D:Spastic Paraparesis

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Disease Term
Synonyms LOWER EXTREMITY WEAKNESS SPASTIC, PARAPARESES SPASTIC, Spastic Lower Extremity Weakness, Spastic Parapareses
Documents 109
Hot Single Events 18
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spastic Paraparesis. They are ordered first by their relevance to Spastic Paraparesis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 97.88
2 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 97.88
3 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 91.68
4 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11 42.72
5 INT283544 Binding of GARS and Bscl2 1 0.01 1.74 0 30.44
6 INT227399 Binding of D5Mit424 and Alms1 1 0.01 0.71 0 22.16
7 INT227398 Binding of H2afy and Alms1 1 0.01 1.42 0 22.16
8 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25 5.00
9 INT236832 CSF2 Regulation of CXCL13 1 0.09 0.34 0.45 5.00
10 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2 5.00
11 INT236833 Binding of CD19 and SDC1 1 0.26 0.54 0.15 5.00
12 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
13 INT236834 Binding of CD19 and CSF2 1 0.17 0.53 0.14 5.00
14 INT348971 Binding of MOG and CARTPT 1 0.06 0.73 0.08 5.00
15 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0 5.00
16 INT264679 IGFALS Positive_regulation of CTSC 1 0.02 1.68 0 5.00
17 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00
18 INT348972 Binding of CSF2 and MOG 1 0.21 0.41 0 5.00
19 INT264678 Binding of SETX and KRT20 1 0.00 2.17 0 5.00
20 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spastic Paraparesis. They are ordered first by their pain relevance and then by number of times they were reported in Spastic Paraparesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283541 Binding of GARS 1 0.01 3.33 0.04 97.96
2 INT283536 Binding of Setx 1 0.36 3.69 0 97.88
3 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 95.60
4 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 92.88
5 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 92.40
6 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 90.84
7 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 87.76
8 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 87.60
9 INT177968 Negative_regulation of Transcription of CSF2 3 0.37 2.8 0.55 87.60
10 INT348975 Negative_regulation of Transcription of ALB 1 0.04 2.2 0.37 87.60
11 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 87.20
12 INT70936 Localization of OPLL 1 0.51 0.61 0.43 85.28
13 INT163613 Transcription of CSF2 16 0.60 12.98 1.62 85.16
14 INT127291 Transcription of ALB 7 0.67 4.26 0.55 84.88
15 INT144112 Regulation of Binding of CPM 1 0.26 0.75 0.22 81.40
16 INT117796 Binding of CPM 5 0.48 2.79 0.45 80.76
17 INT144113 Binding of STX2 1 0.47 0.75 0.21 80.76
18 INT18892 Binding of HTLVR 2 0.25 1.76 0.23 80.56
19 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 79.12
20 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 78.68
21 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 77.04
22 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 76.52
23 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 76.52
24 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 76.52
25 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 76.52
26 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 60.32
27 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 59.76
28 INT264689 Negative_regulation of IGFALS 10 0.33 12.58 0.45 27.76
29 INT125391 Gene_expression of Rim5 2 0.01 1.94 0.11 14.16
30 INT348978 Positive_regulation of MOG 6 0.49 4.2 0.63 11.36
31 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
32 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
33 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
34 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
35 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
36 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
37 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
38 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
39 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
40 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
41 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
42 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
43 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
44 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
45 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
46 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
47 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
48 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
49 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
50 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 5.00
51 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
52 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
53 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 5.00
54 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
55 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
56 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
57 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
58 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
59 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
60 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
61 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
62 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
63 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
64 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 5.00
65 INT179744 Negative_regulation of SLC1A2 16 0.45 12.32 6.14 5.00
66 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 5.00
67 INT87470 Gene_expression of SDC1 27 0.78 24.86 5.81 5.00
68 INT33854 Localization of OPA1 19 0.65 10.55 5.04 5.00
69 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 5.00
70 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
71 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 5.00
72 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 5.00
73 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
74 INT108761 Localization of Alms1 24 0.70 13.92 3.74 5.00
75 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
76 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
77 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 5.00
78 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
79 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 5.00
80 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 5.00
81 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 5.00
82 INT182238 Binding of CXCL13 5 0.33 5.32 2.37 5.00
83 INT14488 Regulation of MBP 5 0.25 5.17 2.25 5.00
84 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 5.00
85 INT95904 Gene_expression of CD27 45 0.76 26.17 1.93 5.00
86 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89 5.00
87 INT26318 Positive_regulation of CD19 7 0.67 5.61 1.8 5.00
88 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 5.00
89 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 5.00
90 INT105569 Binding of IGFALS 13 0.25 17.31 1.36 5.00
91 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 5.00
92 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 5.00
93 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 5.00
94 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 5.00
95 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 5.00
96 INT192785 Regulation of Myo5a 4 0.05 9.05 0.93 5.00
97 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 5.00
98 INT236841 Negative_regulation of Gene_expression of CXCL13 3 0.27 2.17 0.83 5.00
99 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 5.00
100 INT206664 Positive_regulation of Gene_expression of CISH 3 0.20 0.59 0.74 5.00
101 INT196238 Binding of MOG 4 0.36 4.19 0.73 5.00
102 INT160799 Regulation of IGFALS 11 0.29 9.09 0.7 5.00
103 INT236837 Regulation of Negative_regulation of CSF2 2 0.32 1.83 0.61 5.00
104 INT90362 Negative_regulation of Gene_expression of SDC1 3 0.59 2.88 0.59 5.00
105 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 5.00
106 INT240281 Positive_regulation of IGFALS 11 0.31 10.44 0.56 5.00
107 INT320849 Binding of CARTPT 5 0.14 1.85 0.54 5.00
108 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45 5.00
109 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 5.00
110 INT340755 Negative_regulation of CARTPT 2 0.30 2.08 0.4 5.00
111 INT96520 Gene_expression of PRPH 5 0.75 2.55 0.39 5.00
112 INT236846 Localization of CD19 3 0.68 1.55 0.36 5.00
113 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 5.00
114 INT264684 Regulation of Gene_expression of TARDBP 1 0.41 4.21 0.31 5.00
115 INT264685 Gene_expression of TARDBP 4 0.61 8.8 0.31 5.00
116 INT264687 Binding of TARDBP 1 0.33 4.14 0.31 5.00
117 INT224340 Localization of TYMP 3 0.62 2.86 0.3 5.00
118 INT240278 Localization of IGFALS 11 0.53 9.44 0.29 5.00
119 INT236843 Negative_regulation of CXCL13 1 0.27 0.24 0.29 5.00
120 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 5.00
121 INT264686 Positive_regulation of Gene_expression of IGFALS 2 0.28 2.21 0.27 5.00
122 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25 5.00
123 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2 5.00
124 INT214569 Positive_regulation of Localization of CD27 3 0.49 2.16 0.19 5.00
125 INT236840 Positive_regulation of Localization of CD19 1 0.45 0.78 0.19 5.00
126 INT163189 Localization of CD27 7 0.74 5.31 0.18 5.00
127 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18 5.00
128 INT283534 Negative_regulation of Ncs1 2 0.25 0.79 0.17 5.00
129 INT236845 Gene_expression of PTPRCAP 1 0.04 0.62 0.17 5.00
130 INT194332 Localization of MFN2 2 0.74 1.45 0.15 5.00
131 INT302703 Binding of PLAA 1 0.13 0.87 0.15 5.00
132 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 5.00
133 INT302682 Localization of POLG2 1 0.67 1 0.11 5.00
134 INT302693 Localization of C10orf2 1 0.59 1 0.11 5.00
135 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 5.00
136 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 5.00
137 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 5.00
138 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 5.00
139 INT302692 Localization of POLG 1 0.69 0.99 0.1 5.00
140 INT283535 Localization of Bscl2 1 0.72 0 0.1 5.00
141 INT283537 Binding of Bscl2 1 0.36 0.48 0.09 5.00
142 INT13218 Gene_expression of Litaf 2 0.52 0.8 0.09 5.00
143 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 5.00
144 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 5.00
145 INT348980 Positive_regulation of Gene_expression of MOG 1 0.38 0.69 0.08 5.00
146 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 5.00
147 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 5.00
148 INT348977 Positive_regulation of Negative_regulation of CARTPT 1 0.08 0.69 0.08 5.00
149 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 5.00
150 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 5.00
151 INT302700 Localization of TK2 1 0.65 0.65 0.07 5.00
152 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 5.00
153 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 5.00
154 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 5.00
155 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 5.00
156 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 5.00
157 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 5.00
158 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 5.00
159 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 5.00
160 INT302685 Localization of MPV17 1 0.65 0.67 0.07 5.00
161 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 5.00
162 INT348979 Regulation of MOG 1 0.24 1.54 0.06 5.00
163 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
164 INT227397 Localization of Rim5 1 0.02 0.49 0 5.00
165 INT302688 Transcription of OPA1 1 0.68 0.3 0 5.00
166 INT283538 Regulation of Gene_expression of Litaf 1 0.24 0.43 0 5.00
167 INT304409 Negative_regulation of MOG 2 0.44 0.37 0 5.00
168 INT348976 Positive_regulation of CARTPT 1 0.08 0.61 0 5.00
169 INT302687 Regulation of PLAA 1 0.19 0.24 0 5.00
170 INT246981 Gene_expression of DHDDS 2 0.10 0.6 0 5.00
171 INT348974 Transcription of MOG 1 0.60 0.41 0 5.00
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