D:Smith-lemli-opitz Syndrome

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Disease Term
Synonyms 7 Dehydrocholesterol Reductase Deficiency, Rsh, RSH SLO SYNDROME, Rsh Slo Syndromes, RSH SYNDROME, Rsh Syndromes, Smith Lemli Opitz Syndrome, SMITH LEMLI OPITZ SYNDROME 1, SMITH LEMLI OPITZ SYNDROME I, Smith Lemli Opitz Syndrome One, Smith Lemli Opitz Syndrome Type I
Documents 35
Hot Single Events 12
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Smith-lemli-opitz Syndrome. They are ordered first by their relevance to Smith-lemli-opitz Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259451 Binding of DHCR7 and Cyp11a1 1 0.01 0.3 0 100.00
2 INT259452 Binding of STAR and Cyp11a1 1 0.25 0.06 0 58.24
3 INT175561 NAA50 Negative_regulation of PRELID1 1 0.00 0.83 0.1 5.00
4 INT266952 Binding of Aspscr1 and Ap2s1 1 0.01 0.51 0.08 5.00
5 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06 5.00
6 INT175560 Binding of GPER and GHRL 1 0.01 1.14 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Smith-lemli-opitz Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Smith-lemli-opitz Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 100.00
2 INT94006 Negative_regulation of Srd5a3 1 0.06 1.17 0 99.82
3 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 99.82
4 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 99.82
5 INT55916 Binding of Ap2s1 4 0.14 6.56 1.27 96.16
6 INT205273 Gene_expression of Slc37a2 3 0.75 1.79 0.09 94.92
7 INT319791 Positive_regulation of Gene_expression of Slc37a2 1 0.49 0.09 0 94.92
8 INT259445 Gene_expression of Dhcr7 1 0.03 0.09 0 94.64
9 INT10578 Transcription of Cyp11a1 3 0.53 0.84 0.93 85.60
10 INT301374 Localization of Stk11 1 0.23 1.58 0 80.64
11 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 80.24
12 INT9188 Localization of HBG1 12 0.75 8.14 2.24 80.24
13 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7 68.40
14 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 65.32
15 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 62.68
16 INT57359 Positive_regulation of Gene_expression of STAR 8 0.49 2.71 0.24 62.68
17 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61 43.92
18 INT259446 Positive_regulation of Gene_expression of Cyp11a1 1 0.28 0 0 30.96
19 INT176561 Gene_expression of Cyp17a1 3 0.25 1.38 0.04 26.64
20 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
21 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
22 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
23 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
24 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
25 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
26 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
27 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
28 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
29 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
30 INT78695 Regulation of Casp3 24 0.44 9.43 10.48 5.00
31 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
32 INT60148 Regulation of Sigmar1 20 0.43 7.23 7.76 5.00
33 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
34 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02 5.00
35 INT55917 Binding of Sigmar1 26 0.45 12.65 5.58 5.00
36 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26 5.00
37 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
38 INT95131 Binding of Cd4 27 0.37 21.62 5.07 5.00
39 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 5.00
40 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 5.00
41 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 5.00
42 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
43 INT32464 Regulation of Mmp13 12 0.44 6.46 3.61 5.00
44 INT114571 Gene_expression of Sigmar1 39 0.77 36.78 3.4 5.00
45 INT82444 Positive_regulation of Gene_expression of Cd4 10 0.47 4.36 3.12 5.00
46 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01 5.00
47 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 5.00
48 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59 5.00
49 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 5.00
50 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06 5.00
51 INT116280 Transcription of Mmp13 11 0.67 6.52 2.06 5.00
52 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76 5.00
53 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64 5.00
54 INT175563 Negative_regulation of NAA50 9 0.16 11.35 1.53 5.00
55 INT18156 Gene_expression of Fap 18 0.73 27.02 1.46 5.00
56 INT83328 Regulation of Gene_expression of Cd4 6 0.43 2.55 1.42 5.00
57 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
58 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
59 INT19628 Regulation of Xdh 6 0.45 1.9 1.07 5.00
60 INT190031 Binding of Scrib 19 0.36 21.9 1.01 5.00
61 INT173552 Protein_catabolism of Mmp13 5 0.96 3.05 1.01 5.00
62 INT242134 Localization of Apc 8 0.74 4.83 0.88 5.00
63 INT98567 Negative_regulation of Gene_expression of Cd4 8 0.40 6.1 0.75 5.00
64 INT66598 Negative_regulation of GPER 8 0.04 3.83 0.72 5.00
65 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 5.00
66 INT163329 Negative_regulation of GHRL 5 0.58 7.34 0.65 5.00
67 INT121113 Protein_catabolism of Cyp11a1 2 0.65 0.37 0.44 5.00
68 INT74979 Regulation of Ap2s1 2 0.13 0.59 0.42 5.00
69 INT73627 Binding of Fap 8 0.36 11.14 0.4 5.00
70 INT214974 Positive_regulation of Gene_expression of Sigmar1 2 0.52 1.92 0.38 5.00
71 INT175562 Gene_expression of ENHO 1 0.10 2.85 0.37 5.00
72 INT54616 Gene_expression of Babr 6 0.24 3.02 0.24 5.00
73 INT171716 Regulation of Fap 4 0.27 4.05 0.23 5.00
74 INT211343 Gene_expression of Ap2s1 2 0.22 2.84 0.13 5.00
75 INT266950 Positive_regulation of Binding of Ap2s1 1 0.14 0.47 0.1 5.00
76 INT266951 Negative_regulation of Binding of Sigmar1 1 0.32 0.48 0.1 5.00
77 INT266947 Negative_regulation of Binding of Ap2s1 1 0.12 0.47 0.1 5.00
78 INT211344 Regulation of Binding of Sigmar1 2 0.41 0.65 0.1 5.00
79 INT221678 Protein_catabolism of Mki67 3 0.33 1.78 0.09 5.00
80 INT175564 Positive_regulation of SUPT16H 1 0.49 0.48 0.05 5.00
81 INT314906 Gene_expression of REG4 1 0.05 0.51 0.04 5.00
82 INT319839 Gene_expression of AIDA 1 0.20 0.3 0.04 5.00
83 INT286102 Positive_regulation of Fap 5 0.30 8.58 0.04 5.00
84 INT211345 Binding of Aspscr1 1 0.06 2.16 0 5.00
85 INT211346 Binding of D5Mit138 1 0.00 3.33 0 5.00
86 INT319789 Regulation of Slc37a2 1 0.60 0.19 0 5.00
87 INT259449 Gene_expression of RNU5A-1 1 0.65 0.1 0 5.00
88 INT319790 Positive_regulation of Slc37a2 1 0.49 0 0 5.00
89 INT319793 Binding of Slc37a2 1 0.36 0.3 0 5.00
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