D:Strabismus

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Disease Term
Synonyms Comitant Strabismus, Comitant Strabismus Convergent, CONCOMITANT STRABISMUS, Convergent Comitant Strabismus, Convergent Strabismus, Cyclotropia, Divergent Strabismus, Esotropia, EXOTROPIA, Heterotropia, Hypertropia
Documents 567
Hot Single Events 19
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Strabismus. They are ordered first by their relevance to Strabismus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT143972 Chrna7 Negative_regulation of Gene_expression of Trpv1 1 0.01 0.18 0.24 82.88
2 INT232174 GAN Positive_regulation of ODT 1 0.01 0.98 0.14 82.84
3 INT143974 Chrna7 Positive_regulation of Vti1b 1 0.17 0.16 0.2 62.80
4 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2 62.80
5 INT301044 Binding of Csn2 and Trpm1 1 0.09 2.17 0.03 58.96
6 INT263776 Grin1 Positive_regulation of Ltp 2 0.17 0.17 0.54 5.00
7 INT268473 Negative_regulation of CNR1 Negative_regulation of Cysltr1 1 0.00 1.02 0.48 5.00
8 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
9 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21 5.00
10 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18 5.00
11 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18 5.00
12 INT301043 P9Ehs1 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
13 INT301041 Grm6 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
14 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05 5.00
15 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
16 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
17 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05 5.00
18 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
19 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04 5.00
20 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04 5.00
21 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04 5.00
22 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04 5.00
23 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04 5.00
24 INT353287 Prdx2 Positive_regulation of Phosphorylation of Smad7 1 0.22 0.06 0.03 5.00
25 INT353291 Prdx2 Positive_regulation of Smad7 1 0.31 0.06 0.03 5.00
26 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03 5.00
27 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03 5.00
28 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03 5.00
29 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03 5.00
30 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
31 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
32 INT301042 Binding of Csn2 and Nyx 1 0.07 0.51 0 5.00
33 INT212409 Binding of Efna1 and Epha1 1 0.02 0.39 0 5.00
34 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
35 INT273136 Binding of CHED1 and VSX1 1 0.15 0.12 0 5.00
36 INT265964 TNNI2 Regulation of CA2 1 0.22 0.09 0 5.00
37 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
38 INT212408 Binding of Zic1 and Odz2 1 0.00 0.15 0 5.00
39 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
40 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
41 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
42 INT301045 Binding of Csn2 and Grm6 1 0.02 0.51 0 5.00
43 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00
44 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00
45 INT301046 Binding of BCS1L and Csn2 1 0.01 0.62 0 5.00
46 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
47 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Strabismus. They are ordered first by their pain relevance and then by number of times they were reported in Strabismus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 100.00
2 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 99.68
3 INT173545 Gene_expression of LR 16 0.09 13.1 0.69 99.66
4 INT61903 Negative_regulation of Slc43a1 3 0.34 2.18 0.3 99.24
5 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 98.56
6 INT232182 Regulation of ODT 1 0.07 1.07 0.46 97.32
7 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 97.16
8 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 97.00
9 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 93.80
10 INT189634 Regulation of DCN 3 0.25 1.69 0.49 93.20
11 INT239412 Binding of ABL1 8 0.28 5.39 0.18 93.20
12 INT70987 Binding of RAC1 14 0.37 12.14 2.13 92.88
13 INT353274 Transcription of Prdx2 1 0.39 0.51 0.16 88.28
14 INT232181 Positive_regulation of ODT 1 0.12 2.44 1.1 85.40
15 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 83.92
16 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28 83.76
17 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 82.88
18 INT194993 Binding of RB1 15 0.37 10.96 0.4 82.08
19 INT28861 Binding of Gh 61 0.46 25.61 6.38 80.08
20 INT243222 Gene_expression of Rs1 6 0.78 8.49 0.17 79.76
21 INT243226 Positive_regulation of Rs1 3 0.70 5.6 0.31 79.76
22 INT39369 Binding of NARFL 14 0.29 16.7 0.93 79.72
23 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 79.40
24 INT9138 Positive_regulation of Negative_regulation of PFKM 2 0.47 1.32 0.14 76.92
25 INT9140 Negative_regulation of PFKM 14 0.59 12.67 3.61 76.84
26 INT232176 Regulation of Slc43a1 2 0.11 1.51 1.22 75.48
27 INT168250 Gene_expression of Havcr1 4 0.56 2.81 0.42 74.12
28 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36 73.76
29 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 73.12
30 INT27683 Gene_expression of Acpp 4 0.66 4.13 0.41 71.08
31 INT959 Regulation of ATRX 5 0.47 5.04 0.89 69.84
32 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 67.76
33 INT962 Gene_expression of ATRX 2 0.59 1.72 0.27 67.60
34 INT265972 Positive_regulation of Gene_expression of ATRX 1 0.38 1.72 0 67.60
35 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 67.44
36 INT9139 Regulation of Negative_regulation of PFKM 1 0.27 0.77 0.16 65.84
37 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 65.60
38 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59 65.44
39 INT264637 Localization of CLDN4 3 0.73 0.85 0.29 62.92
40 INT264629 Localization of Rac1 8 0.72 5.7 0.79 62.04
41 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 61.68
42 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 60.64
43 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 59.76
44 INT197627 Localization of RB1 3 0.69 4.16 0.13 59.72
45 INT23126 Regulation of HTR3A 10 0.60 5.42 4.81 59.68
46 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 59.28
47 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 58.16
48 INT232178 Localization of Slc43a1 1 0.04 0.81 0.71 57.48
49 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 57.12
50 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 55.20
51 INT265969 Regulation of TNNI2 1 0.45 1.35 0.09 53.12
52 INT265966 Regulation of MYH3 1 0.44 1.35 0.09 53.12
53 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26 52.92
54 INT253219 Binding of Mapk1ip1 1 0.32 0.28 0 51.80
55 INT253218 Negative_regulation of Binding of Mapk1ip1 1 0.37 0.28 0 51.80
56 INT10870 Regulation of IgG 67 0.59 43.27 12.74 51.20
57 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96 51.20
58 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 50.64
59 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 50.36
60 INT232180 Positive_regulation of Slc43a1 2 0.09 1.79 0.98 50.00
61 INT232179 Binding of Slc43a1 1 0.02 1.21 0.43 50.00
62 INT232177 Gene_expression of Slc43a1 2 0.04 1.06 0.4 50.00
63 INT253217 Gene_expression of Mapk1ip1 1 0.58 0.25 0.05 50.00
64 INT253220 Regulation of Gene_expression of Mapk1ip1 1 0.39 0.25 0.05 50.00
65 INT253221 Positive_regulation of Gene_expression of Mapk1ip1 1 0.43 0.25 0.05 50.00
66 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 46.24
67 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 44.56
68 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 43.28
69 INT243843 Negative_regulation of FMT 3 0.07 1.4 0.32 43.28
70 INT50080 Binding of APOE 38 0.45 29.61 2.67 42.00
71 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 41.68
72 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 41.16
73 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51 39.88
74 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 35.76
75 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 35.76
76 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 35.56
77 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 35.56
78 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 35.28
79 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 35.16
80 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 35.16
81 INT265497 Positive_regulation of TTN 2 0.04 0 0.03 34.80
82 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 34.72
83 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 34.16
84 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 34.16
85 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 34.08
86 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 34.08
87 INT279853 Negative_regulation of Gene_expression of Nipbl 1 0.51 2.37 0.19 33.20
88 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 32.88
89 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 32.88
90 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 32.88
91 INT78210 Gene_expression of MCC 7 0.65 1.8 0.98 29.92
92 INT189809 Negative_regulation of HEXA 1 0.57 3.93 0 29.44
93 INT265968 Gene_expression of TNNT3 1 0.65 1.39 0 29.36
94 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 29.04
95 INT161506 Regulation of Gene_expression of S100a8 6 0.45 4.68 2.9 29.04
96 INT265967 Gene_expression of TNNI2 1 0.67 1.39 0 28.56
97 INT265971 Gene_expression of MYH3 1 0.66 1.2 0 28.00
98 INT21032 Gene_expression of Adh1 23 0.78 22.1 6.14 27.96
99 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 27.12
100 INT243842 Localization of FMT 2 0.11 1.17 0.17 26.00
101 INT163461 Regulation of ABL1 8 0.32 5.98 0.14 24.08
102 INT301034 Regulation of Olfr624 1 0.01 0.13 0 23.04
103 INT301035 Localization of Trpm1 1 0.80 2.46 0.37 21.44
104 INT301038 Localization of Olfr624 1 0.01 0.12 0 20.08
105 INT86771 Positive_regulation of TAOK1 2 0.38 4.55 0.29 20.04
106 INT21631 Positive_regulation of Gene_expression of Adh1 4 0.70 12.56 0.39 18.88
107 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 15.44
108 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 13.80
109 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 13.32
110 INT38330 Binding of Adh1 4 0.41 3.98 0.3 13.28
111 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 11.12
112 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 10.32
113 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 7.32
114 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
115 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
116 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
117 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 5.00
118 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
119 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
120 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
121 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
122 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
123 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 5.00
124 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
125 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
126 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
127 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
128 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
129 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
130 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
131 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
132 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
133 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
134 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
135 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
136 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
137 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
138 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
139 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
140 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
141 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
142 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
143 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
144 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
145 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
146 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
147 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
148 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
149 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
150 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
151 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
152 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
153 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
154 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
155 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
156 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
157 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 5.00
158 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 5.00
159 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
160 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
161 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
162 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
163 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
164 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
165 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
166 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 5.00
167 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
168 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
169 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37 5.00
170 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
171 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
172 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 5.00
173 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 5.00
174 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
175 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 5.00
176 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
177 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
178 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 5.00
179 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
180 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
181 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
182 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
183 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
184 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32 5.00
185 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
186 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
187 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
188 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
189 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 5.00
190 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 5.00
191 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78 5.00
192 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
193 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
194 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 5.00
195 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
196 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
197 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 5.00
198 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
199 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
200 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
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