D:Spinal Fractures

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Disease Term
Synonyms FRACTURE SPINAL, Fractures Spinal, Spinal Fracture
Documents 203
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinal Fractures. They are ordered first by their relevance to Spinal Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT259014 Tnfrsf18 Positive_regulation of TNFSF18 1 0.08 0.39 0 67.16
2 INT259017 Binding of TNFSF18 and Tnfrsf18 1 0.08 1.27 0.16 53.84
3 INT259016 Positive_regulation of Binding of TNFSF18 and Relt 1 0.06 0.67 0 53.84
4 INT259018 Positive_regulation of Binding of TNFSF18 and Tnfrsf18 1 0.11 0.67 0 53.84
5 INT259015 Binding of TNFSF18 and Relt 1 0.04 0.67 0 53.84
6 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42 50.00
7 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 44.64
8 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
9 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
10 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
11 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 5.00
12 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37 5.00
13 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 5.00
14 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 5.00
15 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09 5.00
16 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04 5.00
17 INT210593 TNFRSF11B Negative_regulation of Binding of TNFSF11 and TNFRSF11A 2 0.10 1.62 0.04 5.00
18 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 5.00
19 INT329479 Binding of TNFRSF11B and TNF 1 0.04 0.71 0 5.00
20 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0 5.00
21 INT254432 Binding of Best1 and Sost 1 0.12 0.69 0 5.00
22 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
23 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
24 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 5.00
25 INT329480 Binding of TNFRSF11B and TNFSF10 1 0.03 0.71 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinal Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Spinal Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245157 Negative_regulation of Gene_expression of DMD 8 0.57 4.79 0.09 98.36
2 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 98.02
3 INT259010 Gene_expression of TNFSF18 1 0.31 4.54 0.49 94.04
4 INT157400 Gene_expression of Tnfrsf18 15 0.39 7.3 2.13 94.04
5 INT162295 Positive_regulation of EPHX2 1 0.70 2.53 0.52 93.88
6 INT259013 Positive_regulation of TNFSF18 1 0.24 3.64 0.16 84.28
7 INT259007 Positive_regulation of Tnfrsf18 10 0.34 4.94 0.36 84.28
8 INT259012 Positive_regulation of Gene_expression of TNFSF18 1 0.27 2.82 0.06 84.28
9 INT259004 Positive_regulation of Gene_expression of Tnfrsf18 1 0.34 2.73 0.06 84.28
10 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 79.76
11 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 79.00
12 INT211971 Binding of Best1 16 0.22 7.73 0.33 78.04
13 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8 75.76
14 INT211972 Regulation of Best1 18 0.33 12.04 0.67 67.08
15 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 64.24
16 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68 64.00
17 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 53.92
18 INT258998 Positive_regulation of Relt 1 0.18 1.33 0 51.52
19 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
20 INT105021 Binding of GOPC 187 0.40 60.39 20.38 50.00
21 INT93274 Gene_expression of QRFP 12 0.58 7 1.46 50.00
22 INT161600 Negative_regulation of QRFP 3 0.37 1.01 0.11 50.00
23 INT113319 Positive_regulation of QRFP 5 0.40 3.86 0.1 50.00
24 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 33.28
25 INT166467 Negative_regulation of Gene_expression of Tnfrsf11b 6 0.50 5.5 2.04 33.28
26 INT160562 Localization of Cd4 49 0.71 27.58 6.78 32.96
27 INT20373 Localization of Cd8a 28 0.64 8.22 2.07 32.96
28 INT174429 Localization of Cd68 5 0.73 0.82 0.22 32.96
29 INT163188 Localization of Cd19 8 0.62 1.27 0.09 32.96
30 INT259001 Localization of Cd55 2 0.35 1.1 0 32.96
31 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 32.72
32 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 32.72
33 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 29.12
34 INT147582 Negative_regulation of AIS 13 0.37 13.26 2.46 21.28
35 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 14.96
36 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
37 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
38 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
39 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
40 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
41 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
42 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
43 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
44 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
45 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
46 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
47 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
48 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 5.00
49 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
50 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
51 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
52 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
53 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
54 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
55 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
56 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
57 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
58 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
59 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
60 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
61 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
62 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
63 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 5.00
64 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
65 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
66 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
67 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
68 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
69 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 5.00
70 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 5.00
71 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
72 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
73 INT81486 Localization of MMP3 31 0.81 12.94 15.21 5.00
74 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
75 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
76 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
77 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
78 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
79 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
80 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
81 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
82 INT2160 Negative_regulation of Negative_regulation of LH 22 0.58 4.58 11.53 5.00
83 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
84 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
85 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
86 INT38564 Binding of AIS 36 0.38 27.77 9.31 5.00
87 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
88 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
89 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 5.00
90 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 5.00
91 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
92 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
93 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 5.00
94 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 5.00
95 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 5.00
96 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
97 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
98 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
99 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 5.00
100 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 5.00
101 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
102 INT147584 Localization of AIS 38 0.63 12.83 5.27 5.00
103 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8 5.00
104 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 5.00
105 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 5.00
106 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
107 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 5.00
108 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
109 INT20461 Binding of Esr1 34 0.48 9.58 3.66 5.00
110 INT173849 Positive_regulation of Localization of MMP3 7 0.49 4.6 3.65 5.00
111 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
112 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
113 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
114 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 5.00
115 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28 5.00
116 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02 5.00
117 INT10070 Negative_regulation of Fshb 13 0.42 3.48 2.5 5.00
118 INT123016 Gene_expression of Sec22b 11 0.41 5.1 2.5 5.00
119 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 5.00
120 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
121 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 5.00
122 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
123 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 5.00
124 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 5.00
125 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82 5.00
126 INT190302 Regulation of FURIN 3 0.38 2.46 1.7 5.00
127 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61 5.00
128 INT224424 Regulation of TNFRSF11B 12 0.61 6.29 1.61 5.00
129 INT182629 Binding of Cxcr4 12 0.36 5.24 1.47 5.00
130 INT197889 Binding of Sec22b 7 0.04 4.38 1.46 5.00
131 INT37799 Gene_expression of Apob 13 0.56 10.59 1.36 5.00
132 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 5.00
133 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 5.00
134 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
135 INT180580 Binding of HEYL 7 0.17 4.49 1.15 5.00
136 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13 5.00
137 INT13397 Localization of DMD 21 0.78 7.96 1.08 5.00
138 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
139 INT38373 Positive_regulation of Ap3b1 4 0.37 1.01 0.86 5.00
140 INT11949 Negative_regulation of Apob 11 0.09 8.13 0.85 5.00
141 INT62155 Positive_regulation of Gene_expression of DMD 17 0.67 6.17 0.82 5.00
142 INT52879 Negative_regulation of ATP6V0A1 2 0.24 0.64 0.82 5.00
143 INT203739 Negative_regulation of NCF1 2 0.27 1.22 0.82 5.00
144 INT241549 Negative_regulation of Gene_expression of AIS 5 0.37 3.72 0.48 5.00
145 INT37800 Positive_regulation of Apob 7 0.18 11.01 0.48 5.00
146 INT190309 Localization of SGCA 3 0.20 1.94 0.45 5.00
147 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 5.00
148 INT195058 Positive_regulation of Gene_expression of ALPL 3 0.65 1.56 0.42 5.00
149 INT173940 Positive_regulation of Negative_regulation of DMD 8 0.59 2.97 0.36 5.00
150 INT302314 Negative_regulation of SOST 5 0.44 2.22 0.33 5.00
151 INT176586 Positive_regulation of Binding of ESR1 11 0.41 4.64 0.33 5.00
152 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 5.00
153 INT259009 Gene_expression of TNFRSF18 3 0.65 2.15 0.23 5.00
154 INT62068 Transcription of Pth 6 0.67 3.2 0.23 5.00
155 INT259005 Positive_regulation of Gene_expression of Relt 1 0.12 0.95 0.2 5.00
156 INT258999 Gene_expression of Relt 1 0.16 0.94 0.2 5.00
157 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18 5.00
158 INT176571 Negative_regulation of Positive_regulation of ESR1 5 0.47 3.15 0.17 5.00
159 INT257588 Regulation of Negative_regulation of DMD 2 0.03 0.96 0.14 5.00
160 INT259002 Negative_regulation of Tnfrsf18 1 0.18 0.91 0.14 5.00
161 INT259008 Positive_regulation of Gene_expression of TNFRSF18 1 0.49 0.89 0.13 5.00
162 INT294995 Binding of Use1 2 0.02 1.43 0.11 5.00
163 INT254428 Binding of Lrp4 4 0.44 1.52 0.11 5.00
164 INT320132 Positive_regulation of Binding of Sec22b 1 0.02 0.73 0.09 5.00
165 INT302317 Positive_regulation of Gene_expression of SOST 4 0.60 1.58 0.08 5.00
166 INT320131 Positive_regulation of Gene_expression of Sec22b 1 0.02 0.69 0.08 5.00
167 INT302313 Gene_expression of SOST 6 0.67 2.06 0.08 5.00
168 INT217764 Negative_regulation of RALA 6 0.28 3.34 0.08 5.00
169 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06 5.00
170 INT183389 Regulation of Apob 4 0.01 5.17 0.05 5.00
171 INT329487 Positive_regulation of Negative_regulation of SOST 1 0.45 0.62 0.05 5.00
172 INT302316 Negative_regulation of Gene_expression of SOST 4 0.51 1.36 0.05 5.00
173 INT182641 Negative_regulation of Binding of DMD 1 0.05 1.07 0.05 5.00
174 INT254430 Binding of CCDC170 1 0.17 0.14 0.04 5.00
175 INT182637 Positive_regulation of Binding of ERVW-1 1 0.12 0.53 0.04 5.00
176 INT294996 Localization of Use1 1 0.04 0.76 0.04 5.00
177 INT254431 Gene_expression of CCDC170 1 0.32 0.14 0.04 5.00
178 INT133103 Negative_regulation of Localization of COL1A2 2 0.04 1.49 0.03 5.00
179 INT182642 Localization of LTBR 2 0.03 0.64 0.03 5.00
180 INT217763 Regulation of RALA 3 0.29 1.48 0 5.00
181 INT259011 Transcription of TNFSF18 1 0.25 0.25 0 5.00
182 INT241542 Regulation of Gene_expression of Apob 1 0.00 1.8 0 5.00
183 INT259000 Transcription of Tnfrsf18 1 0.30 0 0 5.00
184 INT329486 Regulation of Regulation of TNFRSF11B 1 0.18 0.71 0 5.00
185 INT259006 Regulation of Cd19 2 0.13 1.39 0 5.00
186 INT329484 Regulation of Regulation of TNFSF11 1 0.23 0.71 0 5.00
187 INT259003 Regulation of Cd55 1 0.05 0.17 0 5.00
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