D:Spinal Cord Compression

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Disease Term
Synonyms Compression Spinal Cord, Compressions Spinal Cord, COMPRESSIVE MYELOPATHY, Conus Medullaris Syndrome, CONUS MEDULLARIS SYNDROMES, Extramedullary Spinal Cord Compression, MYELOPATHY COMPRESSIVE, SPINAL CORD COMPRESSION EXTRAMEDULLARY, Spinal Cord Compressions, Syndrome Conus Medullaris, Syndromes Conus Medullaris
Documents 874
Hot Single Events 49
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinal Cord Compression. They are ordered first by their relevance to Spinal Cord Compression and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04 82.44
2 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04 82.12
3 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 74.40
4 INT353208 NEUROG2 Positive_regulation of Gene_expression of HTR1A 1 0.05 0.35 0.31 55.12
5 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13 32.52
6 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13 32.52
7 INT341666 ALPI Positive_regulation of ENPEP 1 0.01 1.05 0 24.72
8 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
9 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 5.00
10 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
11 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57 5.00
12 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56 5.00
13 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56 5.00
14 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22 5.00
15 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13 5.00
16 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
17 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
18 INT278059 XRCC1 Positive_regulation of Gene_expression of IL2 1 0.01 1.06 0.07 5.00
19 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
20 INT198620 CRH Negative_regulation of GH1 1 0.05 0.47 0.05 5.00
21 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05 5.00
22 INT198618 CRH Negative_regulation of Localization of SST 1 0.07 0.53 0.05 5.00
23 INT175625 PAR1 Regulation of Gene_expression of MMP9 1 0.02 1.25 0.05 5.00
24 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
25 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04 5.00
26 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 5.00
27 INT175629 PAR1 Positive_regulation of Positive_regulation of MMP1 1 0.21 0.69 0.04 5.00
28 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03 5.00
29 INT210592 Binding of Cd4 and Vcam1 1 0.01 0.65 0.03 5.00
30 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 5.00
31 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
32 INT197761 Binding of KRT5 and C4a 1 0.02 2.29 0 5.00
33 INT175624 Gene_expression of CDH2 Positive_regulation of CDH1 1 0.00 1.12 0 5.00
34 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 5.00
35 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0 5.00
36 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0 5.00
37 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
38 INT278068 Binding of XRCC1 and Vhl 1 0.02 2.3 0 5.00
39 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
40 INT236171 Binding of LIF and Hmgcr 1 0.02 0 0 5.00
41 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0 5.00
42 INT175630 Binding of PCa and MMRN1 1 0.01 1.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinal Cord Compression. They are ordered first by their pain relevance and then by number of times they were reported in Spinal Cord Compression. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14971 Regulation of Afp 12 0.44 11.35 1.48 99.32
2 INT353223 Gene_expression of Neurog3 1 0.07 3.11 2.41 99.12
3 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 99.00
4 INT286803 Gene_expression of Neurog2 2 0.27 2.73 1.55 98.86
5 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 98.60
6 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 98.46
7 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 98.44
8 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 96.92
9 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 96.52
10 INT10667 Localization of HTR1A 4 0.78 1.43 2.03 95.52
11 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 95.20
12 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 92.68
13 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 91.96
14 INT139475 Negative_regulation of DKK1 14 0.52 9.2 1.76 91.68
15 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 91.56
16 INT155225 Negative_regulation of MYRIP 1 0.42 0.71 0.31 91.32
17 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36 91.08
18 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28 90.68
19 INT920 Localization of PLOD1 223 0.81 42.25 78.7 90.32
20 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 90.32
21 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67 89.76
22 INT196594 Localization of CFD 4 0.65 4.36 0.39 89.20
23 INT196595 Regulation of Localization of CFD 1 0.39 2.03 0.04 89.20
24 INT373 Regulation of Ldha 37 0.61 17.86 11.41 88.76
25 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 88.12
26 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 87.80
27 INT117934 Gene_expression of Cd38 11 0.68 6.5 1.95 87.48
28 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 87.12
29 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 87.12
30 INT57336 Gene_expression of Cd19 5 0.46 4.8 1.6 87.12
31 INT165761 Phosphorylation of Tnfsf11 3 0.75 2.76 0.4 86.60
32 INT232197 Positive_regulation of Phosphorylation of Tnfsf11 1 0.46 0.6 0.04 86.60
33 INT232200 Phosphorylation of Pthlh 1 0.46 1.19 0.09 86.36
34 INT232202 Positive_regulation of Phosphorylation of Pthlh 1 0.28 1.19 0.09 86.36
35 INT232198 Phosphorylation of Tnfrsf11a 1 0.56 0.6 0.04 86.36
36 INT232199 Positive_regulation of Phosphorylation of Tnfrsf11a 1 0.34 0.6 0.04 86.36
37 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 86.12
38 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 86.12
39 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 86.00
40 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 85.68
41 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 85.52
42 INT146661 Positive_regulation of D230030E09Rik 1 0.40 0.92 0.73 85.52
43 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 85.36
44 INT118460 Binding of Bmp7 3 0.46 1.3 0.4 83.24
45 INT64797 Regulation of ALPP 18 0.24 9.71 2.24 82.88
46 INT131851 Positive_regulation of RHOC 3 0.57 9.44 0.41 82.40
47 INT79299 Negative_regulation of NXT1 16 0.32 8.27 3.78 81.48
48 INT131849 Negative_regulation of RHOC 4 0.54 6.46 0.34 80.20
49 INT131852 Positive_regulation of Negative_regulation of RHOC 1 0.46 1.12 0.12 80.20
50 INT131847 Negative_regulation of Gene_expression of RHOC 2 0.39 1.38 0.12 80.00
51 INT904 Positive_regulation of Ptgfr 23 0.49 7.98 5.55 79.92
52 INT125980 Binding of CFD 8 0.42 10.96 1.39 79.80
53 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 79.60
54 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 79.16
55 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 79.12
56 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 79.12
57 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01 79.12
58 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 79.12
59 INT34008 Positive_regulation of Binding of Tbxa2r 5 0.42 1.97 1.46 79.12
60 INT3057 Gene_expression of Ptgfr 60 0.58 14.54 11.73 79.00
61 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 78.88
62 INT68288 Positive_regulation of SERPINB3 14 0.51 16.87 0.41 77.04
63 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 76.36
64 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 75.96
65 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 75.84
66 INT232201 Negative_regulation of Positive_regulation of Tnfrsf11a 1 0.40 1.16 0.04 75.84
67 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69 75.00
68 INT114157 Positive_regulation of CTD 7 0.24 6.94 1.82 75.00
69 INT158167 Binding of Gfra1 1 0.34 2.02 1.73 75.00
70 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 75.00
71 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 75.00
72 INT115475 Negative_regulation of RUNX1 4 0.37 5 0.22 75.00
73 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 74.96
74 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 74.12
75 INT40817 Positive_regulation of Gene_expression of Pla2g1b 5 0.26 1.98 2.19 72.48
76 INT21613 Gene_expression of Pla2g1b 25 0.68 9.05 6.39 72.48
77 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23 72.08
78 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 71.32
79 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 70.92
80 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 70.84
81 INT214574 Positive_regulation of SDC1 4 0.32 3.24 1.28 70.84
82 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 69.72
83 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 68.80
84 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 68.56
85 INT3920 Localization of Ldha 241 0.81 83.08 58.72 68.40
86 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 68.40
87 INT8101 Binding of INCENP 42 0.31 16.2 6.68 68.04
88 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 66.96
89 INT47729 Positive_regulation of Positive_regulation of Pla2g1b 3 0.08 3.65 3.07 66.96
90 INT162056 Negative_regulation of IGFBP4 1 0.12 0.71 0.1 66.16
91 INT70936 Localization of OPLL 1 0.51 0.61 0.43 66.08
92 INT1261 Localization of Adh1 63 0.81 19.36 16.09 63.68
93 INT91598 Positive_regulation of Localization of HTR1A 3 0.49 0.51 1.03 62.12
94 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 61.48
95 INT77586 Positive_regulation of Gene_expression of HTR1A 6 0.46 3.54 1.51 61.48
96 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 60.96
97 INT353219 Regulation of Gene_expression of Neurog2 1 0.10 0.16 0.03 60.56
98 INT48729 Gene_expression of IGFBP4 4 0.46 1 0.68 59.24
99 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 58.20
100 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 55.80
101 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59 53.48
102 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 51.72
103 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 50.52
104 INT52180 Binding of Aes 38 0.42 23.16 6.7 50.40
105 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 50.00
106 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 50.00
107 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 50.00
108 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 50.00
109 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 50.00
110 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 50.00
111 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 50.00
112 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 50.00
113 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 49.92
114 INT173877 Positive_regulation of Gene_expression of INCENP 14 0.08 7.83 1.28 49.92
115 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27 48.40
116 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 46.84
117 INT286477 Negative_regulation of Idua 1 0.03 1.28 0.09 46.40
118 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 46.00
119 INT105598 Negative_regulation of Mtpn 15 0.16 11.83 2.65 46.00
120 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 45.72
121 INT148686 Localization of C6 5 0.31 4.27 0.64 45.56
122 INT225226 Positive_regulation of Negative_regulation of Ccnd1 1 0.14 1.18 0.03 44.52
123 INT20425 Localization of Cpe 23 0.81 5.18 9.14 44.32
124 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 44.12
125 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 44.12
126 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 41.72
127 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 41.52
128 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 40.24
129 INT277886 Localization of Ids 3 0.73 1.09 0.48 39.96
130 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 39.52
131 INT353221 Binding of Neurog3 1 0.04 0.24 0.1 39.40
132 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 39.36
133 INT10729 Positive_regulation of ENPEP 13 0.38 9.65 0.8 39.36
134 INT75932 Binding of Csf2 45 0.37 33.2 8.01 36.60
135 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 36.28
136 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 35.76
137 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 35.56
138 INT153233 Negative_regulation of Ids 5 0.40 2.1 0.12 34.88
139 INT225215 Negative_regulation of Positive_regulation of Ccnd1 2 0.13 1.33 0 34.52
140 INT225220 Positive_regulation of Positive_regulation of Ccnd1 1 0.14 1.2 0 32.92
141 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 32.52
142 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 32.44
143 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 32.40
144 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 32.40
145 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 32.36
146 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52 32.36
147 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 30.08
148 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 29.68
149 INT318136 Positive_regulation of Gene_expression of HBB 1 0.04 2.65 0 29.24
150 INT82118 Positive_regulation of Pthlh 3 0.47 2.46 0.3 29.12
151 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 29.04
152 INT128794 Negative_regulation of Gene_expression of HBB 1 0.59 5.98 0.06 28.84
153 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 28.52
154 INT210587 Binding of Pthlh 1 0.18 1.17 0.03 28.52
155 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 28.48
156 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 27.72
157 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 25.44
158 INT277878 Binding of Ids 4 0.34 0.8 0.24 24.88
159 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 24.72
160 INT277884 Binding of Tas2r111-ps2 1 0.09 0.95 0.19 22.48
161 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 21.68
162 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 19.92
163 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 18.68
164 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 18.24
165 INT912 Localization of FSHR 91 0.79 23.61 15.58 17.84
166 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49 15.32
167 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 15.20
168 INT209108 Positive_regulation of Negative_regulation of GOPC 6 0.33 1.72 0.51 12.36
169 INT341671 Positive_regulation of Negative_regulation of SPP1 1 0.30 0.7 0 12.36
170 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 11.72
171 INT127975 Negative_regulation of SPP1 15 0.42 11.25 0.56 11.72
172 INT310677 Localization of ARSB 1 0.71 5.72 0.14 11.72
173 INT89462 Negative_regulation of PLAG1 7 0.57 3.94 0.36 11.20
174 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6 10.12
175 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87 9.80
176 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 7.08
177 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
178 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
179 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
180 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
181 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
182 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
183 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
184 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 5.00
185 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
186 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
187 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
188 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
189 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
190 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
191 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
192 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
193 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
194 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
195 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
196 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
197 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
198 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
199 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
200 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 5.00
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