D:Spinal Stenosis

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Disease Term
Synonyms Spinal Stenoses, Stenoses Spinal, STENOSIS SPINAL
Documents 922
Hot Single Events 52
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinal Stenosis. They are ordered first by their relevance to Spinal Stenosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17 49.96
2 INT222248 Binding of Cxcr3 and Cxcl10 1 0.35 0.48 0.09 23.76
3 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
4 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
5 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
6 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
7 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86 5.00
8 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86 5.00
9 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65 5.00
10 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55 5.00
11 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55 5.00
12 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55 5.00
13 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55 5.00
14 INT285715 Binding of Lbp and Set 1 0.06 0.33 0.33 5.00
15 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33 5.00
16 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32 5.00
17 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32 5.00
18 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26 5.00
19 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
20 INT307665 Binding of Mpz and Pmp22 1 0.34 0.39 0.08 5.00
21 INT307666 Binding of Pmp22 and Gjb1 1 0.31 0.38 0.08 5.00
22 INT307663 Binding of Pmp22 and Egr2 1 0.33 0.39 0.08 5.00
23 INT307664 Binding of Pmp22 and LOC689781 1 0.03 0.39 0.08 5.00
24 INT339020 SERPINA1 Negative_regulation of ELANE 1 0.07 0.59 0.05 5.00
25 INT302311 PTH Negative_regulation of Gene_expression of SOST 1 0.29 0.59 0 5.00
26 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0 5.00
27 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0 5.00
28 INT308542 Binding of AIM1 and AIM2 1 0.12 0 0 5.00
29 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0 5.00
30 INT302323 Binding of SOST and Wnt2 1 0.02 0.26 0 5.00
31 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinal Stenosis. They are ordered first by their pain relevance and then by number of times they were reported in Spinal Stenosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.88
2 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 99.78
3 INT11562 Regulation of KIAA0101 2 0.26 1.57 0.85 99.60
4 INT222152 Gene_expression of MAP6 1 0.06 3.55 1.08 99.40
5 INT222153 Binding of MAP6 1 0.03 1.83 0.53 99.38
6 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28 99.20
7 INT222237 Negative_regulation of Gene_expression of Ccr2 3 0.37 3.39 2.91 99.20
8 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 99.12
9 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 98.92
10 INT302314 Negative_regulation of SOST 5 0.44 2.22 0.33 98.64
11 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07 98.58
12 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67 98.36
13 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 97.60
14 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 97.44
15 INT9664 Binding of LBP 127 0.48 94.9 63.42 97.20
16 INT165228 Binding of BMI1 13 0.47 25.36 7.97 97.20
17 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 97.12
18 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83 96.80
19 INT222241 Binding of Ccr2 5 0.42 4.09 3.71 96.44
20 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 95.72
21 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 95.72
22 INT953 Positive_regulation of Positive_regulation of GHRH 17 0.67 2.38 8.18 95.68
23 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 95.68
24 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34 95.48
25 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 95.16
26 INT2649 Regulation of Calca 433 0.62 146.05 330.95 94.76
27 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 94.20
28 INT27785 Regulation of HTR2A 11 0.44 8 8.18 93.24
29 INT82881 Regulation of Ccl2 19 0.57 15.29 7.19 92.16
30 INT1026 Binding of Lbp 207 0.48 150.96 119.16 91.40
31 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 90.16
32 INT84561 Binding of COL1A2 18 0.47 11.76 5.09 90.04
33 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 89.88
34 INT9660 Regulation of TNF 363 0.62 312.94 139.99 89.76
35 INT103124 Regulation of Cd8a 3 0.23 1.65 0.68 89.36
36 INT160148 Positive_regulation of Ctsl 2 0.43 0.74 0.52 89.28
37 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 89.04
38 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 88.64
39 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 86.16
40 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 83.32
41 INT312566 Positive_regulation of Gene_expression of CECR 1 0.19 1.67 0.38 83.32
42 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 83.04
43 INT156707 Positive_regulation of SET 6 0.49 1.14 0.26 82.52
44 INT139857 Localization of RT1-M4 2 0.45 1.45 0.15 82.24
45 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 81.48
46 INT3466 Gene_expression of Ptger1 39 0.75 18.34 15.75 81.12
47 INT127145 Gene_expression of SET 46 0.65 10.39 1.7 81.12
48 INT115363 Positive_regulation of MAP6 1 0.49 0.4 0.2 80.80
49 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 80.60
50 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 80.48
51 INT56491 Positive_regulation of Tnfrsf8 4 0.12 3.38 0.59 80.48
52 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 80.32
53 INT156694 Binding of SET 10 0.36 3.77 2.21 79.36
54 INT171820 Localization of Fig4 144 0.65 27.38 20.88 79.28
55 INT1030 Localization of Lbp 52 0.74 38.92 24.91 79.20
56 INT222229 Localization of Tcf21 1 0.57 0.45 0.45 78.64
57 INT39712 Binding of pad 82 0.48 110.92 10.33 78.08
58 INT157589 Binding of Tdrd6 1 0.40 1.12 0.15 77.64
59 INT245736 Gene_expression of DISC1 13 0.61 7.65 1.33 77.52
60 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 76.68
61 INT80640 Gene_expression of RPL4P5 3 0.26 1.09 0.56 75.00
62 INT159041 Negative_regulation of TUSC5 2 0.42 3.46 0.48 74.80
63 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 73.68
64 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98 73.68
65 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 72.84
66 INT103847 Positive_regulation of Ccr5 11 0.55 6.04 5.79 71.08
67 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 70.28
68 INT98109 Regulation of Slc1a3 15 0.52 6.87 14.43 69.20
69 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01 68.64
70 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62 68.24
71 INT87393 Gene_expression of Ccr5 19 0.65 11 10.51 67.96
72 INT3467 Positive_regulation of Ptger1 28 0.54 10.59 8.93 67.12
73 INT77892 Regulation of Pip 4 0.16 0.59 0.89 66.72
74 INT6481 Binding of TNF 624 0.48 510.2 214.82 66.36
75 INT237652 Positive_regulation of Sfn 3 0.49 1.17 0.27 65.36
76 INT28247 Negative_regulation of Positive_regulation of CD8A 3 0.14 2.84 0.24 65.28
77 INT6761 Binding of CALCA 100 0.48 26.71 62.05 65.04
78 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 63.08
79 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 60.24
80 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 59.56
81 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9 59.36
82 INT222225 Regulation of Cxcl10 4 0.23 2.59 2.19 58.56
83 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17 57.96
84 INT169172 Positive_regulation of XIAP 3 0.49 2.54 0.12 57.92
85 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 56.72
86 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 55.56
87 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 55.48
88 INT222226 Negative_regulation of Ccr2 6 0.57 3.69 2.66 53.60
89 INT348999 Regulation of Regulation of Pip 1 0.12 0.05 0.15 51.28
90 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
91 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 50.00
92 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 50.00
93 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 50.00
94 INT11107 Binding of Lbp 12 0.42 4.42 3.41 50.00
95 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96 50.00
96 INT106014 Negative_regulation of Mcts1 1 0.35 0 0 50.00
97 INT333440 Protein_catabolism of Lif 1 0.23 0.2 0.08 48.32
98 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96 48.04
99 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 47.88
100 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 47.76
101 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57 47.76
102 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 45.12
103 INT222233 Gene_expression of Cxcl12 42 0.69 32.64 10.13 45.04
104 INT211045 Positive_regulation of CD6 1 0.49 0.56 0.26 44.56
105 INT67783 Negative_regulation of LARS 3 0.37 1.23 0.5 43.72
106 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 43.68
107 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 43.40
108 INT2519 Negative_regulation of VCF 7 0.43 5.27 1.79 42.24
109 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82 41.52
110 INT97376 Gene_expression of RT1-M4 11 0.33 6.79 8.51 40.52
111 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 38.92
112 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 38.76
113 INT222230 Positive_regulation of Gene_expression of Cxcl12 11 0.59 5.26 2.13 38.32
114 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39 38.32
115 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 37.56
116 INT201130 Localization of AES 31 0.63 25.45 5.12 37.52
117 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49 37.36
118 INT327116 Positive_regulation of Localization of AES 4 0.22 2.69 0.55 36.64
119 INT237655 Binding of Sfn 1 0.42 3.62 2.55 35.04
120 INT185487 Localization of Cxcl10 6 0.61 3.21 3.21 34.76
121 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 34.48
122 INT73768 Positive_regulation of Pip 5 0.59 0.26 0.52 34.24
123 INT156827 Localization of MRI1 25 0.65 16.06 8.33 32.96
124 INT183446 Positive_regulation of C6 4 0.30 0.77 0.33 32.88
125 INT237651 Negative_regulation of Sfn 3 0.51 1.7 0.49 32.24
126 INT136309 Positive_regulation of Cxcl12 24 0.62 12.45 5.58 32.20
127 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 32.04
128 INT339026 Phosphorylation of SERPINA1 1 0.56 0.47 0 31.88
129 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 31.68
130 INT7134 Localization of KNG1 127 0.79 65.73 67.97 31.68
131 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18 31.64
132 INT41916 Gene_expression of Set 7 0.21 5.73 4.95 31.64
133 INT285713 Positive_regulation of Gene_expression of Set 1 0.15 0.5 0.44 31.64
134 INT323930 Localization of MRM1 1 0.21 0.4 0.1 30.40
135 INT323929 Regulation of Localization of MRM1 1 0.12 0.41 0.1 30.40
136 INT143936 Gene_expression of Itpr1 5 0.22 1.49 0.91 30.20
137 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 29.36
138 INT38056 Localization of Crp 71 0.78 53.14 17.03 29.36
139 INT2038 Localization of Esr1 104 0.79 40.12 13.27 29.36
140 INT22340 Gene_expression of Rent1 11 0.05 5.19 4.8 28.64
141 INT323932 Positive_regulation of MRM1 1 0.14 0.87 0.59 28.20
142 INT222231 Transcription of Cxcl12 4 0.55 2.25 0.91 27.80
143 INT306420 Transcription of FTH1 1 0.12 0.18 0.03 25.32
144 INT185482 Binding of Cxcl10 5 0.30 3.76 3.13 23.76
145 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 23.72
146 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49 22.28
147 INT23524 Positive_regulation of VCF 7 0.57 4.25 1.16 16.00
148 INT302312 Localization of Bmpr2 4 0.46 0.47 0 15.44
149 INT10057 Gene_expression of Ldlr 35 0.67 23.99 3.05 14.80
150 INT103845 Gene_expression of Cxcr3 13 0.60 10.65 8.5 12.80
151 INT82882 Localization of Ccl2 61 0.80 41.96 28 12.00
152 INT256243 Transcription of Egfl7 2 0.06 1.07 0 8.88
153 INT4141 Binding of Ptger1 19 0.31 2.96 4.83 7.96
154 INT70262 Gene_expression of Pth 8 0.66 5.64 0.12 7.60
155 INT146805 Positive_regulation of Gene_expression of Pth 4 0.49 4.2 0.07 7.60
156 INT302317 Positive_regulation of Gene_expression of SOST 4 0.60 1.58 0.08 6.64
157 INT302313 Gene_expression of SOST 6 0.67 2.06 0.08 6.64
158 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
159 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
160 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
161 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
162 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
163 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
164 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
165 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
166 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
167 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
168 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
169 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
170 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
171 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
172 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
173 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
174 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
175 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
176 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
177 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
178 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
179 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
180 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
181 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
182 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
183 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
184 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
185 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
186 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
187 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14 5.00
188 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 5.00
189 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
190 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
191 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
192 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97 5.00
193 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
194 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
195 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
196 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
197 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
198 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
199 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
200 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
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