D:Systemic Mastocytosis

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Disease Term
Synonyms Aggressive Systemic Mastocytoses, Aggressive Systemic Mastocytosis, INDOLENT SYSTEMIC MASTOCYTOSES, INDOLENT SYSTEMIC MASTOCYTOSIS, Mast Cell Disease Systemic, Mast Cell Diseases Systemic, Mastocytoses Aggressive Systemic, Mastocytoses Indolent Systemic, Mastocytoses Systemic, Mastocytosis Aggressive Systemic, Mastocytosis Indolent Systemic
Documents 106
Hot Single Events 50
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Systemic Mastocytosis. They are ordered first by their relevance to Systemic Mastocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0 90.72
2 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0 90.72
3 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 31.60
4 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11 23.52
5 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
6 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
7 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
8 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
9 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
10 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
11 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
12 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0 5.00
13 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 5.00
14 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 5.00
15 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 5.00
16 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0 5.00
17 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Systemic Mastocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Systemic Mastocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03 100.00
2 INT69761 Gene_expression of Jag2 5 0.67 6.17 0.53 100.00
3 INT232640 Binding of Jag2 1 0.12 4.1 0.49 100.00
4 INT232637 Localization of Jag2 2 0.21 2.07 0.32 100.00
5 INT277763 Localization of DPM1 1 0.03 2.34 0 100.00
6 INT64827 Binding of Il2ra 5 0.36 6.57 0.79 99.92
7 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91 99.90
8 INT128230 Negative_regulation of tryptase 3 0.57 5.77 0.88 99.90
9 INT232641 Negative_regulation of Gene_expression of tryptase 1 0.40 2.4 0.12 99.90
10 INT232631 Negative_regulation of Gene_expression of Cd2 1 0.27 2.25 0.12 99.90
11 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 99.76
12 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 99.74
13 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.28
14 INT14600 Positive_regulation of Tpsab1 51 0.68 22.1 7.7 99.20
15 INT232630 Regulation of Opa1 1 0.05 0.91 0.06 98.80
16 INT88278 Binding of Kit 33 0.37 24.45 4.13 98.72
17 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 98.62
18 INT192748 Localization of BCR 4 0.68 2.4 0.18 98.26
19 INT241506 Localization of Abl1 2 0.54 2.37 0.04 98.18
20 INT145 Negative_regulation of H1 12 0.39 5.68 5.08 98.08
21 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3 98.00
22 INT26850 Negative_regulation of H2 13 0.32 9.4 1.82 97.94
23 INT232633 Regulation of Gene_expression of Opa1 2 0.27 2.6 0 97.64
24 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 97.06
25 INT41423 Gene_expression of Cd2 3 0.53 2.06 0.16 97.06
26 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 96.72
27 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 95.66
28 INT14598 Gene_expression of Tpsab1 40 0.73 14.55 5.4 95.52
29 INT60423 Positive_regulation of TPSG1 11 0.57 11.02 2.55 95.28
30 INT14599 Localization of Tpsab1 36 0.79 14.58 7.18 95.12
31 INT230873 Regulation of Gene_expression of tryptase 2 0.42 1.02 0.06 94.72
32 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 94.60
33 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 94.56
34 INT155426 Gene_expression of Kit 3 0.49 2.71 0.31 94.08
35 INT66792 Binding of TPSAB1 7 0.16 4.93 1.45 91.68
36 INT10188 Positive_regulation of Il2ra 19 0.45 11.6 3.37 90.48
37 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 90.28
38 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06 90.18
39 INT50740 Positive_regulation of SPG21 18 0.67 8.3 1.65 90.18
40 INT277761 Gene_expression of DPM1 1 0.03 9.23 0.27 90.12
41 INT137698 Binding of Cd68 1 0.29 0.44 0.09 90.08
42 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 89.32
43 INT117687 Positive_regulation of TPSD1 5 0.44 2.63 0.46 88.80
44 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 88.80
45 INT241510 Negative_regulation of Phosphorylation of Kit 3 0.31 2.06 0.03 88.80
46 INT84019 Gene_expression of TPSD1 2 0.07 1.84 0.1 88.20
47 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 88.20
48 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 86.68
49 INT11794 Gene_expression of Cd2 27 0.76 17.31 10.99 86.68
50 INT232635 Positive_regulation of Gene_expression of Opa1 1 0.06 0.6 0.1 85.68
51 INT310747 Regulation of JAK2 2 0.33 1.58 0.05 79.60
52 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 75.00
53 INT74064 Gene_expression of SPG21 9 0.75 4.14 2.45 75.00
54 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 72.24
55 INT18843 Binding of H1 10 0.47 5.44 2.4 71.76
56 INT99572 Localization of Kit 13 0.75 5.23 1.95 67.88
57 INT74777 Positive_regulation of Gene_expression of TPSAB1 4 0.50 3.7 0.92 67.60
58 INT310935 Negative_regulation of Gene_expression of TPSAB1 1 0.13 1.08 0 67.60
59 INT14477 Positive_regulation of TPSAB1 10 0.69 5.88 1.46 67.04
60 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 64.20
61 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51 64.00
62 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 63.44
63 INT350510 Localization of ABL1 1 0.40 2.51 0 60.76
64 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03 55.04
65 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 54.52
66 INT88867 Localization of MCS 19 0.62 28.31 3.88 54.24
67 INT166731 Positive_regulation of Localization of MCS 1 0.28 0.19 0.04 54.24
68 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 53.60
69 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 52.32
70 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 51.92
71 INT213777 Positive_regulation of Phosphorylation of Kit 2 0.58 1.36 0.26 50.72
72 INT229573 Positive_regulation of Positive_regulation of Kit 3 0.39 1.46 0.09 50.72
73 INT232638 Negative_regulation of Gene_expression of Opa1 1 0.31 0.96 0.1 43.56
74 INT277757 Gene_expression of Pmf1 3 0.12 4.14 0.23 37.88
75 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 37.72
76 INT145801 Negative_regulation of Binding of Cysltr1 2 0.39 1.89 0.35 35.84
77 INT232636 Positive_regulation of Binding of Kit 4 0.39 1.98 0.98 32.72
78 INT40104 Binding of Cysltr1 11 0.38 4.56 1.95 30.00
79 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 26.52
80 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 26.00
81 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 23.96
82 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 23.60
83 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 19.60
84 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44 18.40
85 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 18.24
86 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44 16.96
87 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
88 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
89 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
90 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
91 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
92 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
93 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
94 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
95 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
96 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
97 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
98 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
99 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
100 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
101 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
102 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
103 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
104 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
105 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
106 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
107 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
108 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
109 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
110 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
111 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
112 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
113 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
114 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
115 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
116 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
117 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
118 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
119 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
120 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
121 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
122 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
123 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
124 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
125 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 5.00
126 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
127 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
128 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
129 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
130 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
131 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
132 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
133 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
134 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
135 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
136 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
137 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
138 INT701 Localization of IGHE 87 0.80 40.5 10.62 5.00
139 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
140 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
141 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
142 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 5.00
143 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
144 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
145 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
146 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
147 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
148 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
149 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 5.00
150 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
151 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
152 INT60527 Transcription of IL10 16 0.56 13.57 6.42 5.00
153 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
154 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 5.00
155 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
156 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93 5.00
157 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
158 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 5.00
159 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69 5.00
160 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 5.00
161 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
162 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
163 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
164 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 5.00
165 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11 5.00
166 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
167 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 5.00
168 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76 5.00
169 INT60957 Negative_regulation of Abcb1b 18 0.57 6 4.73 5.00
170 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 5.00
171 INT20372 Localization of Il5 26 0.41 18.33 4.27 5.00
172 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 5.00
173 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 5.00
174 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
175 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2 5.00
176 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16 5.00
177 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
178 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 5.00
179 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
180 INT101857 Negative_regulation of BCL2L1 22 0.57 23.56 3.95 5.00
181 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 5.00
182 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
183 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75 5.00
184 INT9223 Localization of Ighg1 22 0.78 11.03 3.67 5.00
185 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
186 INT171998 Binding of DMD 58 0.47 38.13 3.35 5.00
187 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 5.00
188 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
189 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15 5.00
190 INT110445 Phosphorylation of Gtf3a 15 0.09 5.58 3.07 5.00
191 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
192 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 5.00
193 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 5.00
194 INT212394 Gene_expression of Zic2 44 0.78 2.88 2.82 5.00
195 INT133029 Regulation of TLR2 18 0.56 11.31 2.62 5.00
196 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54 5.00
197 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53 5.00
198 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5 5.00
199 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37 5.00
200 INT55952 Transcription of TP53 16 0.61 12.14 2.36 5.00
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