D:Systemic Lupus Erythematosus

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Disease Term
Synonyms Acute Lupus Haemaphagocytic Syndrome, Acute Lupus Hemaphagocytic Syndrome, Butterfly Erythema, DISEASE LIBMAN SACKS, Disseminated Lupus Erythematosus, JACCOUD S ARHTRITIS, Jaccoud S Arthropathy, Libman Sacks Disease, LUPUS, Lupus Erythematosus Disseminatus, LUPUS ERYTHEMATOSUS SYSTEMIC
Documents 2514
Hot Single Events 200
Hot Interactions 159

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Systemic Lupus Erythematosus. They are ordered first by their relevance to Systemic Lupus Erythematosus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38 100.00
2 INT214547 Binding of CD27 and SLEB1 1 0.05 1.38 0.03 100.00
3 INT206207 Binding of SLEB1 and CD24 1 0.03 0.87 0.03 100.00
4 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0 100.00
5 INT214546 Binding of SLEB1 and PCS 1 0.03 0.83 0 100.00
6 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 100.00
7 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15 100.00
8 INT283460 Binding of CTLA4 and DLAT 1 0.06 3.14 0.09 100.00
9 INT333636 Rai1 Negative_regulation of Gene_expression of IFNA1 1 0.05 1.16 0.03 100.00
10 INT333631 Thse Negative_regulation of Gene_expression of IFNA1 1 0.00 1.15 0.03 100.00
11 INT187147 Positive_regulation of Binding of CXCL10 and GOPC 1 0.08 0.53 0.28 100.00
12 INT187143 Binding of CXCL10 and GOPC 1 0.06 0.53 0.28 100.00
13 INT187144 Positive_regulation of Binding of CXCL10 and SLEB1 1 0.02 0.53 0.28 100.00
14 INT187146 Binding of CXCL10 and SLEB1 1 0.02 0.53 0.28 100.00
15 INT187148 SLEB1 Regulation of Gene_expression of CXCR5 1 0.01 0.97 0.6 100.00
16 INT109887 F2 Negative_regulation of F8 1 0.00 1.32 0.16 100.00
17 INT283463 Binding of DLAT and GAGE4 1 0.00 1.1 0.03 100.00
18 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04 99.98
19 INT109886 F2 Negative_regulation of Serpinc1 1 0.00 1.18 0.15 99.92
20 INT319004 Binding of CSF2 and ACCS 1 0.01 3.51 0.12 99.84
21 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 99.28
22 INT319005 Binding of IL6 and ACCS 1 0.01 5.26 0.14 99.26
23 INT213072 Binding of IFNA1 and ACCS 1 0.06 3.85 0.17 99.26
24 INT318999 Binding of IL8 and ACCS 1 0.03 3.52 0.09 99.26
25 INT254374 MR1 Negative_regulation of TNF 1 0.01 0.96 0 99.26
26 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 99.22
27 INT345283 Binding of Ads1 and BDNF-AS 1 0.00 0.26 0 99.20
28 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 99.14
29 INT163301 Binding of IFNA1 and IL6 2 0.04 2.95 0.26 98.96
30 INT319000 Binding of CSF2 and IFNA1 1 0.03 1.76 0.05 98.96
31 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 98.96
32 INT318997 Binding of CSF2 and IL8 1 0.05 1.76 0.05 98.96
33 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25 98.90
34 INT254287 Binding of TNFSF13B and TNFRSF13B 1 0.01 1.33 0.3 98.72
35 INT254288 Binding of ZNF623 and TNFSF13B 1 0.00 1.33 0.3 98.72
36 INT252327 Binding of Cd27 and Cd70 1 0.16 0.82 0.13 98.68
37 INT194642 IL10 Positive_regulation of TNF 1 0.18 0.22 0.04 98.56
38 INT333633 Thse Positive_regulation of Transcription of IRF3 1 0.00 1.13 0.03 98.44
39 INT254390 Binding of FCGR2A and Itgam 1 0.24 0.63 0.04 98.42
40 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 98.40
41 INT206208 MRO Negative_regulation of CD24 1 0.02 1.87 0.32 98.16
42 INT206209 MRO Negative_regulation of Transcription of CD24 1 0.02 0.76 0.14 98.16
43 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07 98.12
44 INT350695 Mir101a Positive_regulation of Protein_catabolism of Icos 1 0.05 0.8 0.1 97.96
45 INT306925 IL36RN Positive_regulation of HAMP 1 0.01 1.39 0.1 97.56
46 INT223520 Erv4 Regulation of Regulation of Fcgr1 1 0.06 0.93 0.05 97.56
47 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 97.12
48 INT46964 C3 Positive_regulation of Tcm 1 0.00 1.26 0.66 97.08
49 INT177977 RUNX1 Regulation of CSF1R 1 0.14 1 0.27 97.04
50 INT285750 IL1B Positive_regulation of Localization of PRL 1 0.05 1.51 0.39 96.88
51 INT285744 IL1B Regulation of Localization of PRL 1 0.05 1.51 0.39 96.88
52 INT350702 Rc3h1 Positive_regulation of Protein_catabolism of Icos 1 0.35 1.56 0.18 96.84
53 INT306924 IL6 Positive_regulation of HAMP 1 0.02 1.38 0.1 96.84
54 INT264332 Olr614 Negative_regulation of Regulation of Igh-6 1 0.01 1.04 0.48 96.68
55 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39 96.64
56 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39 96.64
57 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03 96.56
58 INT276813 NR3C1 Regulation of Gene_expression of Hgs 1 0.03 1.09 0.13 95.52
59 INT276767 NR3C1 Regulation of Gene_expression of UTS2R 1 0.00 1.09 0.13 95.52
60 INT290169 Binding of IFNA1 and Pdc 1 0.05 0.32 0 95.20
61 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18 95.12
62 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18 95.12
63 INT323675 Binding of THBD and BDNF-AS 1 0.02 2.45 0.04 95.12
64 INT323674 Binding of TFPI and THBD 1 0.02 2.45 0.04 95.12
65 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 95.04
66 INT203044 Binding of PDCD1 and DTHD1 1 0.02 3.19 1.87 94.80
67 INT251645 Binding of SERPING1 and CD79A 1 0.10 1.31 0.06 94.80
68 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 94.68
69 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9 94.64
70 INT194641 Binding of IL10 and TNF 2 0.14 1.09 0.35 94.56
71 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89 94.40
72 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04 94.20
73 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21 93.84
74 INT260441 Negative_regulation of Tlr7 Negative_regulation of Positive_regulation of IFNA1 1 0.05 0.96 0.21 93.84
75 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82 93.80
76 INT349220 Binding of CASP3 and CD8A 1 0.00 0.18 0 93.80
77 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 93.52
78 INT290168 Atp6v1e1 Regulation of Localization of IFNA1 1 0.07 0.19 0 92.88
79 INT233324 SHE Positive_regulation of HIVEP1 1 0.00 2.72 0.14 92.40
80 INT350694 Uts2r Negative_regulation of Negative_regulation of Rc3h1 1 0.05 0.79 0.1 92.40
81 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05 92.04
82 INT334258 Binding of Myd88 and Irak4 2 0.26 0.24 0.05 92.04
83 INT319001 Binding of IGHG3 and ACCS 1 0.00 1.76 0.07 91.96
84 INT254375 Binding of IFNA1 and MRC1 1 0.00 0.87 0 91.68
85 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03 91.64
86 INT319002 CSF2 Positive_regulation of Gene_expression of IFNA1 1 0.05 1.02 0.09 90.96
87 INT184388 Binding of fc and DNAI1 1 0.01 1.06 0.15 90.96
88 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 90.24
89 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 89.84
90 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43 89.76
91 INT332699 Binding of KNG1 and TRGC1 1 0.16 3.37 0.75 89.76
92 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56 89.64
93 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03 89.60
94 INT324809 Tlr6 Positive_regulation of Cd14 1 0.12 0.09 0.03 89.60
95 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 89.28
96 INT27871 Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56 89.24
97 INT306943 TF Positive_regulation of Gene_expression of Trf 1 0.01 0.9 0 89.04
98 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04 88.96
99 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04 88.96
100 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79 88.56
101 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 88.56
102 INT242881 SPI1 Negative_regulation of Regulation of TLR2 1 0.04 1.13 0.11 88.36
103 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 88.32
104 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 88.24
105 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 88.12
106 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31 87.76
107 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06 87.60
108 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 87.48
109 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06 87.40
110 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2 87.20
111 INT290160 Atp6v1e1 Positive_regulation of Cd40 1 0.24 0.5 0 87.08
112 INT211781 Binding of NTSR1 and RDBP 1 0.00 0.42 0 87.08
113 INT308701 Binding of AQP4 and DDX41 1 0.15 3.53 0.32 87.00
114 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06 86.84
115 INT290156 Atp6v1e1 Positive_regulation of Cd86 1 0.26 0.5 0 86.72
116 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0 86.60
117 INT175246 Binding of F13A1 and SH2B2 1 0.00 2.24 0 86.52
118 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66 86.28
119 INT218499 Cfb Negative_regulation of ap 1 0.00 0.74 0.13 86.28
120 INT306937 Tnfsf12 Positive_regulation of Gene_expression of Vcam1 1 0.05 1.79 0.27 86.08
121 INT254286 Binding of TNFSF13B and TNFRSF13C 1 0.07 1.26 0.08 85.88
122 INT211777 Binding of NTSR1 and PTBP1 1 0.03 0.82 0 85.84
123 INT232386 Binding of CD22 and SYCP3 1 0.37 0.86 0.16 85.84
124 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 85.52
125 INT332707 Binding of TRGC1 and Klk1 1 0.32 1.64 0.36 85.52
126 INT285745 IL31RA Positive_regulation of Gene_expression of MPL 1 0.19 1.04 0.22 85.44
127 INT177982 Binding of RUNX1 and SNRNP70 1 0.01 0.89 0.21 85.44
128 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27 85.12
129 INT203040 Binding of PDCD1 and PDCD1LG2 3 0.40 4.86 0.98 84.56
130 INT306935 Tnfsf12 Positive_regulation of Gene_expression of Cxcl10 1 0.03 3.55 0.55 84.40
131 INT290164 Atp6v1e1 Positive_regulation of Gene_expression of Cd86 1 0.18 0.17 0 84.40
132 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93 84.08
133 INT290167 Atp6v1e1 Positive_regulation of Localization of IFNA1 1 0.07 0.33 0 83.92
134 INT290162 Atp6v1e1 Regulation of Gene_expression of Cd80 1 0.16 0.28 0 83.80
135 INT203046 Binding of PDCD1 and CD274 2 0.40 3.97 0.68 83.12
136 INT210161 INCENP Positive_regulation of TNFRSF8 1 0.02 0.93 0.12 82.88
137 INT334259 Negative_regulation of Binding of Irak1 and Irak4 1 0.29 0.33 0.04 82.64
138 INT334257 Binding of Irak1 and Irak4 1 0.33 0.49 0.12 82.64
139 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 82.60
140 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4 82.24
141 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4 82.24
142 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 82.12
143 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 82.12
144 INT187145 Positive_regulation of Binding of CXCR3 and CXCL10 1 0.33 0.56 0.4 82.08
145 INT187149 Positive_regulation of Binding of CXCR3 and CXCL9 1 0.29 0.56 0.4 82.08
146 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 82.08
147 INT182159 Binding of HGF and DCPS 1 0.01 2.5 1.17 81.68
148 INT182156 Binding of HGF and IL3RA 1 0.03 1.31 0.62 81.68
149 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 81.68
150 INT203056 Binding of Cd274 and PDCD1LG2 1 0.13 1.61 0.57 81.44
151 INT203041 Binding of CD274 and PDCD1LG2 1 0.03 1.61 0.57 81.44
152 INT47357 Binding of FN1 and ANGPTL5 1 0.20 0.48 0.16 81.40
153 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 81.24
154 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 80.88
155 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 80.84
156 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 80.84
157 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27 80.80
158 INT172022 Binding of F13A1 and FN1 1 0.00 1.33 0.24 80.76
159 INT334269 Iars Negative_regulation of Gene_expression of IFNA1 1 0.03 0.62 0.23 80.08
160 INT306936 Binding of Tnfsf12 and Tnfrsf12a 1 0.05 4.84 0.45 80.00
161 INT203055 Binding of PDCD1 and Cd274 1 0.40 0.8 0.29 80.00
162 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 0.10 4.58 0.84 79.40
163 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36 79.28
164 INT19512 Prl Positive_regulation of Odc1 1 0.01 0.89 0.31 79.20
165 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 78.76
166 INT290170 Atp6v1e1 Positive_regulation of Gene_expression of IFNA1 1 0.07 0.15 0 77.56
167 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 77.44
168 INT232384 Binding of BCR and C6orf25 1 0.00 0.91 0 77.44
169 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 77.28
170 INT354890 Binding of TNF and Tnfsf13b 1 0.01 2.05 0 77.28
171 INT354887 Binding of Tnfsf13b and Gtf3a 1 0.01 2.05 0 76.88
172 INT220902 Binding of C4b and C4bp 1 0.45 1.02 0 76.64
173 INT220907 Binding of C4bp and Cfb 1 0.08 0.52 0 76.64
174 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76 76.48
175 INT194645 Negative_regulation of Tlr4 Positive_regulation of TNF 1 0.01 0.27 0 76.48
176 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11 75.48
177 INT308707 Binding of AQP4 and IGHG3 1 0.01 0.88 0 74.68
178 INT308704 Binding of DDX41 and M1 1 0.02 2.09 0.1 74.56
179 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 74.48
180 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 74.40
181 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35 74.40
182 INT300855 Il1 Regulation of Il6 1 0.01 0.81 0.3 73.92
183 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44 73.84
184 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 73.60
185 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 72.72
186 INT223529 Erv4 Regulation of Gene_expression of Chd9 1 0.20 0.81 0.06 72.48
187 INT223522 Li Regulation of Gene_expression of Chd9 1 0.44 0.82 0.06 72.48
188 INT194927 Binding of CD40LG and Positive_regulation of CD79B 1 0.01 0.4 0 72.36
189 INT19513 Prl Positive_regulation of IL2 1 0.41 0.8 0.27 72.32
190 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47 71.40
191 INT194926 Binding of CD40LG and Positive_regulation of BCR 1 0.04 0.39 0 71.36
192 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32 71.12
193 INT316889 Binding of Cd19 and Cr2 1 0.07 1.7 0.61 70.96
194 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61 70.96
195 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31 70.96
196 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31 70.96
197 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31 70.96
198 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31 70.96
199 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31 70.96
200 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3 70.96

Single Events

The table below shows the top 200 pain related interactions that have been reported for Systemic Lupus Erythematosus. They are ordered first by their pain relevance and then by number of times they were reported in Systemic Lupus Erythematosus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
2 INT156975 Gene_expression of SLEB1 31 0.65 38.83 6.73 100.00
3 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 100.00
4 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 100.00
5 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 100.00
6 INT10228 Positive_regulation of PCS 49 0.67 28.72 7 100.00
7 INT187161 Binding of SLEB1 9 0.05 11.8 1.09 100.00
8 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
9 INT121985 Positive_regulation of SLEB1 10 0.29 10.52 0.64 100.00
10 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 100.00
11 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 100.00
12 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
13 INT254389 Negative_regulation of Gene_expression of DCPS 6 0.08 7.26 0.44 100.00
14 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 100.00
15 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
16 INT187154 Regulation of SLEB1 5 0.03 6.59 1.32 100.00
17 INT65150 Gene_expression of Drb1 10 0.44 12.97 5.82 100.00
18 INT194936 Negative_regulation of SLEB1 6 0.05 5.02 0.82 100.00
19 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 100.00
20 INT182178 Regulation of Gene_expression of DCPS 4 0.07 3.16 0.51 100.00
21 INT254385 Regulation of Gene_expression of MR1 1 0.03 2.54 0.08 100.00
22 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 100.00
23 INT79693 Regulation of Il4 30 0.51 21.96 8.6 100.00
24 INT290134 Regulation of Sle1 1 0.05 2.52 0.11 100.00
25 INT182721 Negative_regulation of SHE 7 0.26 6.51 0.35 100.00
26 INT9210 Regulation of IL6 166 0.62 125.61 49.95 100.00
27 INT175460 Gene_expression of Sle1 2 0.08 3.5 0.09 100.00
28 INT306929 Regulation of Gene_expression of Tnfsf12 1 0.18 4.05 0.4 100.00
29 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 100.00
30 INT187155 Localization of SLEB1 3 0.05 2.83 0.9 100.00
31 INT220586 Positive_regulation of Il1r2 5 0.43 2.76 0.34 100.00
32 INT200383 Positive_regulation of Gene_expression of SLEB1 1 0.18 0.98 0.43 100.00
33 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83 100.00
34 INT220885 Positive_regulation of Sle1 3 0.13 3.06 0.42 100.00
35 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 100.00
36 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 100.00
37 INT214561 Positive_regulation of Binding of SLEB1 1 0.06 1.51 0 100.00
38 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 100.00
39 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93 100.00
40 INT124976 Positive_regulation of Tnfrsf1b 15 0.67 14.92 5.15 100.00
41 INT172876 Positive_regulation of Tnfrsf10b 3 0.03 3.66 0.54 100.00
42 INT334247 Negative_regulation of Transcription of Sle1 1 0.04 1.04 0 100.00
43 INT334222 Transcription of Sle1 1 0.07 1.04 0 100.00
44 INT309698 Negative_regulation of Binding of SLEB1 1 0.04 0.93 0 100.00
45 INT15796 Regulation of IL2 66 0.61 25.43 20.62 100.00
46 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 100.00
47 INT187164 Regulation of Gene_expression of SLEB1 1 0.02 1.9 0.87 100.00
48 INT332988 Negative_regulation of Sle1 1 0.03 0.71 0.53 100.00
49 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 100.00
50 INT232389 Positive_regulation of Negative_regulation of SLEB1 1 0.03 1.01 0.15 100.00
51 INT332991 Positive_regulation of Positive_regulation of Sle1 1 0.03 1.16 0.17 100.00
52 INT132662 Binding of Hcm 11 0.31 14.41 0.73 100.00
53 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 100.00
54 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 100.00
55 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 100.00
56 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 100.00
57 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 100.00
58 INT290142 Localization of Sle1 1 0.08 0.32 0 100.00
59 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 100.00
60 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 100.00
61 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47 100.00
62 INT163592 Localization of CISH 5 0.54 5.9 1.26 100.00
63 INT243756 Regulation of Positive_regulation of Egr1 7 0.45 1.18 0.4 100.00
64 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 100.00
65 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 100.00
66 INT147793 Localization of COPD 70 0.64 89.01 7.3 100.00
67 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63 100.00
68 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32 100.00
69 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64 100.00
70 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 100.00
71 INT88667 Negative_regulation of Gene_expression of F2 11 0.41 5.53 1.62 100.00
72 INT109880 Negative_regulation of Gene_expression of F8 3 0.12 2.12 0.54 100.00
73 INT259031 Negative_regulation of Gene_expression of CADPS 1 0.07 3.04 0.35 100.00
74 INT27363 Negative_regulation of Gene_expression of Serpinc1 5 0.29 3.2 0.3 100.00
75 INT61319 Positive_regulation of Gene_expression of Serpinc1 2 0.06 1.82 0.25 100.00
76 INT174652 Gene_expression of EXTL3 2 0.05 1.49 0.15 100.00
77 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.98
78 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 99.98
79 INT95904 Gene_expression of CD27 45 0.76 26.17 1.93 99.96
80 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.96
81 INT214560 Negative_regulation of Gene_expression of CD27 1 0.42 3.45 0 99.96
82 INT214555 Negative_regulation of Positive_regulation of PCS 1 0.27 1.91 0 99.96
83 INT214565 Negative_regulation of Positive_regulation of CD27 1 0.42 1.8 0 99.96
84 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03 99.96
85 INT224626 Negative_regulation of Il21 3 0.10 3.51 1.67 99.96
86 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.92
87 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96 99.92
88 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 99.92
89 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 99.92
90 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 99.92
91 INT24662 Gene_expression of F2RL3 4 0.55 3.01 0.71 99.92
92 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4 99.90
93 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.90
94 INT102698 Binding of ACCS 54 0.42 66.73 9.06 99.90
95 INT39789 Positive_regulation of Positive_regulation of PCS 2 0.32 3.63 2.04 99.90
96 INT214554 Positive_regulation of Positive_regulation of CD27 1 0.49 3.37 0.07 99.90
97 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 99.90
98 INT182231 Negative_regulation of Gene_expression of CXCR5 6 0.47 6.35 2.65 99.90
99 INT10834 Binding of IL8 65 0.48 41.66 16.53 99.90
100 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 99.90
101 INT124512 Transcription of FCGR2A 1 0.04 1.88 0.65 99.90
102 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.88
103 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.88
104 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 99.88
105 INT150222 Positive_regulation of Gene_expression of TNFSF13B 12 0.11 7.49 2.43 99.88
106 INT319011 Positive_regulation of Gene_expression of TNFSF13 1 0.09 2.1 0.19 99.88
107 INT60600 Binding of PSS 5 0.32 3.59 1.42 99.88
108 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 99.86
109 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.86
110 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21 99.86
111 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.84
112 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 99.84
113 INT249342 Gene_expression of TYROBP 3 0.73 16.71 1.79 99.84
114 INT306930 Gene_expression of Tnfsf12 1 0.31 21.25 1.65 99.84
115 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 99.84
116 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 99.84
117 INT254388 Negative_regulation of Gene_expression of MR1 8 0.32 6.52 0.28 99.84
118 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 99.84
119 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 99.84
120 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.84
121 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 99.84
122 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 99.84
123 INT245196 Negative_regulation of CD209 5 0.11 4.83 0.21 99.84
124 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 99.84
125 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 99.84
126 INT260120 Regulation of Gene_expression of FOXP3 4 0.31 2.74 0.29 99.84
127 INT35584 Binding of ACLY 22 0.35 31.78 7.17 99.84
128 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 99.84
129 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 99.84
130 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 99.84
131 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 99.84
132 INT16404 Regulation of CD4 54 0.61 33.05 10.29 99.84
133 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 99.84
134 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55 99.84
135 INT260794 Positive_regulation of Transcription of Tnfsf10 2 0.43 2.56 0.38 99.84
136 INT201652 Positive_regulation of Tnfsf10 26 0.68 26.79 2.14 99.84
137 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 99.84
138 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 99.84
139 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 99.84
140 INT68701 Positive_regulation of C4bp 7 0.67 3.02 0.46 99.84
141 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.82
142 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 99.82
143 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 99.80
144 INT306931 Binding of Tnfsf12 1 0.19 7.53 0.35 99.80
145 INT211272 Positive_regulation of Igh-VS107 8 0.37 5.79 0.7 99.80
146 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.78
147 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.78
148 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.78
149 INT215469 Positive_regulation of TNFSF13B 9 0.43 7.14 0.7 99.78
150 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 99.78
151 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 99.78
152 INT1938 Positive_regulation of DONSON 3 0.13 3.02 1.07 99.78
153 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 99.74
154 INT214571 Positive_regulation of Gene_expression of CD27 1 0.49 7.77 0 99.72
155 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 99.72
156 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 99.72
157 INT214570 Positive_regulation of Negative_regulation of KRT20 1 0.14 0.93 0 99.72
158 INT73497 Regulation of IL10 33 0.45 22.6 9.19 99.72
159 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 99.72
160 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 99.72
161 INT315714 Phosphorylation of Ddx41 1 0.12 0.97 0.14 99.72
162 INT182226 Regulation of Gene_expression of CXCR5 1 0.44 3.64 2.14 99.72
163 INT214566 Positive_regulation of CD27 1 0.68 13.39 0.17 99.70
164 INT171742 Positive_regulation of CXCR3 17 0.58 12.26 7.72 99.70
165 INT171749 Positive_regulation of Gene_expression of CXCR3 18 0.58 11.03 6.51 99.70
166 INT28680 Positive_regulation of Tnfsf13b 5 0.39 6.46 1.1 99.70
167 INT354864 Positive_regulation of Localization of Tnfsf13b 1 0.16 4.03 0 99.70
168 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 99.70
169 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 99.70
170 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 99.68
171 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 99.68
172 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 99.68
173 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.68
174 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 99.68
175 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21 99.68
176 INT85970 Positive_regulation of Cd40lg 21 0.53 8.51 3.16 99.68
177 INT64767 Negative_regulation of Gene_expression of HLA-E 18 0.57 12.64 5.23 99.68
178 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 99.68
179 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 99.68
180 INT262633 Negative_regulation of Gene_expression of Atp8a1 7 0.57 2.52 0.65 99.68
181 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 99.68
182 INT17561 Localization of Car2 303 0.79 60.95 44.52 99.68
183 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 99.68
184 INT182667 Binding of DLAT 11 0.31 40.75 2.8 99.68
185 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 99.66
186 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 99.66
187 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 99.66
188 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 99.66
189 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 99.66
190 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 99.66
191 INT187158 Positive_regulation of Positive_regulation of CXCL10 2 0.38 1.6 1.03 99.66
192 INT204181 Gene_expression of CD209 22 0.64 30.66 1.47 99.64
193 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6 99.64
194 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 99.64
195 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 99.64
196 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 99.62
197 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.60
198 INT28909 Binding of Acla1 1 0.08 4.52 0.26 99.60
199 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 99.60
200 INT113219 Binding of TNFRSF25 12 0.35 9.77 0.46 99.60
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