D:Spontaneous Rupture

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Disease Term
Synonyms Ruptures Spontaneous, Spontaneous Ruptures
Documents 529
Hot Single Events 17
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spontaneous Rupture. They are ordered first by their relevance to Spontaneous Rupture and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT139538 Binding of CD34 and KIT 2 0.39 2.73 0.14 75.00
2 INT350344 Gene_expression of Kcnn2 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.79 5.00
3 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
4 INT350342 Tbp Positive_regulation of Ltp 1 0.25 0.48 0.64 5.00
5 INT285758 RETNLB Positive_regulation of Gene_expression of TIMP1 1 0.01 1.79 0.55 5.00
6 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42 5.00
7 INT350348 Binding of Car1 and Chrm1 1 0.09 0 0.2 5.00
8 INT350343 Csnk2a2 Regulation of Grin1 1 0.11 0.09 0.11 5.00
9 INT350349 Binding of Chrm1 and Csnk2a2 1 0.11 0.09 0.09 5.00
10 INT350345 Tbp Positive_regulation of Positive_regulation of Grin1 1 0.18 0 0.07 5.00
11 INT350347 Negative_regulation of Prkca Negative_regulation of Chrm1 1 0.08 0 0.03 5.00
12 INT350346 Negative_regulation of Prkca Negative_regulation of Negative_regulation of Chrm1 1 0.08 0 0.03 5.00
13 INT350341 Negative_regulation of Prkca Negative_regulation of Localization of Chrm1 1 0.08 0 0.03 5.00
14 INT347035 Binding of Kit and Cd34 1 0.02 1.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spontaneous Rupture. They are ordered first by their pain relevance and then by number of times they were reported in Spontaneous Rupture. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT74233 Binding of Ssr1 8 0.41 1.67 0.35 100.00
2 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 99.84
3 INT50568 Positive_regulation of HCA1 5 0.44 5.56 1.63 99.64
4 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 99.08
5 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 97.88
6 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 95.92
7 INT159806 Binding of HCA1 4 0.32 1.57 0.24 94.92
8 INT27243 Positive_regulation of SPINK1 13 0.68 26.71 2.92 92.32
9 INT214073 Binding of TSC1 9 0.37 22 1.34 92.16
10 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 91.84
11 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 91.60
12 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 90.64
13 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 88.00
14 INT114519 Gene_expression of Hcm 10 0.57 13.01 0.57 84.20
15 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 83.92
16 INT322758 Positive_regulation of Localization of TSC1 1 0.06 1.4 0 81.44
17 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 80.56
18 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 76.16
19 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 75.00
20 INT21682 Binding of CD34 18 0.47 13.19 1.47 75.00
21 INT128376 Binding of KIT 26 0.48 14.24 0.47 75.00
22 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 75.00
23 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 75.00
24 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 75.00
25 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 75.00
26 INT11033 Positive_regulation of Gene_expression of MUC16 21 0.69 15.75 1.89 75.00
27 INT79140 Binding of HCC 36 0.31 46.96 1.87 75.00
28 INT94881 Negative_regulation of Gene_expression of MUC16 4 0.42 2.51 0.61 75.00
29 INT135731 Gene_expression of NAE1 4 0.29 5.05 0.3 75.00
30 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 74.00
31 INT3117 Regulation of Oxt 103 0.61 17.93 32.28 70.20
32 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 69.76
33 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 69.76
34 INT7207 Regulation of HBG1 27 0.60 22.1 1.12 68.96
35 INT137277 Gene_expression of Acads 2 0.77 1.08 0.05 66.52
36 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 66.16
37 INT184803 Localization of TSC1 5 0.37 6.13 0.32 65.04
38 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 65.04
39 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 64.04
40 INT170062 Negative_regulation of Gene_expression of HBM 3 0.16 4.82 0.25 64.04
41 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 63.56
42 INT14 Regulation of LDHA 22 0.57 15.26 2.14 62.80
43 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26 55.92
44 INT322756 Negative_regulation of Tsc1 1 0.07 1.4 0.26 55.92
45 INT31407 Negative_regulation of HCA1 4 0.38 3.07 1.34 53.72
46 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 51.48
47 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 50.00
48 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 50.00
49 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 49.40
50 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 49.12
51 INT132662 Binding of Hcm 11 0.31 14.41 0.73 46.80
52 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 46.68
53 INT172066 Binding of Mtpn 3 0.02 1.51 0.52 43.40
54 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 37.72
55 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 31.24
56 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 30.48
57 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 30.48
58 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 25.68
59 INT350321 Localization of D5Pas1 1 0.01 0 0.15 22.56
60 INT342470 Negative_regulation of Gene_expression of Ath9 1 0.06 1.52 0.04 14.72
61 INT342474 Gene_expression of Ath9 1 0.10 1.45 0.04 13.36
62 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 8.52
63 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
64 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
65 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 5.00
66 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
67 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
68 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
69 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
70 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
71 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
72 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
73 INT13277 Regulation of Positive_regulation of Ltp 83 0.52 19.68 55.78 5.00
74 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
75 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
76 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
77 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 5.00
78 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22 5.00
79 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02 5.00
80 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88 5.00
81 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
82 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 5.00
83 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 5.00
84 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28 5.00
85 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
86 INT117632 Gene_expression of Trpm8 99 0.78 29.41 30.9 5.00
87 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
88 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 5.00
89 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
90 INT54467 Localization of Ltp 41 0.58 8.86 26.88 5.00
91 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
92 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
93 INT3028 Negative_regulation of Oxt 76 0.58 18.52 24.4 5.00
94 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 5.00
95 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
96 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
97 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
98 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
99 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57 5.00
100 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 5.00
101 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
102 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
103 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
104 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
105 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
106 INT92513 Regulation of Grin1 26 0.59 9.12 13.94 5.00
107 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
108 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 5.00
109 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
110 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
111 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
112 INT54466 Negative_regulation of Gene_expression of Ltp 19 0.38 5.44 10.91 5.00
113 INT3546 Binding of Oxt 54 0.48 9.75 10.81 5.00
114 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
115 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 5.00
116 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
117 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
118 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
119 INT121599 Negative_regulation of Gene_expression of RETNLB 7 0.21 9.28 8.8 5.00
120 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
121 INT134381 Regulation of Trpm8 25 0.54 8.31 8.25 5.00
122 INT110705 Positive_regulation of Positive_regulation of Grin1 11 0.69 4.7 7.33 5.00
123 INT36726 Regulation of Gene_expression of Ltp 14 0.46 4.81 7.05 5.00
124 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
125 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 5.00
126 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
127 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
128 INT139580 Negative_regulation of Trpm8 19 0.58 3.8 6.26 5.00
129 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47 5.00
130 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87 5.00
131 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
132 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
133 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
134 INT4683 Negative_regulation of PDXK 17 0.55 12.81 4.39 5.00
135 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29 5.00
136 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 5.00
137 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
138 INT103463 Localization of CPP 16 0.66 9.63 4.08 5.00
139 INT75688 Binding of KITLG 24 0.30 11.73 4.06 5.00
140 INT68189 Gene_expression of TNNT1 27 0.75 14.87 4.03 5.00
141 INT187360 Gene_expression of Kcnn2 17 0.55 2.51 3.91 5.00
142 INT107415 Regulation of Kcnj9 6 0.62 1 3.87 5.00
143 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 5.00
144 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 5.00
145 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16 5.00
146 INT91418 Transcription of Gabrg1 11 0.62 1.12 3.16 5.00
147 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 5.00
148 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 5.00
149 INT134378 Binding of Trpm8 8 0.48 1.74 2.95 5.00
150 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93 5.00
151 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 5.00
152 INT143841 Positive_regulation of Mtpn 17 0.17 5.46 2.68 5.00
153 INT245671 Positive_regulation of Gene_expression of Car1 15 0.28 4.31 2.67 5.00
154 INT137967 Positive_regulation of Gene_expression of Trpm8 11 0.70 3.29 2.66 5.00
155 INT134377 Regulation of Gene_expression of Trpm8 7 0.59 3.18 2.66 5.00
156 INT123306 Negative_regulation of Positive_regulation of Chrm1 3 0.32 0.72 2.63 5.00
157 INT134380 Negative_regulation of Gene_expression of Trpm8 3 0.43 1.78 2.24 5.00
158 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
159 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 5.00
160 INT33170 Binding of Chrm1 11 0.48 1.58 2.1 5.00
161 INT25737 Regulation of Chrm1 6 0.40 1.4 2 5.00
162 INT79141 Regulation of Gene_expression of NPEPPS 3 0.01 2.95 1.61 5.00
163 INT130241 Positive_regulation of Positive_regulation of Trpm8 5 0.69 0.15 1.45 5.00
164 INT151450 Positive_regulation of Gene_expression of Kit 23 0.69 13.11 1.43 5.00
165 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4 5.00
166 INT126411 Gene_expression of Csnk2a2 11 0.78 1.59 1.3 5.00
167 INT126408 Negative_regulation of Csnk2a2 3 0.38 1.75 1.3 5.00
168 INT55315 Gene_expression of Tbp 32 0.74 14.6 1.17 5.00
169 INT212093 Positive_regulation of CASP2 6 0.17 6.87 1.14 5.00
170 INT57847 Gene_expression of Chrm1 12 0.69 3.55 1.12 5.00
171 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09 5.00
172 INT166859 Regulation of Positive_regulation of Chrm1 2 0.31 0.11 1.07 5.00
173 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95 5.00
174 INT120175 Negative_regulation of HK1 10 0.57 2.57 0.92 5.00
175 INT52454 Localization of Tbp 7 0.76 2.53 0.91 5.00
176 INT50569 Gene_expression of HCA1 10 0.59 3.76 0.89 5.00
177 INT97272 Positive_regulation of Positive_regulation of Chrm1 2 0.34 0.3 0.85 5.00
178 INT137276 Binding of Acads 3 0.32 1.82 0.84 5.00
179 INT71876 Regulation of Tbp 4 0.43 1.03 0.8 5.00
180 INT350317 Positive_regulation of Gene_expression of Kcnn2 1 0.23 0 0.78 5.00
181 INT208334 Localization of Hdl1 22 0.54 18.94 0.74 5.00
182 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 5.00
183 INT262276 Negative_regulation of CASP2 1 0.01 2.98 0.73 5.00
184 INT62786 Negative_regulation of Chrm1 2 0.29 0.52 0.7 5.00
185 INT121717 Positive_regulation of Negative_regulation of Grin1 2 0.66 0.13 0.69 5.00
186 INT191706 Positive_regulation of Gene_expression of TNNT1 5 0.49 3.61 0.64 5.00
187 INT288019 Regulation of Gene_expression of Kcnma1 3 0.00 0.7 0.63 5.00
188 INT160963 Negative_regulation of UGCG 3 0.57 1.69 0.58 5.00
189 INT237791 Gene_expression of Ly6 4 0.11 1.04 0.53 5.00
190 INT197369 Regulation of Gene_expression of Car1 4 0.24 0.25 0.47 5.00
191 INT198884 Gene_expression of Vldlr 13 0.70 2.41 0.44 5.00
192 INT350319 Negative_regulation of Localization of Tbp 1 0.20 0 0.4 5.00
193 INT262273 Positive_regulation of Strs1 1 0.01 1.52 0.39 5.00
194 INT104005 Negative_regulation of Gene_expression of DES 6 0.42 4.82 0.37 5.00
195 INT1626 Binding of Cog1 8 0.21 7.86 0.34 5.00
196 INT262272 Phosphorylation of Strs1 1 0.01 1.07 0.34 5.00
197 INT31408 Localization of HCA1 4 0.28 1.4 0.33 5.00
198 INT262277 Regulation of CASP2 1 0.01 1.27 0.33 5.00
199 INT187410 Localization of Cd320 14 0.78 9.03 0.31 5.00
200 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 5.00
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