D:Sleep Initiation And Maintenance Disorders

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Disease Term
Synonyms Awakening Early, Chronic Insomnia, Dims Disorders Of Initiating Maintaining Sleep, DISORDERS OF INITIATING MAINTAINING SLEEP, Dysfunction Sleep Initiation, Dysfunctions Sleep Initiation, Early Awakening, Insomnia, Insomnia Chronic, Insomnia Disorder, Insomnia Disorders
Documents 252
Hot Single Events 51
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sleep Initiation And Maintenance Disorders. They are ordered first by their relevance to Sleep Initiation And Maintenance Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61 92.56
2 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61 92.56
3 INT144249 CGA Regulation of Gene_expression of TNF 1 0.13 0.83 0.31 92.56
4 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45 91.32
5 INT144237 Negative_regulation of DCSTAMP Positive_regulation of NFKB1 1 0.06 0.72 0.28 76.08
6 INT103134 DCSTAMP Positive_regulation of NFKB1 2 0.07 1.43 0.7 75.08
7 INT327821 GPRC6A Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 74.56
8 INT327822 INCENP Regulation of Gene_expression of Lep 1 0.00 0.5 0.05 74.56
9 INT144239 CTSG Regulation of Positive_regulation of NFKB1 1 0.00 0.67 0.27 69.92
10 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27 68.44
11 INT144251 TNF Positive_regulation of Gene_expression of NFKB1 1 0.43 0.65 0.3 60.24
12 INT144236 CGA Negative_regulation of DCSTAMP Positive_regulation of TNF 1 0.02 0.64 0.3 57.60
13 INT144242 CGA Negative_regulation of Localization of TNF 1 0.12 0.64 0.3 57.60
14 INT144250 CGA Negative_regulation of TNF 1 0.12 0.64 0.3 57.60
15 INT144246 DCSTAMP Positive_regulation of TNF 1 0.06 0.63 0.3 56.92
16 INT144254 DCSTAMP Positive_regulation of Localization of TNF 1 0.06 0.63 0.3 56.92
17 INT144240 TNF Positive_regulation of Transcription of IL1B 1 0.44 0.45 0.24 50.08
18 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22 46.68
19 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22 46.68
20 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22 46.68
21 INT144238 TNF Positive_regulation of Protein_catabolism of NFKB1 1 0.40 0.35 0.22 46.08
22 INT144244 TNF Positive_regulation of Protein_catabolism of NFKBIA 1 0.28 0.34 0.22 46.08
23 INT144253 TNF Positive_regulation of Phosphorylation of NFKBIA 1 0.39 0.34 0.22 46.08
24 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17 38.08
25 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
26 INT349664 PYCARD Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
27 INT349662 Binding of PYCARD and Negative_regulation of Localization of AR 1 0.05 0 0.32 5.00
28 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29 5.00
29 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28 5.00
30 INT335173 Binding of ALG10 and TMEM200A 1 0.00 0.22 0.23 5.00
31 INT267812 Binding of ATF7IP and RLS 1 0.35 2.01 0.21 5.00
32 INT349668 Binding of HRH1 and PYCARD 1 0.00 0.37 0.21 5.00
33 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 5.00
34 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 5.00
35 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17 5.00
36 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
37 INT181740 Il1 Positive_regulation of Csf2 1 0.02 0 0.12 5.00
38 INT327808 EPO Regulation of VEGFA 1 0.07 1.36 0.12 5.00
39 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09 5.00
40 INT349665 Positive_regulation of Binding of AR and TFPI 1 0.02 0 0.05 5.00
41 INT349667 Binding of AR and TFPI 1 0.02 0 0.05 5.00
42 INT349663 Binding of TFPI and PYCARD 1 0.04 0 0.04 5.00
43 INT349661 PYCARD Positive_regulation of AR 1 0.08 0 0.03 5.00
44 INT349666 Binding of AR and PYCARD 1 0.06 0 0 5.00
45 INT235594 Binding of LIFR and Rem1 1 0.02 0.36 0 5.00
46 INT327809 Binding of ADORA2B and IL8 1 0.03 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sleep Initiation And Maintenance Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Sleep Initiation And Maintenance Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 100.00
2 INT45674 Regulation of Gene_expression of Serpina6 3 0.14 0.86 1.14 100.00
3 INT45675 Regulation of Gene_expression of Shbg 6 0.15 4.65 1.03 100.00
4 INT189175 Localization of MTNR1B 4 0.12 2 0.16 99.44
5 INT181238 Binding of ZBTB32 7 0.42 2.22 1.77 99.18
6 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 99.10
7 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 99.10
8 INT45672 Negative_regulation of Serpina6 5 0.43 1.66 2.08 99.10
9 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 98.88
10 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95 98.88
11 INT285477 Positive_regulation of Zeb1 2 0.17 0.86 0.86 98.76
12 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 98.64
13 INT249 Localization of GHRH 215 0.80 78.02 51.87 98.40
14 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 98.34
15 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 98.24
16 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 98.08
17 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 98.08
18 INT45673 Gene_expression of Serpina6 10 0.53 3.47 3 98.08
19 INT189082 Gene_expression of Serpind1 12 0.65 15.56 1.16 97.64
20 INT189172 Regulation of MTNR1B 3 0.06 0.43 0.24 96.08
21 INT274053 Gene_expression of FBXL15 2 0.65 1.56 0.03 95.12
22 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48 95.04
23 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 94.88
24 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 92.88
25 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11 92.88
26 INT327805 Positive_regulation of Rab8a 1 0.07 1.31 0.29 92.88
27 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 92.24
28 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 91.92
29 INT82082 Localization of Lep 63 0.81 26.41 8.56 91.76
30 INT7116 Localization of Rab8a 10 0.70 1.2 1.95 91.76
31 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 91.32
32 INT79231 Positive_regulation of Gene_expression of NFKB1 18 0.67 9.16 3.66 91.20
33 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 91.20
34 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02 89.88
35 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 89.88
36 INT30014 Positive_regulation of HPSE 22 0.70 20.91 4.09 89.68
37 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 89.04
38 INT56084 Negative_regulation of SLC43A3 11 0.39 5.39 2.27 88.92
39 INT264213 Negative_regulation of TST 1 0.18 1.49 0.84 88.72
40 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 88.48
41 INT20227 Regulation of Lta 11 0.35 6.16 1.91 87.52
42 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 87.20
43 INT73641 Regulation of Lep 45 0.62 26.2 12.59 87.12
44 INT235587 Regulation of ITSN2 1 0.43 2.62 0 87.08
45 INT274343 Localization of Mt1 1 0.11 0.84 0.48 87.04
46 INT264214 Negative_regulation of Positive_regulation of TST 1 0.13 0.35 0.07 86.64
47 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 86.00
48 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 84.60
49 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 81.60
50 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 81.20
51 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 81.04
52 INT316178 Negative_regulation of Localization of MTNR1B 1 0.09 0.31 0 78.64
53 INT235591 Positive_regulation of ITSN2 1 0.49 5.77 0 78.00
54 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 76.92
55 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 76.84
56 INT189174 Positive_regulation of Localization of MTNR1B 2 0.09 0.76 0.13 76.80
57 INT78728 Negative_regulation of Binding of NFKB1 18 0.58 6.89 5.39 76.08
58 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 76.08
59 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 76.08
60 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 75.92
61 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 75.40
62 INT185519 Binding of Vms1 5 0.12 4.58 1.37 75.20
63 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 74.56
64 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12 74.56
65 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 74.40
66 INT26861 Localization of Vms1 4 0.10 1.46 1.83 74.04
67 INT26859 Negative_regulation of Vms1 10 0.29 3.05 1.37 74.04
68 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86 73.88
69 INT327817 Negative_regulation of ADORA2A 1 0.17 1.83 0.27 73.88
70 INT131987 Gene_expression of ITSN2 2 0.65 2.08 0 73.60
71 INT85963 Gene_expression of LIFR 23 0.75 9 0.98 73.12
72 INT117893 Binding of Serpind1 15 0.41 24.59 2.41 72.84
73 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 72.16
74 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 70.32
75 INT7812 Negative_regulation of SRI 10 0.59 4.28 1.46 68.44
76 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 68.36
77 INT2541 Binding of Calca 200 0.48 67.14 134.62 68.28
78 INT348096 Regulation of Gene_expression of GJD2 1 0.43 3.3 1.83 68.24
79 INT348094 Regulation of GJD2 1 0.59 2.94 1.76 68.24
80 INT348095 Gene_expression of GJD2 1 0.74 0.88 0.51 68.24
81 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 67.92
82 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62 65.72
83 INT155946 Positive_regulation of Mt1 7 0.45 4.31 1.23 64.64
84 INT350910 Regulation of Positive_regulation of Mt1 1 0.12 0.51 0.44 64.64
85 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 64.52
86 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 63.84
87 INT13716 Positive_regulation of TH 33 0.68 19.11 16 63.16
88 INT44816 Regulation of Serpina6 16 0.62 3.63 8.02 63.12
89 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63 60.64
90 INT52512 Positive_regulation of SLC43A3 21 0.41 5.39 5.27 59.80
91 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 57.36
92 INT258092 Regulation of Gene_expression of Hcrt 2 0.44 2.6 0.29 57.32
93 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 57.24
94 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 56.76
95 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 56.76
96 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16 56.68
97 INT6852 Localization of TNF 883 0.81 705.95 270.84 56.24
98 INT196993 Binding of TMEM200A 9 0.22 1.76 0.39 52.08
99 INT335176 Binding of ALG10 1 0.03 0.67 0 52.08
100 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0 51.56
101 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 50.52
102 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21 50.52
103 INT738 Regulation of POMC 459 0.62 111.19 243.74 50.00
104 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 50.00
105 INT920 Localization of PLOD1 223 0.81 42.25 78.7 50.00
106 INT253 Regulation of PRL 184 0.62 47.27 65.79 50.00
107 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 50.00
108 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 50.00
109 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 50.00
110 INT32165 Binding of CALM1 92 0.48 24.19 29.57 50.00
111 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 50.00
112 INT105021 Binding of GOPC 187 0.40 60.39 20.38 50.00
113 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 50.00
114 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 50.00
115 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 50.00
116 INT7813 Regulation of SRI 25 0.61 6.18 8.13 50.00
117 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 50.00
118 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 50.00
119 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9 50.00
120 INT15606 Localization of FSHB 24 0.78 9.16 2.49 50.00
121 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 50.00
122 INT70526 Binding of CALR 11 0.35 7.09 1.97 50.00
123 INT62127 Localization of SRI 12 0.45 10.21 1.54 50.00
124 INT115502 Gene_expression of SAGE1 12 0.65 6.07 1.39 50.00
125 INT83822 Protein_catabolism of CYP2C9 3 0.46 1.16 1.31 50.00
126 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 50.00
127 INT178455 Localization of LIFR 6 0.61 2.24 0.83 50.00
128 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76 50.00
129 INT178456 Positive_regulation of Gene_expression of LIFR 7 0.50 2.74 0.54 50.00
130 INT94543 Binding of MT2A 5 0.29 0.96 0.36 50.00
131 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27 50.00
132 INT78047 Negative_regulation of GLB1 2 0.51 1.3 0.25 50.00
133 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17 50.00
134 INT97578 Regulation of FSHB 3 0.26 1.41 0.17 50.00
135 INT27817 Gene_expression of PADI1 5 0.52 1.61 0.17 50.00
136 INT274054 Localization of CYP1A1 1 0.12 0 0.07 50.00
137 INT336306 Positive_regulation of Gene_expression of SAGE1 2 0.16 0.31 0.07 50.00
138 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06 50.00
139 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06 50.00
140 INT178453 Regulation of LIFR 3 0.50 0.31 0.03 50.00
141 INT178454 Regulation of Positive_regulation of LIFR 1 0.37 0.19 0 50.00
142 INT178452 Negative_regulation of Positive_regulation of LIFR 1 0.35 0.19 0 50.00
143 INT110184 Binding of HMI 9 0.28 5.52 2.24 49.56
144 INT327818 Binding of GPRC6A 3 0.01 0.28 0.13 49.56
145 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 49.08
146 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 49.08
147 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 48.96
148 INT100601 Localization of PRNP 17 0.66 13.61 0.71 48.96
149 INT236972 Gene_expression of TST 8 0.58 1.02 0.04 48.72
150 INT56078 Negative_regulation of Protein_catabolism of NFKB1 7 0.42 4.44 1.83 46.44
151 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 46.08
152 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51 45.32
153 INT196995 Gene_expression of TMEM200A 22 0.45 4.02 0.53 44.80
154 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79 44.52
155 INT56077 Protein_catabolism of NFKB1 16 0.98 8.03 3.94 44.52
156 INT181246 Positive_regulation of ZBTB32 13 0.61 1.37 2.85 43.72
157 INT75742 Binding of RLS 86 0.42 95.27 19.04 42.00
158 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 41.84
159 INT66209 Negative_regulation of Localization of NFKB1 23 0.58 8.2 5.31 41.56
160 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 40.96
161 INT126685 Gene_expression of Rem1 30 0.65 11.21 3.61 40.08
162 INT182658 Regulation of Gene_expression of Rem1 4 0.20 2.55 0.47 40.08
163 INT264566 Binding of Bzrap1 1 0.01 0.08 0.09 39.88
164 INT134991 Regulation of Rem1 4 0.28 3.45 1.71 39.60
165 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 38.92
166 INT101429 Positive_regulation of PST 10 0.40 2.14 0.6 36.96
167 INT202716 Gene_expression of NMS 4 0.49 4.56 0.57 36.92
168 INT211229 Negative_regulation of Gene_expression of Serpind1 1 0.36 3.33 0.89 36.80
169 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 36.08
170 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38 35.12
171 INT61802 Binding of NDP 6 0.28 0 1.85 29.16
172 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 28.96
173 INT26863 Regulation of Vms1 7 0.09 2.67 2.23 27.32
174 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 26.96
175 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 25.92
176 INT264035 Regulation of Lgsn 5 0.39 6.2 0.86 25.92
177 INT202715 Binding of NMS 3 0.27 6.92 0.65 25.04
178 INT21877 Negative_regulation of Serpind1 3 0.52 6.85 0.93 23.36
179 INT83035 Binding of INSR 16 0.47 9.29 4.11 22.64
180 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 20.56
181 INT54495 Binding of GABBR1 9 0.35 1.82 2.76 16.72
182 INT90082 Positive_regulation of Degs1 2 0.04 6.09 1.9 15.20
183 INT341740 Positive_regulation of Positive_regulation of Degs1 1 0.03 2.14 0.68 15.20
184 INT260328 Negative_regulation of Binding of VPREB1 1 0.04 0.26 0 14.68
185 INT260329 Binding of VPREB1 1 0.04 1.59 0 14.12
186 INT190311 Binding of CDC14A 1 0.02 0.1 0 9.84
187 INT215032 Positive_regulation of TMEM200A 7 0.33 2.23 0.26 6.84
188 INT59433 Gene_expression of PASK 24 0.68 25.13 3.21 6.28
189 INT235584 Binding of Rem1 1 0.05 0.67 0 5.68
190 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
191 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
192 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
193 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
194 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
195 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
196 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
197 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
198 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
199 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
200 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
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