D:Smooth Muscle Tumor

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms MUSCLE TUMOR SMOOTH, Muscle Tumors Smooth, Smooth Muscle Tumors, Tumor Smooth Muscle, Tumors Smooth Muscle
Documents 63
Hot Single Events 21
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Smooth Muscle Tumor. They are ordered first by their relevance to Smooth Muscle Tumor and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT206853 ESR1 Positive_regulation of Gene_expression of PCP4 1 0.08 1.39 0.04 46.60
2 INT206847 ESR1 Negative_regulation of Gene_expression of PTGER3 1 0.08 1.52 0.04 46.60
3 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14 41.28
4 INT320887 Binding of TP63 and olt 1 0.01 2.15 0 31.60
5 INT206849 ESR1 Regulation of Gene_expression of ALDH1A1 1 0.11 2.26 0.04 25.44
6 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95 5.00
7 INT182368 IgG Regulation of Cast 1 0.01 0.99 0.11 5.00
8 INT182367 IgG Regulation of Vim 1 0.00 0.99 0.11 5.00
9 INT206856 Binding of Adm and Calcrl 1 0.04 1.76 0.1 5.00
10 INT206855 Binding of ESR1 and PPARA 1 0.03 1.21 0.07 5.00
11 INT320888 Binding of olt and HCC 1 0.00 1.62 0.06 5.00
12 INT206846 ESR1 Regulation of Gene_expression of PLP1 1 0.06 1.02 0.05 5.00
13 INT206897 Binding of HTR1A and Adm 1 0.02 0.87 0.05 5.00
14 INT206900 Binding of HTR1A and Calca 1 0.01 0.88 0.05 5.00
15 INT206848 PLP1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04 5.00
16 INT206845 ANXA1 Regulation of Gene_expression of ESR1 1 0.07 0.9 0.04 5.00
17 INT206851 NR4A1 Regulation of Gene_expression of ESR1 1 0.08 0.9 0.04 5.00
18 INT206896 ESR1 Positive_regulation of Gene_expression of Nr1i3 1 0.00 0.36 0.04 5.00
19 INT206852 ESR1 Regulation of Gene_expression of CRABP2 1 0.08 1.52 0.04 5.00
20 INT206898 Binding of PPARA and Rxrg 1 0.00 1.36 0.03 5.00
21 INT280543 Binding of GAST and STAT1 1 0.05 0.58 0 5.00
22 INT206895 Binding of ESR1 and Aldh1a1 1 0.03 0 0 5.00
23 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 5.00
24 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
25 INT206854 ESR1 Regulation of IGF1 1 0.01 0.33 0 5.00
26 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 5.00
27 INT206850 Binding of CRABP2 and ESR1 1 0.06 0 0 5.00
28 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
29 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 5.00
30 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 5.00
31 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 5.00
32 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 5.00
33 INT206844 ESR1 Positive_regulation of Gene_expression of ANXA1 1 0.08 0.1 0 5.00
34 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 5.00
35 INT280546 Binding of KIT and TP63 1 0.01 1.19 0 5.00
36 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 5.00
37 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 5.00
38 INT206899 ESR1 Negative_regulation of Gene_expression of Calcrl 1 0.07 0.15 0 5.00
39 INT206843 Binding of ALDH1A1 and ESR1 1 0.07 0 0 5.00
40 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 5.00
41 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 5.00
42 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
43 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 5.00
44 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 5.00
45 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Smooth Muscle Tumor. They are ordered first by their pain relevance and then by number of times they were reported in Smooth Muscle Tumor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT78038 Gene_expression of Oxtr 43 0.78 18.72 9.38 99.50
2 INT85184 Negative_regulation of Gene_expression of Oxtr 2 0.26 1.19 0.07 97.96
3 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 96.04
4 INT113980 Gene_expression of Cald1 4 0.05 7.16 0.33 96.04
5 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 91.64
6 INT21682 Binding of CD34 18 0.47 13.19 1.47 91.20
7 INT128376 Binding of KIT 26 0.48 14.24 0.47 91.20
8 INT96780 Binding of Il5 4 0.35 5.88 0.43 89.96
9 INT78704 Binding of CCL11 10 0.37 11.38 1.44 89.96
10 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 89.92
11 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 84.76
12 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55 84.40
13 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 84.16
14 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 84.00
15 INT48444 Localization of Csf3 28 0.72 14.85 2.11 84.00
16 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 81.20
17 INT96779 Regulation of Gene_expression of Il5 2 0.42 2.05 0.52 81.20
18 INT89774 Gene_expression of NR4A1 13 0.77 9.47 1.02 81.04
19 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 80.88
20 INT71302 Regulation of Gene_expression of CCL11 2 0.44 3.59 0.37 80.88
21 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 80.24
22 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 76.28
23 INT78033 Positive_regulation of Gene_expression of Oxtr 10 0.70 2.5 4.15 75.00
24 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 68.96
25 INT228895 Binding of Tsc2 5 0.30 2.41 0 68.60
26 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 67.56
27 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 67.44
28 INT228902 Gene_expression of RPS6KB1 5 0.75 2.32 0.1 67.44
29 INT228899 Positive_regulation of Gene_expression of PHOSPHO1 1 0.49 0.84 0 67.44
30 INT228900 Positive_regulation of Gene_expression of RPS6KB1 2 0.49 1.6 0 67.44
31 INT228903 Negative_regulation of Gene_expression of PHOSPHO1 1 0.42 0.79 0 67.44
32 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 64.92
33 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 64.64
34 INT228904 Positive_regulation of PHOSPHO1 1 0.45 0.84 0 64.08
35 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 63.52
36 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 56.96
37 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 56.96
38 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 56.96
39 INT229654 Positive_regulation of Gene_expression of Cd34 2 0.45 1.19 0.05 56.96
40 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 55.28
41 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 54.72
42 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 53.52
43 INT214073 Binding of TSC1 9 0.37 22 1.34 52.16
44 INT182354 Positive_regulation of Gene_expression of Klra8 1 0.01 2.99 0.35 51.36
45 INT182357 Gene_expression of Klra8 13 0.65 19.55 0.48 51.00
46 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 50.60
47 INT26585 Gene_expression of Vim 117 0.77 39.97 6 50.60
48 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 50.60
49 INT133905 Gene_expression of Ncam1 24 0.78 10.2 4.62 50.60
50 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 50.60
51 INT248470 Gene_expression of Ighmbp2 5 0.75 3.32 0.68 50.60
52 INT206863 Gene_expression of PCP4 1 0.28 2.88 0.04 45.84
53 INT107619 Gene_expression of PTGER3 42 0.75 15 5.61 43.36
54 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74 43.36
55 INT88278 Binding of Kit 33 0.37 24.45 4.13 42.72
56 INT182369 Regulation of CCL18 2 0.60 2.92 1.13 37.88
57 INT182356 Regulation of Ckm 1 0.01 1.34 0.15 37.88
58 INT206876 Positive_regulation of Gene_expression of ANXA1 3 0.39 1.68 0.51 35.12
59 INT134798 Gene_expression of ANXA1 15 0.75 13.94 2.99 34.72
60 INT18897 Binding of CHGA 11 0.36 10.12 1.17 34.60
61 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58 33.44
62 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 31.60
63 INT44917 Negative_regulation of Gene_expression of PTGDS 6 0.50 2.98 1.27 29.72
64 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 29.28
65 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 28.08
66 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 27.80
67 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 27.20
68 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 25.76
69 INT268686 Gene_expression of JAZF1 2 0.68 9.33 0 25.76
70 INT206880 Gene_expression of ALDH1A1 5 0.45 5.02 0.45 25.00
71 INT206884 Gene_expression of CRABP2 3 0.40 3.57 0.04 25.00
72 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 19.20
73 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41 16.48
74 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29 16.08
75 INT11157 Binding of EGF 88 0.48 53.73 21.25 14.24
76 INT64743 Positive_regulation of olt 19 0.40 16.46 3.86 13.84
77 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 12.32
78 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
79 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
80 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
81 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
82 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
83 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
84 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
85 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
86 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
87 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 5.00
88 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
89 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
90 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
91 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
92 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
93 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
94 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
95 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
96 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
97 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
98 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
99 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
100 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
101 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
102 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
103 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
104 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 5.00
105 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
106 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
107 INT137767 Gene_expression of Eae1 74 0.34 89.32 20.48 5.00
108 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
109 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
110 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
111 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
112 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
113 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
114 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
115 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
116 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
117 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
118 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
119 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
120 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
121 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
122 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
123 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
124 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
125 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
126 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
127 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 5.00
128 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
129 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
130 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
131 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
132 INT110987 Transcription of ESR1 45 0.71 24.16 6.72 5.00
133 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
134 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
135 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
136 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
137 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 5.00
138 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
139 INT109246 Gene_expression of Calcrl 16 0.75 4.71 5.19 5.00
140 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
141 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
142 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 5.00
143 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73 5.00
144 INT109248 Gene_expression of Ramp1 8 0.72 2.45 4.69 5.00
145 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 5.00
146 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 5.00
147 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 5.00
148 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
149 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
150 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
151 INT1155 Binding of GAST 12 0.36 3.64 3.5 5.00
152 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 5.00
153 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 5.00
154 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 5.00
155 INT12844 Binding of TP63 15 0.47 10.57 3.38 5.00
156 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 5.00
157 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
158 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
159 INT192676 Binding of PTEN 14 0.46 10.58 3.06 5.00
160 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 5.00
161 INT200670 Gene_expression of AKT2 25 0.75 16.25 3 5.00
162 INT99574 Positive_regulation of KITLG 10 0.39 6.74 2.96 5.00
163 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79 5.00
164 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
165 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 5.00
166 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 5.00
167 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
168 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
169 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
170 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31 5.00
171 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
172 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26 5.00
173 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23 5.00
174 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 5.00
175 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
176 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
177 INT118884 Gene_expression of IRF1 5 0.66 2.71 2 5.00
178 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
179 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98 5.00
180 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97 5.00
181 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
182 INT93886 Positive_regulation of Gene_expression of PGR 19 0.52 15.78 1.89 5.00
183 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
184 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87 5.00
185 INT23956 Negative_regulation of DES 12 0.42 10.84 1.82 5.00
186 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
187 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
188 INT113147 Positive_regulation of Acta2 6 0.34 4.24 1.66 5.00
189 INT206144 Phosphorylation of JAK1 6 0.57 1.77 1.64 5.00
190 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6 5.00
191 INT167692 Binding of NCAM1 11 0.36 6.73 1.59 5.00
192 INT94614 Binding of PTGER3 7 0.35 2.54 1.58 5.00
193 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
194 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 5.00
195 INT39459 Gene_expression of SOAT1 10 0.75 7.62 1.52 5.00
196 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48 5.00
197 INT128936 Positive_regulation of Gene_expression of PTGER3 12 0.67 3.08 1.45 5.00
198 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41 5.00
199 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 5.00
200 INT121820 Binding of STAT1 9 0.46 2.54 1.4 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox