D:Somatoform Disorder

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Disease Term
Synonyms Body Dysmorphic Disorder, BODY DYSMORPHIC DISORDERS, Briquet Syndrome, Pain Disorder, SOMATISATION, Somatisation Disorder, Somatization, Somatization Disorder, SOMATIZATION DISORDERS, Somatoform, SOMATOFORM DISORDERS
Documents 1317
Hot Single Events 131
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Somatoform Disorder. They are ordered first by their relevance to Somatoform Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27 100.00
2 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 100.00
3 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4 92.56
4 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17 42.60
5 INT217075 Binding of Acsm3 and Slc26a4 1 0.04 2.11 0.04 36.00
6 INT353848 Binding of SCLY and Ubash3a 1 0.30 0.47 0.04 23.36
7 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 14.32
8 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 14.32
9 INT340118 Binding of Sugt1 and Pain1 1 0.00 3.53 3.44 5.00
10 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 5.00
11 INT340117 Binding of Bdnf and Pain1 1 0.01 2.48 2.55 5.00
12 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
13 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 5.00
14 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
15 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21 5.00
16 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99 5.00
17 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
18 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83 5.00
19 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83 5.00
20 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82 5.00
21 INT180496 Binding of CTS and PDXK 1 0.04 0.69 0.77 5.00
22 INT317585 Binding of Lbp and Ppap2b 1 0.03 0.78 0.72 5.00
23 INT317586 Binding of SCLY and Ppap2b 1 0.00 0.78 0.72 5.00
24 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69 5.00
25 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64 5.00
26 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 5.00
27 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28 5.00
28 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28 5.00
29 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 5.00
30 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 5.00
31 INT290376 Binding of CSF1R and MEFV 1 0.29 0.31 0.24 5.00
32 INT290378 NOD2 Negative_regulation of TLR2 1 0.27 0.83 0.23 5.00
33 INT290377 NOD2 Negative_regulation of Positive_regulation of TLR2 1 0.24 0.95 0.23 5.00
34 INT177477 Crh Positive_regulation of Crh Regulation of POMC 1 0.02 0.86 0.22 5.00
35 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21 5.00
36 INT177479 Negative_regulation of Crh Regulation of POMC 1 0.05 0.84 0.21 5.00
37 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15 5.00
38 INT177480 Positive_regulation of Crh Positive_regulation of Regulation of POMC 1 0.06 0.46 0.14 5.00
39 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08 5.00
40 INT282503 Binding of ocd and Dlgap3 1 0.28 1.58 0.03 5.00
41 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0 5.00
42 INT282507 Binding of Grik3 and ocd 1 0.25 0.61 0 5.00
43 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0 5.00
44 INT282502 Negative_regulation of Binding of ocd and Slc1a1 1 0.30 0.48 0 5.00
45 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Somatoform Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Somatoform Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 100.00
2 INT106037 Gene_expression of PEPD 10 0.75 4.18 3.11 100.00
3 INT140401 Binding of PEPD 3 0.47 2.22 2.97 100.00
4 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11 100.00
5 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 100.00
6 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 100.00
7 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 100.00
8 INT297382 Negative_regulation of BMP8B 1 0.09 0.53 0 100.00
9 INT36676 Gene_expression of Pepd 2 0.36 1.41 0.82 100.00
10 INT279823 Gene_expression of Pepd 1 0.19 2 1.14 100.00
11 INT238464 Gene_expression of SOCS6 2 0.22 1.15 0.03 100.00
12 INT106038 Regulation of PEPD 3 0.43 3.93 1.01 100.00
13 INT106039 Negative_regulation of Gene_expression of PEPD 5 0.56 1.37 1.18 100.00
14 INT106036 Negative_regulation of Negative_regulation of PEPD 2 0.42 0.68 0.98 100.00
15 INT137281 Regulation of Csi 15 0.39 1.2 1.56 100.00
16 INT275954 Regulation of Lat 4 0.54 0.75 0.37 100.00
17 INT193663 Binding of Pain1 9 0.36 8.84 8.04 100.00
18 INT57147 Binding of ANIB1 3 0.31 1.65 0.44 99.84
19 INT163682 Phosphorylation of tn 1 0.09 4.25 3.96 99.76
20 INT148864 Localization of DRGX 11 0.17 7.67 8.36 99.74
21 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.72
22 INT247613 Negative_regulation of Regulation of NAV1 1 0.09 0.78 1.07 99.72
23 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 99.64
24 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17 99.64
25 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58 99.44
26 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 99.42
27 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 99.24
28 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 99.24
29 INT247621 Gene_expression of PAMR1 4 0.06 1.49 0.44 99.00
30 INT61011 Regulation of TPH1 4 0.22 1.17 2.09 98.96
31 INT115294 Regulation of Regulation of TPH1 2 0.10 1 0.98 98.96
32 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 98.92
33 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 98.88
34 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 98.66
35 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 98.46
36 INT76399 Binding of Serpina6 4 0.34 3.81 3.46 98.44
37 INT210125 Regulation of Axin1 1 0.02 2.45 0.46 98.44
38 INT5324 Binding of Htr2a 23 0.47 7.14 14.66 98.44
39 INT52115 Positive_regulation of tn 5 0.50 4.68 3.54 98.32
40 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 98.00
41 INT111053 Positive_regulation of Positive_regulation of Nav1 4 0.46 2.97 3.53 98.00
42 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 97.78
43 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 97.70
44 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 97.52
45 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 97.12
46 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 97.08
47 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 96.98
48 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 96.64
49 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 96.60
50 INT62712 Negative_regulation of HGF 19 0.58 7.21 1.67 96.52
51 INT189394 Negative_regulation of MFI2 5 0.42 5.62 0.46 96.52
52 INT132972 Gene_expression of HADH 3 0.65 4.75 1.13 96.24
53 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 96.12
54 INT48912 Localization of NOS1 52 0.77 24.14 10.92 96.00
55 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 95.96
56 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 95.96
57 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 95.96
58 INT122924 Binding of ipv 27 0.42 31.81 1.99 95.96
59 INT341482 Gene_expression of NMNAT1 1 0.01 3.24 2.79 95.84
60 INT10228 Positive_regulation of PCS 49 0.67 28.72 7 95.80
61 INT247617 Positive_regulation of PAMR1 1 0.06 2.3 2.07 95.52
62 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 95.44
63 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 95.36
64 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 94.24
65 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 94.24
66 INT221764 Regulation of TSKU 1 0.14 0.51 0.24 94.04
67 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 93.84
68 INT186453 Gene_expression of TAB1 6 0.65 4.83 0.35 93.84
69 INT157366 Positive_regulation of Positive_regulation of KCNMA1 2 0.05 2.43 1.74 93.84
70 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 93.84
71 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 93.84
72 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 93.84
73 INT247971 Gene_expression of MAFD1 4 0.13 6.41 1.5 93.72
74 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 93.64
75 INT33071 Negative_regulation of Gene_expression of Gnrhr 13 0.53 5.99 4.41 92.92
76 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 92.56
77 INT123419 Binding of NAV1 37 0.48 7.09 26.43 92.44
78 INT290110 Gene_expression of Emp3 3 0.52 4.47 0.26 92.44
79 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 92.04
80 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 91.60
81 INT14368 Regulation of Gene_expression of Gnrhr 13 0.61 3.23 8.45 91.40
82 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 91.08
83 INT127565 Positive_regulation of ENC1 2 0.39 11.67 11.82 91.04
84 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 91.04
85 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89 91.04
86 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 91.04
87 INT198136 Positive_regulation of BCL2A1 7 0.67 5.72 5.05 91.04
88 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 90.92
89 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 90.80
90 INT312392 Positive_regulation of Regulation of DRGX 1 0.05 1.51 0.94 90.76
91 INT140399 Regulation of Scn9a 2 0.45 0.74 0.61 90.64
92 INT149229 Localization of ipv 8 0.65 10.34 1.06 90.52
93 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 90.52
94 INT139350 Binding of SCN1B 2 0.35 1 2.43 90.44
95 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 90.44
96 INT133885 Binding of SCN2A 7 0.47 1.27 1.54 90.44
97 INT139352 Binding of KCNQ2 1 0.33 0.87 0.13 90.44
98 INT139351 Binding of KCNQ3 1 0.33 0.87 0.13 90.44
99 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 90.12
100 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 89.84
101 INT140400 Binding of Scn9a 4 0.36 3.59 2.15 89.44
102 INT290597 Transcription of ZFP91 1 0.04 1.58 0.04 88.56
103 INT111098 Regulation of Dusp1 5 0.27 3.03 2.45 88.24
104 INT247614 Positive_regulation of Gene_expression of PAMR1 1 0.05 0.19 0.09 87.84
105 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 87.76
106 INT49922 Positive_regulation of Positive_regulation of Ngf 21 0.67 14.46 17.68 87.76
107 INT285167 Binding of PSMC4 2 0.04 0.56 0.72 86.16
108 INT262373 Positive_regulation of Fmod 1 0.20 0.89 0.77 85.88
109 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3 85.20
110 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 84.92
111 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53 84.92
112 INT138997 Gene_expression of Dyt1 2 0.67 1.91 0.37 84.92
113 INT125106 Gene_expression of PRKRA 2 0.13 2.35 0.3 84.92
114 INT165571 Gene_expression of ATP1A3 1 0.09 1.22 0.24 84.92
115 INT165572 Gene_expression of SGCE 1 0.09 1.22 0.24 84.92
116 INT165570 Gene_expression of THAP1 2 0.08 2.13 0.24 84.92
117 INT247615 Binding of URI1 2 0.20 1.17 1.13 84.72
118 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 84.44
119 INT139546 Gene_expression of URI1 3 0.75 3 1.49 84.00
120 INT262375 Binding of Fmod 1 0.20 12.37 10.1 82.52
121 INT55223 Regulation of Gene_expression of DRGX 6 0.09 3.77 5.15 82.40
122 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 82.28
123 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 82.28
124 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92 81.68
125 INT262317 Binding of TAF9 7 0.31 9.67 2.15 81.68
126 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 81.44
127 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 81.44
128 INT247619 Regulation of Positive_regulation of DRGX 1 0.03 1 0.97 81.04
129 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 80.92
130 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57 80.32
131 INT353846 Binding of Ubash3a 1 0.27 1.15 0.04 80.20
132 INT60161 Gene_expression of EPHA3 43 0.75 3.66 6.25 79.60
133 INT168312 Positive_regulation of Gene_expression of EPHA3 8 0.49 0.97 1.32 79.60
134 INT167608 Regulation of Rock2 2 0.33 2.47 0.59 78.96
135 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97 78.60
136 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74 77.96
137 INT219079 Gene_expression of WBP1L 2 0.04 1.93 0.68 76.52
138 INT185891 Gene_expression of BMP8B 4 0.54 1.58 0 75.80
139 INT53468 Binding of Acsm3 26 0.24 20.87 2.95 74.64
140 INT47909 Binding of CPP 32 0.48 24.9 13.79 74.56
141 INT76698 Positive_regulation of Pgp 7 0.42 7.37 6.02 74.56
142 INT53594 Binding of Csrp1 5 0.32 11.87 3.84 73.96
143 INT321183 Regulation of Binding of Csrp1 1 0.11 2.64 0.98 73.96
144 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 73.92
145 INT217091 Positive_regulation of Rrm2 5 0.33 4.12 0.6 73.76
146 INT115297 Positive_regulation of TGFB2 4 0.29 1.91 0.65 73.36
147 INT210124 Binding of Brsk1 1 0.01 1.47 0.11 72.96
148 INT195817 Gene_expression of ipv 28 0.58 31.04 1.86 72.84
149 INT291828 Positive_regulation of Gene_expression of ipv 3 0.44 7.4 0.89 72.84
150 INT291827 Positive_regulation of Localization of ipv 1 0.44 0.71 0.07 72.84
151 INT152352 Negative_regulation of Localization of DRGX 2 0.07 0.87 2.14 72.80
152 INT319920 Negative_regulation of Localization of SCN9A 1 0.29 0.31 0.92 72.80
153 INT319919 Localization of SCN9A 1 0.51 0.31 0.92 72.16
154 INT1026 Binding of Lbp 207 0.48 150.96 119.16 71.28
155 INT279818 Gene_expression of Gm4425 1 0.01 0.77 0.47 71.04
156 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 70.72
157 INT28738 Positive_regulation of PLB1 7 0.40 3.36 2.35 70.16
158 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 70.12
159 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33 69.68
160 INT115293 Regulation of Gene_expression of TXN 2 0.19 0.78 0.73 69.68
161 INT210123 Localization of Axin1 1 0.04 0.84 0.17 69.28
162 INT279817 Regulation of Gm4425 1 0.00 1.18 0.45 69.20
163 INT1512 Binding of Prl 73 0.48 26.22 20.63 69.20
164 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18 69.12
165 INT69703 Gene_expression of TXN 20 0.71 3.57 2.01 67.96
166 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49 67.04
167 INT115782 Gene_expression of KCND3 4 0.33 1.85 2.07 66.68
168 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62 66.68
169 INT158 Localization of Prl 2431 0.81 378.96 952.2 65.60
170 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68 64.04
171 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 64.00
172 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 63.96
173 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83 63.76
174 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65 63.52
175 INT115295 Gene_expression of SPERT 1 0.00 0.59 0.59 63.52
176 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 61.52
177 INT297383 Binding of BMP8B 1 0.08 0.34 0.03 60.96
178 INT187363 Phosphorylation of PST 1 0.51 0.48 0.12 59.60
179 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 59.12
180 INT353847 Localization of Ubash3a 1 0.54 0.49 0.03 58.88
181 INT101429 Positive_regulation of PST 10 0.40 2.14 0.6 58.80
182 INT36428 Binding of Chdh 42 0.47 48.04 26.54 58.72
183 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 57.92
184 INT210131 Binding of SCLY 2 0.36 0.59 0.03 56.56
185 INT204928 Positive_regulation of ATF7IP 4 0.49 1.69 0.54 56.00
186 INT162 Regulation of Prl 794 0.62 165.01 322.24 55.68
187 INT79168 Binding of TNC 39 0.47 16.51 7.55 55.64
188 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 55.48
189 INT113377 Positive_regulation of Localization of Nav1 2 0.70 0.23 1.46 54.08
190 INT205639 Transcription of TAS2R20 1 0.19 0.77 0.14 53.56
191 INT341483 Positive_regulation of NMNAT1 1 0.01 0.6 0.76 53.52
192 INT115292 Regulation of TGFB2 4 0.17 2.79 0.58 51.76
193 INT341334 Negative_regulation of Localization of Nav1 1 0.41 0.22 0.42 51.28
194 INT199317 Localization of Slc35b2 2 0.07 3.86 1.44 50.40
195 INT103262 Localization of Nav1 53 0.81 19.23 34.44 50.36
196 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 50.24
197 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 50.00
198 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08 50.00
199 INT202527 Negative_regulation of Gene_expression of DRGX 5 0.07 1.53 2.54 50.00
200 INT65948 Binding of DNASE1L3 8 0.31 1.38 2.21 50.00
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