D:Sperm Disorder

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Disease Term
Synonyms Immotile Spermatozoa, Necrosperm, Sperm Development, Sperm Immotility, Sperm Motility, Spermicidal, SPERMICIDE
Documents 138
Hot Single Events 66
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Sperm Disorder. They are ordered first by their relevance to Sperm Disorder and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330486 MSR1 Negative_regulation of TAC1 1 0.01 0.23 0.13 80.00
2 INT330485 MSR1 Negative_regulation of TACR1 1 0.01 0.23 0.13 80.00
3 INT330491 Binding of Nka1 and SFTPA1 2 0.00 0 0.58 50.00
4 INT330487 Binding of MME and HPSE 1 0.35 0 0.06 50.00
5 INT330490 Binding of TAC3 and Nka1 1 0.02 0 0.05 50.00
6 INT234755 IL10 Positive_regulation of IFN1@ 1 0.08 0.68 0.23 43.52
7 INT297124 Binding of INCENP and Hephl1 1 0.00 0.17 0 27.04
8 INT256486 Si Negative_regulation of Gene_expression of Ces1c 1 0.00 0.19 0 21.84
9 INT347352 Negative_regulation of Binding of Ldha and Sds 1 0.14 0.07 0 9.84
10 INT347353 Binding of Ldha and Sds 1 0.12 0.07 0 7.52
11 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62 5.00
12 INT247475 P2RY6 Positive_regulation of ITPR3 1 0.01 0.45 0.23 5.00
13 INT247507 Grk6 Regulation of LTB4R 1 0.02 0.2 0.18 5.00
14 INT186243 IL36RN Positive_regulation of B4GALNT1 1 0.00 0.43 0.12 5.00
15 INT186240 Binding of AGRP and SCN5A 2 0.13 1.19 0.1 5.00
16 INT186246 Binding of CAT and SCN5A 1 0.03 0.47 0.1 5.00
17 INT186242 Binding of ALB and SCN5A 1 0.04 0.36 0.1 5.00
18 INT186245 Binding of AGRP and CAT 1 0.02 0.53 0.1 5.00
19 INT186244 Binding of AGRP and ALB 1 0.03 0.53 0.1 5.00
20 INT256487 Si Regulation of Csi 1 0.00 0.08 0.06 5.00
21 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
22 INT348881 Atpif1 Positive_regulation of If3 1 0.01 0.08 0.04 5.00
23 INT348885 Atpif1 Positive_regulation of EIF5B 1 0.01 0.08 0.04 5.00
24 INT186249 Binding of ROS1 and SCN5A 1 0.09 0.73 0.03 5.00
25 INT186248 NR5A1 Positive_regulation of Transcription of STAR 1 0.01 0.21 0 5.00
26 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0 5.00
27 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0 5.00
28 INT348334 Gml Positive_regulation of Micrl 1 0.01 0.51 0 5.00
29 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
30 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0 5.00
31 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
32 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
33 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
34 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0 5.00
35 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Sperm Disorder. They are ordered first by their pain relevance and then by number of times they were reported in Sperm Disorder. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4727 Regulation of TAC1 60 0.47 6.74 32.83 99.92
2 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.70
3 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 99.58
4 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 99.20
5 INT54747 Localization of OPRD1 7 0.73 0.69 6.27 99.20
6 INT6210 Binding of Nppa 39 0.47 14.35 7.21 99.00
7 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 98.96
8 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82 98.76
9 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 98.20
10 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 97.64
11 INT278538 Negative_regulation of Negative_regulation of NAV1 2 0.42 0.84 1.56 97.28
12 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 96.84
13 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18 96.64
14 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 96.64
15 INT4776 Localization of TAC1 82 0.78 16.89 45.21 95.08
16 INT136268 Localization of NAV1 22 0.75 2.84 26.23 94.88
17 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 94.84
18 INT5989 Positive_regulation of Dbi 79 0.49 24.38 32.56 94.20
19 INT200020 Negative_regulation of Apbb1 1 0.03 0.34 0.55 94.12
20 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 94.04
21 INT5303 Gene_expression of TAC3 19 0.75 5.25 5.2 93.76
22 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 93.20
23 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65 93.04
24 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 93.04
25 INT4784 Gene_expression of TAC4 25 0.71 9.84 11.54 92.92
26 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 92.36
27 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01 92.16
28 INT79062 Gene_expression of B4GALNT1 42 0.14 18.89 6.98 92.08
29 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 91.96
30 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39 91.52
31 INT174327 Gene_expression of CATSPER1 1 0.60 0.27 0.21 91.36
32 INT174324 Gene_expression of CATSPER2 1 0.45 0.15 0.11 91.36
33 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 91.20
34 INT137043 Transcription of NAV1 16 0.72 6.98 12.12 90.88
35 INT48517 Gene_expression of MMEL1 6 0.67 0.79 0.56 90.72
36 INT278546 Transcription of GNPTAB 3 0.03 2.19 1.1 90.48
37 INT174334 Gene_expression of CATSPER3 1 0.48 0.09 0.04 90.40
38 INT174328 Gene_expression of CATSPER4 1 0.56 0.16 0.03 90.40
39 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 89.88
40 INT27643 Negative_regulation of Gene_expression of BRD2 2 0.42 0.19 0.51 89.88
41 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 89.84
42 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 89.24
43 INT695 Binding of POMC 304 0.48 56.66 126.85 88.96
44 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 88.88
45 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95 88.56
46 INT109470 Negative_regulation of ITK 3 0.24 2.13 0.96 87.92
47 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 87.64
48 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 86.96
49 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16 86.96
50 INT278536 Transcription of OR51B4 1 0.02 0.24 0.43 86.04
51 INT97200 Transcription of BHLHE22 3 0.52 0.59 1.01 85.76
52 INT278543 Transcription of BHLHE23 1 0.13 0.23 0.43 85.36
53 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 85.28
54 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 84.28
55 INT251827 Regulation of POLG 3 0.59 2.94 0.04 82.60
56 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 82.32
57 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 82.32
58 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 82.32
59 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 82.24
60 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1 82.04
61 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 81.48
62 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 81.24
63 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 81.24
64 INT52072 Negative_regulation of Ces1c 6 0.31 1.37 2.13 80.88
65 INT348870 Negative_regulation of Slc26a6 1 0.13 0.26 0.06 80.56
66 INT256473 Gene_expression of Rnase9 1 0.12 0.08 0 80.32
67 INT5127 Localization of Lhb 488 0.80 50.48 162.66 78.72
68 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 78.72
69 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 78.72
70 INT738 Regulation of POMC 459 0.62 111.19 243.74 78.08
71 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 77.84
72 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 77.64
73 INT27642 Regulation of Gene_expression of Dbi 10 0.44 2.55 3.66 77.64
74 INT348871 Regulation of Gene_expression of Slc26a3 1 0.15 0.31 0.06 77.44
75 INT4195 Gene_expression of Ces1c 7 0.44 2.88 0.65 75.24
76 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75 75.16
77 INT200015 Gene_expression of Apbb1 1 0.05 0.4 1.45 75.12
78 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38 75.00
79 INT113913 Binding of Hephl1 23 0.27 1.57 0.19 74.88
80 INT46533 Binding of Ces1c 9 0.12 0.18 0.34 74.48
81 INT348875 Gene_expression of Slc26a3 1 0.26 0.31 0.06 74.24
82 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 74.00
83 INT19058 Positive_regulation of RLN1 8 0.70 2.03 1.73 73.36
84 INT70087 Negative_regulation of TGM1 2 0.50 2.62 0.21 73.12
85 INT266166 Negative_regulation of RPA1 2 0.08 1.65 0.03 73.12
86 INT91872 Gene_expression of RPA1 9 0.77 5.28 1.12 71.44
87 INT56299 Transcription of IL4 15 0.64 10.2 5.44 70.76
88 INT179169 Transcription of IL13 11 0.15 4.22 1.37 70.40
89 INT4130 Regulation of Ces1c 2 0.18 0.36 0.28 70.28
90 INT174325 Transcription of CATSPER4 1 0.44 0.19 0.1 70.16
91 INT73500 Regulation of IL13 12 0.36 10.37 3.53 69.72
92 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 69.32
93 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 69.32
94 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 68.92
95 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 68.88
96 INT266168 Gene_expression of SSBP1 1 0.58 0.4 0 67.20
97 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41 66.84
98 INT79861 Localization of ANPEP 4 0.62 0.54 0.86 65.80
99 INT278542 Binding of SCN4B 1 0.35 0.13 2.29 65.44
100 INT278549 Binding of SCN3B 1 0.34 0.13 2.29 65.44
101 INT278537 Binding of SCN2B 1 0.29 0.13 2.29 65.44
102 INT139350 Binding of SCN1B 2 0.35 1 2.43 65.44
103 INT234761 Binding of IL13 6 0.35 4.18 1.55 65.12
104 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 64.72
105 INT22214 Positive_regulation of Localization of Gpt 14 0.62 8.42 7.89 64.48
106 INT256484 Regulation of Phosphorylation of Ces1c 1 0.04 0.16 0 64.28
107 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 63.84
108 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 63.80
109 INT256479 Phosphorylation of Ces1c 1 0.08 0.16 0 63.76
110 INT8699 Gene_expression of Nka1 45 0.67 6.41 22.56 63.72
111 INT16278 Negative_regulation of Localization of CHGA 2 0.41 0.75 0.59 62.72
112 INT8225 Localization of CHGA 26 0.78 13.52 9.4 62.72
113 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 61.16
114 INT37745 Positive_regulation of Gene_expression of Sdcbp 22 0.60 5.15 6.02 61.16
115 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 60.80
116 INT278545 Gene_expression of SCN7A 1 0.75 0.12 6.24 59.28
117 INT215366 Gene_expression of HSPE1 12 0.74 6.39 1.39 59.04
118 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 58.72
119 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 58.52
120 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 58.08
121 INT48908 Transcription of NOS1 27 0.55 13.46 8.39 58.08
122 INT546 Binding of ALB 311 0.48 85.98 60.14 58.00
123 INT35122 Negative_regulation of Sdcbp 43 0.51 22.01 4.34 57.92
124 INT22213 Localization of Gpt 52 0.78 34.05 12.94 57.36
125 INT54539 Gene_expression of OR10R1P 2 0.02 0.22 0.46 55.44
126 INT256476 Negative_regulation of Gene_expression of Ces1c 1 0.04 0.39 0 54.48
127 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 52.72
128 INT3969 Positive_regulation of Sds 27 0.69 7.52 12.31 52.72
129 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 52.72
130 INT35634 Positive_regulation of Gene_expression of Sds 10 0.37 3.23 3.69 52.72
131 INT54538 Gene_expression of Ndc80 1 0.09 0.21 0.15 52.56
132 INT58904 Localization of TH1L 40 0.68 27.11 10.52 52.40
133 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 52.08
134 INT256475 Regulation of Binding of Ces1c 2 0.04 0.05 0 52.00
135 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 51.72
136 INT62629 Localization of CNR1 35 0.76 11.86 16.3 51.44
137 INT161690 Localization of FAAH 2 0.61 0.38 0.43 51.44
138 INT161693 Localization of NAPEPLD 3 0.44 0.1 0.37 51.44
139 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 50.88
140 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 50.40
141 INT143744 Regulation of FAAH 6 0.61 8.42 1.55 50.32
142 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 50.08
143 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 50.00
144 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 50.00
145 INT8779 Binding of TAC1 50 0.47 11.19 25.57 50.00
146 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 50.00
147 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 50.00
148 INT113538 Regulation of Binding of TAC1 2 0.44 0.15 0.66 50.00
149 INT177436 Binding of HPSE 2 0.47 1.81 0.52 50.00
150 INT209108 Positive_regulation of Negative_regulation of GOPC 6 0.33 1.72 0.51 50.00
151 INT161692 Regulation of NAPEPLD 2 0.17 0.9 0.45 49.52
152 INT256478 Negative_regulation of Gene_expression of Hesx1 1 0.01 0.07 0 49.04
153 INT19948 Gene_expression of Sds 34 0.63 14.69 15.44 48.80
154 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 48.72
155 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 48.16
156 INT5851 Positive_regulation of Gene_expression of Penk 52 0.70 14.57 25.05 48.16
157 INT236490 Positive_regulation of SCN11A 2 0.48 0.91 2.37 47.20
158 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 45.84
159 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 45.52
160 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 45.00
161 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 44.40
162 INT256485 Gene_expression of Hesx1 1 0.01 0.07 0 43.92
163 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 43.12
164 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 41.92
165 INT28546 Regulation of SHBG 23 0.54 16.35 3.88 39.96
166 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 39.44
167 INT74423 Localization of IL10 91 0.80 61.6 22.95 37.12
168 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 36.24
169 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 36.24
170 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 35.84
171 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 35.84
172 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 34.48
173 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 34.12
174 INT278540 Binding of SCN7A 1 0.36 0 0.7 33.52
175 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 33.40
176 INT104663 Positive_regulation of SCN9A 3 0.60 0.42 2.54 32.56
177 INT200016 Positive_regulation of Apbb1 1 0.04 0.08 0.55 32.56
178 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 31.92
179 INT123419 Binding of NAV1 37 0.48 7.09 26.43 31.20
180 INT74983 Transcription of NA 9 0.41 1.71 2.79 30.80
181 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 30.72
182 INT193112 Negative_regulation of Gene_expression of Bcl2l10 5 0.02 3.03 0.45 30.72
183 INT221994 Positive_regulation of Gene_expression of Bcl2l10 2 0.07 1.12 0.1 30.72
184 INT278550 Positive_regulation of SCN8A 1 0.48 0 1.31 29.84
185 INT23598 Binding of SCN5A 32 0.40 16 5.35 28.80
186 INT108405 Gene_expression of FAAH 48 0.78 28.22 9.97 28.08
187 INT86890 Gene_expression of Si 6 0.37 0.38 0.47 27.72
188 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34 27.48
189 INT13021 Positive_regulation of SCN4A 7 0.49 1.61 2.42 27.44
190 INT102601 Positive_regulation of Psmd11 1 0.69 0.85 0.31 27.12
191 INT8101 Binding of INCENP 42 0.31 16.2 6.68 27.04
192 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 26.96
193 INT153599 Gene_expression of SCN1A 8 0.75 7.01 1.47 26.60
194 INT161691 Gene_expression of PLD1 1 0.02 0 0.38 25.84
195 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 25.72
196 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 25.64
197 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 25.60
198 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 25.44
199 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 25.44
200 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 25.44
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