D:Spinal Diseases

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Disease Term
Synonyms Disease Spinal, Diseases Spinal, SPINAL DISEASE
Documents 250
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinal Diseases. They are ordered first by their relevance to Spinal Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73 50.00
2 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26 33.04
3 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
4 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
5 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
6 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
7 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
8 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
9 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42 5.00
10 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinal Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Spinal Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156694 Binding of SET 10 0.36 3.77 2.21 99.80
2 INT636 Binding of MRAP 54 0.48 40.36 18.77 99.76
3 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.68
4 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 99.04
5 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.98
6 INT156707 Positive_regulation of SET 6 0.49 1.14 0.26 98.56
7 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99 96.96
8 INT45003 Gene_expression of Glo1 1 0.01 0.93 0.71 96.44
9 INT28861 Binding of Gh 61 0.46 25.61 6.38 95.00
10 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 93.64
11 INT6481 Binding of TNF 624 0.48 510.2 214.82 93.60
12 INT13520 Binding of HLA-DRB4 30 0.42 32.65 6.74 86.12
13 INT143494 Binding of DCPS 24 0.29 24.41 3.67 82.08
14 INT211226 Regulation of Positive_regulation of Serpind1 1 0.38 1.99 0.2 77.76
15 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 77.56
16 INT21877 Negative_regulation of Serpind1 3 0.52 6.85 0.93 76.16
17 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 75.00
18 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 75.00
19 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 75.00
20 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 75.00
21 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 75.00
22 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 75.00
23 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 75.00
24 INT86437 Binding of IL6 154 0.48 121.22 29.3 75.00
25 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 74.24
26 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 73.68
27 INT110075 Binding of FTH1 10 0.36 1.12 1.13 71.44
28 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 70.00
29 INT1938 Positive_regulation of DONSON 3 0.13 3.02 1.07 69.60
30 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 69.20
31 INT56286 Binding of HLA-DRB6 2 0.01 2.12 0.52 68.72
32 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 67.20
33 INT101441 Positive_regulation of FTH1 15 0.54 7.03 3.22 64.68
34 INT117893 Binding of Serpind1 15 0.41 24.59 2.41 58.80
35 INT127145 Gene_expression of SET 46 0.65 10.39 1.7 53.40
36 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 50.00
37 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 50.00
38 INT12082 Localization of IL6 365 0.81 241.78 105.78 50.00
39 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 50.00
40 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 50.00
41 INT9210 Regulation of IL6 166 0.62 125.61 49.95 50.00
42 INT22454 Regulation of Crp 213 0.62 160.67 49.24 50.00
43 INT2774 Binding of Crp 241 0.48 195.89 44.39 50.00
44 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 50.00
45 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 50.00
46 INT38056 Localization of Crp 71 0.78 53.14 17.03 50.00
47 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 50.00
48 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 50.00
49 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 50.00
50 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 50.00
51 INT187819 Regulation of IFN1@ 25 0.60 12.89 3.55 50.00
52 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98 50.00
53 INT119962 Negative_regulation of Negative_regulation of Crp 2 0.45 3.24 0.81 50.00
54 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73 50.00
55 INT189082 Gene_expression of Serpind1 12 0.65 15.56 1.16 49.60
56 INT211229 Negative_regulation of Gene_expression of Serpind1 1 0.36 3.33 0.89 49.60
57 INT323928 Negative_regulation of MRM1 1 0.16 0.88 0.54 47.04
58 INT113319 Positive_regulation of QRFP 5 0.40 3.86 0.1 46.24
59 INT171998 Binding of DMD 58 0.47 38.13 3.35 43.84
60 INT9660 Regulation of TNF 363 0.62 312.94 139.99 37.04
61 INT350378 Localization of Lrba 1 0.64 1.09 0.29 36.40
62 INT350379 Positive_regulation of Lrba 1 0.40 1.09 0.29 36.40
63 INT18954 Negative_regulation of OLAH 9 0.09 8.31 3.67 25.00
64 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 24.88
65 INT161600 Negative_regulation of QRFP 3 0.37 1.01 0.11 20.88
66 INT306420 Transcription of FTH1 1 0.12 0.18 0.03 20.08
67 INT3055 Binding of OLAH 9 0.28 7.14 3.99 13.92
68 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 10.76
69 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
70 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
71 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
72 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
73 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
74 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
75 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
76 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
77 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
78 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
79 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
80 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
81 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
82 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
83 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
84 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
85 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
86 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
87 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
88 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
89 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
90 INT132178 Binding of CD80 41 0.47 15.55 12.98 5.00
91 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
92 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
93 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 5.00
94 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
95 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
96 INT3353 Localization of HLA-B 25 0.75 16.05 8.62 5.00
97 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
98 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 5.00
99 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
100 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
101 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
102 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
103 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87 5.00
104 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 5.00
105 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 5.00
106 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
107 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
108 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 5.00
109 INT154303 Negative_regulation of DCPS 27 0.36 33.83 5.45 5.00
110 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
111 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 5.00
112 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
113 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 5.00
114 INT64653 Binding of CD2 17 0.44 6.74 4.45 5.00
115 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 5.00
116 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
117 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44 5.00
118 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 5.00
119 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 5.00
120 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 5.00
121 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 5.00
122 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 5.00
123 INT16463 Gene_expression of FTH1 15 0.65 6.28 2.66 5.00
124 INT83642 Gene_expression of CD63 22 0.77 10.06 2.63 5.00
125 INT164645 Binding of Csi 9 0.48 4.6 2.46 5.00
126 INT105761 Binding of GFAP 13 0.36 14.94 2.32 5.00
127 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18 5.00
128 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 5.00
129 INT198568 Regulation of DCPS 17 0.34 16.26 1.86 5.00
130 INT65611 Regulation of OR3A1 3 0.03 0.74 1.77 5.00
131 INT93274 Gene_expression of QRFP 12 0.58 7 1.46 5.00
132 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42 5.00
133 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 5.00
134 INT61749 Negative_regulation of Csi 9 0.42 4.04 1.35 5.00
135 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3 5.00
136 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27 5.00
137 INT155787 Localization of Csi 4 0.64 1.65 1.19 5.00
138 INT9257 Positive_regulation of SELPLG 5 0.45 3.57 1.16 5.00
139 INT323931 Regulation of MRM1 1 0.12 1.29 1.15 5.00
140 INT22830 Negative_regulation of Binding of IL2 4 0.55 4.8 1.06 5.00
141 INT131161 Binding of CD58 5 0.17 3.54 1.03 5.00
142 INT65610 Negative_regulation of OR3A1 2 0.05 0.64 0.97 5.00
143 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
144 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84 5.00
145 INT157382 Gene_expression of Csi 17 0.58 3.93 0.82 5.00
146 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74 5.00
147 INT67988 Positive_regulation of ROM1 7 0.41 1.9 0.7 5.00
148 INT186136 Negative_regulation of Binding of CD2 2 0.29 2.06 0.68 5.00
149 INT323932 Positive_regulation of MRM1 1 0.14 0.87 0.59 5.00
150 INT257885 Negative_regulation of Positive_regulation of CYP27A1 2 0.37 1.62 0.57 5.00
151 INT257884 Protein_catabolism of DMD 1 0.22 1.17 0.56 5.00
152 INT107652 Gene_expression of C7 4 0.60 2.06 0.56 5.00
153 INT131160 Negative_regulation of Binding of CD58 2 0.15 1.83 0.53 5.00
154 INT211228 Localization of Serpind1 3 0.63 6.11 0.51 5.00
155 INT9208 Positive_regulation of Csi 6 0.59 2.12 0.49 5.00
156 INT141782 Binding of CEACAM7 5 0.31 3.2 0.45 5.00
157 INT211227 Positive_regulation of Gene_expression of Serpind1 1 0.42 1.34 0.43 5.00
158 INT353079 Regulation of Regulation of OR3A1 1 0.00 0.15 0.4 5.00
159 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38 5.00
160 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35 5.00
161 INT113916 Localization of C2 4 0.60 1.88 0.32 5.00
162 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31 5.00
163 INT323927 Gene_expression of MRM1 1 0.19 0.31 0.31 5.00
164 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3 5.00
165 INT211223 Regulation of Serpind1 3 0.38 2.61 0.21 5.00
166 INT192952 Negative_regulation of DIS3 1 0.21 0.42 0.15 5.00
167 INT323930 Localization of MRM1 1 0.21 0.4 0.1 5.00
168 INT323929 Regulation of Localization of MRM1 1 0.12 0.41 0.1 5.00
169 INT297259 Regulation of ACVRL1 1 0.18 0.55 0 5.00
170 INT297260 Regulation of ETFA 1 0.33 0.55 0 5.00
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