D:Spondylarthritis

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Disease Term
Synonyms Arthritis Spinal, SPINAL ARTHRITIDES, Spinal Arthritis, SPONDYLARTHRITIDES
Documents 133
Hot Single Events 18
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spondylarthritis. They are ordered first by their relevance to Spondylarthritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT162742 Binding of HLA-A and KIR3DL1 1 0.40 0.68 0.58 98.64
2 INT162743 Binding of HLA-A and TNFRSF10B 1 0.40 0.4 0.25 74.56
3 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42 71.56
4 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99 65.92
5 INT348173 Binding of HLA-B and IL23R 1 0.15 0.92 0.49 9.04
6 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49 8.48
7 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 5.00
8 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
9 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
10 INT346266 MTX1 Regulation of IL17A 1 0.08 1.33 0.89 5.00
11 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76 5.00
12 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73 5.00
13 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7 5.00
14 INT341594 Binding of ESR1 and HLA-B 1 0.01 0.72 0.57 5.00
15 INT341593 Binding of HLA-E and IL23R 1 0.15 1.15 0.5 5.00
16 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 5.00
17 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
18 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47 5.00
19 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39 5.00
20 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33 5.00
21 INT315369 Binding of IL6 and Crp 1 0.10 2.09 0.3 5.00
22 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29 5.00
23 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 0.05 0.86 0.28 5.00
24 INT300546 Binding of Il23a and Il1 1 0.01 0.5 0.25 5.00
25 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spondylarthritis. They are ordered first by their pain relevance and then by number of times they were reported in Spondylarthritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.84
2 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 99.68
3 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09 99.18
4 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 98.92
5 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.66
6 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.04
7 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 97.92
8 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 97.72
9 INT137400 Regulation of Mtx1 16 0.52 9.19 9.45 95.44
10 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 93.80
11 INT50006 Regulation of HLA-E 12 0.44 8.78 2.37 92.92
12 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 91.96
13 INT231694 Negative_regulation of IGKV2-19 14 0.03 7.09 2.64 89.44
14 INT213886 Binding of IL23R 7 0.46 16.79 6.94 89.28
15 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 86.40
16 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 84.08
17 INT162745 Regulation of KIR3DL1 3 0.45 1.39 0.65 83.52
18 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 82.00
19 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06 79.60
20 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 77.64
21 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 76.44
22 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 76.28
23 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 75.00
24 INT252 Localization of GH1 529 0.80 227.4 122.05 75.00
25 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 75.00
26 INT27314 Negative_regulation of CNOT4 4 0.00 1.64 0.98 75.00
27 INT248324 Regulation of IGKV2-19 4 0.00 2.3 1.27 74.84
28 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 73.20
29 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 73.20
30 INT12082 Localization of IL6 365 0.81 241.78 105.78 73.16
31 INT38056 Localization of Crp 71 0.78 53.14 17.03 72.80
32 INT6481 Binding of TNF 624 0.48 510.2 214.82 70.00
33 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 69.68
34 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 69.68
35 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 68.48
36 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 68.48
37 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 67.68
38 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 67.68
39 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 67.20
40 INT135408 Transcription of Il17a 8 0.64 10.7 3.39 66.64
41 INT231573 Binding of PTPN22 5 0.44 7.94 2.33 62.08
42 INT9664 Binding of LBP 127 0.48 94.9 63.42 61.52
43 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 53.64
44 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 50.00
45 INT103910 Binding of NOD2 19 0.47 12.24 2.93 50.00
46 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69 50.00
47 INT132532 Positive_regulation of Gene_expression of MRAP 1 0.49 0.63 0.28 50.00
48 INT132529 Binding of TAPBP 8 0.47 1.43 0.18 50.00
49 INT132530 Positive_regulation of Binding of TAPBP 1 0.67 0.08 0 50.00
50 INT132527 Positive_regulation of Gene_expression of TAPBP 1 0.49 0.84 0 50.00
51 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 49.28
52 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 46.24
53 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 41.08
54 INT341599 Regulation of Gene_expression of ORMDL3 1 0.42 4.12 2.58 39.96
55 INT341596 Gene_expression of ORMDL3 1 0.63 6.09 4.07 39.40
56 INT341595 Transcription of ORMDL3 1 0.65 1.4 0.92 29.60
57 INT10835 Regulation of IL8 79 0.49 53.04 24.14 29.56
58 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 11.52
59 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 11.52
60 INT159709 Binding of ERAP1 12 0.47 3.42 2.91 8.48
61 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 8.16
62 INT183809 Regulation of IL17A 11 0.25 6.6 2.37 8.16
63 INT183808 Regulation of Gene_expression of IL17A 6 0.42 4.12 2.01 8.16
64 INT156689 Regulation of CD177 2 0.01 1.76 1.16 7.48
65 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
66 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
67 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
68 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
69 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
70 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
71 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
72 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
73 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
74 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
75 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
76 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
77 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
78 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
79 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
80 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
81 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
82 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
83 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
84 INT22454 Regulation of Crp 213 0.62 160.67 49.24 5.00
85 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
86 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
87 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
88 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
89 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
90 INT118343 Positive_regulation of Eae1 121 0.39 136.06 34.87 5.00
91 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
92 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
93 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
94 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
95 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
96 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
97 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
98 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 5.00
99 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
100 INT182031 Gene_expression of Cia1 38 0.24 46.37 19.64 5.00
101 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 5.00
102 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
103 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 5.00
104 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
105 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
106 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 5.00
107 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
108 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
109 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
110 INT176453 Negative_regulation of Cia1 23 0.14 28.27 12.33 5.00
111 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
112 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06 5.00
113 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
114 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
115 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 5.00
116 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87 5.00
117 INT181344 Gene_expression of Ccr6 28 0.61 24.34 9.78 5.00
118 INT181405 Gene_expression of Ccl20 26 0.65 23.02 9.46 5.00
119 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 5.00
120 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
121 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
122 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 5.00
123 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 5.00
124 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58 5.00
125 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47 5.00
126 INT36960 Gene_expression of vs 33 0.43 20.77 6.97 5.00
127 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
128 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
129 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
130 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32 5.00
131 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
132 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02 5.00
133 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 5.00
134 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94 5.00
135 INT124705 Binding of Il18 29 0.47 19.02 5.59 5.00
136 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
137 INT173584 Localization of IL17A 14 0.74 10.83 5.19 5.00
138 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11 5.00
139 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 5.00
140 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
141 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
142 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12 5.00
143 INT151736 Binding of Hand1 15 0.26 9.77 4.04 5.00
144 INT235510 Binding of Il17a 14 0.34 10.67 3.99 5.00
145 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 5.00
146 INT121818 Binding of STAT3 25 0.47 11.16 3.67 5.00
147 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
148 INT155011 Negative_regulation of IL17A 8 0.54 6.43 3.64 5.00
149 INT70051 Transcription of IL12A 7 0.25 5.61 3.39 5.00
150 INT174807 Gene_expression of IL26 7 0.37 8.06 3.26 5.00
151 INT163269 Binding of Il23a 11 0.44 7.2 3.14 5.00
152 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
153 INT240544 Gene_expression of TBX21 12 0.75 5.96 2.97 5.00
154 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6 5.00
155 INT159056 Gene_expression of IL27 4 0.75 5.02 2.58 5.00
156 INT15765 Localization of PON1 8 0.75 3.61 2.08 5.00
157 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06 5.00
158 INT300539 Gene_expression of Rorc 2 0.47 5.8 2 5.00
159 INT160241 Negative_regulation of Positive_regulation of Il10 6 0.39 6.33 1.92 5.00
160 INT219191 Localization of IL22 5 0.31 3.6 1.88 5.00
161 INT221791 Transcription of TH1L 4 0.45 3.98 1.84 5.00
162 INT33892 Positive_regulation of CD177 5 0.23 2.96 1.84 5.00
163 INT165617 Localization of STAT3 28 0.78 9.04 1.72 5.00
164 INT224626 Negative_regulation of Il21 3 0.10 3.51 1.67 5.00
165 INT236349 Positive_regulation of Positive_regulation of Il17a 7 0.46 5.96 1.67 5.00
166 INT97062 Binding of PML 10 0.41 11.63 1.65 5.00
167 INT300540 Positive_regulation of Gene_expression of Ccr6 2 0.55 3.75 1.53 5.00
168 INT89858 Positive_regulation of STAT6 10 0.66 7.81 1.47 5.00
169 INT284034 Regulation of Gene_expression of Cia1 2 0.12 3.12 1.35 5.00
170 INT276331 Gene_expression of Il22ra1 6 0.46 6.88 1.31 5.00
171 INT300541 Negative_regulation of Gene_expression of Il17f 3 0.26 2.6 1.27 5.00
172 INT169525 Positive_regulation of Serpinb1a 4 0.44 6.48 1.24 5.00
173 INT181384 Positive_regulation of Ccr6 3 0.55 2.53 1.24 5.00
174 INT59319 Negative_regulation of Positive_regulation of Il4 6 0.57 3.48 1.17 5.00
175 INT246028 Positive_regulation of IL23R 3 0.46 2.74 1.15 5.00
176 INT234422 Gene_expression of PML 14 0.75 15.93 1.14 5.00
177 INT284669 Gene_expression of LRRK2 3 0.65 4.58 1.14 5.00
178 INT348185 Gene_expression of MUC19 1 0.62 2.71 1.14 5.00
179 INT300538 Negative_regulation of Il17f 2 0.26 1.98 1.07 5.00
180 INT237762 Regulation of Positive_regulation of Eae1 3 0.03 3.15 0.96 5.00
181 INT192404 Localization of Ighm 15 0.48 5.8 0.85 5.00
182 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81 5.00
183 INT346272 Regulation of Gene_expression of IL22 1 0.19 1.04 0.77 5.00
184 INT346268 Transcription of UBASH3B 1 0.17 1.19 0.76 5.00
185 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72 5.00
186 INT262726 Localization of PML 6 0.57 7.13 0.72 5.00
187 INT348186 Binding of KIF21B 1 0.31 1.35 0.64 5.00
188 INT300542 Binding of Il17f 2 0.05 1.68 0.5 5.00
189 INT250324 Negative_regulation of Rpsa 2 0.21 0.89 0.47 5.00
190 INT341598 Gene_expression of GSDMB 1 0.45 0.62 0.44 5.00
191 INT305084 Positive_regulation of Gene_expression of Serpinb1a 1 0.11 0.94 0.43 5.00
192 INT215120 Negative_regulation of Localization of IgG 5 0.16 3.44 0.43 5.00
193 INT300543 Regulation of Il21 1 0.04 0.98 0.4 5.00
194 INT276311 Gene_expression of Irf4 6 0.64 4.95 0.37 5.00
195 INT348180 Localization of IL23R 1 0.34 0.91 0.36 5.00
196 INT348181 Phosphorylation of IL23R 1 0.27 0.91 0.36 5.00
197 INT348183 Binding of IL12B 1 0.46 0.97 0.33 5.00
198 INT300537 Positive_regulation of Regulation of Il17a 1 0.39 1.74 0.29 5.00
199 INT300550 Positive_regulation of Gene_expression of TBX21 1 0.45 0.47 0.27 5.00
200 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26 5.00
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