D:Supranuclear Palsy

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Disease Term
Synonyms Ophthalmoplegia Progressive Supranuclear, Ophthalmoplegias Progressive Supranuclear, PALSY PROGRESSIVE SUPRANUCLEAR, PROGRESSIVE SUPRANUCLEAR OPHTHALMOPLEGIA, Progressive Supranuclear Ophthalmoplegias, Progressive Supranuclear Palsies, Progressive Supranuclear Palsy, Steele Richardson Olszewski Disease, STEELE RICHARDSON OLSZEWSKI SYNDROME, Supranuclear Ophthalmoplegia Progressive, SUPRANUCLEAR OPHTHALMOPLEGIAS PROGRESSIVE
Documents 66
Hot Single Events 36
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Supranuclear Palsy. They are ordered first by their relevance to Supranuclear Palsy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11 99.92
2 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1 83.00
3 INT255808 SMN2 Positive_regulation of SMN1 1 0.41 0.89 0.14 52.08
4 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01 5.00
5 INT218037 Binding of ALB and Penk 1 0.13 0 0.81 5.00
6 INT282708 Binding of MAPT and Y301C7L 1 0.00 0.54 0.16 5.00
7 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 5.00
8 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 5.00
9 INT281879 Cat Negative_regulation of Fig4 1 0.01 0.96 0.06 5.00
10 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0 5.00
11 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0 5.00
12 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 5.00
13 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0 5.00
14 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 5.00
15 INT255809 Binding of SF1 and U2AF2 1 0.21 0.3 0 5.00
16 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
17 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0 5.00
18 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 5.00
19 INT255810 SLU7 Positive_regulation of Binding of SNRPA 1 0.01 0.23 0 5.00
20 INT217397 Binding of Bace1 and Alph1 1 0.02 0.73 0 5.00
21 INT281880 Binding of Aco1 and Cish 1 0.00 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Supranuclear Palsy. They are ordered first by their pain relevance and then by number of times they were reported in Supranuclear Palsy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51819 Negative_regulation of MSMB 8 0.49 4.5 4 100.00
2 INT60554 Binding of Coq10a 30 0.40 7.99 3.02 100.00
3 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 99.76
4 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 99.76
5 INT169479 Negative_regulation of Rcan1 1 0.23 0.62 0.29 98.86
6 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 98.76
7 INT87741 Localization of Msr1 5 0.60 4.77 0.5 98.28
8 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 98.08
9 INT150155 Binding of TPO 3 0.30 3.98 0.58 97.52
10 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 96.92
11 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 96.84
12 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 96.56
13 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 94.68
14 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0 94.36
15 INT13501 Binding of Drd2 65 0.48 23.76 35.6 93.80
16 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 93.72
17 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 92.88
18 INT255824 Regulation of Gene_expression of MAPT 2 0.44 2.62 0 92.88
19 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 90.80
20 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 90.72
21 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2 88.80
22 INT282705 Regulation of Mapt 1 0.25 2.64 0 88.44
23 INT5648 Negative_regulation of Mptp1 7 0.37 6.64 3.08 87.48
24 INT145654 Negative_regulation of Sod2 4 0.59 2.81 1.33 87.48
25 INT281868 Negative_regulation of Park7 1 0.00 1.69 0.14 87.48
26 INT341570 Positive_regulation of CCNA1 2 0.45 1.09 0.11 86.88
27 INT31780 Binding of DIO2 17 0.36 10.07 10 86.48
28 INT148884 Negative_regulation of HCRTR1 7 0.23 7.23 0.53 85.36
29 INT105021 Binding of GOPC 187 0.40 60.39 20.38 85.04
30 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 84.72
31 INT211315 Binding of FGFR3 7 0.35 0.97 0.75 84.64
32 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95 84.16
33 INT135644 Binding of Aco1 2 0.19 2.6 0.22 83.00
34 INT281876 Regulation of Aco1 4 0.11 4 0.22 82.48
35 INT91158 Regulation of Ros1 26 0.25 17 4.23 81.44
36 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 80.16
37 INT115528 Binding of Ros1 37 0.41 22.96 5.5 79.96
38 INT7715 Regulation of Drd2 35 0.62 10.79 22.3 79.12
39 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 78.68
40 INT188016 Gene_expression of TP53BP1 6 0.64 5.54 0.35 78.68
41 INT202218 Positive_regulation of Aco1 4 0.27 12.31 1.06 76.28
42 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 75.00
43 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 74.64
44 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 74.64
45 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 74.40
46 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 74.32
47 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 74.00
48 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 73.76
49 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36 73.76
50 INT319758 Localization of Dcx 2 0.73 0.87 0.1 68.04
51 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 66.16
52 INT281874 Localization of Aco1 1 0.32 3.67 0.23 65.64
53 INT281877 Regulation of Localization of Aco1 1 0.18 1.36 0.04 65.64
54 INT281871 Positive_regulation of Localization of Aco1 1 0.20 1.37 0.04 65.64
55 INT228540 Localization of Coq10a 12 0.63 3.5 0.3 65.36
56 INT281870 Regulation of Localization of Ros1 1 0.03 1.35 0.04 64.96
57 INT281869 Regulation of Regulation of Ros1 1 0.02 1.68 0.04 64.96
58 INT55343 Localization of Ros1 39 0.60 34.51 12.5 64.56
59 INT187508 Positive_regulation of Localization of Ros1 7 0.15 3.85 0.71 64.56
60 INT90357 Regulation of BCL10 3 0.05 3.23 0.56 63.20
61 INT27627 Binding of Rac1 41 0.41 22.88 13.68 61.56
62 INT228547 Transcription of Coq10a 3 0.58 1.21 0.03 61.08
63 INT49566 Positive_regulation of LMOD1 16 0.61 5.74 5.92 60.36
64 INT255827 Positive_regulation of Gene_expression of MAPT 3 0.49 2.63 0.1 59.28
65 INT281878 Positive_regulation of Gene_expression of Aco1 35 0.31 17.15 1.98 59.04
66 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 57.76
67 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 57.04
68 INT83654 Positive_regulation of Binding of HTR2A 2 0.49 2.08 0.24 57.04
69 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02 56.16
70 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 54.60
71 INT320843 Negative_regulation of Gene_expression of Npc1 2 0.59 5.82 0.07 53.88
72 INT170346 Gene_expression of Npc1 18 0.78 7.69 0.48 53.52
73 INT68297 Binding of MAPT 9 0.47 4.45 0.75 52.32
74 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 51.76
75 INT340749 Positive_regulation of ZNF807 1 0.00 3.79 0 51.76
76 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 51.12
77 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0 47.84
78 INT108902 Localization of GNAS 5 0.13 1.31 0.23 46.76
79 INT232667 Binding of Pd 17 0.16 20.76 3.58 45.32
80 INT281872 Positive_regulation of Positive_regulation of Aco1 1 0.20 1.3 0.12 44.20
81 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 42.24
82 INT255821 Binding of RFX1 1 0.03 0.2 0 41.32
83 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 37.92
84 INT55537 Positive_regulation of Coq10a 22 0.58 8.17 8.33 36.24
85 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76 35.76
86 INT218035 Positive_regulation of Positive_regulation of FGFR3 1 0.10 0 0.37 35.76
87 INT235663 Gene_expression of CCNA1 4 0.75 5.61 0.22 33.60
88 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 31.92
89 INT36893 Negative_regulation of Coq10a 36 0.55 22.24 5.47 31.36
90 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 30.08
91 INT7411 Localization of FGFR3 40 0.78 4.77 10.24 27.92
92 INT340753 Gene_expression of ZNF807 1 0.00 1.49 0 27.72
93 INT203640 Regulation of MR1 7 0.34 3.8 1.26 27.68
94 INT296766 Transcription of IKBKG 1 0.04 1.02 0.17 25.04
95 INT97859 Localization of Npc1 12 0.75 6.66 0.35 23.76
96 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 22.68
97 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 20.96
98 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18 20.96
99 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 19.44
100 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38 19.44
101 INT14890 Localization of ACHE 5 0.80 0.47 2.21 17.52
102 INT334212 Negative_regulation of DLEU1 2 0.28 8.84 0.53 12.44
103 INT340754 Negative_regulation of Negative_regulation of CSF2 1 0.31 1.25 0 12.44
104 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33 10.48
105 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92 10.48
106 INT92756 Negative_regulation of Binding of LMOD1 4 0.54 3.83 3.08 10.00
107 INT349609 Regulation of Regulation of LMOD1 1 0.41 0.65 0.63 7.68
108 INT49568 Regulation of LMOD1 6 0.43 2.57 5 7.20
109 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
110 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
111 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
112 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
113 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
114 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
115 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
116 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
117 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
118 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
119 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
120 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
121 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
122 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
123 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 5.00
124 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
125 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
126 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
127 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
128 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
129 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
130 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
131 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
132 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
133 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
134 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
135 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
136 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
137 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
138 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 5.00
139 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
140 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
141 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
142 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
143 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
144 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
145 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
146 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
147 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 5.00
148 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 5.00
149 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
150 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 5.00
151 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
152 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 5.00
153 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 5.00
154 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
155 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 5.00
156 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
157 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
158 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46 5.00
159 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
160 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
161 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
162 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 5.00
163 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
164 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 5.00
165 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73 5.00
166 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
167 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
168 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
169 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 5.00
170 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
171 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
172 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
173 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 5.00
174 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 5.00
175 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43 5.00
176 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1 5.00
177 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 5.00
178 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 5.00
179 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
180 INT108931 Negative_regulation of BDNF 38 0.59 19.61 8.84 5.00
181 INT3622 Regulation of CTSB 34 0.58 16.08 8.76 5.00
182 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 5.00
183 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
184 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 5.00
185 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
186 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76 5.00
187 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 5.00
188 INT202868 Positive_regulation of Car1 30 0.44 15.48 7.42 5.00
189 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 5.00
190 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36 5.00
191 INT197493 Localization of Apoe 61 0.79 27.48 7.06 5.00
192 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 5.00
193 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 5.00
194 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
195 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 5.00
196 INT29794 Regulation of DIO2 13 0.44 5.02 6.84 5.00
197 INT11276 Localization of Penk 10 0.00 2.94 6.63 5.00
198 INT40178 Binding of Penk 11 0.44 0.23 6.21 5.00
199 INT223568 Gene_expression of GYPE 21 0.65 5.83 6.12 5.00
200 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 5.00
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