D:Systemic Inflammatory Response Syndrome

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Disease Term
Synonyms INFLAMMATORY RESPONSE SYNDROME SYSTEMIC, Sepsis Syndrome, Sepsis Syndromes, Syndrome Sepsis, Syndromes Sepsis
Documents 281
Hot Single Events 200
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Systemic Inflammatory Response Syndrome. They are ordered first by their relevance to Systemic Inflammatory Response Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34 99.12
2 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34 99.12
3 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34 99.12
4 INT320696 C5 Regulation of Gene_expression of TNF 1 0.34 2.15 0.34 99.12
5 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34 99.12
6 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 88.52
7 INT86951 Ads3 Positive_regulation of Gene_expression of Il10 1 0.00 0.42 0.16 87.76
8 INT287438 HTS Negative_regulation of Nfkb1 1 0.01 1.77 0.37 84.00
9 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 80.64
10 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49 70.80
11 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49 70.80
12 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47 69.92
13 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 61.32
14 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55 60.08
15 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46 60.08
16 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03 56.04
17 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02 51.16
18 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01 50.84
19 INT320695 TNF Positive_regulation of Localization of Il1 1 0.05 1.38 0.44 41.20
20 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 34.72
21 INT343794 Binding of F8 and PTPRC 1 0.00 0.69 0.09 34.36
22 INT316129 Binding of HLA-DRA and IL10 1 0.12 3.1 0.17 33.24
23 INT132801 IL4 Positive_regulation of Localization of IL6 2 0.26 1.47 0.26 19.60
24 INT353041 IL4 Positive_regulation of Localization of IL1B 1 0.02 0.99 0.16 19.60
25 INT353036 IL4 Positive_regulation of Localization of IL10 1 0.03 0.99 0.16 19.60
26 INT353038 IL4 Positive_regulation of Localization of IL2 1 0.02 0.99 0.16 19.60
27 INT353039 IL4 Positive_regulation of Localization of IL8 1 0.02 0.99 0.16 19.60
28 INT316131 IL10 Regulation of Regulation of HLA-DRA 1 0.09 1.31 0.09 19.40
29 INT353037 IL4 Positive_regulation of IL2 1 0.02 0.99 0.16 18.92
30 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47 18.68
31 INT353040 IL4 Positive_regulation of IL8 1 0.02 0.99 0.16 18.68
32 INT316132 IL10 Regulation of MARCH1 1 0.11 2.12 0.17 15.48
33 INT316122 IL10 Regulation of Gene_expression of MARCH1 1 0.19 2.12 0.17 15.48
34 INT316125 IL10 Regulation of KRT20 1 0.00 1.06 0.08 15.48
35 INT316127 IL10 Regulation of UBR1 1 0.00 1.06 0.08 15.48
36 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07 11.52
37 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01 5.00
38 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95 5.00
39 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68 5.00
40 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
41 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61 5.00
42 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 5.00
43 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
44 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31 5.00
45 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23 5.00
46 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 5.00
47 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
48 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99 5.00
49 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
50 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
51 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
52 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84 5.00
53 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84 5.00
54 INT293011 GPM6A Regulation of GOPC 1 0.00 0 0.81 5.00
55 INT228054 Fpr3 Positive_regulation of Il10 1 0.05 0.9 0.79 5.00
56 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
57 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69 5.00
58 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69 5.00
59 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68 5.00
60 INT293010 ELANE Regulation of Localization of LTF 1 0.00 0.54 0.67 5.00
61 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66 5.00
62 INT179203 NLRP1 Regulation of Gene_expression of TNF 1 0.31 1.73 0.6 5.00
63 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6 5.00
64 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59 5.00
65 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58 5.00
66 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54 5.00
67 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53 5.00
68 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52 5.00
69 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49 5.00
70 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49 5.00
71 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49 5.00
72 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
73 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
74 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
75 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
76 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
77 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48 5.00
78 INT196634 IFNG Negative_regulation of DNAH8 1 0.03 1.49 0.47 5.00
79 INT316121 IL10 Regulation of Gene_expression of HLA-DRA 1 0.09 0.46 0.42 5.00
80 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42 5.00
81 INT182100 Positive_regulation of Binding of TNF and Il6 1 0.03 0.66 0.41 5.00
82 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4 5.00
83 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
84 INT319729 Binding of Rela and Crebbp 1 0.02 0.88 0.37 5.00
85 INT179201 NLRP1 Regulation of Gene_expression of IL10 1 0.06 0.77 0.36 5.00
86 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36 5.00
87 INT179202 NLRP1 Regulation of Gene_expression of IL6 1 0.07 0.77 0.36 5.00
88 INT196644 PTGER2 Positive_regulation of Gene_expression of NA 1 0.00 0.93 0.35 5.00
89 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
90 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34 5.00
91 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
92 INT262307 CAPNS1 Regulation of TAF9 1 0.04 1.23 0.33 5.00
93 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32 5.00
94 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32 5.00
95 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32 5.00
96 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32 5.00
97 INT196605 Binding of DNAH8 and SPANXB1 Positive_regulation of DNAH8 1 0.00 0.08 0.3 5.00
98 INT196604 Binding of DNAH8 and SPANXB1 Positive_regulation of NA 1 0.00 0.08 0.3 5.00
99 INT250738 Binding of hs and Serpinc1 1 0.00 0.46 0.3 5.00
100 INT323654 Igfbp1 Negative_regulation of Binding of Igf1 and Igfbp1 1 0.21 1.14 0.29 5.00
101 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
102 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29 5.00
103 INT285327 Binding of Cox8b and Gtf2ird2 1 0.00 0.9 0.29 5.00
104 INT196612 Binding of KNG1 and Negative_regulation of NA 1 0.01 0.19 0.29 5.00
105 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29 5.00
106 INT196621 PTGER2 Negative_regulation of Gene_expression of DNAH8 1 0.00 0.33 0.28 5.00
107 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28 5.00
108 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28 5.00
109 INT196626 Binding of DNAH8 and KNG1 1 0.00 0.08 0.27 5.00
110 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27 5.00
111 INT196637 Binding of DNAH8 and SPANXB1 1 0.00 0.08 0.27 5.00
112 INT196613 Binding of KNG1 and NA 1 0.01 0.08 0.27 5.00
113 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27 5.00
114 INT196616 Binding of NA and SPANXB1 1 0.00 0.08 0.27 5.00
115 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26 5.00
116 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26 5.00
117 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26 5.00
118 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
119 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
120 INT179200 Binding of ICAM1 and IL8 1 0.03 1.02 0.25 5.00
121 INT196614 TNF Positive_regulation of Positive_regulation of NA 1 0.03 0.88 0.24 5.00
122 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
123 INT196615 TNF Positive_regulation of Negative_regulation of DNAH8 1 0.02 0.88 0.24 5.00
124 INT196609 IFNG Positive_regulation of Positive_regulation of NA 1 0.03 0.87 0.24 5.00
125 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24 5.00
126 INT196622 IFNG Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.87 0.24 5.00
127 INT196647 IFNG Negative_regulation of NA 1 0.04 0.79 0.24 5.00
128 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
129 INT196620 TNF Positive_regulation of Positive_regulation of DNAH8 1 0.03 0.88 0.24 5.00
130 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24 5.00
131 INT196646 IFNG Positive_regulation of Negative_regulation of DNAH8 1 0.03 0.87 0.24 5.00
132 INT329311 Spp1 Positive_regulation of IFN1@ 1 0.20 1.2 0.23 5.00
133 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23 5.00
134 INT295329 ecs Positive_regulation of TF 1 0.00 1.2 0.23 5.00
135 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23 5.00
136 INT324868 Binding of Jun and Tlr4 1 0.02 1.54 0.22 5.00
137 INT196629 PTGER2 Negative_regulation of Gene_expression of NA 1 0.00 0.24 0.22 5.00
138 INT324873 Binding of Jun and Tlr3 1 0.01 1.54 0.22 5.00
139 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21 5.00
140 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2 5.00
141 INT329310 Spp1 Positive_regulation of Gene_expression of IFN1@ 1 0.48 0.88 0.19 5.00
142 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19 5.00
143 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19 5.00
144 INT329309 Spp1 Regulation of Gene_expression of IFN1@ 1 0.26 0.82 0.19 5.00
145 INT253776 Binding of THBD and F2 1 0.00 1.15 0.18 5.00
146 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
147 INT314534 Ptger2 Regulation of Gene_expression of Itgam 1 0.02 1 0.17 5.00
148 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17 5.00
149 INT316123 Binding of HLA-DRA and BCAR1 1 0.02 0.48 0.16 5.00
150 INT329305 Spp1 Positive_regulation of Gene_expression of Il12a 1 0.12 0.88 0.16 5.00
151 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16 5.00
152 INT316124 TLR2 Positive_regulation of Gene_expression of HLA-DRA 1 0.14 0.34 0.16 5.00
153 INT221899 Rb1 Positive_regulation of Transcription of Ccl20 1 0.01 0.62 0.16 5.00
154 INT221908 Rb1 Positive_regulation of Transcription of TNIP2 1 0.01 0.62 0.16 5.00
155 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
156 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15 5.00
157 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15 5.00
158 INT195770 Binding of CPB1 and MIF 1 0.01 0.47 0.15 5.00
159 INT196608 TNF Negative_regulation of CFTR 1 0.16 0.11 0.14 5.00
160 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
161 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14 5.00
162 INT272024 Gene_expression of GOPC Positive_regulation of Localization of COL7A1 1 0.10 0.86 0.14 5.00
163 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14 5.00
164 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13 5.00
165 INT316130 IRF6 Positive_regulation of Gene_expression of HLA-DRA 1 0.02 0.27 0.13 5.00
166 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
167 INT329304 Spp1 Negative_regulation of Gene_expression of Il10 1 0.06 0.93 0.13 5.00
168 INT316126 IL10 Regulation of CD14 1 0.12 0.22 0.13 5.00
169 INT196648 PTGER2 Regulation of DNAH8 1 0.00 0.14 0.12 5.00
170 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12 5.00
171 INT319703 Binding of Rela and Crebbp Positive_regulation of Binding of Rela 1 0.00 0.37 0.12 5.00
172 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12 5.00
173 INT319726 Crebbp Positive_regulation of Binding of Rela 1 0.02 0.37 0.12 5.00
174 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12 5.00
175 INT329303 Spp1 Positive_regulation of Localization of Il12a 1 0.12 0.92 0.12 5.00
176 INT196636 PTGER2 Regulation of NA 1 0.00 0.14 0.12 5.00
177 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12 5.00
178 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12 5.00
179 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11 5.00
180 INT254215 Binding of Tlr4 and Ticam1 2 0.09 0.76 0.11 5.00
181 INT324869 Binding of Jun and Ticam1 1 0.01 0.76 0.11 5.00
182 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11 5.00
183 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11 5.00
184 INT324870 Binding of Ticam1 and Tlr3 1 0.03 0.76 0.11 5.00
185 INT324876 Tlr4 Positive_regulation of Tlr4 Positive_regulation of Tlr2 1 0.09 0.92 0.1 5.00
186 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1 5.00
187 INT196627 IL1B Regulation of DNAH8 1 0.00 0.63 0.09 5.00
188 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09 5.00
189 INT196643 IL1B Regulation of NA 1 0.00 0.63 0.09 5.00
190 INT196619 KNG1 Regulation of DNAH8 1 0.00 0.62 0.09 5.00
191 INT324863 Ros1 Regulation of Gene_expression of Tlr4 1 0.02 0.71 0.09 5.00
192 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09 5.00
193 INT250729 Crlf1 Positive_regulation of Localization of TNF 1 0.02 0.92 0.09 5.00
194 INT263450 NFKB2 Positive_regulation of Protein_catabolism of NFKBIA 1 0.17 0.17 0.09 5.00
195 INT196645 KNG1 Regulation of NA 1 0.00 0.62 0.09 5.00
196 INT196642 IL1B Positive_regulation of Gene_expression of DNAH8 1 0.00 0 0.08 5.00
197 INT196640 PTGER2 Negative_regulation of DNAH8 1 0.00 0.46 0.08 5.00
198 INT196611 PTGER2 Negative_regulation of NA 1 0.00 0.46 0.08 5.00
199 INT253774 THBD Regulation of F2 1 0.00 0.61 0.08 5.00
200 INT253764 Atp9a Positive_regulation of Apex1 1 0.00 0.39 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Systemic Inflammatory Response Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Systemic Inflammatory Response Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 100.00
2 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 99.90
3 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.90
4 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.88
5 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 99.84
6 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 99.84
7 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.60
8 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.56
9 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 99.56
10 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.56
11 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 99.56
12 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 99.56
13 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.44
14 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.42
15 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 99.40
16 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.24
17 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.12
18 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.12
19 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 99.12
20 INT11807 Gene_expression of Il2 266 0.78 112 64.97 99.12
21 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 99.08
22 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 98.92
23 INT72219 Gene_expression of METTL3 45 0.24 9.58 7.61 98.84
24 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 98.72
25 INT124705 Binding of Il18 29 0.47 19.02 5.59 98.72
26 INT9210 Regulation of IL6 166 0.62 125.61 49.95 98.64
27 INT22454 Regulation of Crp 213 0.62 160.67 49.24 98.60
28 INT246520 Positive_regulation of Positive_regulation of Tnnc1 1 0.49 2.54 0.33 98.58
29 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.56
30 INT9660 Regulation of TNF 363 0.62 312.94 139.99 98.56
31 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.48
32 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 98.44
33 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 98.44
34 INT69303 Positive_regulation of Gene_expression of Il4 27 0.68 20.01 14.8 98.44
35 INT76416 Positive_regulation of Gene_expression of Il5 9 0.08 4.16 1.65 98.44
36 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 98.38
37 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 98.36
38 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73 98.28
39 INT78044 Regulation of Tnnc1 9 0.52 12.3 1.76 98.24
40 INT209355 Binding of SLC9A6 8 0.42 14.9 0.09 98.16
41 INT157226 Positive_regulation of Gene_expression of Tnnc1 11 0.49 6.21 0.57 98.12
42 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 98.00
43 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48 97.92
44 INT297907 Regulation of Positive_regulation of Cxcl1 1 0.16 0.66 0.11 97.88
45 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55 97.84
46 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 97.84
47 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 97.80
48 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 97.80
49 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06 97.80
50 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 97.72
51 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 97.64
52 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49 97.64
53 INT220332 Transcription of LBP 2 0.50 2.2 0.08 97.64
54 INT220334 Transcription of UROD 1 0.26 1.88 0.03 97.64
55 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 97.40
56 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08 97.40
57 INT82079 Positive_regulation of Lep 79 0.70 40 11.07 97.36
58 INT51576 Positive_regulation of Cxcl1 42 0.69 20.12 16.41 97.36
59 INT93788 Regulation of Gene_expression of Tnnc1 2 0.44 1.34 0.29 97.28
60 INT220316 Binding of Aliq1 4 0.10 5.71 0.61 97.20
61 INT343804 Protein_catabolism of METTL3 1 0.01 0.65 0.12 97.18
62 INT306952 Regulation of NAMPT 4 0.53 8.52 0.33 97.14
63 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 97.08
64 INT159472 Localization of NPPB 32 0.79 33.67 3.59 97.04
65 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 97.00
66 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 96.92
67 INT23257 Regulation of CRP 127 0.62 100.05 21.87 96.88
68 INT250735 Binding of Radil 1 0.30 0.94 0.08 96.88
69 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 96.80
70 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 96.68
71 INT224154 Positive_regulation of TREM1 14 0.56 22.65 2.71 96.52
72 INT252991 Regulation of TAF9 2 0.44 3.54 0.08 96.32
73 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 96.16
74 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 95.96
75 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 95.72
76 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 95.48
77 INT62831 Negative_regulation of Positive_regulation of SELE 3 0.36 1.63 0.69 95.48
78 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 95.48
79 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97 95.48
80 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 95.28
81 INT55343 Localization of Ros1 39 0.60 34.51 12.5 95.28
82 INT343805 Transcription of CORO7 1 0.07 0.34 0.15 95.28
83 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 95.28
84 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 95.20
85 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13 95.04
86 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96 95.04
87 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 95.00
88 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22 94.96
89 INT61626 Transcription of IL6 73 0.72 42.04 17.86 94.80
90 INT97798 Localization of IRF6 86 0.73 33.27 20.94 94.72
91 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 94.56
92 INT70539 Negative_regulation of Cxcl1 13 0.57 7.15 4.58 94.48
93 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 94.36
94 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18 94.32
95 INT174987 Binding of AIRN 12 0.32 6.79 1.21 94.32
96 INT141015 Regulation of Il18 14 0.59 6.3 3.73 94.28
97 INT12339 Localization of IL8 437 0.81 251.87 117.39 94.24
98 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 94.12
99 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 94.12
100 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49 94.12
101 INT299470 Regulation of Gene_expression of HMGB1 1 0.18 1.58 0 94.12
102 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44 94.00
103 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 93.76
104 INT93482 Localization of Rela 56 0.78 24.52 14.82 93.60
105 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 93.60
106 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 93.28
107 INT10706 Regulation of Il6 150 0.62 93.23 62.34 93.24
108 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 93.24
109 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 93.12
110 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 93.04
111 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38 93.04
112 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 93.04
113 INT60552 Localization of TNNI3 56 0.79 20.05 1.44 92.96
114 INT247662 Positive_regulation of Localization of TNNI3 7 0.68 2.51 0.05 92.96
115 INT75425 Binding of Tnnc1 7 0.35 5.39 0.91 92.92
116 INT218598 Localization of Amigo2 2 0.15 2.15 0.35 92.92
117 INT297905 Localization of Cotl1 1 0.20 1.93 0.22 92.92
118 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 92.80
119 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 92.64
120 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 92.64
121 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 92.60
122 INT68443 Positive_regulation of METTL3 9 0.12 3.54 2.39 92.24
123 INT60034 Positive_regulation of VWF 40 0.68 30.42 8.15 92.24
124 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 92.24
125 INT178884 Positive_regulation of dds 1 0.40 1.76 0.18 92.12
126 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 92.00
127 INT100861 Binding of CRP 179 0.48 175.2 26.45 92.00
128 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 91.92
129 INT15133 Regulation of HLA-DRA 19 0.34 5.84 3.9 91.68
130 INT174986 Gene_expression of AIRN 20 0.57 6.13 0.64 91.64
131 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 91.60
132 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12 91.52
133 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15 91.52
134 INT145502 Binding of dds 2 0.39 4.44 0.16 91.44
135 INT220335 Gene_expression of UROD 34 0.54 24.53 2.89 91.28
136 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09 91.12
137 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02 91.04
138 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 90.64
139 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 90.60
140 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19 90.48
141 INT90693 Transcription of TNNI3 2 0.55 1.56 0.15 90.40
142 INT1030 Localization of Lbp 52 0.74 38.92 24.91 89.96
143 INT38056 Localization of Crp 71 0.78 53.14 17.03 89.96
144 INT86950 Negative_regulation of Gene_expression of Il10 26 0.42 18.92 12.73 89.84
145 INT11360 Localization of SERPINE1 41 0.80 33.98 5.61 89.84
146 INT50878 Positive_regulation of Positive_regulation of TNNI3 7 0.50 5.57 0.97 89.60
147 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 89.60
148 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 89.44
149 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 89.44
150 INT72220 Negative_regulation of METTL3 6 0.10 1.76 0.88 89.08
151 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 89.08
152 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 89.08
153 INT49197 Binding of SELE 7 0.41 7.95 0.74 89.04
154 INT6481 Binding of TNF 624 0.48 510.2 214.82 88.88
155 INT299469 Regulation of HMGB1 2 0.18 2.27 0.03 88.76
156 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 88.76
157 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 88.64
158 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 88.52
159 INT262317 Binding of TAF9 7 0.31 9.67 2.15 88.48
160 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 88.16
161 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23 88.12
162 INT77602 Binding of VCAM1 8 0.41 8.66 2.86 88.12
163 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 87.88
164 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58 87.88
165 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 87.88
166 INT86948 Gene_expression of Ads3 1 0.00 0.42 0.16 87.76
167 INT248115 Positive_regulation of FABP2 8 0.49 4.91 1.39 87.16
168 INT255182 Positive_regulation of Gene_expression of FABP2 1 0.49 1.73 0.11 87.16
169 INT139896 Phosphorylation of Ins1 29 0.77 24.03 2.35 87.12
170 INT254132 Positive_regulation of Localization of NPPB 2 0.40 2.9 0.58 87.00
171 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 86.52
172 INT248112 Gene_expression of FABP2 3 0.75 4.78 0.58 86.44
173 INT86949 Positive_regulation of Ads3 1 0.00 0.42 0.16 86.40
174 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 86.32
175 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64 86.32
176 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 86.28
177 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 86.24
178 INT163290 Binding of MIF 9 0.31 7.57 2.8 86.04
179 INT86947 Gene_expression of Arigg3 6 0.58 3.62 0.57 85.96
180 INT127378 Localization of Mpo 21 0.78 26.36 8.28 85.92
181 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 85.52
182 INT343797 Negative_regulation of CORO7 1 0.04 0.37 0.17 85.40
183 INT12035 Regulation of F2 21 0.45 12.66 1.47 85.36
184 INT316083 Regulation of Regulation of F2 1 0.44 1.55 0 85.36
185 INT209354 Gene_expression of SLC9A6 15 0.58 37.52 0.29 85.20
186 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55 84.96
187 INT328633 Transcription of GPER 2 0.06 2.57 0.54 84.64
188 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 84.56
189 INT218545 Positive_regulation of Localization of Cst7 1 0.10 0.99 0.13 84.32
190 INT218546 Localization of Cst7 1 0.15 0.99 0.13 84.32
191 INT114747 Negative_regulation of CD6 1 0.06 0.39 0.86 84.24
192 INT11493 Positive_regulation of KLK1 21 0.67 9.22 5 84.16
193 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 84.12
194 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76 84.00
195 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 84.00
196 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53 84.00
197 INT232784 Localization of Ctsa 3 0.41 3.05 0.74 83.92
198 INT102515 Binding of Nos3 19 0.45 9.41 4.01 83.92
199 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 83.76
200 INT254143 Negative_regulation of CC2D1A 10 0.35 13.81 0.82 83.76
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