D:Sleep Apnea Syndromes

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Disease Term
Synonyms Apnea Sleep, Apnea Syndrome Sleep, Apnea Syndromes Sleep, APNEAS SLEEP, BREATHING SLEEP DISORDERED, Hypersomnia With Periodic Respiration, Hypopnea Sleep, Hypopneas Sleep, Mixed Central Obstructive Sleep Apnea, Mixed Sleep Apnea, Mixed Sleep Apneas
Documents 156
Hot Single Events 28
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sleep Apnea Syndromes. They are ordered first by their relevance to Sleep Apnea Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118786 Binding of KIAA0101 and NANS 1 0.28 4.67 0.3 100.00
2 INT186548 Binding of KRT1 and MAX 1 0.01 0.15 0 50.00
3 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11 44.32
4 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
5 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
6 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
7 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 5.00
8 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04 5.00
9 INT249046 Binding of LEP and ARID1B 1 0.01 1.3 0.03 5.00
10 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03 5.00
11 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0 5.00
12 INT249047 CENPJ Negative_regulation of LEP 1 0.22 0.8 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sleep Apnea Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Sleep Apnea Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT161574 Localization of CENPJ 7 0.73 6.11 1.54 100.00
2 INT7620 Localization of TPO 4 0.26 5.35 0.88 100.00
3 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 98.04
4 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 97.44
5 INT252 Localization of GH1 529 0.80 227.4 122.05 96.68
6 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 95.52
7 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 94.84
8 INT126685 Gene_expression of Rem1 30 0.65 11.21 3.61 93.96
9 INT58770 Gene_expression of MSSE 9 0.56 5.75 0.08 93.72
10 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 93.60
11 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 92.80
12 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 92.80
13 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 92.80
14 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 92.80
15 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 92.80
16 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 92.48
17 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 92.44
18 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 92.16
19 INT154102 Negative_regulation of ARID1B 5 0.35 6.45 0.1 90.84
20 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43 90.72
21 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 90.56
22 INT249049 Positive_regulation of ARID1B 14 0.56 24.77 0.71 88.96
23 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 88.32
24 INT1893 Localization of Gh 1041 0.79 340.23 256.58 88.12
25 INT34777 Localization of IGF1 82 0.80 42.68 8.62 87.24
26 INT18773 Localization of ALB 117 0.80 69.18 13.8 83.76
27 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 81.44
28 INT267703 Regulation of ARID1B 6 0.21 6.85 0.45 81.08
29 INT812 Localization of INS 1026 0.81 515.6 145.31 80.00
30 INT296875 Positive_regulation of AHI1 2 0.15 3.53 0.16 79.28
31 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 78.32
32 INT75908 Regulation of LEP 77 0.60 60.16 15.19 78.32
33 INT318165 Regulation of Regulation of ARID1B 1 0.21 0.41 0 77.36
34 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 76.16
35 INT277161 Gene_expression of UFD1L 1 0.78 8.73 0.39 74.64
36 INT249 Localization of GHRH 215 0.80 78.02 51.87 72.24
37 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 71.68
38 INT296871 Positive_regulation of Sxbq1 1 0.10 1.63 0.24 70.36
39 INT1530 Regulation of Gh 382 0.61 115.96 112.47 67.72
40 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 66.64
41 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 65.84
42 INT296873 Binding of Sxbq1 1 0.09 3.24 0.43 63.88
43 INT1682 Negative_regulation of Rem1 28 0.37 7.38 8.4 62.80
44 INT277157 Positive_regulation of UFD1L 1 0.69 3.55 0 62.08
45 INT274191 Gene_expression of Ppcs 1 0.04 1.44 0.09 59.52
46 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 58.72
47 INT258092 Regulation of Gene_expression of Hcrt 2 0.44 2.6 0.29 58.72
48 INT70970 Binding of COPD 144 0.42 180.34 18.29 56.92
49 INT267698 Gene_expression of ARID1B 18 0.63 20.47 0.47 53.64
50 INT251515 Positive_regulation of Gene_expression of REM1 5 0.18 0.99 1.06 51.28
51 INT309863 Positive_regulation of Gene_expression of ARID1B 3 0.40 2.03 0.05 51.28
52 INT29637 Localization of KRT1 6 0.20 5.55 0.4 50.00
53 INT120321 Regulation of Transcription of POMC 1 0.18 0.95 0.17 50.00
54 INT103003 Gene_expression of MAX 10 0.75 1.03 0.13 50.00
55 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 50.00
56 INT186552 Positive_regulation of Gene_expression of MAX 1 0.49 0.21 0 50.00
57 INT108463 Binding of Ppcs 6 0.37 3.16 0.15 48.60
58 INT1416 Transcription of POMC 40 0.72 10.71 15.38 48.40
59 INT154104 Binding of ARID1B 47 0.39 69.82 1.49 47.12
60 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93 46.04
61 INT58769 Binding of MSSE 2 0.31 1.34 0.1 44.00
62 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 42.96
63 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 42.96
64 INT80624 Regulation of CNBP 5 0.36 3.36 0.45 40.36
65 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41 40.16
66 INT65356 Localization of LEP 46 0.79 41.17 5.43 39.80
67 INT174517 Localization of AHI1 2 0.24 1.62 0.68 39.40
68 INT296870 Localization of Sxbq1 1 0.15 1.4 0.04 39.40
69 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 36.40
70 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 36.24
71 INT148883 Gene_expression of HCRTR1 8 0.36 24.82 1.35 32.16
72 INT156533 Transcription of LEP 9 0.69 4.35 0.74 30.56
73 INT142735 Regulation of RLS 33 0.53 45.83 11.35 27.28
74 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 25.00
75 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 25.00
76 INT5118 Regulation of SST 97 0.62 34.35 51.74 25.00
77 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 25.00
78 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 25.00
79 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 23.28
80 INT274190 Positive_regulation of Binding of Ppcs 1 0.03 0.54 0.04 20.80
81 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 18.32
82 INT277160 Positive_regulation of Regulation of GOPC 2 0.10 0.86 0 13.04
83 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 11.12
84 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 6.64
85 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 6.04
86 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
87 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
88 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
89 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
90 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
91 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
92 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
93 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
94 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
95 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 5.00
96 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
97 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
98 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
99 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
100 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
101 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
102 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
103 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
104 INT403 Localization of Trh 241 0.81 28.55 81.45 5.00
105 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
106 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
107 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
108 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
109 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
110 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
111 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
112 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
113 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
114 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
115 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
116 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
117 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
118 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
119 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
120 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
121 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
122 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
123 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
124 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 5.00
125 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
126 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
127 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
128 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
129 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
130 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
131 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
132 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 5.00
133 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 5.00
134 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
135 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
136 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
137 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
138 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
139 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 5.00
140 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 5.00
141 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
142 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
143 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
144 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
145 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
146 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
147 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 5.00
148 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 5.00
149 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
150 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
151 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
152 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
153 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
154 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
155 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 5.00
156 INT138216 Negative_regulation of PER1 13 0.37 9.66 4.55 5.00
157 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 5.00
158 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
159 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 5.00
160 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
161 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
162 INT28166 Positive_regulation of Rem1 8 0.40 7.96 3.19 5.00
163 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
164 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
165 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 5.00
166 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 5.00
167 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47 5.00
168 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
169 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3 5.00
170 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 5.00
171 INT106055 Negative_regulation of Gene_expression of Hcrt 15 0.46 5.64 2.09 5.00
172 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
173 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
174 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
175 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 5.00
176 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 5.00
177 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
178 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 5.00
179 INT19483 Positive_regulation of Ppcs 3 0.37 14.1 1.36 5.00
180 INT78050 Positive_regulation of Positive_regulation of Selp 3 0.43 3.63 1.02 5.00
181 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
182 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99 5.00
183 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 5.00
184 INT68186 Gene_expression of GOT2 11 0.65 6.01 0.91 5.00
185 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
186 INT118254 Negative_regulation of Ppcs 4 0.39 2.49 0.79 5.00
187 INT274193 Negative_regulation of PES1 7 0.57 3.25 0.77 5.00
188 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 5.00
189 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
190 INT242371 Regulation of Gene_expression of ADHD1 3 0.37 5.2 0.65 5.00
191 INT89616 Gene_expression of FABP3 9 0.78 5.35 0.62 5.00
192 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
193 INT170746 Regulation of REM1 3 0.20 1.3 0.56 5.00
194 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
195 INT274343 Localization of Mt1 1 0.11 0.84 0.48 5.00
196 INT211905 Negative_regulation of RIOK3 2 0.07 2.25 0.48 5.00
197 INT274342 Gene_expression of Epha1 1 0.01 0 0.46 5.00
198 INT274341 Positive_regulation of Gene_expression of Epha1 1 0.01 0 0.46 5.00
199 INT170747 Binding of REM1 5 0.10 1.65 0.44 5.00
200 INT263327 Positive_regulation of Positive_regulation of NFKB2 2 0.08 2.95 0.42 5.00
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