D:Substance Abuse

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Abuse Drug, Abuse Substance, Abuses Substance, Addiction Drug, Addiction Substance, ALCOHOL ABUSE, ALCOHOL OTHER DRUGS ABUSE, AOD ABUSE, Chemical Abuse, Dependence Drug, Dependence Substance
Documents 80
Hot Single Events 21
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Substance Abuse. They are ordered first by their relevance to Substance Abuse and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 98.40
2 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11 14.16
3 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 13.92
4 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 13.52
5 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
6 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
7 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31 5.00
8 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31 5.00
9 INT258766 Binding of Csf2 and ADHD1 1 0.01 0.69 0.27 5.00
10 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25 5.00
11 INT258761 Binding of Slc6a3 and ADHD1 1 0.03 0.51 0.12 5.00
12 INT258765 Lmo1 Regulation of ADHD1 1 0.05 1.98 0.09 5.00
13 INT258758 Binding of Drd4 and Lmo1 1 0.04 0.64 0.08 5.00
14 INT258756 Binding of Drd5 and Lmo1 1 0.03 0.64 0.08 5.00
15 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Substance Abuse. They are ordered first by their pain relevance and then by number of times they were reported in Substance Abuse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT154607 Negative_regulation of DDOST 2 0.37 0.68 0.75 99.84
2 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 98.60
3 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 98.00
4 INT211051 Gene_expression of FITM1 2 0.28 0.55 0.15 97.90
5 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 97.88
6 INT13703 Regulation of Phc1 7 0.23 3.92 2.71 97.60
7 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99 97.44
8 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 97.00
9 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 96.24
10 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 95.12
11 INT157720 Localization of ADHD1 15 0.64 15.84 1.69 93.72
12 INT153417 Gene_expression of DDOST 6 0.67 1.81 2.18 92.52
13 INT101414 Gene_expression of Phc1 27 0.60 9.55 7.58 87.36
14 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 86.84
15 INT165811 Binding of Phc1 13 0.15 5.99 3.09 86.64
16 INT184815 Regulation of ETF1 3 0.40 1.83 0.54 85.72
17 INT268737 Positive_regulation of Gene_expression of DDOST 2 0.44 0.58 0.89 84.48
18 INT215946 Localization of Phc1 33 0.10 8.41 1.39 84.20
19 INT280450 Localization of IER5 1 0.02 0.48 0.12 84.04
20 INT36674 Negative_regulation of Phc1 11 0.37 2.71 4.22 82.56
21 INT184852 Positive_regulation of Gene_expression of ADHD1 6 0.40 5.06 1.66 82.36
22 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 78.08
23 INT177609 Negative_regulation of GREM1 4 0.06 1.73 0.19 74.32
24 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 74.08
25 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93 71.92
26 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 71.36
27 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 70.68
28 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73 66.56
29 INT72916 Binding of Npy 2 0.41 1.5 1.37 62.36
30 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 61.20
31 INT154867 Gene_expression of CECR 28 0.57 6.97 3.72 56.96
32 INT280449 Positive_regulation of Gene_expression of Phc1 1 0.05 1.79 1.09 55.36
33 INT210326 Binding of DDOST 6 0.48 4.27 6.26 54.56
34 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66 54.40
35 INT227500 Negative_regulation of Gene_expression of ADHD1 5 0.34 4.9 1.32 50.12
36 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 48.40
37 INT58211 Gene_expression of FURIN 7 0.57 0.62 1.15 42.16
38 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 37.48
39 INT76625 Positive_regulation of Phc1 14 0.36 5.1 3.49 25.76
40 INT189862 Gene_expression of OSR1 2 0.10 3.62 0.04 24.44
41 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 17.96
42 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85 17.96
43 INT184864 Gene_expression of Lmo1 16 0.26 8.09 8.48 17.96
44 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27 17.96
45 INT53008 Gene_expression of Nr4a2 25 0.74 4.89 1.5 17.96
46 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 15.68
47 INT258746 Binding of Rends1 1 0.01 1.57 0.68 9.44
48 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
49 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
50 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
51 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 5.00
52 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 5.00
53 INT2783 Gene_expression of Slc3a1 86 0.65 8.84 45.4 5.00
54 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
55 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
56 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
57 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28 5.00
58 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 5.00
59 INT2650 Positive_regulation of Slc3a1 50 0.57 2.95 27.52 5.00
60 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41 5.00
61 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 5.00
62 INT12484 Binding of Drd2 45 0.48 15.17 24.72 5.00
63 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 5.00
64 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38 5.00
65 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
66 INT7952 Localization of Slc3a1 32 0.81 1.28 15.69 5.00
67 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24 5.00
68 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57 5.00
69 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
70 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
71 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 5.00
72 INT13296 Transcription of Drd2 17 0.66 2.7 9.07 5.00
73 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03 5.00
74 INT34268 Binding of WAS 14 0.47 4.41 8.67 5.00
75 INT15189 Localization of Npy 26 0.79 9.09 8.28 5.00
76 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 5.00
77 INT88868 Binding of MCS 45 0.40 37.43 7.98 5.00
78 INT28457 Positive_regulation of Slc6a3 26 0.50 3.64 7.76 5.00
79 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55 5.00
80 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.00
81 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 5.00
82 INT71418 Binding of CES1 42 0.40 29.78 5.01 5.00
83 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
84 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 5.00
85 INT88867 Localization of MCS 19 0.62 28.31 3.88 5.00
86 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
87 INT46725 Localization of Anxa3 4 0.48 4.53 3.43 5.00
88 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29 5.00
89 INT61686 Positive_regulation of Gene_expression of Slc3a1 5 0.24 1.74 2.13 5.00
90 INT184857 Positive_regulation of Lmo1 4 0.23 4.59 2.03 5.00
91 INT172622 Localization of EP300 8 0.65 2.56 1.72 5.00
92 INT214577 Positive_regulation of Gene_expression of PCS 4 0.29 2.07 1.56 5.00
93 INT199317 Localization of Slc35b2 2 0.07 3.86 1.44 5.00
94 INT38964 Negative_regulation of Lsd 3 0.37 0.52 1.32 5.00
95 INT77216 Localization of DRD2 3 0.75 0 1.19 5.00
96 INT169643 Binding of Ods 3 0.18 2.89 1.15 5.00
97 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 5.00
98 INT258745 Binding of Lmo1 3 0.11 5.92 0.84 5.00
99 INT226221 Binding of Dusp1 1 0.04 0.92 0.68 5.00
100 INT219793 Negative_regulation of Renbp 5 0.13 3.42 0.61 5.00
101 INT258759 Regulation of Localization of ADHD1 3 0.38 4.71 0.32 5.00
102 INT258747 Positive_regulation of Regulation of Slc3a1 1 0.03 1.14 0.16 5.00
103 INT189864 Positive_regulation of Positive_regulation of ADHD1 3 0.44 3.43 0.07 5.00
104 INT124020 Negative_regulation of Gene_expression of WAS 2 0.06 0.25 0.05 5.00
105 INT211053 Positive_regulation of Gene_expression of FITM1 2 0.18 0.13 0 5.00
106 INT273009 Positive_regulation of Localization of Phc1 1 0.02 0.07 0 5.00
107 INT258760 Phosphorylation of ADHD1 1 0.25 0.98 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox