D:Skin Diseases

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Disease Term
Synonyms DERMATOSES, Dermatosis, Disease Skin, Diseases Skin, Skin Disease
Documents 861
Hot Single Events 200
Hot Interactions 17

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Skin Diseases. They are ordered first by their relevance to Skin Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 97.76
2 INT142371 Trpv1 Positive_regulation of Positive_regulation of Pla2g1b 1 0.35 0.3 0.29 97.44
3 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 97.36
4 INT277692 Binding of Atp9a and Tnfrsf10b 1 0.00 1.47 0.1 96.64
5 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31 96.40
6 INT163918 Ntp Negative_regulation of Gene_expression of Tacr1 1 0.04 0.74 0.38 95.52
7 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 94.92
8 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 94.28
9 INT263007 Binding of HLA-DRB6 and IL23R 1 0.01 1.09 0.21 92.00
10 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 89.28
11 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 89.28
12 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2 89.12
13 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14 88.36
14 INT154538 SF Regulation of Gene_expression of PPY 1 0.11 1 0.14 87.68
15 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1 87.20
16 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68 86.48
17 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28 84.56
18 INT235008 Binding of DSG1 and Dsg3 1 0.11 4.82 0 77.36
19 INT159538 SERPINB1 Regulation of Gene_expression of CALCA 1 0.01 0.8 0.45 76.96
20 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61 75.44
21 INT154539 SF Regulation of Protein_catabolism of PPY 1 0.12 0.85 0.11 71.52
22 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 71.44
23 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13 68.44
24 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13 68.44
25 INT154537 SF Positive_regulation of Gene_expression of PPY 1 0.15 0.81 0.11 67.96
26 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32 67.76
27 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32 67.76
28 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32 67.76
29 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41 67.68
30 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82 66.88
31 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32 61.60
32 INT355566 IL1RL1 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17 61.12
33 INT355569 IRF6 Positive_regulation of Gene_expression of NOS2 1 0.00 0.27 0.17 60.16
34 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 55.64
35 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 55.64
36 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43 52.56
37 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 50.04
38 INT263008 Binding of DEFB1 and DEFB103A 1 0.06 0 0 47.52
39 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22 46.16
40 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22 46.16
41 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79 42.32
42 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36 38.36
43 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17 37.92
44 INT238005 Binding of Cxcr3 and Cxcl10 2 0.38 3.73 1.42 36.84
45 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43 35.24
46 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8 34.88
47 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 34.40
48 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44 34.36
49 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44 34.36
50 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25 33.92
51 INT162396 Binding of LCE3B and LCE3C 1 0.32 1.08 0.45 25.00
52 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0 25.00
53 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 11.28
54 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 11.28
55 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 11.04
56 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 11.04
57 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 11.04
58 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
59 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
60 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
61 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85 5.00
62 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
63 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
64 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
65 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14 5.00
66 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1 0.00 1.55 1.76 5.00
67 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6 5.00
68 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59 5.00
69 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
70 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
71 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37 5.00
72 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 5.00
73 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16 5.00
74 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11 5.00
75 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
76 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 5.00
77 INT252602 Binding of Cxcl10 and Ppig 1 0.08 1.55 0.96 5.00
78 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 5.00
79 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93 5.00
80 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91 5.00
81 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91 5.00
82 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
83 INT237083 Binding of Cxcl10 and Cxcl9 2 0.39 3.19 0.87 5.00
84 INT237084 Binding of Cxcl9 and Cxcl11 2 0.34 3.19 0.87 5.00
85 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
86 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72 5.00
87 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72 5.00
88 INT252603 Ppig Positive_regulation of Gene_expression of Cx3cl1 1 0.10 1.8 0.69 5.00
89 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69 5.00
90 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
91 INT252605 Ppig Positive_regulation of Gene_expression of Cx3cr1 1 0.09 1.81 0.69 5.00
92 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
93 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
94 INT221847 Binding of Calca and Ntrk1 1 0.03 0.9 0.65 5.00
95 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64 5.00
96 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
97 INT252601 Binding of Cxcl10 and Cxcl11 1 0.34 1.68 0.6 5.00
98 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57 5.00
99 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57 5.00
100 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55 5.00
101 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54 5.00
102 INT243276 Hrh4 Positive_regulation of Hrh3 1 0.25 0.78 0.52 5.00
103 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5 5.00
104 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 5.00
105 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
106 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 5.00
107 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
108 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48 5.00
109 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48 5.00
110 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46 5.00
111 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43 5.00
112 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43 5.00
113 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43 5.00
114 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43 5.00
115 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43 5.00
116 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
117 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 0.17 0.62 0.39 5.00
118 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
119 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
120 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
121 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38 5.00
122 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37 5.00
123 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37 5.00
124 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37 5.00
125 INT329170 DCPS Positive_regulation of Gene_expression of IFN1@ 1 0.04 1.55 0.36 5.00
126 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
127 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
128 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
129 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
130 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
131 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
132 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
133 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 5.00
134 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
135 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
136 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
137 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
138 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
139 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
140 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
141 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
142 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
143 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31 5.00
144 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
145 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
146 INT329173 Binding of PDC and RARRES2 1 0.07 1.02 0.3 5.00
147 INT252599 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Cxcr3 1 0.45 0.49 0.29 5.00
148 INT243273 Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 5.00
149 INT243280 Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 5.00
150 INT243278 Positive_regulation of Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 5.00
151 INT252604 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Hand1 1 0.24 0.5 0.29 5.00
152 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 0.02 0.88 0.29 5.00
153 INT243274 Positive_regulation of Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 5.00
154 INT266766 Binding of PGR and GOPC 1 0.00 1.08 0.29 5.00
155 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
156 INT264472 Mapk1 Regulation of Positive_regulation of Jun 1 0.02 0 0.28 5.00
157 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28 5.00
158 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28 5.00
159 INT264474 Il6 Regulation of Positive_regulation of Jun 1 0.15 0 0.28 5.00
160 INT101510 PPARA Regulation of IL6 1 0.31 0.53 0.27 5.00
161 INT101508 PPARA Regulation of IL8 1 0.31 0.53 0.27 5.00
162 INT101509 PPARA Regulation of Gene_expression of IL8 1 0.31 0.53 0.27 5.00
163 INT101511 PPARA Regulation of Gene_expression of IL6 1 0.31 0.53 0.27 5.00
164 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26 5.00
165 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26 5.00
166 INT266803 Dlst Positive_regulation of VEGFA 1 0.01 0.96 0.25 5.00
167 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25 5.00
168 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25 5.00
169 INT266801 Dlst Positive_regulation of IL8 1 0.00 0.95 0.25 5.00
170 INT325312 IL20 Positive_regulation of Phosphorylation of STAT3 1 0.13 0.58 0.24 5.00
171 INT325316 IL22 Positive_regulation of Phosphorylation of STAT3 1 0.19 0.58 0.24 5.00
172 INT325315 Binding of STAT3 and TH1L 1 0.16 0.6 0.23 5.00
173 INT325313 IL23A Positive_regulation of Gene_expression of IL22 1 0.20 0.48 0.23 5.00
174 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23 5.00
175 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23 5.00
176 INT289955 Binding of APCS and KLF1 1 0.00 0.21 0.23 5.00
177 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22 5.00
178 INT325317 Binding of IL12A and TH1L 1 0.18 0.59 0.22 5.00
179 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21 5.00
180 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
181 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21 5.00
182 INT337168 DCPS Negative_regulation of CD86 1 0.02 1.54 0.21 5.00
183 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
184 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2 5.00
185 INT264503 Mapk1 Positive_regulation of Il1a Positive_regulation of Il6 1 0.01 0.18 0.2 5.00
186 INT264477 Il1a Positive_regulation of Jun 1 0.02 0.17 0.2 5.00
187 INT264470 Il1a Positive_regulation of Il6 1 0.06 0.18 0.2 5.00
188 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
189 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2 5.00
190 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19 5.00
191 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 5.00
192 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 5.00
193 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
194 INT198700 Binding of DSG3 and Pv 1 0.15 1.45 0.18 5.00
195 INT252606 IFNA1 Positive_regulation of Gene_expression of Cxcl10 1 0.02 0.56 0.18 5.00
196 INT252600 Ppig Regulation of Hand1 1 0.06 0.43 0.17 5.00
197 INT264478 Mapk1 Positive_regulation of Jun 1 0.02 0.12 0.17 5.00
198 INT252598 Ppig Regulation of Gene_expression of Hand1 1 0.06 0.43 0.17 5.00
199 INT337180 CD40 Positive_regulation of Gene_expression of CD83 1 0.17 1.07 0.17 5.00
200 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Skin Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Skin Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 100.00
2 INT71601 Positive_regulation of ACD 11 0.60 6.55 0.9 100.00
3 INT43907 Binding of CD79A 28 0.48 28.11 3.04 100.00
4 INT38268 Positive_regulation of BEST1 16 0.17 14.54 1.93 100.00
5 INT184803 Localization of TSC1 5 0.37 6.13 0.32 100.00
6 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 99.80
7 INT107540 Gene_expression of MSD 8 0.58 2.54 1.23 99.80
8 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 99.64
9 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 99.64
10 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 99.60
11 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 99.56
12 INT82829 Gene_expression of COMP 104 0.78 57 9.81 99.24
13 INT25263 Negative_regulation of Hrh1 11 0.58 3.35 4.61 99.24
14 INT70860 Binding of SNRPB 17 0.35 7 1.46 99.20
15 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 99.12
16 INT102659 Gene_expression of CSF3 32 0.77 21.93 2.39 99.08
17 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 99.08
18 INT48141 Binding of Csf3 18 0.39 9.93 1.71 99.08
19 INT65305 Gene_expression of MC2R 6 0.22 2.44 1.58 98.92
20 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 98.90
21 INT173508 Negative_regulation of Fgfr1 4 0.55 5.08 0.66 98.72
22 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42 98.72
23 INT303544 Positive_regulation of Negative_regulation of Fgfr1 1 0.47 1.07 0.03 98.72
24 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03 98.72
25 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 98.68
26 INT234930 Binding of Dsg3 25 0.48 20.73 0.44 98.68
27 INT320746 Binding of Dsg1a 1 0.48 6.43 0 98.68
28 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.48
29 INT14600 Positive_regulation of Tpsab1 51 0.68 22.1 7.7 98.38
30 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 98.32
31 INT39413 Negative_regulation of SNRPB 7 0.31 2.57 2.36 98.28
32 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 98.20
33 INT193334 Gene_expression of HPYR1 11 0.53 10.36 0.88 98.16
34 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.04
35 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 98.04
36 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 98.02
37 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 97.92
38 INT313785 Gene_expression of Dsg1a 3 0.78 18.92 0 97.84
39 INT234857 Gene_expression of Dsg3 42 0.78 27.75 0.14 97.84
40 INT5214 Localization of Cpe 49 0.73 13.3 44.36 97.76
41 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2 97.76
42 INT235510 Binding of Il17a 14 0.34 10.67 3.99 97.76
43 INT170960 Protein_catabolism of MYO3A 1 0.17 0.87 0 97.68
44 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48 97.56
45 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 97.44
46 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 97.40
47 INT306723 Binding of Il22 3 0.11 2.44 0.97 97.36
48 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 97.12
49 INT186805 Transcription of TLR2 12 0.63 9.66 3.04 97.04
50 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 97.00
51 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73 96.72
52 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.64
53 INT261118 Binding of Tnfrsf10b 3 0.07 4.03 0.1 96.64
54 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 96.56
55 INT92934 Gene_expression of GRPR 2 0.67 5.13 1.57 96.48
56 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 96.40
57 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 96.36
58 INT303543 Gene_expression of Il1f8 1 0.42 3.28 1.43 96.36
59 INT11807 Gene_expression of Il2 266 0.78 112 64.97 96.04
60 INT100861 Binding of CRP 179 0.48 175.2 26.45 96.04
61 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 96.04
62 INT273143 Negative_regulation of Tat 1 0.01 2.3 0 95.96
63 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 95.96
64 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 95.80
65 INT14946 Binding of SPARCL1 5 0.31 6.57 1.29 95.24
66 INT162398 Regulation of LCE3A 1 0.43 2.11 0.93 95.24
67 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 95.16
68 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 95.16
69 INT186136 Negative_regulation of Binding of CD2 2 0.29 2.06 0.68 94.92
70 INT131160 Negative_regulation of Binding of CD58 2 0.15 1.83 0.53 94.92
71 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42 94.80
72 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22 94.80
73 INT67597 Negative_regulation of Das 17 0.37 9.95 5.05 94.60
74 INT234864 Gene_expression of Dsp 30 0.47 17.72 0.37 94.40
75 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 94.36
76 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 94.36
77 INT82379 Negative_regulation of Cd7 1 0.16 1.18 0 94.36
78 INT131161 Binding of CD58 5 0.17 3.54 1.03 94.28
79 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 94.20
80 INT118095 Regulation of COMP 7 0.43 9.69 3.33 94.20
81 INT187616 Negative_regulation of Gene_expression of Mmp1 3 0.44 2.37 1.73 94.16
82 INT9210 Regulation of IL6 166 0.62 125.61 49.95 94.08
83 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 94.08
84 INT10835 Regulation of IL8 79 0.49 53.04 24.14 94.08
85 INT105378 Regulation of IL12A 6 0.26 8.82 2.15 94.08
86 INT64653 Binding of CD2 17 0.44 6.74 4.45 94.04
87 INT88867 Localization of MCS 19 0.62 28.31 3.88 93.92
88 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 93.68
89 INT263019 Gene_expression of DEFA6 4 0.25 4.14 1.17 93.68
90 INT263025 Positive_regulation of Gene_expression of DEFA6 2 0.16 1 0.28 93.68
91 INT285491 Negative_regulation of Col12a1 1 0.15 1.08 0.1 93.68
92 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 93.64
93 INT75158 Gene_expression of Fgf5 5 0.28 2.12 3.58 93.56
94 INT141565 Gene_expression of Cdt1 7 0.19 2.61 0.39 93.56
95 INT285497 Gene_expression of Traip 1 0.08 1.03 0.11 93.56
96 INT285504 Gene_expression of Cdc7 2 0.44 1.31 0.1 93.56
97 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 93.52
98 INT16322 Gene_expression of Il2rb 19 0.51 15.88 12.18 93.52
99 INT56286 Binding of HLA-DRB6 2 0.01 2.12 0.52 93.44
100 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 93.32
101 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12 93.32
102 INT77651 Negative_regulation of Transcription of IL8 8 0.43 4.48 2.16 93.32
103 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92 93.32
104 INT121376 Negative_regulation of Transcription of MIF 3 0.37 2.26 0.87 93.32
105 INT59718 Regulation of Htr1a 10 0.44 3.9 5.44 93.28
106 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 93.20
107 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 92.96
108 INT285484 Negative_regulation of Col10a1 2 0.14 1.32 0.13 92.96
109 INT253337 Localization of MT1E 4 0.59 8.89 0.41 92.92
110 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 92.88
111 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 92.88
112 INT285489 Positive_regulation of Gene_expression of Il22 9 0.32 10.97 3.63 92.88
113 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 92.84
114 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 92.84
115 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 92.80
116 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 92.80
117 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 92.80
118 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 92.80
119 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95 92.76
120 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 92.72
121 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 92.44
122 INT232969 Positive_regulation of KRT5 1 0.27 1.24 0 92.40
123 INT285502 Negative_regulation of Col8a1 1 0.14 1.08 0.1 92.24
124 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24 92.16
125 INT221531 Gene_expression of Plxna1 7 0.75 4.51 1.31 92.16
126 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 92.16
127 INT61626 Transcription of IL6 73 0.72 42.04 17.86 92.04
128 INT52107 Transcription of IL8 63 0.72 41.66 16.06 92.04
129 INT121375 Transcription of MIF 4 0.62 2.85 1.1 92.04
130 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 91.92
131 INT17326 Binding of Plg 14 0.43 11.72 1.94 91.76
132 INT285505 Negative_regulation of Col5a2 1 0.14 1.08 0.1 91.60
133 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06 91.48
134 INT756 Gene_expression of C3 138 0.75 100.6 19.2 91.44
135 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 91.44
136 INT22454 Regulation of Crp 213 0.62 160.67 49.24 91.00
137 INT68285 Gene_expression of SERPINB3 24 0.75 25.4 0.45 90.96
138 INT146829 Negative_regulation of Mefv 2 0.39 5.73 0.95 90.68
139 INT256598 Gene_expression of DEFB103A 8 0.65 5.06 1.49 90.40
140 INT263016 Negative_regulation of Gene_expression of DEFB103A 1 0.19 1.37 0.35 90.40
141 INT263029 Negative_regulation of DEFB103A 1 0.19 0.18 0.05 90.40
142 INT48877 Binding of Tacr1 16 0.43 5.26 8.04 90.28
143 INT69749 Binding of Tacr3 3 0.06 2.2 0.81 90.28
144 INT104394 Positive_regulation of Gene_expression of Cxcl10 28 0.65 25.64 8.79 90.20
145 INT213886 Binding of IL23R 7 0.46 16.79 6.94 90.20
146 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 90.16
147 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 89.92
148 INT3034 Localization of Ngf 126 0.81 50.81 72.84 89.84
149 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41 89.84
150 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 89.76
151 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 89.76
152 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 89.76
153 INT107541 Positive_regulation of MSD 7 0.43 5.41 1.45 89.68
154 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 89.68
155 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48 89.68
156 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 89.60
157 INT263018 Negative_regulation of Gene_expression of DEFB4A 1 0.39 0.18 0.05 89.60
158 INT214529 Negative_regulation of DEFB4A 2 0.39 0.76 0.05 89.60
159 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 89.56
160 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 89.56
161 INT99782 Negative_regulation of Cxcl10 21 0.55 18.4 6.5 89.52
162 INT18990 Positive_regulation of GRP 32 0.70 5.22 11.23 89.32
163 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 89.04
164 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 88.88
165 INT23519 Positive_regulation of Localization of Tacr1 12 0.41 3.84 10.82 88.88
166 INT4940 Negative_regulation of Localization of Tacr1 8 0.37 4.29 8.25 88.88
167 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 88.76
168 INT50105 Localization of CTSB 29 0.78 10.98 5.21 88.72
169 INT335648 Localization of CTSS 1 0.08 1.39 0.41 88.72
170 INT94410 Gene_expression of Grp 4 0.67 2.49 1.97 88.44
171 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 88.44
172 INT74818 Transcription of KNG1 6 0.67 2.71 1.59 88.32
173 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 88.32
174 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 88.32
175 INT94428 Negative_regulation of Gene_expression of NOS2 20 0.47 11.61 5.62 88.32
176 INT443 Localization of POMC 1020 0.81 284.52 443.17 88.24
177 INT5454 Localization of CRH 124 0.79 79.18 41.53 88.24
178 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52 88.16
179 INT107401 Regulation of Das 9 0.18 3.02 1.31 88.16
180 INT118054 Regulation of ARMC9 23 0.34 11.32 1.06 88.08
181 INT69786 Positive_regulation of Gene_expression of MYOC 4 0.50 1.36 0.55 88.08
182 INT200470 Positive_regulation of Gene_expression of COMP 13 0.69 13.73 2.93 87.96
183 INT82828 Positive_regulation of COMP 45 0.61 35.12 6.2 87.96
184 INT397 Localization of SST 232 0.81 58.05 101.19 87.88
185 INT244123 Localization of Defa1 5 0.78 3.42 1.23 87.84
186 INT58904 Localization of TH1L 40 0.68 27.11 10.52 87.84
187 INT186914 Localization of DEFB1 4 0.78 1.27 0.44 87.84
188 INT234867 Localization of Jup 1 0.24 2.84 0.03 87.84
189 INT69782 Gene_expression of MYOC 12 0.78 8.44 0.61 87.72
190 INT100821 Localization of Ros1 59 0.60 45.26 11.92 87.68
191 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.52
192 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 87.44
193 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 87.32
194 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 86.96
195 INT147607 Binding of TERT 16 0.48 12.36 1.31 86.92
196 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97 86.84
197 INT86641 Regulation of Gene_expression of KRT16 1 0.40 0.42 0.74 86.68
198 INT298384 Gene_expression of CYB5B 1 0.77 23.1 0.03 86.56
199 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69 86.48
200 INT27758 Positive_regulation of PTGDS 20 0.67 10.74 4.22 86.28
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