D:Skin Atrophy

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Disease Term
Synonyms Atrophic Condition Of The Skin, ATROPHIC DISORDERS OF THE SKIN, ATROPHIC SKIN, Atrophy Of The Skin, Dermal Thinning, Paper Skin
Documents 53
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skin Atrophy. They are ordered first by their relevance to Skin Atrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16 5.00
2 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93 5.00
3 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91 5.00
4 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57 5.00
5 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5 5.00
6 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48 5.00
7 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48 5.00
8 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 0.17 0.62 0.39 5.00
9 INT325312 IL20 Positive_regulation of Phosphorylation of STAT3 1 0.13 0.58 0.24 5.00
10 INT325316 IL22 Positive_regulation of Phosphorylation of STAT3 1 0.19 0.58 0.24 5.00
11 INT325315 Binding of STAT3 and TH1L 1 0.16 0.6 0.23 5.00
12 INT325313 IL23A Positive_regulation of Gene_expression of IL22 1 0.20 0.48 0.23 5.00
13 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22 5.00
14 INT325317 Binding of IL12A and TH1L 1 0.18 0.59 0.22 5.00
15 INT232653 Binding of CD2 and MLL 1 0.02 0.27 0.1 5.00
16 INT232652 Binding of CD2 and ITGAL 1 0.03 0.28 0.09 5.00
17 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skin Atrophy. They are ordered first by their pain relevance and then by number of times they were reported in Skin Atrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 96.48
2 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 95.68
3 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 86.60
4 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 86.60
5 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 86.16
6 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 85.80
7 INT69785 Positive_regulation of MYOC 8 0.70 6.24 1.36 85.60
8 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 85.32
9 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 68.88
10 INT6481 Binding of TNF 624 0.48 510.2 214.82 68.36
11 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 60.84
12 INT286429 Positive_regulation of Gene_expression of ANTXR2 2 0.25 1.46 0.23 60.84
13 INT244169 Localization of RNGTT 8 0.23 1.92 1.81 58.20
14 INT289474 Regulation of GLI2 2 0.06 1.08 0.87 48.84
15 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 47.32
16 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 47.08
17 INT327714 Localization of CNC 1 0.10 0.79 0.09 46.68
18 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 44.16
19 INT64653 Binding of CD2 17 0.44 6.74 4.45 39.96
20 INT131161 Binding of CD58 5 0.17 3.54 1.03 35.00
21 INT51316 Regulation of NR3C1 7 0.51 4.23 2.09 31.20
22 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 30.84
23 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 17.68
24 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 16.96
25 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 11.12
26 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 10.72
27 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21 5.24
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
29 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
30 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
31 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
32 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
33 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
34 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
35 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
36 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
37 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
38 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
39 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
40 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
41 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
42 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
43 INT6437 Binding of YY1 154 0.47 26.3 90.46 5.00
44 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
45 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
46 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
47 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
48 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
49 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
50 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
51 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
52 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
53 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
54 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
55 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
56 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
57 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 5.00
58 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
59 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
60 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
61 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
62 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
63 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
64 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
65 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
66 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
67 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 5.00
68 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
69 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
70 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
71 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
72 INT97798 Localization of IRF6 86 0.73 33.27 20.94 5.00
73 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
74 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
75 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 5.00
76 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
77 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
78 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
79 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 5.00
80 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
81 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
82 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
83 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
84 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
85 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
86 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
87 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13 5.00
88 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63 5.00
89 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
90 INT99586 Binding of IRF6 60 0.36 27.87 13.2 5.00
91 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
92 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 5.00
93 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 5.00
94 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
95 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 5.00
96 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
97 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
98 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
99 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
100 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
101 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 5.00
102 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 5.00
103 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
104 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 5.00
105 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
106 INT77249 Positive_regulation of Gene_expression of gr 24 0.67 16.09 8.17 5.00
107 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76 5.00
108 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26 5.00
109 INT81493 Transcription of CCL2 20 0.65 13.63 6.78 5.00
110 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
111 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
112 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
113 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
114 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49 5.00
115 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
116 INT77252 Gene_expression of Nr3c1 17 0.67 9.71 5.38 5.00
117 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 5.00
118 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 5.00
119 INT175312 Positive_regulation of Gene_expression of IL23A 17 0.45 14.8 5.05 5.00
120 INT90350 Gene_expression of Gast 27 0.78 14.07 4.74 5.00
121 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 5.00
122 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57 5.00
123 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
124 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31 5.00
125 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 5.00
126 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 5.00
127 INT51445 Binding of B3GAT1 9 0.47 4.64 3.95 5.00
128 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 5.00
129 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
130 INT48390 Negative_regulation of Localization of CSF2 10 0.51 7.39 3.28 5.00
131 INT139660 Transcription of CCL18 13 0.70 7.12 3.05 5.00
132 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96 5.00
133 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
134 INT77250 Positive_regulation of Gene_expression of Nr3c1 4 0.44 3.32 2.64 5.00
135 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 5.00
136 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43 5.00
137 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 5.00
138 INT92648 Positive_regulation of IL12B 7 0.20 4.55 2.19 5.00
139 INT47780 Gene_expression of CREM 17 0.74 5.37 2.13 5.00
140 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05 5.00
141 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 5.00
142 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 5.00
143 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
144 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78 5.00
145 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7 5.00
146 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 5.00
147 INT88746 Positive_regulation of Transcription of IL2 7 0.51 2.14 1.6 5.00
148 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53 5.00
149 INT200186 Binding of Igfals 5 0.19 4.46 1.52 5.00
150 INT131671 Negative_regulation of Prlhr 3 0.59 1.61 1.48 5.00
151 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 5.00
152 INT97142 Localization of IL12B 5 0.73 1.73 1.46 5.00
153 INT62824 Negative_regulation of Positive_regulation of ICAM1 7 0.53 2.94 1.39 5.00
154 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 5.00
155 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
156 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 5.00
157 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32 5.00
158 INT170979 Transcription of IL5 7 0.33 5.08 1.21 5.00
159 INT236329 Regulation of IL12B 3 0.02 0.78 1.2 5.00
160 INT289470 Transcription of MAPKAP1 1 0.09 2.61 1.13 5.00
161 INT178674 Positive_regulation of RNGTT 6 0.15 1.05 1.09 5.00
162 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 5.00
163 INT288676 Negative_regulation of CREM 3 0.18 1.34 0.96 5.00
164 INT76915 Localization of Gpx3 6 0.14 4.48 0.89 5.00
165 INT87321 Binding of ITGAX 4 0.47 3.72 0.8 5.00
166 INT197494 Gene_expression of Apoa4 9 0.05 7.33 0.78 5.00
167 INT113102 Transcription of Ccl11 4 0.52 2.48 0.77 5.00
168 INT306740 Localization of IL23A 3 0.58 2.66 0.69 5.00
169 INT289467 Transcription of IL11 6 0.57 1.5 0.67 5.00
170 INT177972 Transcription of IL3 2 0.20 1.81 0.66 5.00
171 INT27818 Regulation of PADI1 7 0.34 3.77 0.66 5.00
172 INT69782 Gene_expression of MYOC 12 0.78 8.44 0.61 5.00
173 INT244157 Negative_regulation of RNGTT 2 0.12 0.17 0.61 5.00
174 INT289473 Transcription of TRAF3IP1 1 0.03 1.3 0.56 5.00
175 INT289469 Negative_regulation of Transcription of TRAF3IP1 1 0.03 1.31 0.56 5.00
176 INT69786 Positive_regulation of Gene_expression of MYOC 4 0.50 1.36 0.55 5.00
177 INT200206 Negative_regulation of Gene_expression of Igfals 4 0.21 3.83 0.5 5.00
178 INT289471 Negative_regulation of Negative_regulation of IRF6 1 0.10 0.31 0.45 5.00
179 INT200193 Gene_expression of Col4a4 8 0.12 5.75 0.43 5.00
180 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4 5.00
181 INT176149 Phosphorylation of NFKBIB 4 0.16 1.63 0.38 5.00
182 INT316210 Positive_regulation of TEAD4 1 0.01 0.87 0.37 5.00
183 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34 5.00
184 INT100644 Gene_expression of Igf2bp2 3 0.19 0.68 0.31 5.00
185 INT287487 Protein_catabolism of NFKBIB 3 0.19 2.4 0.31 5.00
186 INT232656 Localization of MLL 2 0.05 2.33 0.29 5.00
187 INT67349 Localization of Ghr 6 0.66 2.53 0.23 5.00
188 INT289468 Protein_catabolism of DUSP1 1 0.21 0.55 0.22 5.00
189 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 5.00
190 INT316209 Regulation of TEAD4 1 0.00 0.39 0.2 5.00
191 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
192 INT199768 Gene_expression of Fmo3 3 0.50 3.11 0.17 5.00
193 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 5.00
194 INT274290 Binding of Fhl1 3 0.03 1.16 0.1 5.00
195 INT316212 Binding of SPRN 1 0.12 0.38 0.1 5.00
196 INT316211 Negative_regulation of TEAD4 2 0.01 1.24 0.09 5.00
197 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 5.00
198 INT327715 Binding of CNC 1 0.07 1.21 0.07 5.00
199 INT200184 Positive_regulation of Igf2bp2 2 0.08 1.21 0.07 5.00
200 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07 5.00
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