D:Spontaneous Fractures

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Disease Term
Synonyms FRACTURE PATHOLOGIC, Fracture Pathological, FRACTURE SPONTANEOUS, Fractures Pathologic, Fractures Pathological, Pathologic Fracture, Pathologic Fractures, PATHOLOGICAL FRACTURE, Pathological Fractures, Spontaneous Fracture
Documents 1132
Hot Single Events 113
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spontaneous Fractures. They are ordered first by their relevance to Spontaneous Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335743 Binding of PDB1 and Salpa1 1 0.01 1.66 0.09 95.96
2 INT335742 Binding of PDB1 and Dpyd 1 0.02 1.75 0.09 95.96
3 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 90.12
4 INT153740 TNFRSF11A Positive_regulation of Vcp 1 0.04 1.15 0.13 90.12
5 INT153739 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.05 1.14 0.13 90.12
6 INT153742 TNFRSF11A Positive_regulation of Tnfrsf11b 1 0.00 1.15 0.13 90.12
7 INT153738 TNFRSF11A Positive_regulation of SQSTM1 1 0.05 1.22 0.13 90.12
8 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17 88.92
9 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14 87.76
10 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19 75.32
11 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19 75.32
12 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19 74.64
13 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19 74.64
14 INT313308 Binding of SQSTM1 and KEAP1 1 0.46 1.16 0.1 70.44
15 INT313301 SQSTM1 Regulation of Protein_catabolism of KEAP1 1 0.43 0.58 0.1 67.28
16 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 58.12
17 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08 54.20
18 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0 52.56
19 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13 42.96
20 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17 39.40
21 INT237669 Binding of PDB1 and SQSTM1 1 0.27 2.55 0 34.28
22 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93 34.04
23 INT280276 Binding of Tgfb1 and Positive_regulation of VEGFA 1 0.02 1.27 0 28.84
24 INT280262 Binding of Tgfb1 and Positive_regulation of Cxcr4 1 0.07 1.27 0 28.28
25 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03 27.28
26 INT237670 SQSTM1 Regulation of PDB1 1 0.34 1.13 0.06 11.36
27 INT313295 Binding of SQSTM1 and GABARAPL2 1 0.32 0.13 0 8.08
28 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
29 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
30 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
31 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
32 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
33 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
34 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57 5.00
35 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56 5.00
36 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56 5.00
37 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56 5.00
38 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42 5.00
39 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 5.00
40 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
41 INT101810 Binding of NFE2L2 and KEAP1 7 0.53 4.12 0.29 5.00
42 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
43 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
44 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22 5.00
45 INT283520 Binding of DLAT and Pain1 1 0.27 0.65 0.22 5.00
46 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21 5.00
47 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
48 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 5.00
49 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2 5.00
50 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19 5.00
51 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19 5.00
52 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19 5.00
53 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19 5.00
54 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19 5.00
55 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19 5.00
56 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19 5.00
57 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
58 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19 5.00
59 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
60 INT298641 PPARA Regulation of STAT3 1 0.23 0.98 0.16 5.00
61 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 5.00
62 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14 5.00
63 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
64 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12 5.00
65 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
66 INT293411 IL8 Regulation of IL11 1 0.03 1.17 0.1 5.00
67 INT293417 HRAS Regulation of IL11 1 0.00 1.17 0.1 5.00
68 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1 5.00
69 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1 5.00
70 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1 5.00
71 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1 5.00
72 INT341294 DRG1 Positive_regulation of Atf3 1 0.01 0 0.1 5.00
73 INT293408 HRAS Regulation of VEGFA 1 0.00 1.18 0.1 5.00
74 INT293409 IL8 Regulation of VEGFA 1 0.04 1.18 0.1 5.00
75 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09 5.00
76 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 5.00
77 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09 5.00
78 INT293415 HRAS Positive_regulation of Localization of IL8 1 0.01 0.73 0.09 5.00
79 INT298634 Binding of IL6 and STAT3 1 0.04 1.41 0.08 5.00
80 INT217486 Binding of PDB1 and Sqstm1 1 0.03 1.19 0.08 5.00
81 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
82 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
83 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
84 INT301411 Enpp2 Positive_regulation of Csf2 1 0.04 0.59 0.07 5.00
85 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07 5.00
86 INT301403 Enpp2 Positive_regulation of Tnfrsf11a 1 0.05 0.59 0.07 5.00
87 INT283521 PREB Regulation of Fam89b 1 0.00 1.08 0.07 5.00
88 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05 5.00
89 INT298638 IL6 Positive_regulation of IL6R 1 0.00 0.9 0.05 5.00
90 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05 5.00
91 INT340274 Cd14 Regulation of Gene_expression of TNFRSF11A 1 0.05 0.8 0.05 5.00
92 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05 5.00
93 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
94 INT175625 PAR1 Regulation of Gene_expression of MMP9 1 0.02 1.25 0.05 5.00
95 INT298635 PPARA Negative_regulation of Localization of ZDHHC2 1 0.01 0.21 0.05 5.00
96 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05 5.00
97 INT233303 Binding of CD4 and SRY 1 0.07 0.34 0.05 5.00
98 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05 5.00
99 INT338988 SULT2A1 Positive_regulation of PPARA 1 0.00 0.42 0.05 5.00
100 INT175631 F2RL1 Positive_regulation of Positive_regulation of MMP1 1 0.08 0.69 0.04 5.00
101 INT298683 ecs Positive_regulation of Gene_expression of VEGFA 1 0.02 1.41 0.04 5.00
102 INT340271 Fig4 Positive_regulation of Localization of RELA 1 0.01 0.68 0.04 5.00
103 INT331172 Binding of IFNA1 and IL2 1 0.00 0.46 0.04 5.00
104 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04 5.00
105 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04 5.00
106 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04 5.00
107 INT343540 Binding of PPP1R12A and MLC1 1 0.09 0.15 0.04 5.00
108 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04 5.00
109 INT232207 Binding of Tgfb1 and Tnfrsf11a 1 0.02 0.51 0.04 5.00
110 INT175629 PAR1 Positive_regulation of Positive_regulation of MMP1 1 0.21 0.69 0.04 5.00
111 INT298637 ZDHHC2 Negative_regulation of Gene_expression of VEGFA 1 0.01 0.27 0.04 5.00
112 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03 5.00
113 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03 5.00
114 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03 5.00
115 INT298633 STAT3 Regulation of MCL1 1 0.04 0.85 0.03 5.00
116 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03 5.00
117 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 5.00
118 INT210592 Binding of Cd4 and Vcam1 1 0.01 0.65 0.03 5.00
119 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03 5.00
120 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03 5.00
121 INT283462 Binding of DLAT and HLA-DRB1 1 0.07 1.06 0.03 5.00
122 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03 5.00
123 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03 5.00
124 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03 5.00
125 INT298640 IL6R Positive_regulation of STAT3 1 0.01 0.73 0.03 5.00
126 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03 5.00
127 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03 5.00
128 INT340214 BGLAP Regulation of Gene_expression of NFATC1 1 0.02 0.76 0 5.00
129 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0 5.00
130 INT313305 SQSTM1 Regulation of NFE2L2 1 0.35 0.09 0 5.00
131 INT340270 Negative_regulation of Tnfsf11 Positive_regulation of TRAP 1 0.03 0.37 0 5.00
132 INT335736 Binding of Map1lc3a and Map1lc3b 1 0.19 0.36 0 5.00
133 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
134 INT313307 TERT Positive_regulation of NFE2L2 1 0.01 0 0 5.00
135 INT313293 Binding of KEAP1 and GOPC 1 0.04 0.24 0 5.00
136 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0 5.00
137 INT175624 Gene_expression of CDH2 Positive_regulation of CDH1 1 0.00 1.12 0 5.00
138 INT313298 Negative_regulation of SQSTM1 Positive_regulation of KEAP1 1 0.39 0.39 0 5.00
139 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 5.00
140 INT340275 NFATC1 Positive_regulation of Binding of Ahr 1 0.10 0.51 0 5.00
141 INT280265 Binding of Cxcr4 and Tgfb1 1 0.06 0.89 0 5.00
142 INT301410 Binding of Lpar1 and Lpar2 2 0.20 0.65 0 5.00
143 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0 5.00
144 INT343541 PTHLH Positive_regulation of GYPA 1 0.03 0.95 0 5.00
145 INT313297 SQSTM1 Positive_regulation of Positive_regulation of NFE2L2 1 0.26 0 0 5.00
146 INT313304 Binding of SQSTM1 and GOPC 1 0.04 0.24 0 5.00
147 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
148 INT171991 Binding of DMD and ERAL1 1 0.01 0.54 0 5.00
149 INT233304 Binding of SRY and SLC22A8 1 0.34 0.93 0 5.00
150 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0 5.00
151 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0 5.00
152 INT313299 Negative_regulation of Binding of NFE2L2 and KEAP1 1 0.24 0.14 0 5.00
153 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
154 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
155 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0 5.00
156 INT217487 Binding of PDB1 and Tnfrsf11a 1 0.03 0.76 0 5.00
157 INT280272 VEGFA Regulation of Cxcr4 1 0.05 0.87 0 5.00
158 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0 5.00
159 INT304618 Binding of Lta and Omt2a 1 0.01 0.19 0 5.00
160 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0 5.00
161 INT205121 Binding of CD4 and CD7 1 0.05 0.51 0 5.00
162 INT211067 Pth Regulation of DMD 1 0.01 0.12 0 5.00
163 INT280269 Tgfb1 Regulation of Cxcr4 1 0.04 0.88 0 5.00
164 INT313296 Binding of KEAP1 and PGAM5 1 0.11 0.15 0 5.00
165 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0 5.00
166 INT301401 Binding of Enpp1 and Enpp2 1 0.23 0.54 0 5.00
167 INT280264 Negative_regulation of Binding of Cxcr4 and Tgfb1 1 0.07 0.89 0 5.00
168 INT313290 Binding of NFE2L2 and Positive_regulation of Binding of NFE2L2 KEAP1 1 0.16 0.38 0 5.00
169 INT313303 Negative_regulation of SQSTM1 Positive_regulation of GOPC 1 0.05 0.39 0 5.00
170 INT313292 Positive_regulation of SQSTM1 Regulation of NFE2L2 1 0.26 0.09 0 5.00
171 INT280273 Tgfb1 Regulation of VEGFA 1 0.01 0.88 0 5.00
172 INT197545 KEAP1 Regulation of NFE2L2 3 0.49 0.8 0 5.00
173 INT298632 STAT3 Positive_regulation of MIR21 1 0.03 0.84 0 5.00
174 INT340277 Tnfsf11 Positive_regulation of TRAP 1 0.03 0.76 0 5.00
175 INT313310 KEAP1 Regulation of Gene_expression of SQSTM1 1 0.43 0.35 0 5.00
176 INT293413 GOPC Regulation of Localization of IL11 1 0.03 0.6 0 5.00
177 INT313302 Regulation of TERT Positive_regulation of SQSTM1 1 0.01 0 0 5.00
178 INT340272 Tnfsf11 Positive_regulation of Gene_expression of NFATC1 1 0.09 0.56 0 5.00
179 INT313311 SQSTM1 Positive_regulation of Positive_regulation of KEAP1 1 0.45 0 0 5.00
180 INT277703 Binding of Pdgfrb and Pdgfb 1 0.02 0.23 0 5.00
181 INT293410 HRAS Regulation of Localization of SPP1 1 0.00 0.8 0 5.00
182 INT313291 TERT Positive_regulation of SQSTM1 1 0.02 0 0 5.00
183 INT313306 KEAP1 Positive_regulation of SPARC 1 0.02 0.37 0 5.00
184 INT301407 Binding of Lpar6 and Dmbx1 1 0.13 0 0 5.00
185 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0 5.00
186 INT175630 Binding of PCa and MMRN1 1 0.01 1.24 0 5.00
187 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0 5.00
188 INT301409 Binding of Lpar6 and Gpr87 2 0.09 0 0 5.00
189 INT333978 Binding of ELF3 and TRAP 1 0.15 0.06 0 5.00
190 INT283461 Binding of IL2 and SLC4A2 1 0.01 0.98 0 5.00
191 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0 5.00
192 INT313294 Negative_regulation of SQSTM1 Positive_regulation of Positive_regulation of KEAP1 1 0.39 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spontaneous Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Spontaneous Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1 99.92
2 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.76
3 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.34
4 INT9784 Binding of B2M 9 0.47 6.18 1.44 99.14
5 INT209118 Regulation of Etfdh 12 0.18 7.77 3.91 98.88
6 INT117636 Negative_regulation of Tnfrsf11b 2 0.23 1.58 0.31 98.72
7 INT68216 Binding of NF1 40 0.48 51.24 4.59 98.64
8 INT125227 Positive_regulation of CHIT1 5 0.21 3.52 0.33 98.24
9 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 98.04
10 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 97.92
11 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 97.56
12 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 97.56
13 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 97.48
14 INT313318 Negative_regulation of Localization of SQSTM1 1 0.39 0.59 0.14 97.40
15 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 97.38
16 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 97.20
17 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 97.16
18 INT322778 Localization of Rcc1 1 0.61 1.43 0 97.12
19 INT313320 Localization of SQSTM1 1 0.68 0.59 0.14 97.04
20 INT19775 Localization of Il1 183 0.78 145.5 50.91 96.96
21 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 96.80
22 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 96.72
23 INT260340 Gene_expression of Rcc1 4 0.58 5.36 0.21 96.52
24 INT95670 Regulation of PDB1 4 0.60 5.59 0.55 96.20
25 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57 95.56
26 INT194031 Regulation of SQSTM1 2 0.41 2.07 0.27 95.36
27 INT335728 Positive_regulation of Dpyd 1 0.17 1.74 0.09 95.32
28 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 95.12
29 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 95.12
30 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 94.88
31 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 94.84
32 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 94.84
33 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19 94.60
34 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 94.48
35 INT93017 Binding of PDB1 8 0.36 6.36 0.51 94.12
36 INT39513 Positive_regulation of TRAP 14 0.48 5.11 1.67 94.08
37 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 94.04
38 INT61818 Positive_regulation of Ocln 6 0.23 4.11 0.22 93.88
39 INT61819 Positive_regulation of Ostf1 1 0.00 1.25 0.09 93.88
40 INT41610 Positive_regulation of IGHD@ 2 0.42 1.5 0.23 93.84
41 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 93.84
42 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 93.84
43 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41 93.84
44 INT104906 Negative_regulation of Alpl 5 0.31 1.72 0.21 93.60
45 INT1168 Binding of PROC 62 0.38 44.15 9.04 92.60
46 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 92.28
47 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 91.76
48 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 91.72
49 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 91.68
50 INT150237 Localization of Ccr1 10 0.75 9.25 4.72 91.68
51 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 91.56
52 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 90.96
53 INT55962 Positive_regulation of Localization of PROC 9 0.20 7.76 1.87 90.60
54 INT194030 Regulation of UBAP1 1 0.03 1.34 0.13 90.40
55 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 90.36
56 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 90.36
57 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 90.32
58 INT95667 Positive_regulation of Nfkb2 3 0.22 3.95 0.8 90.08
59 INT4535 Localization of PROC 106 0.73 76.24 21.1 90.00
60 INT135920 Binding of SRY 9 0.45 3.57 1.45 89.64
61 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 89.56
62 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 89.48
63 INT27534 Negative_regulation of Gba 10 0.57 6.23 0.38 89.04
64 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 89.04
65 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 89.00
66 INT9118 Gene_expression of Ceacam1 37 0.75 17.19 6.12 88.92
67 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 88.84
68 INT273531 Gene_expression of BRON-J 1 0.31 5.53 0.75 88.68
69 INT373 Regulation of Ldha 37 0.61 17.86 11.41 88.32
70 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 88.20
71 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 87.12
72 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 87.04
73 INT313313 Positive_regulation of Gene_expression of SQSTM1 1 0.63 1.25 0.23 86.96
74 INT188446 Gene_expression of SQSTM1 5 0.71 5.34 0.18 86.96
75 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 86.80
76 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 86.80
77 INT45868 Regulation of PRS 3 0.23 3.49 0.25 86.56
78 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 86.28
79 INT125980 Binding of CFD 8 0.42 10.96 1.39 86.08
80 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 85.92
81 INT105021 Binding of GOPC 187 0.40 60.39 20.38 85.76
82 INT239085 Binding of KAT2B 1 0.18 2.04 0.09 85.76
83 INT239082 Binding of BCAM 1 0.03 2.03 0.09 85.76
84 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14 85.60
85 INT141611 Positive_regulation of Gene_expression of Ccr1 25 0.69 20.32 6.42 85.60
86 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 85.08
87 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 85.08
88 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 84.52
89 INT61817 Gene_expression of Rhoc 1 0.18 1.49 0.08 84.48
90 INT69543 Positive_regulation of Negative_regulation of PTH 2 0.43 1.8 0.17 84.44
91 INT277698 Transcription of Pdgfrb 1 0.09 2.67 0 84.00
92 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 83.80
93 INT146660 Negative_regulation of Ctsk 9 0.43 6.01 2.07 83.36
94 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 82.80
95 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 82.80
96 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 82.64
97 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 82.48
98 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4 81.40
99 INT69478 Negative_regulation of GBA 16 0.55 7.9 0.59 81.40
100 INT24459 Positive_regulation of PDB1 7 0.46 7 0.5 81.28
101 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 81.24
102 INT81175 Localization of Pthlh 4 0.70 7.64 0.5 81.00
103 INT172559 Localization of Proc 16 0.02 21.49 2.08 81.00
104 INT179823 Localization of Il11 13 0.78 2.18 0.95 81.00
105 INT103094 Binding of PPARA 308 0.47 177.26 34.75 80.72
106 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 80.68
107 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 80.48
108 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4 80.48
109 INT130047 Localization of TGFB2 3 0.16 3.65 0.53 80.48
110 INT343551 Positive_regulation of Localization of TGFB2 1 0.10 1.48 0.08 80.48
111 INT15610 Localization of GOPC 223 0.65 68.26 28.7 80.16
112 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 80.16
113 INT239086 Localization of BCAM 2 0.54 2.32 0.09 80.16
114 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 79.48
115 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 79.12
116 INT12339 Localization of IL8 437 0.81 251.87 117.39 78.92
117 INT37363 Localization of PTHLH 14 0.68 13.23 2.92 78.92
118 INT127724 Localization of CSF1 12 0.73 9.35 1.56 78.92
119 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78 78.92
120 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 78.72
121 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 78.28
122 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 78.24
123 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 77.68
124 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 77.20
125 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87 76.80
126 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 76.80
127 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 76.72
128 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 75.92
129 INT84399 Negative_regulation of Igll1 1 0.35 0.83 0.06 75.88
130 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 75.76
131 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0 75.60
132 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0 75.60
133 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 75.48
134 INT213533 Positive_regulation of Gene_expression of Proc 6 0.01 5.55 0.49 75.44
135 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 75.36
136 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 75.36
137 INT87905 Binding of PRS 2 0.36 1.01 1.09 75.00
138 INT46704 Negative_regulation of KNTC1 1 0.42 0.88 0.26 75.00
139 INT46705 Positive_regulation of Negative_regulation of KNTC1 1 0.45 0.88 0.26 75.00
140 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 74.76
141 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 74.16
142 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 74.16
143 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 74.16
144 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 73.96
145 INT4097 Localization of Pth 66 0.81 47.17 4.36 73.76
146 INT24458 Negative_regulation of PDB1 8 0.41 4.5 1.5 73.52
147 INT155775 Gene_expression of PDB1 12 0.65 10.18 0.41 73.52
148 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 73.44
149 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 73.44
150 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 73.44
151 INT131123 Gene_expression of Gba 22 0.78 3.74 3.14 73.28
152 INT143142 Negative_regulation of Gene_expression of Gba 3 0.43 1.78 0.2 73.28
153 INT143143 Positive_regulation of Gene_expression of Gba 3 0.44 1.83 0.16 73.28
154 INT10835 Regulation of IL8 79 0.49 53.04 24.14 73.28
155 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 72.40
156 INT313329 Positive_regulation of Binding of KEAP1 1 0.46 0.44 0.11 72.40
157 INT313312 Positive_regulation of Binding of SQSTM1 1 0.46 0.44 0.11 72.40
158 INT89118 Protein_catabolism of MIB1 1 0.26 1.18 0.12 72.32
159 INT72628 Regulation of CSF1 7 0.25 1.95 0.75 72.28
160 INT197563 Regulation of KEAP1 10 0.56 3.18 0.11 72.24
161 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 72.00
162 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 71.84
163 INT37467 Gene_expression of Gaa 2 0.17 1.71 0.22 71.68
164 INT143141 Positive_regulation of Gene_expression of Gaa 1 0.03 1.57 0.15 71.68
165 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 71.52
166 INT188444 Binding of SQSTM1 5 0.44 4.69 0.54 70.44
167 INT101815 Binding of KEAP1 6 0.44 5.29 0.39 70.44
168 INT241799 Negative_regulation of CHIT1 13 0.42 4.37 0.44 69.64
169 INT333984 Localization of CHIT1 1 0.26 0.32 0.09 69.64
170 INT264884 Gene_expression of LIMA1 1 0.65 0.68 0.06 68.96
171 INT39512 Negative_regulation of TRAP 22 0.56 8.18 4.76 68.84
172 INT86946 Localization of TRAP 5 0.74 2.87 0.34 68.84
173 INT3920 Localization of Ldha 241 0.81 83.08 58.72 68.68
174 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 68.68
175 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 68.64
176 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23 68.28
177 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 67.44
178 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 67.04
179 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02 67.04
180 INT89294 Gene_expression of Ccr3 53 0.68 43.9 12.62 66.80
181 INT13397 Localization of DMD 21 0.78 7.96 1.08 66.76
182 INT197575 Protein_catabolism of KEAP1 4 0.91 3.44 0.23 66.44
183 INT162056 Negative_regulation of IGFBP4 1 0.12 0.71 0.1 65.16
184 INT245872 Positive_regulation of HLA-G 1 0.02 0.78 0 64.76
185 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62 64.40
186 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 62.84
187 INT335738 Positive_regulation of VCP 1 0.06 1.88 0.06 62.64
188 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 62.56
189 INT70242 Localization of HCC 18 0.66 23.95 2.35 62.44
190 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 62.24
191 INT4096 Regulation of Localization of Pth 7 0.58 3.97 0.95 60.56
192 INT217442 Regulation of Sqstm1 3 0.59 3.86 0.65 59.64
193 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 58.92
194 INT172479 Positive_regulation of NFE2L2 74 0.70 35.22 0.79 58.88
195 INT177875 Positive_regulation of Positive_regulation of NFE2L2 18 0.66 9.4 0.4 58.88
196 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 58.32
197 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 58.32
198 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 58.32
199 INT48729 Gene_expression of IGFBP4 4 0.46 1 0.68 58.24
200 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 57.52
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