D:Systemic Sclerosis

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Disease Term
Synonyms LINEAR SCLEROSIS, Mctd, Mixed Connective Tissue Disease, Morphea, Raynaud S Phenomenon, SCLERODERMA, SCLERODERMA SYSTEMIC, Sclerosis Systemic, Systemic Scleroderma
Documents 817
Hot Single Events 200
Hot Interactions 20

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Systemic Sclerosis. They are ordered first by their relevance to Systemic Sclerosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252020 Binding of HLA-A and ELOVL1 1 0.01 1.41 0 100.00
2 INT181994 Binding of Mmp9 and ELOVL1 1 0.00 0.57 0 100.00
3 INT350163 Regulation of Binding of DURS1 and ELOVL1 1 0.00 1.48 0.11 100.00
4 INT350164 Binding of DURS1 and ELOVL1 1 0.00 1.47 0.11 100.00
5 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61 100.00
6 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6 100.00
7 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 100.00
8 INT323675 Binding of THBD and BDNF-AS 1 0.02 2.45 0.04 98.80
9 INT323674 Binding of TFPI and THBD 1 0.02 2.45 0.04 98.80
10 INT204091 Binding of HLA-G and KIR2DL1 1 0.15 0.86 0.32 97.52
11 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 97.36
12 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 94.32
13 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 94.32
14 INT242340 Binding of COL7A1 and PAH 1 0.00 1.35 0 92.04
15 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 92.00
16 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 87.16
17 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38 86.44
18 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0 82.96
19 INT172022 Binding of F13A1 and FN1 1 0.00 1.33 0.24 82.20
20 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 0.10 4.58 0.84 82.16
21 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36 78.96
22 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44 73.28
23 INT172023 Binding of FN1 and PRTN3 1 0.00 1.05 0.37 71.04
24 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41 70.80
25 INT316889 Binding of Cd19 and Cr2 1 0.07 1.7 0.61 69.92
26 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61 69.92
27 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31 69.92
28 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31 69.92
29 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31 69.92
30 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31 69.92
31 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31 69.92
32 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3 69.92
33 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3 69.92
34 INT355539 Gnptg Positive_regulation of Mmp23 1 0.00 1.18 0.35 69.56
35 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89 69.36
36 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38 66.60
37 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17 66.36
38 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17 66.36
39 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38 66.20
40 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05 64.84
41 INT322208 HRCT1 Positive_regulation of PDX1 1 0.01 1.31 0.34 63.72
42 INT346151 Binding of ADM and GPER 1 0.01 0.99 0.41 62.56
43 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63 57.96
44 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 57.12
45 INT221068 Cd79a Regulation of Gene_expression of IgG 1 0.01 0.93 0.1 56.52
46 INT221067 Cd79a Regulation of IgG 1 0.01 0.93 0.1 56.52
47 INT221066 Cd79a Regulation of Gene_expression of Ighm 1 0.01 0.93 0.1 56.32
48 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44 53.28
49 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 43.60
50 INT316824 Negative_regulation of Sparc Negative_regulation of Gene_expression of Col7a1 1 0.10 0.82 0.09 43.52
51 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 43.44
52 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28 41.04
53 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27 40.44
54 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42 35.60
55 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 33.96
56 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72 31.24
57 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29 30.56
58 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 0.05 0.86 0.28 30.56
59 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06 21.84
60 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 21.68
61 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 16.96
62 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 16.96
63 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0 12.68
64 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43 11.08
65 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 10.40
66 INT316818 Sparc Regulation of Gene_expression of Col7a1 1 0.06 0.74 0.09 5.68
67 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
68 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
69 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
70 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
71 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69 5.00
72 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 5.00
73 INT240730 Binding of CRYGD and MTRF1 4 0.03 4.18 1.39 5.00
74 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
75 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
76 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
77 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03 5.00
78 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 5.00
79 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98 5.00
80 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
81 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 5.00
82 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96 5.00
83 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94 5.00
84 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
85 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
86 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89 5.00
87 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
88 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
89 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8 5.00
90 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
91 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78 5.00
92 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78 5.00
93 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78 5.00
94 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76 5.00
95 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76 5.00
96 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75 5.00
97 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74 5.00
98 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7 5.00
99 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 5.00
100 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
101 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67 5.00
102 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
103 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65 5.00
104 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65 5.00
105 INT288266 Binding of AFA and CRYGD 1 0.08 1.85 0.64 5.00
106 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63 5.00
107 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62 5.00
108 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 5.00
109 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
110 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61 5.00
111 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59 5.00
112 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59 5.00
113 INT345180 Binding of Lpar4 and Gpr87 1 0.06 0.69 0.59 5.00
114 INT345192 Binding of Gpr87 and Lpar5 1 0.07 0.69 0.59 5.00
115 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58 5.00
116 INT318488 LTB4R Regulation of FPR2 1 0.01 1.07 0.58 5.00
117 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57 5.00
118 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53 5.00
119 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53 5.00
120 INT278819 EDNRA Negative_regulation of Binding of EDNRA and EDNRB 1 0.04 1.65 0.53 5.00
121 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53 5.00
122 INT346146 ADM Positive_regulation of Gene_expression of PERP 1 0.02 1.54 0.51 5.00
123 INT288263 Binding of AFA and MTRF1 1 0.02 1.28 0.49 5.00
124 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49 5.00
125 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
126 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
127 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47 5.00
128 INT261603 Il6 Regulation of Gene_expression of Vcam1 1 0.16 1.74 0.46 5.00
129 INT288265 Binding of FLG and NEUROG1 1 0.02 1.06 0.46 5.00
130 INT176469 Binding of CXCL10 and CXCL9 1 0.01 0.84 0.46 5.00
131 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
132 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
133 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 5.00
134 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 5.00
135 INT318483 Binding of LTB4R and FPR2 1 0.02 0.98 0.42 5.00
136 INT346148 Binding of ADM and VTN 1 0.15 0.93 0.39 5.00
137 INT346150 Binding of ADM and FN1 1 0.10 0.93 0.39 5.00
138 INT346140 Positive_regulation of Binding of ADM and MMRN1 1 0.04 0.93 0.39 5.00
139 INT346139 Binding of ADM and MMRN1 1 0.03 0.93 0.39 5.00
140 INT346135 Positive_regulation of Binding of ADM and FN1 1 0.13 0.93 0.39 5.00
141 INT346142 Positive_regulation of Binding of ADM and VTN 1 0.20 0.93 0.39 5.00
142 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
143 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39 5.00
144 INT224423 Binding of TNFRSF11B and TNFRSF11A 3 0.19 2.36 0.37 5.00
145 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
146 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36 5.00
147 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
148 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
149 INT346145 Binding of ADM and TPX2 1 0.01 1.05 0.35 5.00
150 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
151 INT171874 Binding of SQLE and MRAP 1 0.00 1.29 0.35 5.00
152 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35 5.00
153 INT278820 EDNRA Negative_regulation of Binding of EDN1 and EDNRB 1 0.03 1.1 0.35 5.00
154 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35 5.00
155 INT261597 Binding of PAH and COPD 1 0.00 1.08 0.34 5.00
156 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
157 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34 5.00
158 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
159 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
160 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
161 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
162 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33 5.00
163 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
164 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
165 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
166 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
167 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
168 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33 5.00
169 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
170 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
171 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
172 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
173 INT261605 Il6 Regulation of smc 1 0.02 1.19 0.3 5.00
174 INT204090 Binding of KIR2DL2 and KIR2DS1 1 0.03 0.41 0.29 5.00
175 INT204089 Binding of KIR2DL3 and KIR2DS1 1 0.03 0.41 0.29 5.00
176 INT318480 IRF6 Positive_regulation of Gene_expression of LTB4R 1 0.01 1.63 0.29 5.00
177 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
178 INT261609 Binding of PAH and Hypt 1 0.00 1.26 0.28 5.00
179 INT154755 Tnf Positive_regulation of Gene_expression of Ccl2 2 0.23 1.7 0.27 5.00
180 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27 5.00
181 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27 5.00
182 INT318477 Regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1 0.27 5.00
183 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
184 INT300546 Binding of Il23a and Il1 1 0.01 0.5 0.25 5.00
185 INT316815 Ctgf Negative_regulation of Gene_expression of Sparc 1 0.47 0.64 0.24 5.00
186 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24 5.00
187 INT318485 Positive_regulation of IRF6 Positive_regulation of LTB4R 1 0.00 1.03 0.23 5.00
188 INT346134 ADM Regulation of Gene_expression of MMRN1 1 0.04 1.29 0.23 5.00
189 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
190 INT346143 ADM Regulation of Gene_expression of TPX2 1 0.02 1.29 0.23 5.00
191 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00
192 INT316810 Sparc Regulation of Col1a1 1 0.13 0.48 0.21 5.00
193 INT345196 Lpar2 Positive_regulation of Gene_expression of VEGFA 1 0.08 2.14 0.2 5.00
194 INT345186 Lpar2 Positive_regulation of Gene_expression of Plau 1 0.05 2.2 0.2 5.00
195 INT345172 Lpar1 Positive_regulation of S1pr1 1 0.21 0.19 0.19 5.00
196 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
197 INT278817 EDNRA Negative_regulation of Binding of EDN1 and EDNRA 1 0.02 0.55 0.18 5.00
198 INT278818 EDNRA Negative_regulation of Binding of EDNRB and EDNRB 1 0.06 0.55 0.18 5.00
199 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17 5.00
200 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Systemic Sclerosis. They are ordered first by their pain relevance and then by number of times they were reported in Systemic Sclerosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 100.00
2 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 100.00
3 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 100.00
4 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 100.00
5 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 100.00
6 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 100.00
7 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49 100.00
8 INT285473 Gene_expression of Nid2 1 0.24 2.3 0.19 100.00
9 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 100.00
10 INT204720 Gene_expression of CD53 3 0.09 1.38 0.1 100.00
11 INT266354 Gene_expression of S100A7 9 0.58 7.35 0.75 100.00
12 INT182474 Gene_expression of Cdh5 17 0.57 14.58 1.23 100.00
13 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21 100.00
14 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 100.00
15 INT285507 Gene_expression of Col5a2 1 0.18 1.12 0.09 100.00
16 INT198614 Phosphorylation of ELOVL1 2 0.11 1.79 0.25 100.00
17 INT181993 Regulation of Gene_expression of ELOVL1 1 0.00 1.23 0.19 100.00
18 INT181990 Positive_regulation of Gene_expression of ELOVL1 1 0.01 1.06 0.14 100.00
19 INT172101 Negative_regulation of Binding of ELOVL1 1 0.36 0.78 0.12 100.00
20 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 100.00
21 INT198613 Localization of ELOVL1 2 0.56 1.84 0.52 100.00
22 INT163153 Positive_regulation of Col18a1 3 0.41 2.19 0.51 100.00
23 INT181991 Positive_regulation of Positive_regulation of ELOVL1 1 0.01 1.7 0.51 100.00
24 INT170178 Regulation of Elovl1 1 0.26 0.86 0.08 100.00
25 INT170177 Positive_regulation of Elovl1 1 0.49 0.67 0 100.00
26 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 99.98
27 INT18025 Binding of Pah 32 0.45 30.72 7.93 99.98
28 INT213215 Gene_expression of SS18L1 2 0.58 3.71 0.29 99.92
29 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 99.88
30 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 99.84
31 INT80329 Positive_regulation of THBD 12 0.47 20.96 2.45 99.84
32 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 99.84
33 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 99.84
34 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 99.84
35 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.84
36 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 99.84
37 INT130351 Positive_regulation of Vwf 18 0.59 5.99 3.48 99.84
38 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 99.82
39 INT39948 Binding of FLNA 45 0.42 58.05 4.27 99.80
40 INT156131 Binding of Hand2 14 0.25 10.35 3.99 99.80
41 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 99.80
42 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 99.80
43 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 99.80
44 INT163189 Localization of CD27 7 0.74 5.31 0.18 99.80
45 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 99.76
46 INT135408 Transcription of Il17a 8 0.64 10.7 3.39 99.76
47 INT9110 Binding of PAH 32 0.41 42.1 3.1 99.76
48 INT180920 Positive_regulation of Positive_regulation of Timp1 2 0.38 1.59 0.46 99.76
49 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52 99.76
50 INT181989 Regulation of Negative_regulation of Mmp9 1 0.22 0.91 0.18 99.76
51 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 99.76
52 INT65150 Gene_expression of Drb1 10 0.44 12.97 5.82 99.72
53 INT9085 Localization of Nppb 32 0.81 15.1 3.47 99.70
54 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73 99.70
55 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 99.68
56 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.68
57 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 99.68
58 INT190691 Negative_regulation of APOA1 12 0.42 15.9 0.39 99.68
59 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 99.68
60 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14 99.68
61 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71 99.68
62 INT116164 Positive_regulation of Gene_expression of S1pr1 5 0.66 4.72 2.42 99.68
63 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84 99.68
64 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 99.66
65 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01 99.66
66 INT124512 Transcription of FCGR2A 1 0.04 1.88 0.65 99.64
67 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38 99.56
68 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9 99.50
69 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 99.50
70 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 99.50
71 INT155992 Gene_expression of THBD 16 0.66 17 1.24 99.46
72 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 99.40
73 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 99.40
74 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 99.40
75 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 99.40
76 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 99.40
77 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 99.36
78 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27 99.34
79 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 99.32
80 INT64065 Gene_expression of Btg3 5 0.65 12.62 1.41 99.32
81 INT197196 Negative_regulation of DURS1 2 0.43 30.6 2.37 99.28
82 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 99.28
83 INT294824 Positive_regulation of Gene_expression of Sparc 10 0.69 7.64 0.81 99.28
84 INT41775 Gene_expression of NEUROG1 10 0.71 5.46 2.14 99.28
85 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 99.28
86 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 99.28
87 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 99.28
88 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.24
89 INT76573 Negative_regulation of Vcam1 26 0.58 24.36 9.84 99.24
90 INT81411 Negative_regulation of Sele 8 0.38 7 2.7 99.24
91 INT35360 Positive_regulation of Ve 3 0.22 3.55 0.81 99.20
92 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 99.20
93 INT178483 Gene_expression of Col18a1 12 0.75 11.87 1.03 99.08
94 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 99.06
95 INT23468 Gene_expression of Fbn1 7 0.76 8.04 0.76 99.04
96 INT95641 Regulation of Fbn1 3 0.45 3.67 0.91 99.04
97 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 99.04
98 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.00
99 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 99.00
100 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 99.00
101 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.00
102 INT10729 Positive_regulation of ENPEP 13 0.38 9.65 0.8 99.00
103 INT20238 Regulation of APOB 9 0.61 11.52 1.26 98.98
104 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14 98.96
105 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79 98.96
106 INT170314 Positive_regulation of Gene_expression of Col4a1 7 0.18 3.52 0.49 98.92
107 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93 98.92
108 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 98.92
109 INT27878 Gene_expression of FCGR1B 22 0.26 20.62 2.04 98.88
110 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 98.88
111 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 98.88
112 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 98.80
113 INT138490 Positive_regulation of Il13 9 0.36 5.42 2.06 98.80
114 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 98.80
115 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 98.76
116 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 98.76
117 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 98.74
118 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.68
119 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 98.68
120 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 98.68
121 INT260114 Regulation of ISG20 5 0.37 4.98 1.27 98.66
122 INT145419 Negative_regulation of Scl1 1 0.00 0.51 0 98.64
123 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 98.62
124 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 98.60
125 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 98.58
126 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 98.58
127 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.54
128 INT350166 Regulation of Negative_regulation of DURS1 1 0.20 1.58 0.12 98.52
129 INT8112 Regulation of EPO 38 0.58 22.04 2.76 98.48
130 INT89971 Localization of Sparc 10 0.80 10.25 1.85 98.44
131 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 98.44
132 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 98.38
133 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 98.38
134 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 98.38
135 INT331114 Gene_expression of DURS1 2 0.49 3.93 0.45 98.38
136 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 98.36
137 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 98.36
138 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 98.32
139 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 98.24
140 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 98.24
141 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 98.12
142 INT12039 Localization of TFPI 22 0.68 9.88 5.35 98.12
143 INT173914 Regulation of Gene_expression of LRP2 3 0.60 6.49 0.78 98.08
144 INT46646 Localization of FLNA 19 0.73 18.83 2.53 98.00
145 INT134651 Binding of TLR4 89 0.48 66.96 23.19 97.96
146 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 97.92
147 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 97.84
148 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 97.84
149 INT36575 Gene_expression of TNFRSF10A 10 0.65 10.1 4.17 97.84
150 INT5186 Regulation of Ifng 11 0.45 8.78 5.9 97.80
151 INT22556 Positive_regulation of Gene_expression of COL3A1 5 0.37 4.25 0.64 97.76
152 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 97.76
153 INT240127 Binding of Nppb 19 0.37 22.42 3.3 97.76
154 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03 97.76
155 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6 97.76
156 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22 97.76
157 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 97.70
158 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 97.68
159 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 97.68
160 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 97.68
161 INT173920 Transcription of LRP2 1 0.52 2.63 0.4 97.64
162 INT172100 Binding of TOP1 2 0.14 1.31 0.11 97.60
163 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 97.60
164 INT182667 Binding of DLAT 11 0.31 40.75 2.8 97.60
165 INT201005 Gene_expression of APOL1 9 0.75 4.66 0.53 97.56
166 INT64952 Binding of HLA-DQA2 11 0.10 7.23 1.39 97.52
167 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 97.52
168 INT204113 Binding of KIR2DL1 1 0.10 3.22 1.13 97.52
169 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 97.48
170 INT332262 Positive_regulation of Gene_expression of Cma1 1 0.41 4.94 0.38 97.48
171 INT168603 Negative_regulation of Positive_regulation of Mmp9 3 0.37 2.32 2.42 97.48
172 INT81757 Regulation of Gene_expression of Adm 6 0.44 2.86 1.16 97.48
173 INT48037 Regulation of Adm 8 0.44 3.96 1.24 97.48
174 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21 97.40
175 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 97.36
176 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 97.36
177 INT36780 Negative_regulation of Gene_expression of Mln 4 0.34 2.28 1.69 97.36
178 INT11948 Negative_regulation of Gene_expression of Vip 9 0.43 2.8 1.54 97.36
179 INT181988 Negative_regulation of Negative_regulation of Mmp9 1 0.39 1.39 0.41 97.36
180 INT150488 Gene_expression of CAST 4 0.73 1.33 0.43 97.28
181 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36 97.24
182 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 97.20
183 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 97.16
184 INT104476 Protein_catabolism of Timp1 6 0.41 5.75 2.61 97.08
185 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19 97.08
186 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 97.08
187 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 97.04
188 INT181987 Negative_regulation of Negative_regulation of Timp1 1 0.23 1.39 0.41 97.00
189 INT24845 Gene_expression of Gnptg 9 0.48 11.42 0.8 97.00
190 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 96.92
191 INT22966 Negative_regulation of Positive_regulation of Pah 2 0.50 2.03 1.56 96.92
192 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 96.88
193 INT244959 Gene_expression of Snx1 5 0.70 3.22 0.22 96.88
194 INT285493 Positive_regulation of Gene_expression of Fbrs 1 0.11 1.1 0.13 96.76
195 INT136388 Gene_expression of Cxcl5 13 0.75 21.45 2.98 96.64
196 INT98739 Gene_expression of Fbrs 6 0.52 4.77 0.4 96.52
197 INT74101 Negative_regulation of Adm 3 0.06 1.2 0.53 96.46
198 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42 96.42
199 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19 96.40
200 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 96.40
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