D:Spina Bifida

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Disease Term
Synonyms Bifida Spina, Congenital Spina Bifida, Dysraphia Spinal, Dysraphias Spinal, Dysraphicus Status, DYSRAPHISM SPINAL, Dysraphisms Spinal, Rachischises, Rachischisis, SCHISTORRHACHIS, Spina Bifida Congenital
Documents 246
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spina Bifida. They are ordered first by their relevance to Spina Bifida and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT87555 TPSAB1 Positive_regulation of IGHE 1 0.42 0.71 0.43 77.84
2 INT87556 TPSAB1 Positive_regulation of CD79A 1 0.40 0.7 0.42 77.84
3 INT170656 Ntf3 Positive_regulation of Csf2 1 0.35 1.46 0.44 42.88
4 INT170654 Binding of Ntf3 and Ngf 1 0.38 1.66 1.54 5.00
5 INT170655 Binding of Csf2 and Ngf 1 0.36 1.25 1.18 5.00
6 INT170653 Ngf Regulation of Csf2 1 0.34 1.11 1.05 5.00
7 INT170658 Binding of Ntf3 and Csf2 1 0.33 0.8 0.74 5.00
8 INT170657 Ntf3 Regulation of Csf2 1 0.31 0.46 0.43 5.00
9 INT194358 Binding of Ddt and Scgb1d2 1 0.01 0 0.31 5.00
10 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 5.00
11 INT194360 SNRPD1 Negative_regulation of Dbh 1 0.00 0 0.14 5.00
12 INT205537 ATP8A2 Negative_regulation of Negative_regulation of RHOXF2 1 0.01 0 0.07 5.00
13 INT312800 NOVA2 Regulation of TRPV1 1 0.12 0.1 0 5.00
14 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spina Bifida. They are ordered first by their pain relevance and then by number of times they were reported in Spina Bifida. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 99.98
2 INT212271 Binding of ARMC9 14 0.27 3.29 0.43 99.76
3 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 97.80
4 INT24961 Positive_regulation of Defb22 8 0.03 3.56 6.04 97.80
5 INT139780 Binding of AQP1 7 0.32 4.62 0.54 97.72
6 INT106031 Binding of Nat2 1 0.44 1.33 0 97.48
7 INT249052 Protein_catabolism of SMN1 1 0.02 1.98 0.1 93.28
8 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 91.56
9 INT301884 Gene_expression of SHROOM3 1 0.67 3.57 0.08 91.40
10 INT168505 Localization of S100A10 2 0.58 2.03 0.08 87.92
11 INT301899 Negative_regulation of SHROOM3 1 0.38 1.1 0 84.00
12 INT196967 Gene_expression of mea 9 0.27 1.47 1.55 83.08
13 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 82.88
14 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 79.92
15 INT216401 Negative_regulation of THEM4 1 0.12 0.56 0 75.20
16 INT92990 Binding of Mthfr 2 0.37 2.42 0.25 75.00
17 INT347732 Binding of Shc2 1 0.14 0.58 0 74.72
18 INT23598 Binding of SCN5A 32 0.40 16 5.35 72.24
19 INT68216 Binding of NF1 40 0.48 51.24 4.59 71.52
20 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 69.44
21 INT205541 Regulation of RHOXF2 1 0.06 0.2 0.21 63.92
22 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 63.44
23 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58 61.48
24 INT237384 Positive_regulation of Localization of VUR 2 0.43 2.85 0 56.76
25 INT237382 Localization of VUR 11 0.72 14.58 0.11 55.80
26 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 50.00
27 INT38672 Binding of KRT20 69 0.39 48.01 6.31 50.00
28 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 47.40
29 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51 47.40
30 INT152060 Gene_expression of VUR 75 0.67 83.83 2.34 44.00
31 INT69203 Positive_regulation of Ntf3 43 0.66 19.16 16.49 42.88
32 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 42.08
33 INT105761 Binding of GFAP 13 0.36 14.94 2.32 39.40
34 INT141782 Binding of CEACAM7 5 0.31 3.2 0.45 38.40
35 INT230768 Regulation of INVS 2 0.07 1.36 0 36.32
36 INT214025 Negative_regulation of INVS 4 0.07 3.36 0 36.32
37 INT102698 Binding of ACCS 54 0.42 66.73 9.06 33.36
38 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 32.64
39 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 32.16
40 INT16257 Regulation of Gene_expression of Ntf3 8 0.43 4 5.63 32.16
41 INT122368 Regulation of Regulation of Ngf 1 0.27 1.37 1.27 32.16
42 INT155052 Regulation of Gene_expression of Csf2 6 0.37 7.75 0.8 32.16
43 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 31.84
44 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 31.68
45 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 31.68
46 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 31.68
47 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07 31.68
48 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 29.52
49 INT301891 Gene_expression of ATP10D 1 0.57 2.94 0.08 29.52
50 INT301880 Gene_expression of BEND5 1 0.60 1.95 0 29.52
51 INT301893 Regulation of ATP10D 1 0.20 1.52 0.07 28.12
52 INT301887 Regulation of BEND5 1 0.18 1.5 0.07 27.80
53 INT301897 Regulation of SHROOM3 1 0.24 1.52 0.07 27.52
54 INT141132 Regulation of ACCS 14 0.29 13.92 1.89 26.20
55 INT38379 Positive_regulation of VUR 15 0.58 15 0.71 21.44
56 INT17081 Binding of Ttpa 7 0.27 2.12 0.34 20.40
57 INT161749 Regulation of VUR 9 0.39 9.3 0.46 9.48
58 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 6.28
59 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
60 INT1045 Localization of LH 1211 0.81 87.04 456.25 5.00
61 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
62 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 5.00
63 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
64 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
65 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
66 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
67 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
68 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 5.00
69 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
70 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
71 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
72 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
73 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
74 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
75 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
76 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
77 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 5.00
78 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
79 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
80 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
81 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
82 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
83 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 5.00
84 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
85 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
86 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
87 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
88 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
89 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
90 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
91 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 5.00
92 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
93 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
94 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 5.00
95 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
96 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
97 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
98 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
99 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
100 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 5.00
101 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
102 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
103 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
104 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
105 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
106 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
107 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
108 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
109 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25 5.00
110 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 5.00
111 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
112 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
113 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
114 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 5.00
115 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
116 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
117 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
118 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
119 INT65907 Negative_regulation of Gene_expression of Ngf 36 0.59 19.5 20.03 5.00
120 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
121 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
122 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
123 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
124 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
125 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
126 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
127 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
128 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
129 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
130 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
131 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
132 INT18720 Localization of Csf2 72 0.67 13.65 13.41 5.00
133 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
134 INT75224 Positive_regulation of Gene_expression of Ntf3 23 0.69 11.79 13.08 5.00
135 INT3521 Regulation of Csf2 38 0.54 11.09 12.73 5.00
136 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
137 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
138 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
139 INT76434 Negative_regulation of PRKG1 25 0.58 10.36 10.81 5.00
140 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 5.00
141 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37 5.00
142 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
143 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 5.00
144 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 5.00
145 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
146 INT16356 Regulation of NPPA 33 0.62 13.24 9.53 5.00
147 INT75997 Positive_regulation of Localization of Ngf 14 0.69 7.78 9.41 5.00
148 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
149 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
150 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
151 INT73558 Regulation of IK 23 0.23 12.02 8.73 5.00
152 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
153 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
154 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 5.00
155 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
156 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
157 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
158 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
159 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
160 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91 5.00
161 INT71689 Localization of Ntf3 23 0.73 11.1 7.91 5.00
162 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49 5.00
163 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
164 INT68279 Positive_regulation of Gene_expression of Csf2 30 0.67 16.31 6.88 5.00
165 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 5.00
166 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
167 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
168 INT7873 Positive_regulation of Ugt2b 36 0.70 0.72 6.59 5.00
169 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 5.00
170 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
171 INT92662 Negative_regulation of Gene_expression of Ntf3 9 0.57 7.44 6.22 5.00
172 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
173 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69 5.00
174 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
175 INT116055 Phosphorylation of PRKG1 33 0.80 2.22 5.58 5.00
176 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
177 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
178 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02 5.00
179 INT16621 Negative_regulation of Esr1 20 0.54 8.2 4.84 5.00
180 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
181 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
182 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
183 INT108354 Negative_regulation of Phosphorylation of Prkaca 18 0.41 6.24 4.37 5.00
184 INT61118 Gene_expression of Nefl 11 0.75 4.02 4.02 5.00
185 INT112692 Localization of Bax 31 0.80 20.97 3.98 5.00
186 INT6507 Binding of C5 23 0.48 15.35 3.91 5.00
187 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81 5.00
188 INT64817 Positive_regulation of Binding of Jun 16 0.69 6.78 3.81 5.00
189 INT20461 Binding of Esr1 34 0.48 9.58 3.66 5.00
190 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 5.00
191 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56 5.00
192 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
193 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 5.00
194 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
195 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
196 INT151123 Negative_regulation of Gene_expression of Csf2 21 0.53 21.76 3.22 5.00
197 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 5.00
198 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
199 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 5.00
200 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 5.00
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