D:T-cell Leukemia

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Disease Term
Synonyms Leukemia Lymphocytic T Cell, Leukemia T Cell, Leukemia T Cell Lymphocytic, Leukemia T Lymphocytic, Leukemias T Cell, Leukemias T Cell Lymphocytic, Leukemias T Lymphocytic, Lymphocytic Leukemia T, Lymphocytic Leukemia T Cell, Lymphocytic Leukemias T, Lymphocytic Leukemias T Cell
Documents 30
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for T-cell Leukemia. They are ordered first by their relevance to T-cell Leukemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 43.44
2 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 29.84
3 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 26.72
4 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
5 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49 5.00
6 INT228809 Gtf3a Regulation of Rgs1 1 0.00 0.25 0.09 5.00
7 INT228808 Smad7 Regulation of Rgs1 1 0.19 0.24 0.09 5.00
8 INT228810 Vwf Regulation of Stap1 1 0.00 0.24 0.09 5.00
9 INT228811 Gtf3a Regulation of Stap1 1 0.00 0.24 0.09 5.00
10 INT228807 Vwf Regulation of Rgs1 1 0.05 0.24 0.09 5.00
11 INT228812 Smad7 Regulation of Stap1 1 0.00 0.24 0.09 5.00
12 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
13 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
14 INT205862 CNTN2 Positive_regulation of TNF 1 0.01 0.08 0.04 5.00
15 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
16 INT296712 Binding of H2-K1 and GOPC 1 0.00 0.41 0.04 5.00
17 INT351952 Sag Positive_regulation of Gene_expression of Tnfrsf1a 1 0.17 1.11 0 5.00
18 INT343701 Binding of UTS2R and LOC100364739 1 0.00 0 0 5.00
19 INT205863 Binding of FDPS and HTLVR 1 0.00 0.07 0 5.00
20 INT351951 Negative_regulation of Binding of Fas and Fasl 1 0.29 1.13 0 5.00
21 INT353985 Binding of GYPA and POMT1 1 0.04 0.72 0 5.00
22 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0 5.00
23 INT205121 Binding of CD4 and CD7 1 0.05 0.51 0 5.00
24 INT205875 Binding of FDPS and G4 1 0.02 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for T-cell Leukemia. They are ordered first by their pain relevance and then by number of times they were reported in T-cell Leukemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69705 Positive_regulation of TXN 8 0.63 2.35 0.89 100.00
2 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98 100.00
3 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 100.00
4 INT69703 Gene_expression of TXN 20 0.71 3.57 2.01 99.66
5 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 99.04
6 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 99.04
7 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.24
8 INT10763 Localization of IL2 157 0.80 81.11 33.21 96.32
9 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 94.20
10 INT173159 Localization of PPARA 96 0.74 64.55 10.26 92.52
11 INT36892 Positive_regulation of Trav6-3 57 0.68 12.15 3.8 91.84
12 INT351938 Positive_regulation of Sag 1 0.23 0.92 0 91.84
13 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 91.76
14 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 91.04
15 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 89.28
16 INT82918 Binding of AMBP 23 0.39 23.31 1.71 87.48
17 INT121871 Localization of Camk4 9 0.81 4.67 3.84 84.84
18 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 83.08
19 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51 79.72
20 INT69700 Transcription of MC1R 15 0.71 4.32 5.62 79.16
21 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 75.00
22 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 75.00
23 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64 75.00
24 INT91327 Positive_regulation of CCL4 12 0.67 8.55 4.1 75.00
25 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 75.00
26 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85 75.00
27 INT21737 Binding of MC1R 129 0.48 45.45 56.54 75.00
28 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 75.00
29 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 75.00
30 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 75.00
31 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 75.00
32 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 75.00
33 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 75.00
34 INT79234 Positive_regulation of CCL3 15 0.67 11.43 4.15 75.00
35 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 75.00
36 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 75.00
37 INT28784 Positive_regulation of Gene_expression of CNDP1 3 0.22 3.87 1 75.00
38 INT3957 Gene_expression of CNDP1 6 0.52 3.7 0.96 75.00
39 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 72.92
40 INT56375 Positive_regulation of AMBP 25 0.60 21.24 2.22 72.48
41 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 70.24
42 INT25797 Positive_regulation of OR2AL1P 5 0.09 5.14 0.99 70.24
43 INT65219 Positive_regulation of Negative_regulation of OR2AL1P 1 0.06 1.38 0.1 70.24
44 INT55807 Negative_regulation of GPT 4 0.42 4.11 0.44 69.52
45 INT65220 Negative_regulation of OR2AL1P 1 0.06 1.37 0.1 69.32
46 INT343685 Gene_expression of LOC100364739 1 0.10 0.6 0 65.12
47 INT234419 Phosphorylation of TSPYL2 1 0.16 2.05 0.06 59.04
48 INT234409 Gene_expression of TSPYL2 2 0.21 5.16 0.03 54.12
49 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 52.00
50 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 51.52
51 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 46.40
52 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 40.36
53 INT93003 Binding of CD40 28 0.47 20.25 7.13 39.20
54 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 34.72
55 INT1261 Localization of Adh1 63 0.81 19.36 16.09 25.00
56 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 21.12
57 INT58756 Binding of GPI 10 0.48 7.17 3 19.88
58 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 19.68
59 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 19.28
60 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 19.28
61 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 8.24
62 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
63 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
64 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
65 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
66 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
67 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
68 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
69 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
70 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
71 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
72 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
73 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
74 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
75 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
76 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
77 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
78 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
79 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
80 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
81 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
82 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
83 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
84 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
85 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
86 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
87 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
88 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
89 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
90 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 5.00
91 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 5.00
92 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 5.00
93 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
94 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
95 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
96 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 5.00
97 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
98 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
99 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
100 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
101 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
102 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
103 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16 5.00
104 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
105 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
106 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
107 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
108 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
109 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 5.00
110 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
111 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
112 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 5.00
113 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
114 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
115 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24 5.00
116 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
117 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
118 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
119 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
120 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
121 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
122 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55 5.00
123 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
124 INT16404 Regulation of CD4 54 0.61 33.05 10.29 5.00
125 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
126 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
127 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
128 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 5.00
129 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
130 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
131 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
132 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22 5.00
133 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 5.00
134 INT66213 Localization of RELA 63 0.78 14.71 8.77 5.00
135 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 5.00
136 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
137 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
138 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
139 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
140 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 5.00
141 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 5.00
142 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
143 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93 5.00
144 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
145 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
146 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 5.00
147 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.00
148 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
149 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96 5.00
150 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 5.00
151 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
152 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 5.00
153 INT148968 Gene_expression of Gpbar1 29 0.56 11.9 5.66 5.00
154 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63 5.00
155 INT126177 Positive_regulation of Atf3 14 0.70 14.34 5.56 5.00
156 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 5.00
157 INT85683 Regulation of Gpbar1 16 0.60 3.3 5.5 5.00
158 INT164656 Negative_regulation of Gene_expression of CD36 24 0.57 6.51 5.39 5.00
159 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
160 INT87420 Gene_expression of BCL2L1 56 0.75 48.84 5.32 5.00
161 INT16405 Regulation of CD8A 38 0.45 19.04 5.31 5.00
162 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
163 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
164 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
165 INT15131 Gene_expression of CD2 20 0.75 9.47 5.01 5.00
166 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 5.00
167 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 5.00
168 INT116464 Negative_regulation of Birc5 53 0.59 45.4 4.91 5.00
169 INT74447 Gene_expression of Vwf 39 0.76 21.96 4.66 5.00
170 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
171 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44 5.00
172 INT69395 Gene_expression of CNTN2 28 0.68 13.29 4.37 5.00
173 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 5.00
174 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 5.00
175 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
176 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
177 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
178 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 5.00
179 INT78023 Gene_expression of DDX41 13 0.65 23.55 3.84 5.00
180 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
181 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 5.00
182 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 5.00
183 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
184 INT130351 Positive_regulation of Vwf 18 0.59 5.99 3.48 5.00
185 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 5.00
186 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29 5.00
187 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26 5.00
188 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 5.00
189 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19 5.00
190 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
191 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
192 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 5.00
193 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 5.00
194 INT145298 Gene_expression of Jak3 5 0.78 7.69 3.07 5.00
195 INT151441 Positive_regulation of Gene_expression of Trav6-3 22 0.65 10.21 3.05 5.00
196 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
197 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 5.00
198 INT15745 Negative_regulation of GYPA 18 0.43 8.01 2.74 5.00
199 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 5.00
200 INT203048 Gene_expression of PDCD1 13 0.78 8.5 2.62 5.00
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