D:Syndactyly

Disease Term Synonyms Polysyndactyly, Syndactylia, Syndactylias, Syndactylies Documents 4 Hot Single Events 6 Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Syndactyly. They are ordered first by their relevance to Syndactyly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT335887	Akt1 Regulation of Lrp6	1	0.06	0.15	0	51.84
2	INT335884	Akt1 Regulation of Positive_regulation of Wnt5a	1	0.03	0.15	0	50.64
3	INT254433	Binding of Lrp5 and Sost	2	0.39	1.51	0.03	40.36
4	INT335883	Binding of Lrp6 and Wnt5a	1	0.27	0.08	0	34.88
5	INT335888	Lrp5 Negative_regulation of Gene_expression of Tph1	1	0.22	0.15	0.21	5.00
6	INT335886	Binding of Sost and Lrp4	1	0.28	0.65	0.07	5.00
7	INT335890	Binding of Dkk1 and Lrp4	1	0.37	0.64	0.07	5.00
8	INT335882	Dkk1 Negative_regulation of Wnt2	1	0.02	0.15	0	5.00
9	INT335891	Binding of Dkk1 and Lrp5	1	0.39	0.57	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Syndactyly. They are ordered first by their pain relevance and then by number of times they were reported in Syndactyly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT297757	Transcription of Lrp5	2	0.68	0.82	0	89.88
2	INT297820	Regulation of Transcription of Lrp5	2	0.44	0.83	0	89.88
3	INT335866	Regulation of Transcription of Lrp6	1	0.42	0.25	0	89.88
4	INT335873	Transcription of Lrp6	1	0.64	0.25	0	89.88
5	INT335878	Localization of Sost	3	0.69	1.11	0.22	86.08
6	INT213503	Regulation of Wnt2	9	0.37	3.54	0.56	83.12
7	INT297804	Regulation of Lrp5	6	0.60	2.31	0.27	79.28
8	INT335875	Regulation of Lrp6	1	0.57	0.43	0.27	79.28
9	INT111156	Negative_regulation of Dkk1	21	0.58	20.08	4.27	74.32
10	INT335876	Negative_regulation of Sost	11	0.51	6.77	0.67	69.92
11	INT335868	Negative_regulation of Gene_expression of Sost	2	0.58	1.12	0.04	62.60
12	INT335864	Gene_expression of Sost	4	0.77	2.36	0.2	61.88
13	INT87022	Gene_expression of Apc	68	0.67	46.98	5.22	59.16
14	INT335870	Regulation of Gene_expression of Tnfrsf11b	1	0.13	0.11	0	55.60
15	INT123459	Gene_expression of Tnfrsf11b	35	0.58	24.16	7.26	55.04
16	INT254426	Gene_expression of Lrp5	5	0.67	3.28	0.06	51.92
17	INT108519	Binding of Lrp6	8	0.44	1.47	1.19	50.72
18	INT254427	Binding of Lrp5	10	0.48	5.43	0.26	50.72
19	INT162576	Positive_regulation of Wnt5a	3	0.48	0.71	0.08	47.28
20	INT335872	Positive_regulation of Gene_expression of Lrp6	1	0.46	0.18	0	46.24
21	INT335881	Gene_expression of Lrp6	1	0.62	0.09	0	44.80
22	INT335861	Localization of Lrp6	1	0.69	0.54	0.17	41.76
23	INT188047	Positive_regulation of Wnt2	51	0.58	31.41	2.94	41.36
24	INT201777	Phosphorylation of Wnt2	2	0.03	1.31	0.05	41.36
25	INT335865	Positive_regulation of Phosphorylation of Lrp6	1	0.64	0.46	0.05	40.48
26	INT335869	Binding of Sost	6	0.32	1.79	0.18	40.36
27	INT335862	Phosphorylation of Lrp6	1	0.76	0.37	0.05	39.36
28	INT335880	Regulation of Wnt5a	1	0.32	0.07	0	27.12
29	INT254429	Negative_regulation of Lrp5	4	0.57	1.95	0.18	9.72
30	INT124371	Negative_regulation of Gsk3b	170	0.55	87.92	15.51	5.00
31	INT129883	Gene_expression of Dkk1	56	0.77	45.42	12.52	5.00
32	INT135372	Positive_regulation of Gsk3b	72	0.70	50.03	9.28	5.00
33	INT167284	Phosphorylation of Gsk3b	88	0.82	36.03	4.21	5.00
34	INT126659	Gene_expression of Tph1	22	0.78	2.04	4.04	5.00
35	INT198885	Gene_expression of Lrp1	33	0.57	10.2	1.91	5.00
36	INT242153	Negative_regulation of Wnt2	19	0.49	11.87	1.37	5.00
37	INT208536	Positive_regulation of Positive_regulation of Gsk3b	6	0.30	4.83	1.11	5.00
38	INT165338	Binding of Dkk1	4	0.37	3.64	1.04	5.00
39	INT124374	Binding of Wnt2	21	0.31	10.16	0.99	5.00
40	INT182010	Regulation of Tnfrsf11b	2	0.18	1.13	0.67	5.00
41	INT242137	Negative_regulation of Positive_regulation of Gsk3b	7	0.39	2.99	0.67	5.00
42	INT245721	Localization of FRZB	6	0.78	4.3	0.6	5.00
43	INT201524	Localization of Wnt2	14	0.62	9.24	0.46	5.00
44	INT277463	Localization of Sfrp1	2	0.23	0.64	0.36	5.00
45	INT335874	Regulation of Lrp4	1	0.18	0	0.23	5.00
46	INT312604	Gene_expression of Lrp4	2	0.71	1.48	0.21	5.00
47	INT335879	Negative_regulation of Gene_expression of Tph1	1	0.19	0.15	0.21	5.00
48	INT254428	Binding of Lrp4	4	0.44	1.52	0.11	5.00
49	INT335860	Negative_regulation of Sfrp1	1	0.18	0.91	0.06	5.00
50	INT335871	Negative_regulation of Sfrp2	1	0.18	0.91	0.06	5.00
51	INT335859	Regulation of Sfrp1	1	0.08	0.43	0.03	5.00
52	INT335867	Positive_regulation of Negative_regulation of Sfrp2	1	0.14	0.49	0.03	5.00
53	INT198907	Positive_regulation of Gene_expression of Lrp1	7	0.49	3.2	0	5.00