D:Stable Angina Pectoris

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Disease Term
Synonyms None
Documents 1804
Hot Single Events 200
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Stable Angina Pectoris. They are ordered first by their relevance to Stable Angina Pectoris and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT337762 Tnf Regulation of Gene_expression of Tlr4 1 0.49 1.16 0.18 98.32
2 INT118344 Binding of Crp and F7 1 0.01 0.19 0 94.16
3 INT139974 Adp Positive_regulation of Gene_expression of Selp 1 0.00 1.79 0.34 93.84
4 INT90252 Binding of PPBP and TAT 1 0.39 5.55 0.48 77.80
5 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48 77.80
6 INT90263 Binding of PPBP and Pf4 1 0.03 3.71 0.31 76.24
7 INT167169 Nfkb1 Regulation of Gene_expression of Crp 1 0.09 1.76 1.38 75.00
8 INT97820 Serpine1 Negative_regulation of TIMP1 1 0.00 0.29 0.17 75.00
9 INT11641 Binding of SERPINE1 and Serpinc1 1 0.00 0.78 0.13 75.00
10 INT11632 Binding of SERPINE1 and TAT 1 0.11 0.78 0.13 75.00
11 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13 74.96
12 INT169646 Binding of Csrp1 and Il6 1 0.00 1.69 0.36 73.04
13 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66 70.40
14 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2 69.76
15 INT281005 Hdlcl1 Regulation of OTOR 1 0.00 1.62 0.26 68.52
16 INT139302 Binding of CRP and TLR4 1 0.38 1.18 0.19 67.28
17 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12 63.60
18 INT239236 Prkca Regulation of CYBB 1 0.00 0.98 0.2 62.48
19 INT239235 Prkca Positive_regulation of Prkca Regulation of Nos3 1 0.01 0.97 0.2 62.48
20 INT239227 Prkca Regulation of Nos3 1 0.02 0.97 0.2 62.48
21 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63 61.44
22 INT174861 Binding of FGF2 and VEGFA 1 0.34 0.59 0.2 35.04
23 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 5.00
24 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5 5.00
25 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26 5.00
26 INT329586 Binding of UBAP1 and ACCS 1 0.00 1.08 0.25 5.00
27 INT239238 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.01 0.46 0.24 5.00
28 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1 5.00
29 INT239237 TCN2 Positive_regulation of Gene_expression of Serpine1 1 0.00 0.68 0.08 5.00
30 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07 5.00
31 INT239229 Regulation of Binding of Edn1 and Ednra 1 0.01 0.37 0.03 5.00
32 INT262994 Binding of CRP and HSD11B1 1 0.15 3.02 0.03 5.00
33 INT239225 Binding of Edn1 and Ednrb 1 0.02 0.36 0.03 5.00
34 INT239228 Regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03 5.00
35 INT239224 Positive_regulation of Binding of Edn1 and Ednrb 1 0.02 0.37 0.03 5.00
36 INT180470 Cdh23 Positive_regulation of Lpl 1 0.06 1.23 0 5.00
37 INT227796 Binding of Acsl1 and Nos3 1 0.16 1.16 0 5.00
38 INT221402 Binding of INS and LPA 1 0.00 0.63 0 5.00
39 INT180469 Apo Positive_regulation of Lpl 1 0.04 1.23 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Stable Angina Pectoris. They are ordered first by their pain relevance and then by number of times they were reported in Stable Angina Pectoris. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 100.00
2 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 100.00
3 INT100593 Gene_expression of UBAP1 8 0.65 13.81 5.74 100.00
4 INT68675 Regulation of APCS 10 0.62 7.61 3.01 100.00
5 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 100.00
6 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 100.00
7 INT48412 Gene_expression of Apcs 26 0.54 7.16 1.53 100.00
8 INT89044 Negative_regulation of Entpd1 7 0.54 3.29 2.05 100.00
9 INT125182 Negative_regulation of Regulation of Entpd1 1 0.42 2.01 1.29 100.00
10 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 99.84
11 INT112506 Transcription of HGF 14 0.64 16.71 1.64 99.84
12 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 99.80
13 INT25244 Positive_regulation of Sftpa1 7 0.03 2.98 1.89 99.80
14 INT83193 Binding of Olr1 6 0.42 10 2.43 99.76
15 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.72
16 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 99.72
17 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.72
18 INT63869 Positive_regulation of IL1RAP 8 0.45 3.84 2.63 99.72
19 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 99.72
20 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.68
21 INT337755 Protein_catabolism of Acsl1 1 0.21 0.72 0.65 99.62
22 INT337756 Gene_expression of Uap1 1 0.65 1.42 0.48 99.60
23 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.56
24 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.52
25 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 99.52
26 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 99.52
27 INT18967 Positive_regulation of Gene_expression of HLA-DRB1 14 0.49 13.56 5.99 99.52
28 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 99.48
29 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 99.48
30 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.48
31 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 99.40
32 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 99.40
33 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 99.34
34 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 99.34
35 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52 99.34
36 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99 99.32
37 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 99.32
38 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41 99.32
39 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54 99.32
40 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.30
41 INT22454 Regulation of Crp 213 0.62 160.67 49.24 99.28
42 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 99.28
43 INT10173 Binding of Tnf 45 0.48 35.6 14.32 99.28
44 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77 99.28
45 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9 99.28
46 INT37390 Regulation of Crp 39 0.46 28.74 11.45 99.28
47 INT54113 Positive_regulation of AOS 2 0.43 0.98 0.26 99.28
48 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 99.28
49 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.20
50 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 99.16
51 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 99.16
52 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 99.12
53 INT70996 Positive_regulation of Positive_regulation of Icam1 8 0.60 6.02 3.74 99.12
54 INT139804 Binding of PTX3 6 0.48 7.42 1.21 99.12
55 INT102252 Positive_regulation of UBAP1 1 0.05 1.07 0.92 99.08
56 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 99.04
57 INT329588 Positive_regulation of Regulation of PTX3 1 0.47 1.85 0.74 99.04
58 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33 99.04
59 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 99.00
60 INT101363 Regulation of OLR1 16 0.39 9.27 2.54 98.98
61 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 98.96
62 INT51474 Binding of Il6 55 0.48 44.99 20.52 98.96
63 INT5194 Positive_regulation of Lpo 63 0.70 26.44 8.37 98.96
64 INT10553 Regulation of GPER 13 0.15 2.12 3.02 98.96
65 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 98.92
66 INT44616 Positive_regulation of Klk1 2 0.02 2.12 0.98 98.92
67 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 98.88
68 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 98.80
69 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 98.80
70 INT85985 Localization of TNNT1 10 0.78 6.66 3.26 98.76
71 INT149687 Positive_regulation of PRG2 3 0.39 2.19 0.87 98.64
72 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 98.52
73 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 98.44
74 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42 98.44
75 INT67424 Positive_regulation of Gene_expression of Selp 36 0.68 17.08 7.95 98.40
76 INT61036 Negative_regulation of Selp 12 0.50 7.45 4.46 98.40
77 INT76573 Negative_regulation of Vcam1 26 0.58 24.36 9.84 98.40
78 INT81411 Negative_regulation of Sele 8 0.38 7 2.7 98.40
79 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 98.40
80 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 98.40
81 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 98.32
82 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 98.32
83 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 98.32
84 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 98.32
85 INT38056 Localization of Crp 71 0.78 53.14 17.03 98.32
86 INT123458 Positive_regulation of Tnfrsf11b 9 0.43 14.3 2.01 98.24
87 INT142477 Gene_expression of GP6 12 0.76 12.53 1.79 98.20
88 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 98.20
89 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.20
90 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77 98.20
91 INT2733 Negative_regulation of Tbxas1 33 0.57 12.12 6.97 98.08
92 INT41691 Negative_regulation of Negative_regulation of Tbxas1 3 0.36 0.53 0.88 98.08
93 INT139803 Gene_expression of PTX3 22 0.75 26.21 5.07 98.04
94 INT323018 Regulation of PTX3 1 0.27 6.86 1.59 98.04
95 INT162636 Localization of PTX3 8 0.78 9.73 1.77 98.04
96 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 98.00
97 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 97.92
98 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 97.72
99 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 97.72
100 INT135722 Positive_regulation of Gene_expression of ANGPTL5 5 0.39 4.52 1.05 97.72
101 INT9055 Positive_regulation of Cog1 22 0.68 14.08 2.95 97.72
102 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 97.68
103 INT48270 Negative_regulation of RNF130 44 0.57 21.31 6.14 97.68
104 INT2774 Binding of Crp 241 0.48 195.89 44.39 97.64
105 INT117307 Negative_regulation of PRG2 1 0.12 0.39 0.54 97.48
106 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 97.44
107 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96 97.44
108 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 97.40
109 INT3364 Binding of SGCG 87 0.47 31.93 17.24 97.32
110 INT119003 Regulation of Binding of SGCG 1 0.44 0.45 0.1 97.32
111 INT24904 Negative_regulation of PAPPA 13 0.57 9.93 2.74 97.28
112 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25 97.24
113 INT174870 Negative_regulation of Transcription of FGF2 1 0.37 1.66 0.38 97.24
114 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 97.24
115 INT115317 Transcription of FGF2 14 0.62 12.79 3 97.24
116 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 97.24
117 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 97.08
118 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12 97.08
119 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.04
120 INT61626 Transcription of IL6 73 0.72 42.04 17.86 97.04
121 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 97.04
122 INT21670 Localization of Lama5 1 0.31 1.11 1.1 97.00
123 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84 97.00
124 INT60115 Transcription of F8 2 0.08 3.05 0.58 96.92
125 INT60110 Transcription of Serpinc1 2 0.35 1.45 0.31 96.92
126 INT39407 Binding of OLR1 18 0.48 14.79 2.51 96.76
127 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 96.72
128 INT106843 Regulation of Tnnt3 2 0.61 1.76 0.48 96.72
129 INT76191 Regulation of TNNT1 9 0.60 5.4 2.9 96.72
130 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 96.60
131 INT6365 Localization of Edn1 56 0.81 18.84 13.83 96.60
132 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 96.60
133 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 96.56
134 INT8541 Gene_expression of Csrp1 42 0.76 23.72 6.9 96.56
135 INT97077 Gene_expression of Entpd1 16 0.78 11.89 6.47 96.52
136 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 96.48
137 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 96.40
138 INT16371 Positive_regulation of Gene_expression of NPPA 7 0.45 3.62 0.96 96.40
139 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 96.40
140 INT162 Regulation of Prl 794 0.62 165.01 322.24 96.40
141 INT75908 Regulation of LEP 77 0.60 60.16 15.19 96.40
142 INT116721 Positive_regulation of Olr1 11 0.49 5.43 1.31 96.36
143 INT102711 Regulation of Gene_expression of Crp 3 0.44 1.63 1.47 96.16
144 INT251 Regulation of INS 398 0.62 232.47 55.04 96.08
145 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 95.96
146 INT119485 Regulation of Entpd1 1 0.27 1.26 0.93 95.96
147 INT17769 Positive_regulation of Dnase1 5 0.69 4.21 2.86 95.94
148 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 95.84
149 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 95.80
150 INT62945 Negative_regulation of Gene_expression of SELL 12 0.58 12.86 3.23 95.80
151 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 95.80
152 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 95.76
153 INT26477 Regulation of ACE 26 0.45 16.31 4.33 95.76
154 INT83190 Gene_expression of Olr1 26 0.59 12.47 2.91 95.72
155 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 95.72
156 INT51458 Negative_regulation of Gene_expression of Selp 29 0.57 12.64 8.1 95.72
157 INT861 Negative_regulation of Ptger1 9 0.37 3.84 3.48 95.60
158 INT235268 Positive_regulation of Gene_expression of Acsl1 2 0.49 1.96 0.17 95.56
159 INT57424 Positive_regulation of TNNT1 42 0.67 31.84 9.7 95.52
160 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 95.52
161 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 95.44
162 INT2609 Localization of ELANE 111 0.81 50.22 26.63 95.40
163 INT2442 Localization of Mb 38 0.80 24.74 6.33 95.36
164 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 95.24
165 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 95.16
166 INT54114 Negative_regulation of AOS 2 0.09 1.08 0.65 95.12
167 INT170739 Gene_expression of Acsl1 8 0.65 7.02 0.5 95.04
168 INT68952 Localization of PCNA 17 0.62 5.64 1.78 95.00
169 INT15744 Localization of GYPA 12 0.64 7.19 2.61 94.96
170 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 94.92
171 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8 94.80
172 INT30777 Negative_regulation of SELL 20 0.56 18.05 7.32 94.76
173 INT20100 Binding of Serpine1 16 0.29 6.78 1.18 94.76
174 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 94.40
175 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 94.38
176 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46 94.28
177 INT28699 Binding of F7 9 0.35 3.47 0.67 94.16
178 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 94.16
179 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 94.12
180 INT114055 Regulation of Apol7e 3 0.05 1.49 0.38 94.08
181 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 93.92
182 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 93.80
183 INT86805 Localization of HGF 49 0.71 28.48 6.35 93.76
184 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74 93.60
185 INT159782 Phosphorylation of Tnf 2 0.79 1.51 0.36 93.60
186 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 93.60
187 INT49801 Positive_regulation of SELP 21 0.48 21.34 5.25 93.48
188 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93 93.36
189 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 93.24
190 INT63170 Positive_regulation of Selp 27 0.68 24.1 6.3 93.20
191 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 93.04
192 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 92.96
193 INT174868 Regulation of Negative_regulation of VEGFA 4 0.43 4.51 0.63 92.96
194 INT174869 Regulation of Negative_regulation of FGF2 1 0.39 1.59 0.22 92.96
195 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18 92.88
196 INT114056 Negative_regulation of AP4E1 1 0.00 0.59 0.17 92.88
197 INT145759 Regulation of Gene_expression of Tlr2 3 0.43 0.98 0.14 92.88
198 INT10890 Binding of F8 11 0.36 7.27 1.15 92.84
199 INT5440 Negative_regulation of Ina 85 0.58 10.52 28.98 92.84
200 INT10888 Binding of Vwf 32 0.46 22.87 5.21 92.84
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