D:Syndactyly

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pChart

Disease Term
Synonyms Polysyndactyly, Syndactylia, Syndactylias, Syndactylies
Documents 4
Hot Single Events 6
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Syndactyly. They are ordered first by their relevance to Syndactyly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335887 Akt1 Regulation of Lrp6 1 0.06 0.15 0 51.84
2 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0 50.64
3 INT254433 Binding of Lrp5 and Sost 2 0.39 1.51 0.03 40.36
4 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0 34.88
5 INT335888 Lrp5 Negative_regulation of Gene_expression of Tph1 1 0.22 0.15 0.21 5.00
6 INT335886 Binding of Sost and Lrp4 1 0.28 0.65 0.07 5.00
7 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07 5.00
8 INT335882 Dkk1 Negative_regulation of Wnt2 1 0.02 0.15 0 5.00
9 INT335891 Binding of Dkk1 and Lrp5 1 0.39 0.57 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Syndactyly. They are ordered first by their pain relevance and then by number of times they were reported in Syndactyly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT297757 Transcription of Lrp5 2 0.68 0.82 0 89.88
2 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0 89.88
3 INT335866 Regulation of Transcription of Lrp6 1 0.42 0.25 0 89.88
4 INT335873 Transcription of Lrp6 1 0.64 0.25 0 89.88
5 INT335878 Localization of Sost 3 0.69 1.11 0.22 86.08
6 INT213503 Regulation of Wnt2 9 0.37 3.54 0.56 83.12
7 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27 79.28
8 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27 79.28
9 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27 74.32
10 INT335876 Negative_regulation of Sost 11 0.51 6.77 0.67 69.92
11 INT335868 Negative_regulation of Gene_expression of Sost 2 0.58 1.12 0.04 62.60
12 INT335864 Gene_expression of Sost 4 0.77 2.36 0.2 61.88
13 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 59.16
14 INT335870 Regulation of Gene_expression of Tnfrsf11b 1 0.13 0.11 0 55.60
15 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 55.04
16 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06 51.92
17 INT108519 Binding of Lrp6 8 0.44 1.47 1.19 50.72
18 INT254427 Binding of Lrp5 10 0.48 5.43 0.26 50.72
19 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08 47.28
20 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0 46.24
21 INT335881 Gene_expression of Lrp6 1 0.62 0.09 0 44.80
22 INT335861 Localization of Lrp6 1 0.69 0.54 0.17 41.76
23 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 41.36
24 INT201777 Phosphorylation of Wnt2 2 0.03 1.31 0.05 41.36
25 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05 40.48
26 INT335869 Binding of Sost 6 0.32 1.79 0.18 40.36
27 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05 39.36
28 INT335880 Regulation of Wnt5a 1 0.32 0.07 0 27.12
29 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18 9.72
30 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 5.00
31 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52 5.00
32 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 5.00
33 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 5.00
34 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04 5.00
35 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91 5.00
36 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 5.00
37 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11 5.00
38 INT165338 Binding of Dkk1 4 0.37 3.64 1.04 5.00
39 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 5.00
40 INT182010 Regulation of Tnfrsf11b 2 0.18 1.13 0.67 5.00
41 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67 5.00
42 INT245721 Localization of FRZB 6 0.78 4.3 0.6 5.00
43 INT201524 Localization of Wnt2 14 0.62 9.24 0.46 5.00
44 INT277463 Localization of Sfrp1 2 0.23 0.64 0.36 5.00
45 INT335874 Regulation of Lrp4 1 0.18 0 0.23 5.00
46 INT312604 Gene_expression of Lrp4 2 0.71 1.48 0.21 5.00
47 INT335879 Negative_regulation of Gene_expression of Tph1 1 0.19 0.15 0.21 5.00
48 INT254428 Binding of Lrp4 4 0.44 1.52 0.11 5.00
49 INT335860 Negative_regulation of Sfrp1 1 0.18 0.91 0.06 5.00
50 INT335871 Negative_regulation of Sfrp2 1 0.18 0.91 0.06 5.00
51 INT335859 Regulation of Sfrp1 1 0.08 0.43 0.03 5.00
52 INT335867 Positive_regulation of Negative_regulation of Sfrp2 1 0.14 0.49 0.03 5.00
53 INT198907 Positive_regulation of Gene_expression of Lrp1 7 0.49 3.2 0 5.00
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