D:Skin Appendage Disease

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Disease Term
Synonyms Acne, ALOPECIA, Beau S Lines, BROMRHIDROSIS, Digital Clubbing, Habit Tic Dystrophy, HYPERHIDROSIS, HYPERTRICHOSIS, Keratinous Cyst, Koilonychia, Miliaria
Documents 474
Hot Single Events 71
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skin Appendage Disease. They are ordered first by their relevance to Skin Appendage Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97889 Binding of RQCD1 and NPS 1 0.13 1.69 0.17 87.92
2 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08 69.44
3 INT205989 Binding of SLC7A7 and PDAP1 1 0.02 1.77 0 47.12
4 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
5 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 5.00
6 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 5.00
7 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
8 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14 5.00
9 INT325295 Binding of SGCA and C14orf166 1 0.04 0.54 0.08 5.00
10 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
11 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
12 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
13 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
14 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05 5.00
15 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
16 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
17 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
18 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 5.00
19 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
20 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
21 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
22 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
23 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
24 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skin Appendage Disease. They are ordered first by their pain relevance and then by number of times they were reported in Skin Appendage Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT59900 Binding of MATN3 13 0.42 17.19 3.59 100.00
2 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 99.76
3 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 99.68
4 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13 99.60
5 INT38207 Positive_regulation of Tes 7 0.40 3.47 1.7 99.52
6 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 99.48
7 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 99.28
8 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.18
9 INT27627 Binding of Rac1 41 0.41 22.88 13.68 99.10
10 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7 99.08
11 INT264629 Localization of Rac1 8 0.72 5.7 0.79 99.04
12 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 98.98
13 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 98.88
14 INT21941 Regulation of CALR 7 0.53 3.88 1.96 98.34
15 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 98.28
16 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 98.08
17 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4 98.08
18 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 97.84
19 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 97.64
20 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 97.64
21 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 97.64
22 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 97.16
23 INT233003 Negative_regulation of Gene_expression of KRT17 1 0.25 2.13 0.1 96.72
24 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 96.68
25 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 96.44
26 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 96.32
27 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 96.32
28 INT164975 Binding of ELN 6 0.35 6.38 0.64 96.12
29 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 96.12
30 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 95.96
31 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 95.44
32 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 94.32
33 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 94.32
34 INT292298 Positive_regulation of GOT2 5 0.45 3.7 1.46 94.32
35 INT67038 Positive_regulation of Positive_regulation of ALPP 5 0.08 2.61 0.77 94.32
36 INT16012 Binding of Rac1 17 0.37 6.9 0.53 94.20
37 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 94.04
38 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59 94.00
39 INT135093 Negative_regulation of T2 6 0.37 1.9 0.27 93.68
40 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 93.04
41 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 93.04
42 INT70987 Binding of RAC1 14 0.37 12.14 2.13 92.80
43 INT214 Localization of AVP 370 0.81 208.51 91.09 92.76
44 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 91.36
45 INT29950 Negative_regulation of GGH 3 0.25 2.18 0.29 91.36
46 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 91.04
47 INT264637 Localization of CLDN4 3 0.73 0.85 0.29 90.80
48 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13 88.80
49 INT245577 Localization of SFTPD 7 0.63 10.43 1.84 88.72
50 INT34778 Localization of IGF2 5 0.62 4.78 0.59 88.36
51 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 87.40
52 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 86.76
53 INT97890 Binding of NPS 2 0.32 1.72 1.04 86.28
54 INT136397 Gene_expression of bt2 1 0.08 1.29 0.14 86.20
55 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 86.16
56 INT170281 Negative_regulation of Gene_expression of PDAP1 2 0.21 1.15 0.37 86.16
57 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 85.60
58 INT892 Regulation of TRH 23 0.60 8.46 8.54 85.44
59 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 84.80
60 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 83.84
61 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 83.24
62 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 83.24
63 INT296385 Binding of IDUA 12 0.39 20.73 0.93 83.04
64 INT233005 Gene_expression of CAPN9 1 0.02 1.76 0.1 82.88
65 INT626 Localization of CALCA 289 0.81 125.39 221.15 82.76
66 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 82.76
67 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 82.24
68 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 82.24
69 INT44642 Positive_regulation of Positive_regulation of T2 1 0.11 1.67 0.08 80.76
70 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 80.72
71 INT142491 Positive_regulation of Positive_regulation of SCN10A 6 0.61 3.48 0.35 80.36
72 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63 79.96
73 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 79.68
74 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92 79.36
75 INT44643 Positive_regulation of T2 2 0.11 1.65 0.07 79.08
76 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 78.36
77 INT58883 Gene_expression of T2 12 0.63 2.56 0.71 77.88
78 INT58884 Gene_expression of SLC25A5 4 0.75 4.53 1.43 77.56
79 INT2513 Binding of Napa 80 0.42 4.29 6.51 75.96
80 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 75.08
81 INT153090 Transcription of Ea2 1 0.27 1.25 0.08 75.00
82 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 73.72
83 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84 73.72
84 INT64468 Positive_regulation of Gene_expression of Prtn3 1 0.00 2.33 0.29 70.92
85 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 69.20
86 INT37122 Gene_expression of Prtn3 3 0.60 3.65 1.04 68.64
87 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 68.52
88 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92 68.40
89 INT113987 Localization of IK 29 0.23 16.73 8.25 68.16
90 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 67.84
91 INT9188 Localization of HBG1 12 0.75 8.14 2.24 66.80
92 INT233006 Binding of KRT17 1 0.28 0.8 0.04 66.48
93 INT50580 Binding of PPIG 39 0.36 11.17 12.34 66.40
94 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3 64.48
95 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69 64.48
96 INT545 Binding of GC 15 0.45 10.74 3.47 64.00
97 INT113367 Positive_regulation of Binding of GC 1 0.05 1 0.12 64.00
98 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 63.80
99 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08 63.68
100 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 63.36
101 INT250978 Binding of FMOD 4 0.16 12.32 8.75 63.12
102 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 61.28
103 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 60.08
104 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 60.08
105 INT59680 Binding of Lynx1 10 0.12 1.53 2.19 58.96
106 INT37458 Binding of nt 9 0.24 3.85 2.02 58.96
107 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 57.76
108 INT38283 Positive_regulation of Cebpg 2 0.04 1.96 0.69 57.44
109 INT251741 Regulation of Gene_expression of SCN10A 1 0.45 1.08 0.06 57.16
110 INT251742 Regulation of Positive_regulation of SCN10A 1 0.27 1.37 0.06 57.16
111 INT82919 Negative_regulation of KRT75 2 0.36 0.15 0.77 56.92
112 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 56.80
113 INT48688 Positive_regulation of HTR4 12 0.67 1.94 2.81 56.68
114 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 56.56
115 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57 56.48
116 INT92966 Positive_regulation of FGF1 4 0.38 2.25 1.33 56.12
117 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 56.08
118 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 53.20
119 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 51.32
120 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 50.16
121 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 50.08
122 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 50.00
123 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 50.00
124 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99 50.00
125 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25 49.44
126 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 48.68
127 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 47.92
128 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 39.84
129 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 39.44
130 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 38.80
131 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 38.80
132 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 38.80
133 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 38.80
134 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 38.80
135 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 36.48
136 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0 36.16
137 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 36.08
138 INT34777 Localization of IGF1 82 0.80 42.68 8.62 35.16
139 INT5008 Localization of Calca 204 0.81 80.35 125.16 34.24
140 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 34.24
141 INT227013 Positive_regulation of KRT17 2 0.27 2.4 0 33.92
142 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 32.80
143 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 32.48
144 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 32.24
145 INT29885 Gene_expression of GGH 13 0.67 12.77 0.96 31.68
146 INT3364 Binding of SGCG 87 0.47 31.93 17.24 29.84
147 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 28.40
148 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 27.04
149 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 27.04
150 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 27.04
151 INT279349 Localization of IDUA 7 0.76 4.97 0.07 26.60
152 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 24.64
153 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 24.28
154 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 20.32
155 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 19.44
156 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69 18.68
157 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 17.96
158 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 17.08
159 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 16.88
160 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 16.80
161 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 16.68
162 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 15.00
163 INT70362 Transcription of GH1 9 0.56 2.01 0.69 15.00
164 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 14.24
165 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 11.28
166 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 11.28
167 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 11.28
168 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 11.28
169 INT232920 Regulation of Gene_expression of Krt27 1 0.00 0.11 0.04 10.00
170 INT232919 Gene_expression of Krt27 1 0.01 0.11 0.04 10.00
171 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 9.12
172 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 8.80
173 INT3167 Binding of KNG1 48 0.48 23.26 26.77 8.80
174 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
175 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
176 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
177 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
178 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
179 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
180 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
181 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
182 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
183 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
184 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
185 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
186 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
187 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
188 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
189 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
190 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
191 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
192 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
193 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
194 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 5.00
195 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
196 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
197 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
198 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
199 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
200 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
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