopic Eczema, Atopic Neurodermatitides, Atopic Neurodermatitis, CONTACT DERMATITIS, CUTANEOUS ALLERGY, Cutaneous Hypersensitivity, Dermatitides Atopic, Dermatitis Atopic
Documents 143
Hot Single Events 27
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skin Allergy. They are ordered first by their relevance to Skin Allergy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163799 Binding of GRIN1 and Rvm 1 0.16 0.96 1.13 99.00
2 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41 85.52
3 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82 84.72
4 INT161048 Nrm Positive_regulation of Prdm4 1 0.56 1.47 0.86 60.16
5 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13 5.00
6 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 5.00
7 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
8 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
9 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
10 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
11 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
12 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
13 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
14 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
15 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
16 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
17 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13 5.00
18 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05 5.00
19 INT278446 Binding of EGFR and EMR1 1 0.00 0.75 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skin Allergy. They are ordered first by their pain relevance and then by number of times they were reported in Skin Allergy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 99.84
2 INT335648 Localization of CTSS 1 0.08 1.39 0.41 99.36
3 INT161047 Negative_regulation of Positive_regulation of Nrm 1 0.37 1.24 0.78 99.24
4 INT85426 Transcription of CSPG4 1 0.23 1.03 0.3 99.12
5 INT74818 Transcription of KNG1 6 0.67 2.71 1.59 98.96
6 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53 98.30
7 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 98.28
8 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.28
9 INT50105 Localization of CTSB 29 0.78 10.98 5.21 98.28
10 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 97.92
11 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 97.68
12 INT108260 Positive_regulation of Par2 20 0.54 10.77 5.94 97.64
13 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 97.40
14 INT44745 Localization of Nrm 5 0.65 2.04 4.92 96.40
15 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 96.04
16 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 95.84
17 INT152074 Gene_expression of KLK7 2 0.71 29.66 2.01 92.60
18 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 89.88
19 INT98226 Negative_regulation of Cd79a 5 0.49 3.99 2.66 88.44
20 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 88.16
21 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57 87.56
22 INT193251 Binding of CYSLTR1 13 0.32 8.32 2.57 84.72
23 INT104990 Positive_regulation of Rapgef4 1 0.08 0.82 0.37 83.16
24 INT70049 Positive_regulation of Gene_expression of LTA 7 0.32 4.66 3.25 81.20
25 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77 81.00
26 INT104989 Positive_regulation of Negative_regulation of Prkaca 2 0.33 0.81 0.37 81.00
27 INT18990 Positive_regulation of GRP 32 0.70 5.22 11.23 80.40
28 INT8775 Binding of IGHE 167 0.48 102.61 23.54 77.12
29 INT109097 Positive_regulation of Gene_expression of GGT5 2 0.05 2.19 0.24 75.20
30 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 75.12
31 INT19044 Positive_regulation of GGT5 10 0.65 7.7 1.11 75.12
32 INT153097 Negative_regulation of LY75 1 0.32 1.33 0.69 75.00
33 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 75.00
34 INT84946 Gene_expression of GGT5 5 0.06 2.31 0.31 73.80
35 INT14497 Gene_expression of GRP 82 0.78 17.67 32.27 73.60
36 INT92935 Binding of GRPR 2 0.32 1.99 0.62 72.84
37 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 69.84
38 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 65.68
39 INT142682 Binding of EMR1 2 0.26 2.4 0.06 61.28
40 INT335647 Gene_expression of OSMR 1 0.48 2.78 0.72 60.24
41 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 57.60
42 INT7134 Localization of KNG1 127 0.79 65.73 67.97 57.36
43 INT701 Localization of IGHE 87 0.80 40.5 10.62 52.36
44 INT26217 Binding of Calca 22 0.48 5.22 12.57 52.32
45 INT6761 Binding of CALCA 100 0.48 26.71 62.05 51.88
46 INT15284 Positive_regulation of Lgals3 21 0.47 8.88 5.52 50.80
47 INT133331 Positive_regulation of Gene_expression of Lgals3 5 0.59 5.14 1.35 50.80
48 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 50.44
49 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 47.40
50 INT25263 Negative_regulation of Hrh1 11 0.58 3.35 4.61 46.08
51 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 45.88
52 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 37.56
53 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 30.20
54 INT425 Localization of PRL 455 0.81 189.64 144.8 29.84
55 INT212304 Regulation of Positive_regulation of FANCE 1 0.04 0.06 0.03 29.40
56 INT212303 Positive_regulation of FANCE 1 0.04 0.06 0.03 28.88
57 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 26.24
58 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 24.00
59 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 24.00
60 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21 24.00
61 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 23.60
62 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 23.60
63 INT334332 Protein_catabolism of SPARCL1 1 0.01 1.65 0.15 12.64
64 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
65 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
66 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
67 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
68 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
69 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
70 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 5.00
71 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
72 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
73 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
74 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
75 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
76 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
77 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
78 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
79 INT442 Localization of PDYN 99 0.81 11.87 72.75 5.00
80 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
81 INT6926 Regulation of Pag1 72 0.39 55.79 65.09 5.00
82 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
83 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 5.00
84 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 5.00
85 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
86 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
87 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
88 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 5.00
89 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
90 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
91 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
92 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 5.00
93 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
94 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
95 INT4862 Localization of PENK 62 0.81 11.57 40.28 5.00
96 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
97 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
98 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
99 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
100 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
101 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54 5.00
102 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
103 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
104 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
105 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
106 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
107 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
108 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
109 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 5.00
110 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
111 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 5.00
112 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
113 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 5.00
114 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
115 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
116 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
117 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 5.00
118 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
119 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
120 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
121 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
122 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
123 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
124 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
125 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28 5.00
126 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
127 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
128 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
129 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 5.00
130 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
131 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06 5.00
132 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81 5.00
133 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
134 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
135 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
136 INT52243 Phosphorylation of Ltp 13 0.54 2.84 8.7 5.00
137 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
138 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
139 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 5.00
140 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 5.00
141 INT95340 Gene_expression of GRIN2A 12 0.77 1.5 7.39 5.00
142 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
143 INT154115 Positive_regulation of Localization of PENK 5 0.49 3.15 6.93 5.00
144 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
145 INT132822 Localization of IL13 26 0.67 22.85 6.66 5.00
146 INT73499 Positive_regulation of IL13 23 0.39 20.03 6.53 5.00
147 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 5.00
148 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
149 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
150 INT59718 Regulation of Htr1a 10 0.44 3.9 5.44 5.00
151 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
152 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 5.00
153 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
154 INT71716 Binding of Hbegf 21 0.28 6.54 4.51 5.00
155 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
156 INT14947 Localization of SPARCL1 7 0.46 11.97 3.6 5.00
157 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
158 INT47674 Positive_regulation of Myoz1 21 0.54 4.37 3.57 5.00
159 INT9999 Regulation of Gene_expression of IGHE 32 0.60 15.75 3.53 5.00
160 INT73500 Regulation of IL13 12 0.36 10.37 3.53 5.00
161 INT12385 Localization of NGFR 6 0.81 3.05 3.47 5.00
162 INT188355 Binding of Cd28 25 0.34 8.29 3.38 5.00
163 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33 5.00
164 INT206194 Transcription of Ltp 6 0.58 3.28 3.32 5.00
165 INT85971 Positive_regulation of Gene_expression of Cd40lg 14 0.66 7.61 3.29 5.00
166 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
167 INT8103 Binding of TP53 46 0.44 40.2 2.96 5.00
168 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
169 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87 5.00
170 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
171 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
172 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 5.00
173 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 5.00
174 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 5.00
175 INT96199 Negative_regulation of PGP 15 0.59 1.07 2.35 5.00
176 INT79440 Localization of LEPROT 2 0.09 1.32 2.25 5.00
177 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
178 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 5.00
179 INT75939 Positive_regulation of SPARCL1 6 0.28 8.74 2.11 5.00
180 INT105536 Regulation of Myoz1 6 0.17 3.45 2.01 5.00
181 INT218578 Positive_regulation of GYPC 10 0.37 5.7 1.92 5.00
182 INT129240 Positive_regulation of Stat6 6 0.67 1.96 1.92 5.00
183 INT256260 Positive_regulation of Binding of Ltp 3 0.03 1.2 1.89 5.00
184 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
185 INT84548 Positive_regulation of HLA-DQA1 5 0.49 1.68 1.75 5.00
186 INT64807 Positive_regulation of Positive_regulation of CA2 10 0.41 1.21 1.7 5.00
187 INT84512 Binding of Myoz1 7 0.30 4.48 1.7 5.00
188 INT96200 Gene_expression of PGP 9 0.76 0.79 1.63 5.00
189 INT102428 Binding of C2 17 0.32 5.12 1.58 5.00
190 INT100672 Transcription of Hand2 9 0.42 2.84 1.47 5.00
191 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44 5.00
192 INT179169 Transcription of IL13 11 0.15 4.22 1.37 5.00
193 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
194 INT14946 Binding of SPARCL1 5 0.31 6.57 1.29 5.00
195 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 5.00
196 INT9081 Positive_regulation of Positive_regulation of IGHE 5 0.42 7.13 1 5.00
197 INT68692 Regulation of HTT 8 0.60 4.06 0.89 5.00
198 INT303465 Binding of KAR 1 0.03 0.25 0.84 5.00
199 INT130727 Regulation of C2 12 0.32 5.95 0.81 5.00
200 INT121334 Binding of HTT 11 0.47 6.66 0.78 5.00
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