D:Spinal Osteophytosis

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Disease Term
Synonyms Barre Lieou Syndrome, Osteophytoses Spinal, Osteophytosis Spinal, Posterior Cervical Sympathetic Syndrome, Spinal Osteophytoses, Spondyloses, Spondylosis, SPONDYLOSIS DEFORMANS, Syndrome Barre Lieou
Documents 11
Hot Single Events 6
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinal Osteophytosis. They are ordered first by their relevance to Spinal Osteophytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245733 Binding of VDR and DISC1 1 0.03 0.75 0 94.64
2 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 71.20
3 INT245727 Binding of SUGT1 and DISC1 1 0.00 1.57 0 70.64
4 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23 5.00
5 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26 5.00
6 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26 5.00
7 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25 5.00
8 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 5.00
9 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 5.00
10 INT311923 OAP Positive_regulation of Gtf3a 1 0.00 0.7 0.19 5.00
11 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13 5.00
12 INT311912 Gene_expression of Smad1 Positive_regulation of Gene_expression of Mmp13 1 0.08 0.51 0.12 5.00
13 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08 5.00
14 INT245732 Binding of COL9A2 and DISC1 1 0.07 1.34 0.08 5.00
15 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06 5.00
16 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06 5.00
17 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06 5.00
18 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06 5.00
19 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06 5.00
20 INT311909 Gene_expression of Smad6 Negative_regulation of Gene_expression of Col10a1 1 0.02 0.54 0.04 5.00
21 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03 5.00
22 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0 5.00
23 INT245731 Binding of COL5A2 and DISC1 1 0.01 0.42 0 5.00
24 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 5.00
25 INT245730 RENBP Regulation of DISC1 1 0.01 0.58 0 5.00
26 INT245734 Binding of COL9A1 and COL9A2 1 0.26 0.52 0 5.00
27 INT245728 Binding of TRNAP2 and DISC1 1 0.03 0.54 0 5.00
28 INT245729 Binding of COL9A1 and COL9A3 1 0.29 0.52 0 5.00
29 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinal Osteophytosis. They are ordered first by their pain relevance and then by number of times they were reported in Spinal Osteophytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245744 Protein_catabolism of DISC1 1 0.18 4.92 0.21 99.14
2 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 96.32
3 INT156850 Binding of VDR 40 0.47 24.86 4.87 96.16
4 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 96.12
5 INT245748 Binding of DISC1 1 0.07 5.21 1.08 93.04
6 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 87.28
7 INT171254 Binding of OAP 7 0.39 8.04 3.42 79.52
8 INT245736 Gene_expression of DISC1 13 0.61 7.65 1.33 71.52
9 INT102638 Regulation of VDR 21 0.44 9.92 2.54 64.64
10 INT245759 Localization of DISC1 1 0.14 2.85 0.04 58.84
11 INT151033 Positive_regulation of Gene_expression of Col10a1 2 0.26 1.06 0.86 50.80
12 INT151037 Gene_expression of Col10a1 13 0.68 4.47 2.64 50.40
13 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0 38.08
14 INT245765 Binding of SOX9 1 0.31 0.87 0 33.28
15 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 28.80
16 INT18639 Positive_regulation of OAP 16 0.69 10.49 4.57 26.08
17 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 24.72
18 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11 24.72
19 INT245764 Regulation of DISC1 1 0.08 1.23 0.38 19.36
20 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 10.96
21 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58 10.96
22 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09 10.96
23 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 9.36
24 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
25 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
26 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
27 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
28 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 5.00
29 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
30 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
31 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
32 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
33 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
34 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
35 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
36 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
37 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
38 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
39 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
40 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
41 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91 5.00
42 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
43 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
44 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71 5.00
45 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 5.00
46 INT12859 Localization of Insrr 16 0.32 2.68 8.07 5.00
47 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 5.00
48 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
49 INT48555 Binding of SP1 30 0.46 11.38 6.53 5.00
50 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 5.00
51 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 5.00
52 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
53 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
54 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
55 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 5.00
56 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
57 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05 5.00
58 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 5.00
59 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
60 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
61 INT171989 Gene_expression of Ank 8 0.78 11.76 4.36 5.00
62 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24 5.00
63 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 5.00
64 INT181922 Binding of RENBP 16 0.36 13.92 3.71 5.00
65 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
66 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
67 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 5.00
68 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
69 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 5.00
70 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15 5.00
71 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 5.00
72 INT172001 Gene_expression of ANKH 2 0.38 11.92 3.12 5.00
73 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02 5.00
74 INT231737 Localization of OAP 5 0.50 7.4 2.63 5.00
75 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
76 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
77 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48 5.00
78 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
79 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25 5.00
80 INT18636 Negative_regulation of OAP 9 0.37 5.05 2.13 5.00
81 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
82 INT164407 Negative_regulation of Gene_expression of Col2a1 6 0.39 4 1.78 5.00
83 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 5.00
84 INT220992 Protein_catabolism of Col2a1 8 0.40 5.55 1.64 5.00
85 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 5.00
86 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 5.00
87 INT102989 Regulation of Gene_expression of MMP3 10 0.53 3.29 1.47 5.00
88 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44 5.00
89 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4 5.00
90 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38 5.00
91 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34 5.00
92 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34 5.00
93 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24 5.00
94 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17 5.00
95 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1 5.00
96 INT43484 Binding of Runx2 7 0.37 3.22 0.95 5.00
97 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87 5.00
98 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 5.00
99 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81 5.00
100 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8 5.00
101 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78 5.00
102 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72 5.00
103 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69 5.00
104 INT311921 Negative_regulation of Gene_expression of OAP 1 0.02 0.94 0.69 5.00
105 INT173794 Gene_expression of Maf 3 0.12 1.39 0.68 5.00
106 INT311920 Regulation of Gene_expression of OAP 1 0.02 0.92 0.67 5.00
107 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 5.00
108 INT101177 Regulation of COL5A2 12 0.45 4.03 0.62 5.00
109 INT209948 Gene_expression of CLEC3B 3 0.78 11.51 0.6 5.00
110 INT311922 Protein_catabolism of OAP 1 0.03 1.06 0.55 5.00
111 INT119708 Transcription of VDR 11 0.71 5.43 0.48 5.00
112 INT285501 Gene_expression of Smad1 6 0.42 3.09 0.41 5.00
113 INT311882 Negative_regulation of Smad1 1 0.25 0.99 0.39 5.00
114 INT211361 Regulation of RENBP 5 0.08 2.8 0.38 5.00
115 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37 5.00
116 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35 5.00
117 INT245741 Negative_regulation of Gene_expression of DISC1 2 0.17 1.29 0.34 5.00
118 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34 5.00
119 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34 5.00
120 INT171995 Binding of PTH1R 8 0.35 1.16 0.31 5.00
121 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3 5.00
122 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3 5.00
123 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29 5.00
124 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29 5.00
125 INT172003 Regulation of ERAL1 2 0.07 0.62 0.25 5.00
126 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 5.00
127 INT245763 Regulation of SOX9 4 0.43 1.68 0.21 5.00
128 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2 5.00
129 INT311886 Phosphorylation of Tgfbr1 1 0.40 0.7 0.19 5.00
130 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19 5.00
131 INT311891 Phosphorylation of Smad1 4 0.51 1.34 0.18 5.00
132 INT245756 Regulation of Binding of DISC1 1 0.08 0.63 0.16 5.00
133 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14 5.00
134 INT254334 Negative_regulation of Gene_expression of Col10a1 2 0.03 0.92 0.14 5.00
135 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14 5.00
136 INT285484 Negative_regulation of Col10a1 2 0.14 1.32 0.13 5.00
137 INT217082 Negative_regulation of Bmpr1a 2 0.09 0.36 0.12 5.00
138 INT311896 Negative_regulation of Acvr1 1 0.08 0.3 0.12 5.00
139 INT311892 Regulation of Positive_regulation of Smad2 1 0.23 0.24 0.12 5.00
140 INT311897 Negative_regulation of Bmpr1b 1 0.09 0.3 0.12 5.00
141 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 5.00
142 INT245740 Binding of COL9A3 2 0.31 1.85 0.08 5.00
143 INT245743 Positive_regulation of Gene_expression of DISC1 1 0.09 0.72 0.07 5.00
144 INT245760 Regulation of Gene_expression of DISC1 1 0.08 0.72 0.07 5.00
145 INT245754 Regulation of Positive_regulation of COL9A2 1 0.34 0.74 0.06 5.00
146 INT311885 Positive_regulation of Gene_expression of Tgfbr1 2 0.44 0.35 0.06 5.00
147 INT245747 Positive_regulation of Binding of COL9A3 1 0.42 1.05 0.06 5.00
148 INT245738 Positive_regulation of COL9A2 1 0.38 0.72 0.06 5.00
149 INT254790 Localization of Smad4 2 0.37 0.54 0.06 5.00
150 INT245750 Regulation of COL9A3 1 0.20 0.7 0.06 5.00
151 INT311883 Phosphorylation of Smad9 1 0.13 0.18 0.06 5.00
152 INT245737 Positive_regulation of Protein_catabolism of DISC1 1 0.09 1.04 0.06 5.00
153 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06 5.00
154 INT119703 Regulation of Gene_expression of VDR 4 0.44 2.43 0.06 5.00
155 INT311879 Phosphorylation of Smad5 1 0.31 0.18 0.06 5.00
156 INT245751 Gene_expression of COL9A2 4 0.65 1.83 0.04 5.00
157 INT311890 Binding of Smad1 2 0.23 0.46 0.04 5.00
158 INT311898 Positive_regulation of Gene_expression of Smad6 1 0.33 0.53 0.04 5.00
159 INT245746 Positive_regulation of Localization of DISC1 1 0.09 0.35 0.04 5.00
160 INT172971 Gene_expression of Smad6 2 0.37 1.77 0.04 5.00
161 INT245742 Positive_regulation of DISC1 1 0.13 0.83 0.04 5.00
162 INT311888 Negative_regulation of Phosphorylation of Smad1 1 0.25 0.48 0.03 5.00
163 INT245753 Regulation of Transcription of COL5A2 1 0.08 0.64 0 5.00
164 INT245725 Positive_regulation of Negative_regulation of Col1a1 1 0.21 0.7 0 5.00
165 INT245755 Gene_expression of COL9A3 1 0.57 0.54 0 5.00
166 INT171996 Regulation of Regulation of VDR 1 0.44 0.05 0 5.00
167 INT245739 Gene_expression of COL9A1 1 0.54 0.53 0 5.00
168 INT119701 Regulation of Transcription of VDR 2 0.61 0.57 0 5.00
169 INT171994 Regulation of Positive_regulation of DMD 4 0.15 0.82 0 5.00
170 INT245757 Localization of SOX9 4 0.62 0.8 0 5.00
171 INT245745 Regulation of TRNAP2 1 0.16 0.45 0 5.00
172 INT245762 Transcription of COL5A2 4 0.09 2.82 0 5.00
173 INT245749 Gene_expression of TRNAP2 1 0.27 1.16 0 5.00
174 INT171993 Regulation of Gene_expression of ERAL1 1 0.07 0.06 0 5.00
175 INT245761 Positive_regulation of Regulation of COL5A2 1 0.06 0.76 0 5.00
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