D:Stress Fractures

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Disease Term
Synonyms FATIGUE FRACTURE, FATIGUE FRACTURES, Fracture Fatigue, Fracture March, FRACTURE STRESS, FRACTURES FATIGUE, Fractures March, March Fracture, MARCH FRACTURES, Stress Fracture
Documents 768
Hot Single Events 43
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Stress Fractures. They are ordered first by their relevance to Stress Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT342385 Positive_regulation of Binding of Lrp5 and Vdr 1 0.53 0.98 0 100.00
2 INT342381 Binding of Lrp5 and Vdr 1 0.55 0.97 0 99.76
3 INT342382 Binding of Car1 and Lrp5 1 0.40 0.9 0 99.74
4 INT342387 Binding of CALCR and Car1 1 0.11 0.83 0 99.44
5 INT342379 Binding of Car1 and Sugt1 1 0.01 0.83 0 99.44
6 INT342388 Binding of CALCR and Vdr 1 0.12 0.83 0 99.44
7 INT254434 Binding of Lrp5 and Best1 3 0.29 2.53 0 93.88
8 INT354105 BCAT1 Regulation of PTH 1 0.07 0.48 0 90.76
9 INT342386 Binding of CALCR and Best1 1 0.01 0.96 0 89.68
10 INT342378 Binding of Vdr and Best1 1 0.05 0.4 0 89.68
11 INT342383 Binding of Srp14 and Best1 1 0.00 0.56 0 85.64
12 INT354106 Binding of BCAT1 and PTH 1 0.04 0 0 47.60
13 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
14 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
15 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Stress Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Stress Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT94095 Negative_regulation of BCAT1 9 0.49 0.97 4.91 99.92
2 INT262107 Binding of Vdr 9 0.48 6.56 0.71 99.76
3 INT103298 Binding of CALCR 5 0.47 6.03 2.15 99.76
4 INT142719 Binding of Col1a1 7 0.34 5.83 1.47 99.76
5 INT130739 Binding of Col1a2 2 0.35 2.38 0.34 99.76
6 INT54763 Binding of Il6 82 0.48 63.27 12.89 99.76
7 INT342374 Negative_regulation of Gene_expression of Pth 1 0.15 0.94 0 99.28
8 INT342376 Positive_regulation of Binding of Vdr 1 0.46 0.86 0 99.24
9 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 99.16
10 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 98.88
11 INT160633 Gene_expression of Vdr 21 0.77 10.01 2.73 98.88
12 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 98.80
13 INT70262 Gene_expression of Pth 8 0.66 5.64 0.12 98.72
14 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06 98.52
15 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 98.36
16 INT342375 Positive_regulation of Binding of Lrp5 1 0.46 0.85 0 97.68
17 INT3343 Regulation of PTH 24 0.62 11.18 1.62 97.20
18 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 97.04
19 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 95.64
20 INT262060 Positive_regulation of Vdr 8 0.58 2.84 0.67 93.48
21 INT262063 Localization of Vdr 3 0.75 1.76 0.33 93.44
22 INT22145 Binding of Sugt1 16 0.13 8.31 4.37 91.00
23 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 91.00
24 INT262079 Negative_regulation of Vdr 2 0.42 0.71 0.04 90.48
25 INT192156 Negative_regulation of Col1a1 6 0.39 3.92 0.8 90.28
26 INT139317 Negative_regulation of Col1a2 8 0.41 7.17 1.54 89.96
27 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18 89.48
28 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 88.68
29 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 88.40
30 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61 88.36
31 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 88.08
32 INT178834 Localization of MR1 8 0.21 6.52 0.48 88.08
33 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 86.24
34 INT126368 Gene_expression of MSX2 12 0.65 7.2 2.71 86.24
35 INT211971 Binding of Best1 16 0.22 7.73 0.33 85.64
36 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 85.48
37 INT158016 Positive_regulation of VEGFC 7 0.49 6.58 2.18 85.28
38 INT34927 Negative_regulation of Smc1b 2 0.25 0.49 0.09 83.04
39 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27 82.40
40 INT127591 Binding of Ceacam1 7 0.35 2.18 0.79 82.00
41 INT134654 Localization of CALCR 5 0.39 3.21 0.85 81.84
42 INT197365 Localization of Car1 7 0.73 1.11 0.94 81.84
43 INT146660 Negative_regulation of Ctsk 9 0.43 6.01 2.07 80.44
44 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 79.96
45 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 79.96
46 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 79.28
47 INT4863 Positive_regulation of ap 22 0.37 9.13 6.11 79.08
48 INT47371 Negative_regulation of ap 32 0.32 9.8 1.96 79.08
49 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 78.64
50 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 74.80
51 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 74.80
52 INT354107 Positive_regulation of BCAT1 1 0.05 0.15 0 74.36
53 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 72.68
54 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 72.64
55 INT280854 Regulation of Regulation of MSX2 1 0.11 0.07 0 72.64
56 INT9500 Negative_regulation of Ceacam1 26 0.58 6.89 3.91 67.44
57 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 66.84
58 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 64.92
59 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 64.92
60 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 62.76
61 INT76633 Regulation of BCAT1 2 0.04 0.79 1.61 62.64
62 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 60.76
63 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 57.04
64 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24 57.04
65 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 54.28
66 INT912 Localization of FSHR 91 0.79 23.61 15.58 53.96
67 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 50.00
68 INT11937 Localization of Il6 228 0.81 139.83 64.39 50.00
69 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 50.00
70 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18 50.00
71 INT39820 Gene_expression of CALCR 16 0.37 4.96 0.74 50.00
72 INT28094 Binding of PTH 29 0.37 13.57 3.09 47.60
73 INT192804 Regulation of Binding of PTH 2 0.45 0.43 0 47.60
74 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 46.72
75 INT70067 Regulation of KNCN 2 0.07 1.71 1.17 46.72
76 INT105425 Binding of BCAT1 5 0.42 0.78 1.17 43.84
77 INT2544 Localization of PTH 39 0.81 30.55 2.22 43.44
78 INT62361 Negative_regulation of Positive_regulation of PTH 4 0.43 2.22 0.23 43.04
79 INT210673 Gene_expression of Gpx4 2 0.48 3.54 0.09 37.80
80 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 36.40
81 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 30.16
82 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 29.40
83 INT42244 Regulation of Gene_expression of PTH 5 0.45 3.95 0.34 27.52
84 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 24.00
85 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 23.16
86 INT111890 Binding of MSD 26 0.41 8.05 1.71 21.36
87 INT114664 Binding of BMP2 12 0.37 6.54 0.91 17.12
88 INT316570 Binding of BMP7 3 0.37 0.95 0.07 17.12
89 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 12.68
90 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 10.16
91 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
92 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
93 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
94 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
95 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
96 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
97 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
98 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
99 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
100 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
101 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 5.00
102 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
103 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
104 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 5.00
105 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
106 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
107 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
108 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6 5.00
109 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
110 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
111 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3 5.00
112 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 5.00
113 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
114 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
115 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
116 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
117 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
118 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
119 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
120 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
121 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
122 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
123 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
124 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
125 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
126 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 5.00
127 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 5.00
128 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
129 INT203020 Positive_regulation of PYY 37 0.68 18.81 9.63 5.00
130 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 5.00
131 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11 5.00
132 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91 5.00
133 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 5.00
134 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
135 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 5.00
136 INT143996 Positive_regulation of CISH 28 0.49 17.31 7.17 5.00
137 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 5.00
138 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
139 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
140 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 5.00
141 INT118124 Binding of USE1 24 0.16 16.64 5.44 5.00
142 INT4342 Localization of ALPP 27 0.69 15.19 5.32 5.00
143 INT178763 Binding of HHIP 37 0.08 6.3 5.29 5.00
144 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
145 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 5.00
146 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
147 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 5.00
148 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 5.00
149 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
150 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 5.00
151 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
152 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
153 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
154 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65 5.00
155 INT176892 Binding of MR1 36 0.32 15.55 2.58 5.00
156 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 5.00
157 INT145970 Negative_regulation of MSD 11 0.50 4.7 2.26 5.00
158 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 5.00
159 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 5.00
160 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 5.00
161 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91 5.00
162 INT166819 Gene_expression of IMPA1 12 0.65 3.85 1.77 5.00
163 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 5.00
164 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 5.00
165 INT24736 Positive_regulation of SERPINA5 17 0.49 9.55 1.47 5.00
166 INT76596 Gene_expression of BCAT1 5 0.58 0.73 1.32 5.00
167 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 5.00
168 INT203640 Regulation of MR1 7 0.34 3.8 1.26 5.00
169 INT116524 Regulation of COP 5 0.35 0.63 1.25 5.00
170 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 5.00
171 INT177593 Positive_regulation of Gene_expression of MR1 17 0.43 9.36 1.13 5.00
172 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 5.00
173 INT19849 Positive_regulation of Smc1b 8 0.50 4.09 1.01 5.00
174 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01 5.00
175 INT92288 Binding of Igfals 3 0.13 3.14 1 5.00
176 INT189130 Regulation of AIS 11 0.39 7.64 0.99 5.00
177 INT15186 Negative_regulation of HRH2 8 0.51 2.26 0.99 5.00
178 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92 5.00
179 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85 5.00
180 INT269764 Positive_regulation of Localization of CYP27A1 4 0.38 2.45 0.8 5.00
181 INT108308 Gene_expression of ENOX1 10 0.77 1.65 0.74 5.00
182 INT148291 Positive_regulation of CSF3 9 0.61 6.37 0.7 5.00
183 INT170625 Binding of SERPINA5 8 0.32 8.42 0.69 5.00
184 INT296720 Protein_catabolism of AOS 1 0.05 1.28 0.69 5.00
185 INT73226 Regulation of Vmo1 2 0.18 2.19 0.68 5.00
186 INT2395 Binding of MB 18 0.36 7.53 0.68 5.00
187 INT151157 Negative_regulation of SERPINA5 5 0.23 3.68 0.64 5.00
188 INT89239 Negative_regulation of Gene_expression of VEGFC 2 0.39 1.11 0.59 5.00
189 INT93686 Regulation of TNKS 2 0.60 0.06 0.55 5.00
190 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 5.00
191 INT306058 Positive_regulation of ZGLP1 5 0.21 2.1 0.51 5.00
192 INT274254 Gene_expression of Mtss1 1 0.06 2.13 0.48 5.00
193 INT161035 Positive_regulation of Mtss1 2 0.58 1.99 0.48 5.00
194 INT178830 Negative_regulation of MR1 16 0.50 7.63 0.44 5.00
195 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 5.00
196 INT274255 Positive_regulation of Gene_expression of Mtss1 1 0.05 0.63 0.42 5.00
197 INT173810 Positive_regulation of Gene_expression of CYP27A1 5 0.49 1.35 0.4 5.00
198 INT255851 Positive_regulation of Tauph 2 0.02 1.51 0.39 5.00
199 INT221858 Localization of TNKS 2 0.78 1.67 0.37 5.00
200 INT240825 Gene_expression of Irs2 14 0.78 3.88 0.32 5.00
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