D:Systolic Heart Failure

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Disease Term
Synonyms Heart Failures Systolic, Systolic Heart Failures
Documents 47
Hot Single Events 7
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Systolic Heart Failure. They are ordered first by their relevance to Systolic Heart Failure and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT139004 Mtpn Regulation of NFKB1 1 0.33 0.55 0 90.96
2 INT345289 CRS Regulation of REN 1 0.03 1.02 0.12 71.12
3 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
4 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
5 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
6 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
7 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 5.00
8 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 5.00
9 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
10 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43 5.00
11 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43 5.00
12 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
13 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 5.00
14 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28 5.00
15 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21 5.00
16 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
17 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
18 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12 5.00
19 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
20 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1 5.00
21 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
22 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
23 INT345292 Binding of Lcn2 and Havcr1 1 0.00 1.17 0.07 5.00
24 INT345297 Binding of NAGLU and Lcn2 1 0.01 1.24 0.07 5.00
25 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
26 INT230818 Ins1 Positive_regulation of Gene_expression of Agt 1 0.07 1.11 0.04 5.00
27 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
28 INT230820 Ins1 Positive_regulation of ras 1 0.12 1.1 0.04 5.00
29 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
30 INT230817 Ins1 Positive_regulation of Regulation of Agt 1 0.07 1.11 0.04 5.00
31 INT230816 Binding of ras and Ren1 1 0.11 0.77 0.04 5.00
32 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03 5.00
33 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03 5.00
34 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
35 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00
36 INT345287 Binding of SCN10A and RAPGEF5 1 0.01 0.67 0 5.00
37 INT334894 Binding of CALCR and ARMC9 1 0.01 0.41 0 5.00
38 INT182818 EEF1A2 Negative_regulation of STAR 1 0.01 1.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Systolic Heart Failure. They are ordered first by their pain relevance and then by number of times they were reported in Systolic Heart Failure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.88
2 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 90.84
3 INT70970 Binding of COPD 144 0.42 180.34 18.29 89.92
4 INT230803 Regulation of Negative_regulation of Ace 2 0.39 1.89 0.81 89.28
5 INT95606 Positive_regulation of ADRM1 6 0.40 1.99 0.28 87.76
6 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 87.12
7 INT67279 Localization of PRTN3 11 0.50 14.18 4.3 84.88
8 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 79.52
9 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 70.24
10 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 70.04
11 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37 64.72
12 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 57.12
13 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 56.24
14 INT258075 Regulation of Negative_regulation of DNAH8 2 0.17 1.78 0 56.16
15 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 55.76
16 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 55.32
17 INT12003 Gene_expression of Ang 4 0.64 3.87 0.44 51.20
18 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39 51.00
19 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44 51.00
20 INT8065 Binding of AGT 54 0.48 20.54 10.85 51.00
21 INT55606 Binding of Ace 14 0.37 10.73 1.82 51.00
22 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42 50.04
23 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 50.00
24 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 50.00
25 INT24019 Negative_regulation of HPS1 7 0.37 7.94 1.04 50.00
26 INT88734 Regulation of CREM 10 0.27 2.01 0.21 50.00
27 INT115503 Gene_expression of RAB3D 3 0.65 0.94 0.07 50.00
28 INT157747 Gene_expression of SLC22A16 2 0.65 0.35 0.05 50.00
29 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 49.48
30 INT5440 Negative_regulation of Ina 85 0.58 10.52 28.98 45.24
31 INT11996 Gene_expression of Ina 34 0.67 4.8 13.82 45.24
32 INT183172 Positive_regulation of Gene_expression of Ina 5 0.34 0.94 0.53 45.24
33 INT13118 Positive_regulation of Ina 48 0.69 7.39 13.85 44.64
34 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 38.04
35 INT241211 Negative_regulation of CIMT 8 0.37 2.67 0 35.28
36 INT6791 Binding of NA 55 0.46 5.36 17.59 15.16
37 INT178832 Gene_expression of GCOM1 2 0.06 0.43 0.19 15.12
38 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98 15.04
39 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 10.12
40 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 5.00
41 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
42 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
43 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
44 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
45 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
46 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
47 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
48 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
49 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
50 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
51 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
52 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
53 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
54 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
55 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
56 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
57 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
58 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 5.00
59 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
60 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
61 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
62 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
63 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
64 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
65 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
66 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
67 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
68 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
69 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
70 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
71 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
72 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
73 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
74 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
75 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
76 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 5.00
77 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
78 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
79 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
80 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
81 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 5.00
82 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
83 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 5.00
84 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
85 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
86 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
87 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
88 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
89 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
90 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
91 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
92 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
93 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
94 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
95 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
96 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
97 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
98 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
99 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 5.00
100 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
101 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
102 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
103 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
104 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
105 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
106 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
107 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
108 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
109 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 5.00
110 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
111 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
112 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
113 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
114 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
115 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
116 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
117 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
118 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
119 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
120 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
121 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
122 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
123 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
124 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 5.00
125 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
126 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
127 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 5.00
128 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 5.00
129 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 5.00
130 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26 5.00
131 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 5.00
132 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
133 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
134 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
135 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
136 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
137 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
138 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
139 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 5.00
140 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
141 INT6365 Localization of Edn1 56 0.81 18.84 13.83 5.00
142 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
143 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
144 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 5.00
145 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
146 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
147 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 5.00
148 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
149 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 5.00
150 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
151 INT7132 Localization of NPPA 53 0.81 19.79 10.86 5.00
152 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
153 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 5.00
154 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
155 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
156 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
157 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
158 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
159 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
160 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
161 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
162 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
163 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.00
164 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
165 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
166 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
167 INT6384 Regulation of Eef1a1 21 0.61 2.95 7.97 5.00
168 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
169 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
170 INT25958 Regulation of Ace 26 0.59 11.88 7.87 5.00
171 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
172 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 5.00
173 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 5.00
174 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 5.00
175 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
176 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
177 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
178 INT1973 Positive_regulation of NAGLU 36 0.65 14.78 7 5.00
179 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 5.00
180 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 5.00
181 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
182 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
183 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
184 INT5254 Positive_regulation of Pla2g2a 22 0.68 10.42 6.37 5.00
185 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 5.00
186 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27 5.00
187 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
188 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 5.00
189 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
190 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
191 INT677 Positive_regulation of CST3 20 0.67 17.47 6 5.00
192 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 5.00
193 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
194 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 5.00
195 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
196 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
197 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47 5.00
198 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43 5.00
199 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 5.00
200 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
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