D:Suppurative Otitis Media

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pChart

Disease Term
Synonyms Otitis Media Purulent, Purulent Otitis Media
Documents 48
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Suppurative Otitis Media. They are ordered first by their relevance to Suppurative Otitis Media and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09 68.72
2 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 46.04
3 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 46.04
4 INT267596 KNG1 Positive_regulation of Gene_expression of PLA2G6 1 0.01 0.87 0.25 46.04
5 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25 46.04
6 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
7 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
8 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
9 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
10 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
11 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
12 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
13 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
14 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 5.00
15 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 5.00
16 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27 5.00
17 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 5.00
18 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 5.00
19 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24 5.00
20 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18 5.00
21 INT267627 Il1 Positive_regulation of Gene_expression of TNF 1 0.02 0.45 0.17 5.00
22 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09 5.00
23 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09 5.00
24 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07 5.00
25 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Suppurative Otitis Media. They are ordered first by their pain relevance and then by number of times they were reported in Suppurative Otitis Media. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT184729 Transcription of COL2A1 4 0.67 1.1 0 98.24
2 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 97.64
3 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 97.12
4 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 96.84
5 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 95.20
6 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 88.68
7 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 87.40
8 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82 83.84
9 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 83.72
10 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2 82.92
11 INT26312 Positive_regulation of PLA2G6 26 0.70 7.41 3.2 82.92
12 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 80.56
13 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 68.32
14 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 67.68
15 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 65.92
16 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 64.48
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 53.48
18 INT78774 Gene_expression of PLA2G6 15 0.61 8.39 1.56 46.04
19 INT99586 Binding of IRF6 60 0.36 27.87 13.2 39.36
20 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 23.88
21 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 11.52
22 INT299499 Positive_regulation of Cm9 1 0.10 1.78 0.06 6.24
23 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
24 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
25 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
26 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
27 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
28 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
29 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
30 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
31 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
32 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
33 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
34 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
35 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
36 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
37 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
38 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
39 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
40 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
41 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
42 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
43 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
44 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
45 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
46 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
47 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
48 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
49 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
50 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
51 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
52 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
53 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
54 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
55 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
56 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
57 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
58 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
59 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
60 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
61 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
62 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
63 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
64 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
65 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
66 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
67 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
68 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
69 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
70 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
71 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
72 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
73 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
74 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
75 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
76 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
77 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
78 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
79 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
80 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
81 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
82 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
83 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
84 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
85 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
86 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
87 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
88 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
89 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
90 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
91 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 5.00
92 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
93 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
94 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
95 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
96 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 5.00
97 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
98 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
99 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 5.00
100 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
101 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
102 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 5.00
103 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
104 INT81399 Regulation of Vcam1 24 0.46 23.53 7.68 5.00
105 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
106 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 5.00
107 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
108 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 5.00
109 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
110 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 5.00
111 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31 5.00
112 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17 5.00
113 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 5.00
114 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 5.00
115 INT63979 Regulation of Sele 13 0.54 10.64 3.7 5.00
116 INT118615 Negative_regulation of IL4 20 0.41 13.79 3.49 5.00
117 INT63425 Positive_regulation of Gene_expression of SELP 23 0.67 15.34 3.48 5.00
118 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 5.00
119 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
120 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
121 INT230758 Positive_regulation of Gene_expression of PTPRC 11 0.49 6.04 2.45 5.00
122 INT173005 Transcription of MUC1 11 0.63 10.15 2.24 5.00
123 INT77651 Negative_regulation of Transcription of IL8 8 0.43 4.48 2.16 5.00
124 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15 5.00
125 INT145650 Localization of PLA2G6 15 0.76 8.87 2.06 5.00
126 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02 5.00
127 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 5.00
128 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75 5.00
129 INT132163 Positive_regulation of Localization of MUC1 9 0.19 8.96 1.54 5.00
130 INT19432 Positive_regulation of Gene_expression of CD79A 14 0.45 13.49 1.49 5.00
131 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 5.00
132 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19 5.00
133 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 5.00
134 INT103389 Negative_regulation of Negative_regulation of IL8 3 0.39 2.2 0.86 5.00
135 INT139840 Positive_regulation of Negative_regulation of MAPK14 2 0.21 1.55 0.67 5.00
136 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63 5.00
137 INT215183 Positive_regulation of MUC5AC 4 0.45 2.78 0.6 5.00
138 INT267615 Positive_regulation of Localization of PTPRC 3 0.01 3.41 0.46 5.00
139 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43 5.00
140 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37 5.00
141 INT202349 Positive_regulation of Map2k3 3 0.52 1.26 0.36 5.00
142 INT181304 Binding of CD48 3 0.08 2.43 0.34 5.00
143 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
144 INT267616 Positive_regulation of Positive_regulation of MUC5AC 1 0.14 1.15 0.16 5.00
145 INT267610 Negative_regulation of Negative_regulation of MAPK14 1 0.03 1.08 0.15 5.00
146 INT238021 Negative_regulation of NNT 1 0.04 0.39 0.13 5.00
147 INT261093 Positive_regulation of Gene_expression of PLA2G6 2 0.31 0.93 0.1 5.00
148 INT257450 Localization of MUC5B 2 0.62 1.14 0.09 5.00
149 INT112332 Positive_regulation of Gene_expression of GNPTAB 6 0.31 1.86 0.08 5.00
150 INT184798 Positive_regulation of Localization of PLA2G6 2 0.16 2.41 0.05 5.00
151 INT267608 Positive_regulation of MUC2 1 0.11 0.86 0.04 5.00
152 INT267609 Positive_regulation of Transcription of MUC2 1 0.11 0.86 0.04 5.00
153 INT173007 Transcription of MUC2 2 0.64 0.98 0.04 5.00
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