D:Spherocytosis

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pChart

Disease Term
Synonyms Hereditary Spherocytoses, Hereditary Spherocytosis, Spherocytoses Hereditary, SPHEROCYTOSIS HEREDITARY
Documents 44
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spherocytosis. They are ordered first by their relevance to Spherocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214014 Binding of Dysf and Nav1 1 0.00 0.5 0.1 78.24
2 INT214016 Dysf Negative_regulation of Binding of Dysf and Nav1 1 0.00 0.5 0.1 78.24
3 INT214011 Negative_regulation of Binding of Ank1 and Nav1 1 0.01 0.51 0.1 77.72
4 INT214012 Binding of Ank1 and Nav1 1 0.01 0.51 0.1 77.32
5 INT214015 Negative_regulation of Binding of Dnahc8 and Ank2 1 0.04 1.09 0.04 25.92
6 INT214013 Binding of Dnahc8 and Ank2 1 0.03 1.08 0.04 25.28
7 INT193193 Binding of CRS and RAPH1 1 0.12 1.47 0 9.52

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spherocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Spherocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2367 Binding of Sct 34 0.42 8.46 8.62 100.00
2 INT214010 Binding of Spnb1 2 0.01 0.38 0.07 99.74
3 INT213993 Negative_regulation of Spnb1 2 0.02 0.37 0.07 99.42
4 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 90.48
5 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 90.48
6 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 83.96
7 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 79.08
8 INT310513 Gene_expression of Twsg1 1 0.17 3.97 0.28 77.24
9 INT193196 Regulation of MNX1 2 0.19 2.53 0.64 74.40
10 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 74.12
11 INT214008 Negative_regulation of Ank1 4 0.03 1.49 0.09 67.16
12 INT192918 Negative_regulation of HAMP 3 0.57 2.29 0.09 64.96
13 INT310527 Gene_expression of MDFIC 1 0.05 1.87 0.29 53.44
14 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 40.16
15 INT310522 Regulation of Transcription of HAMP 1 0.60 1.36 0.05 40.16
16 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88 37.80
17 INT193195 Localization of MNX1 1 0.59 1.01 0.03 30.40
18 INT99003 Regulation of Vcam1 7 0.41 6.91 1.04 24.36
19 INT33431 Localization of Dnahc8 8 0.67 3.49 1.68 23.88
20 INT214002 Localization of Slc8a1 1 0.34 1.07 0.04 23.56
21 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 22.72
22 INT214007 Negative_regulation of Ank2 1 0.43 2.63 0.14 18.96
23 INT211657 Localization of Arg1 4 0.53 3.48 0.2 17.28
24 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 15.92
25 INT213997 Negative_regulation of Gene_expression of Ank2 1 0.43 5.06 0.22 12.76
26 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 10.08
27 INT22882 Negative_regulation of IMPA1 10 0.57 5.19 0.31 7.28
28 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
29 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
30 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
31 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
32 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
33 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
34 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 5.00
35 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 5.00
36 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
37 INT246315 Localization of Ednra 22 0.15 2.73 4.64 5.00
38 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
39 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
40 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
41 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
42 INT31414 Gene_expression of Gcg 25 0.73 7.28 3.25 5.00
43 INT110039 Positive_regulation of Nppb 38 0.53 34.54 2.88 5.00
44 INT59784 Binding of DES 22 0.47 19.48 2.27 5.00
45 INT92129 Positive_regulation of Gene_expression of F3 13 0.08 12.13 2.02 5.00
46 INT49377 Negative_regulation of Scd1 11 0.49 9.84 1.88 5.00
47 INT30168 Gene_expression of Dnahc8 20 0.65 4.17 1.73 5.00
48 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 5.00
49 INT205952 Gene_expression of Shbdp1 14 0.24 2.46 1.27 5.00
50 INT108423 Negative_regulation of Pde12 3 0.06 1.81 1.26 5.00
51 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
52 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 5.00
53 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
54 INT34141 Positive_regulation of IMPA1 8 0.50 2.38 1.12 5.00
55 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 5.00
56 INT34144 Localization of IMPA1 3 0.37 0.88 0.76 5.00
57 INT183037 Gene_expression of MNX1 12 0.53 4.27 0.69 5.00
58 INT39865 Regulation of Positive_regulation of PLOD1 2 0.27 0.71 0.66 5.00
59 INT69098 Positive_regulation of Gene_expression of F2 5 0.66 3.79 0.58 5.00
60 INT310529 Positive_regulation of MDFIC 1 0.05 6.21 0.52 5.00
61 INT26073 Gene_expression of Scd1 17 0.70 9.17 0.47 5.00
62 INT214004 Regulation of Gene_expression of Ank2 1 0.45 2.79 0.38 5.00
63 INT183075 Binding of Hypt 7 0.22 7.47 0.38 5.00
64 INT50530 Binding of MDFIC 2 0.17 1.88 0.38 5.00
65 INT193199 Gene_expression of RAPH1 6 0.60 4.55 0.36 5.00
66 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 5.00
67 INT16808 Binding of Scd1 5 0.00 7.18 0.33 5.00
68 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31 5.00
69 INT310530 Positive_regulation of Gene_expression of HAMP 3 0.49 4.16 0.28 5.00
70 INT214006 Negative_regulation of Gene_expression of Dnahc8 2 0.03 1.28 0.24 5.00
71 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 5.00
72 INT334907 Protein_catabolism of Nppb 2 0.56 8.28 0.22 5.00
73 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 5.00
74 INT334908 Localization of Pde12 1 0.06 1.25 0.19 5.00
75 INT213999 Phosphorylation of Ank2 1 0.82 0.21 0.19 5.00
76 INT213996 Negative_regulation of Phosphorylation of Ank2 1 0.43 0.21 0.19 5.00
77 INT310528 Negative_regulation of Positive_regulation of HRASLS 1 0.01 1.6 0.18 5.00
78 INT308962 Regulation of SLC7A7 3 0.16 1.2 0.18 5.00
79 INT310523 Localization of MDFIC 1 0.05 0.83 0.14 5.00
80 INT170734 Positive_regulation of Gene_expression of Scd1 5 0.48 5.87 0.13 5.00
81 INT213998 Phosphorylation of Gcg 3 0.17 0.94 0.12 5.00
82 INT214000 Binding of Ank2 1 0.48 1.12 0.12 5.00
83 INT213994 Negative_regulation of Phosphorylation of Gcg 1 0.09 0.1 0.1 5.00
84 INT310526 Gene_expression of HFE2 2 0.32 1.14 0.09 5.00
85 INT310525 Negative_regulation of Gene_expression of HAMP 1 0.57 0.58 0.08 5.00
86 INT296384 Regulation of SLC40A1 2 0.01 0.83 0.03 5.00
87 INT214001 Protein_catabolism of Ank2 1 0.66 0.08 0 5.00
88 INT214003 Regulation of Ank2 1 0.45 0 0 5.00
89 INT193197 Localization of RAPH1 1 0.51 1.2 0 5.00
90 INT213995 Positive_regulation of Ank2 1 0.50 2.86 0 5.00
91 INT214009 Positive_regulation of Gene_expression of Ank2 1 0.70 2.86 0 5.00
92 INT193198 Positive_regulation of Binding of DES 1 0.18 0.49 0 5.00
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