D:Targeted Disruption

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Disease Term
Synonyms Antisen, Humanised Mouse, HUMANIZED MOUSE, KNOCK, Knock In, KNOCK IN MOUSE, Knock Mouse, KNOCK OUT MOUSE, Knockin Mouse, KNOCKOUT, TRANSGENIC
Documents 4843
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Targeted Disruption. They are ordered first by their relevance to Targeted Disruption and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27 100.00
2 INT258146 Binding of IGFBP3 and Hcrt 1 0.23 2.04 0 100.00
3 INT239185 Binding of Clk1 and Shc1 1 0.04 2.42 0 100.00
4 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1 100.00
5 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 100.00
6 INT217308 Binding of Vcan and Timd4 1 0.01 0.79 0 100.00
7 INT337812 Dgkb Regulation of Igkv4-54 1 0.07 1.27 0.08 100.00
8 INT242960 Binding of Ins1 and Ffar1 1 0.19 1.33 0.04 100.00
9 INT301143 Gopc Regulation of Gene_expression of TNF 1 0.07 0.56 0.09 100.00
10 INT225620 Gene_expression of IGHD6-13 Negative_regulation of Binding of Asc2 1 0.12 0.87 0 100.00
11 INT167565 Binding of ERG and LRP5 1 0.02 0.94 0.03 100.00
12 INT239321 Binding of Abca1 and Apoa1 1 0.11 1.61 0 100.00
13 INT239341 Binding of Abca1 and Hdl1 1 0.04 4.78 0 100.00
14 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0 100.00
15 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2 100.00
16 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0 100.00
17 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 100.00
18 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 100.00
19 INT332896 Binding of Hdac3 and Ncor1 1 0.31 1.38 0 100.00
20 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 100.00
21 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1 100.00
22 INT222494 Negative_regulation of Il1a Negative_regulation of Positive_regulation of Il6 1 0.00 0.79 0.19 100.00
23 INT305503 Binding of Nr5a1 and Slc17a6 1 0.08 0.37 0.08 100.00
24 INT257344 Gene_expression of Cyba Positive_regulation of Nox1 1 0.23 1.15 0 100.00
25 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 100.00
26 INT224582 Binding of IL1B and Positive_regulation of Gene_expression of TNF 1 0.05 1.33 0.37 100.00
27 INT217396 Binding of Abca1 and App 1 0.26 0.83 0 100.00
28 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57 100.00
29 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56 100.00
30 INT160246 Msr1 Negative_regulation of Binding of Col11a1 and Crygs 1 0.00 0.17 0.41 100.00
31 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4 100.00
32 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 100.00
33 INT224456 Il1 Regulation of VEGFA 1 0.04 0.52 0.14 100.00
34 INT303878 Fig4 Negative_regulation of Nav1 1 0.11 0.4 0.05 100.00
35 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 100.00
36 INT252343 Gene_expression of Cd70 Positive_regulation of Positive_regulation of Cd27 1 0.20 0.45 0.03 100.00
37 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0 100.00
38 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0 100.00
39 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0 100.00
40 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0 100.00
41 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0 100.00
42 INT254703 Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 0.91 0 100.00
43 INT254708 Map2k2 Positive_regulation of Phosphorylation of MAPK1 1 0.11 0.86 0 100.00
44 INT254706 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0 100.00
45 INT241265 DNMT1 Positive_regulation of OPCML 1 0.31 0.68 0 100.00
46 INT254704 Positive_regulation of Map2k1 Positive_regulation of Phosphorylation of MAPK1 1 0.10 1.43 0 100.00
47 INT254702 Map2k1 Positive_regulation of Phosphorylation of MAPK3 1 0.07 0.91 0 100.00
48 INT241269 DNMT1 Positive_regulation of Gene_expression of GOPC 1 0.04 0.68 0 100.00
49 INT257346 Gene_expression of Lox Positive_regulation of Nox1 1 0.02 0.57 0 100.00
50 INT241254 DNMT1 Positive_regulation of GOPC 1 0.04 0.68 0 100.00
51 INT254705 Map2k2 Positive_regulation of Phosphorylation of MAPK3 1 0.08 0.86 0 100.00
52 INT201490 Gene_expression of SPINK1 Negative_regulation of PRSS1 1 0.44 0.82 0.03 99.98
53 INT342783 Prdm16 Positive_regulation of Gene_expression of Gal 1 0.02 0.72 0.37 99.98
54 INT188470 Binding of Gpi1 and Il27ra 1 0.00 0.86 0.16 99.98
55 INT228137 Binding of Serpinb1-ps1 and Trav6-3 2 0.02 1.93 0.08 99.98
56 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34 99.98
57 INT250250 Gene_expression of AQP4 Positive_regulation of Gene_expression of SLC1A2 1 0.37 1.1 0.39 99.98
58 INT123808 Sst Regulation of Localization of Sstr2 1 0.41 0.55 0.46 99.96
59 INT113972 Regulation of Binding of Oprd1 and Smu1 1 0.00 0.45 0.84 99.96
60 INT113971 Binding of Oprd1 and Smu1 1 0.00 0.45 0.84 99.96
61 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 99.96
62 INT147475 co Positive_regulation of Gene_expression of Nfe2l2 1 0.01 0.57 0.36 99.96
63 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82 99.96
64 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82 99.96
65 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06 99.96
66 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52 99.96
67 INT334670 Gria2 Regulation of Gene_expression of Gopc 1 0.31 0.27 0.29 99.92
68 INT334668 Gria2 Regulation of Gene_expression of Insrr 1 0.01 0.27 0.29 99.92
69 INT186957 Nsdhl Positive_regulation of Tmed4 1 0.04 0.71 0.23 99.84
70 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42 99.84
71 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0 99.84
72 INT291394 Gene_expression of HTT Negative_regulation of Gene_expression of Slc1a2 1 0.11 0.96 0.34 99.84
73 INT204995 Ppp1r15b Regulation of Gene_expression of Pink1 1 0.01 0.97 0 99.78
74 INT204999 Hmmr Positive_regulation of Pink1 1 0.01 0.58 0.06 99.78
75 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05 99.78
76 INT342150 Ca2 Positive_regulation of Localization of Gast 1 0.03 0.27 0.14 99.78
77 INT328408 Nlrp1a Positive_regulation of Pdgfb 1 0.07 0.74 0.03 99.76
78 INT174679 Homer1 Regulation of Luc7l3 1 0.02 0.67 0.21 99.76
79 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28 99.76
80 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23 99.70
81 INT80067 Penk Positive_regulation of Gene_expression of Glb1 1 0.07 0.1 0.05 99.68
82 INT204998 Hmmr Positive_regulation of Eri1 1 0.00 0.58 0.06 99.66
83 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03 99.66
84 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59 99.66
85 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59 99.66
86 INT328366 GPR39 Regulation of Localization of Ghrl 1 0.11 0.2 0.07 99.66
87 INT258143 Binding of Hcrt and Atxn3 1 0.15 1.93 0.08 99.66
88 INT147472 co Positive_regulation of Gene_expression of Hmox1 1 0.01 0.57 0.36 99.64
89 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 99.64
90 INT354073 Oxt Positive_regulation of Localization of Avp 1 0.18 0.37 0.11 99.62
91 INT270680 Fos Regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 1 0.03 0.39 1.05 99.62
92 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54 99.60
93 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22 99.60
94 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23 99.60
95 INT108811 Esr2 Positive_regulation of Binding of Oprm1 1 0.46 0.44 0.79 99.60
96 INT304101 Il13 Positive_regulation of CCL11 1 0.43 0.69 0.04 99.60
97 INT129594 St13 Positive_regulation of Positive_regulation of Tnf 1 0.26 0.85 0.21 99.58
98 INT129592 St13 Positive_regulation of Protein_catabolism of Stat3 1 0.26 0.84 0.16 99.58
99 INT129593 St13 Positive_regulation of Positive_regulation of Stat3 1 0.28 0.84 0.16 99.58
100 INT194021 Cysltr1 Negative_regulation of Acc 1 0.02 1.2 0.91 99.56
101 INT204992 Hmmr Positive_regulation of Hras1 1 0.00 0.58 0.06 99.56
102 INT267252 Bax Regulation of Bak1 1 0.05 1.09 0 99.54
103 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8 99.54
104 INT247819 Cxadr Regulation of Gene_expression of Rasa1 1 0.06 1.04 0.04 99.54
105 INT305506 Binding of Pgk1 and Slc17a6 1 0.04 0.31 0.11 99.54
106 INT320769 Atp11c Regulation of Dsg1a 1 0.05 5.87 0 99.52
107 INT247820 Gjc1 Regulation of Gja5 1 0.08 1.24 0 99.52
108 INT171823 Nrgn Positive_regulation of Prkcg 1 0.18 0.53 0.36 99.52
109 INT305504 Slc17a6 Positive_regulation of Ex 1 0.05 0.67 0.22 99.52
110 INT202809 Cd3e Positive_regulation of Positive_regulation of Cxcl5 1 0.00 0.5 0.21 99.48
111 INT294910 Pax3 Regulation of Positive_regulation of Il1 1 0.02 2.03 0.42 99.48
112 INT245571 Runx1 Positive_regulation of Tbx15 Positive_regulation of Ntrk1 1 0.02 0.91 0.25 99.48
113 INT275283 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Ros1 1 0.24 0.36 0.32 99.48
114 INT275289 Positive_regulation of Trpv1 Positive_regulation of Ros1 1 0.24 0.36 0.32 99.48
115 INT197235 Binding of Grik1 and Kars 1 0.32 0.1 0.25 99.48
116 INT197237 Binding of Kars and Grik4 1 0.17 0.1 0.25 99.48
117 INT197232 Binding of Grik5 and Kars 1 0.17 0.1 0.25 99.48
118 INT184827 Binding of Thy1 and Tg(CAG-EGFP)D4Nagy 1 0.06 0.18 0.07 99.48
119 INT301787 Dtna Regulation of Prkx 1 0.00 0.1 0 99.48
120 INT122567 Mog Positive_regulation of Eae1 8 0.31 10.18 4.26 99.46
121 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93 99.46
122 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82 99.44
123 INT218845 Ppp1cc Positive_regulation of Positive_regulation of Cysltr1 1 0.02 0.92 0.6 99.44
124 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24 99.44
125 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73 99.44
126 INT211671 Gtf3a Regulation of Tnni2 1 0.01 0.33 0 99.42
127 INT170237 Lpl Regulation of CETP 1 0.02 0.99 0 99.42
128 INT323498 Ghsr Positive_regulation of Ins1 1 0.24 0.23 0.05 99.42
129 INT294906 Binding of Pax3 and Tac4 1 0.01 1.15 0.71 99.40
130 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18 99.40
131 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16 99.40
132 INT211669 Tnni2 Negative_regulation of Dnahc8 1 0.01 0.57 0 99.40
133 INT144433 Gene_expression of Erbb2 Positive_regulation of Positive_regulation of Mapk3 1 0.41 0.56 0.21 99.40
134 INT196877 Trpv1 Positive_regulation of Localization of Calca 1 0.11 0.41 0.62 99.38
135 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0 99.36
136 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94 99.36
137 INT351760 Adarb1 Regulation of Gria2 1 0.30 1.7 0.07 99.36
138 INT330426 Pcyt2 Regulation of Gene_expression of Aldh2 1 0.09 0.46 0.03 99.36
139 INT301144 Nos1 Regulation of Gene_expression of TNF 1 0.11 0.55 0.09 99.32
140 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02 99.32
141 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95 99.32
142 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05 99.30
143 INT170236 Lpl Regulation of HSD11B1 1 0.04 0.98 0 99.30
144 INT208554 Phosphorylation of YWHAQ Positive_regulation of Binding of YWHAQ and Akt1 1 0.32 1.04 0.08 99.30
145 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7 99.28
146 INT218842 Ppp1r9a Regulation of Gria2 1 0.19 0.87 0.32 99.28
147 INT245141 hIL Positive_regulation of Gene_expression of Hbb-ar 1 0.54 0.86 0.17 99.28
148 INT316824 Negative_regulation of Sparc Negative_regulation of Gene_expression of Col7a1 1 0.10 0.82 0.09 99.28
149 INT98379 Regulation of Binding of Pomc and Oprd1 1 0.01 0.35 0.23 99.28
150 INT98380 Binding of Pomc and Oprd1 1 0.02 0.35 0.23 99.28
151 INT203151 Binding of Rnase1 and Trav6-3 1 0.03 1.51 0.36 99.28
152 INT329476 SLC7A7 Regulation of Gpr55 1 0.12 0.1 0.09 99.28
153 INT188702 St6galnac2 Positive_regulation of Gene_expression of Stab1 1 0.00 5.09 1.23 99.24
154 INT55295 Slc2a1 Regulation of Ins1 1 0.17 0.41 0.19 99.24
155 INT55296 Slc2a4 Regulation of Ins1 1 0.17 0.41 0.19 99.24
156 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5 99.24
157 INT294757 Binding of Dob1 and Serpinb1-ps1 1 0.00 0.72 0.08 99.22
158 INT264839 Positive_regulation of Binding of Eno2 and Tpr 1 0.00 0.17 0.1 99.22
159 INT264838 Binding of Eno2 and Spp1 1 0.00 0.17 0.1 99.22
160 INT264836 Binding of Eno2 and Tpr 1 0.00 0.17 0.1 99.22
161 INT199369 DST Regulation of Igf1 1 0.02 0.8 0 99.20
162 INT172464 Binding of Rab27a and Myc 1 0.13 0.69 0 99.20
163 INT354885 Amy1 Regulation of Gene_expression of Il10 1 0.03 1.41 0.13 99.20
164 INT354888 Amy1 Regulation of Il10 1 0.02 1.41 0.13 99.20
165 INT323027 Binding of Il9 and Gtf3a 1 0.03 0.66 0.03 99.20
166 INT183708 Tlr3 Regulation of Binding of Tlr3 and Ducm1 1 0.02 0.99 0.14 99.18
167 INT181453 Gene_expression of Ccl2 Positive_regulation of Gene_expression of Il12rb1 1 0.06 1.87 0.34 99.16
168 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 99.16
169 INT176551 Binding of Pik3r1 and Spp1 1 0.03 0.65 0 99.16
170 INT328422 Protein_catabolism of Neu1 Positive_regulation of Dnase2b 1 0.01 0.67 0 99.16
171 INT178267 Alb Positive_regulation of Gene_expression of a 1 0.19 0.9 0 99.12
172 INT178268 Alb Regulation of Gene_expression of a 1 0.18 0.9 0 99.12
173 INT103889 Pdyn Regulation of Gene_expression of Creb1 1 0.03 0.19 0.15 99.12
174 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22 99.12
175 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 99.12
176 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 99.12
177 INT241913 AAVS1 Positive_regulation of Cat 1 0.04 0.46 0.1 99.12
178 INT354065 Pomc Regulation of Cort 1 0.07 1.69 0.12 99.08
179 INT354072 Cort Regulation of Pomc 1 0.07 1.22 0.08 99.08
180 INT188695 St6galnac2 Positive_regulation of Stab1 1 0.00 2.53 0.61 99.08
181 INT188693 Regulation of St6galnac2 Positive_regulation of Stab1 1 0.00 2.64 0.61 99.08
182 INT274449 Binding of Cd4 and H2 2 0.05 1.25 0.1 99.08
183 INT215395 Csf2 Positive_regulation of Ppara 1 0.12 1.33 0.32 99.08
184 INT188705 St6galnac2 Positive_regulation of Localization of Stab1 1 0.00 1.27 0.31 99.08
185 INT124353 Prkcg Positive_regulation of Positive_regulation of Gorasp2 1 0.02 1.19 0.73 99.08
186 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49 99.08
187 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46 99.08
188 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49 99.06
189 INT354889 Binding of TNF and Gtf3a 1 0.00 2.05 0 99.04
190 INT356379 DMD Positive_regulation of Negative_regulation of Utrn 1 0.54 0.84 0.07 99.04
191 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56 99.02
192 INT313120 Positive_regulation of Binding of Polr2a and Carf 1 0.06 0.69 0 99.00
193 INT313115 Binding of Polr2a and Carf 1 0.05 0.69 0 99.00
194 INT170212 Gene_expression of PLTP Positive_regulation of HSD11B1 1 0.12 3.01 0 99.00
195 INT242961 Ffar1 Regulation of Localization of Ins1 1 0.23 2.08 0.08 98.96
196 INT255997 Binding of Il1rn and H7 1 0.01 1.21 0.63 98.96
197 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63 98.96
198 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62 98.96
199 INT242959 Ffar1 Positive_regulation of Localization of Ins1 1 0.26 0.97 0 98.96
200 INT291450 Kcnn3 Negative_regulation of Gene_expression of SK 1 0.10 0.53 0.08 98.96

Single Events

The table below shows the top 200 pain related interactions that have been reported for Targeted Disruption. They are ordered first by their pain relevance and then by number of times they were reported in Targeted Disruption. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31 100.00
2 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
3 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 100.00
4 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 100.00
5 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 100.00
6 INT303796 Gene_expression of Tdp1 1 0.77 70.15 2.55 100.00
7 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 100.00
8 INT55251 Gene_expression of a 142 0.67 81.21 23.03 100.00
9 INT310891 Gene_expression of 53T 28 0.50 35.4 7.17 100.00
10 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 100.00
11 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
12 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 100.00
13 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 100.00
14 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74 100.00
15 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 100.00
16 INT175455 Gene_expression of Hspb8 54 0.76 59.87 3.9 100.00
17 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 100.00
18 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 100.00
19 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 100.00
20 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 100.00
21 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
22 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 100.00
23 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39 100.00
24 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 100.00
25 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 100.00
26 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 100.00
27 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 100.00
28 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
29 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 100.00
30 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 100.00
31 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 100.00
32 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 100.00
33 INT172452 Gene_expression of Myc 121 0.78 69.56 1.36 100.00
34 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 100.00
35 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 100.00
36 INT89657 Gene_expression of Kcnj9 24 0.77 15.15 18.86 100.00
37 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21 100.00
38 INT234933 Gene_expression of Dsg2 3 0.71 38.52 0.2 100.00
39 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 100.00
40 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 100.00
41 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38 100.00
42 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 100.00
43 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 100.00
44 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 100.00
45 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 100.00
46 INT204971 Gene_expression of Pink1 42 0.77 23.95 4.75 100.00
47 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 100.00
48 INT267196 Gene_expression of Cryab 17 0.64 22.5 0.38 100.00
49 INT251079 Gene_expression of G0s2 32 0.77 36.32 2.01 100.00
50 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 100.00
51 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 100.00
52 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 100.00
53 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 100.00
54 INT269254 Gene_expression of Mecr 1 0.78 10.69 0.14 100.00
55 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 100.00
56 INT115046 Gene_expression of Crem 68 0.77 27.24 10.01 100.00
57 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 100.00
58 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 100.00
59 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 100.00
60 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 100.00
61 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 100.00
62 INT238800 Gene_expression of Tmc1 1 0.10 24.17 0.35 100.00
63 INT172438 Gene_expression of Rab27b 8 0.77 10.95 0.27 100.00
64 INT192541 Gene_expression of Tg(Foxn1)E1Hon 20 0.20 8.98 2.4 100.00
65 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 100.00
66 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 100.00
67 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 100.00
68 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 100.00
69 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 100.00
70 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36 100.00
71 INT199253 Transcription of Vmn1r66 1 0.07 7.33 0.73 100.00
72 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 100.00
73 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 100.00
74 INT122041 Binding of Ppara 308 0.48 189.17 51.48 100.00
75 INT97912 Gene_expression of Sod3 25 0.78 22.44 3.28 100.00
76 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87 100.00
77 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 100.00
78 INT189088 Gene_expression of Psmb9 2 0.75 18.79 0.75 100.00
79 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 100.00
80 INT175512 Positive_regulation of Gene_expression of Igf2 16 0.70 22.75 0.08 100.00
81 INT224367 Negative_regulation of Ager 15 0.46 25.57 0.78 100.00
82 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 100.00
83 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73 100.00
84 INT169943 Gene_expression of Eri1 22 0.35 10.45 0.41 100.00
85 INT258328 Gene_expression of Aicda 76 0.71 58.29 16.86 100.00
86 INT82829 Gene_expression of COMP 104 0.78 57 9.81 100.00
87 INT174158 Negative_regulation of Cxadr 23 0.55 13.74 0.72 100.00
88 INT245593 Gene_expression of PTPN3 32 0.38 10.68 5.09 100.00
89 INT310892 Positive_regulation of Gene_expression of 53T 1 0.32 6.77 0.89 100.00
90 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28 100.00
91 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 100.00
92 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 100.00
93 INT117197 Gene_expression of Zmat3 19 0.05 8.3 2.05 100.00
94 INT269253 Positive_regulation of Gene_expression of Mecr 1 0.70 6.95 0.06 100.00
95 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 100.00
96 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 100.00
97 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 100.00
98 INT203490 Gene_expression of Runx3 19 0.76 27.56 12.57 100.00
99 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 100.00
100 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76 100.00
101 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 100.00
102 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 100.00
103 INT121870 Positive_regulation of Gene_expression of Camk4 24 0.70 15.63 5.83 100.00
104 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07 100.00
105 INT224369 Binding of Ager 43 0.42 40.57 3.86 100.00
106 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
107 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 100.00
108 INT69311 Gene_expression of Scn10a 31 0.78 15.54 14.64 100.00
109 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05 100.00
110 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 100.00
111 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 100.00
112 INT218825 Positive_regulation of Ppp1r9a 1 0.28 6.31 2.39 100.00
113 INT199256 Transcription of Tg(Foxn1)E1Hon 1 0.19 4.34 0.17 100.00
114 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 100.00
115 INT158669 Negative_regulation of Camk4 43 0.58 26.82 5.04 100.00
116 INT65502 Regulation of App 77 0.62 52.05 19.44 100.00
117 INT173693 Localization of Gopc 249 0.65 70.49 38.81 100.00
118 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47 100.00
119 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 100.00
120 INT218812 Gene_expression of Ppp1r9a 1 0.36 6.85 2.77 100.00
121 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 100.00
122 INT228279 Regulation of Gene_expression of Egf 7 0.43 6.64 0.65 100.00
123 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
124 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 100.00
125 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 100.00
126 INT139535 Gene_expression of Avpr1b 4 0.73 14.2 1.78 100.00
127 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56 100.00
128 INT256282 Gene_expression of Efnb2 3 0.76 17.61 16.41 100.00
129 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 100.00
130 INT310883 Negative_regulation of Gene_expression of 53T 1 0.37 6.27 0.76 100.00
131 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77 100.00
132 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 100.00
133 INT119544 Gene_expression of Nfe2l2 50 0.77 19.32 4.19 100.00
134 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 100.00
135 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01 100.00
136 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 100.00
137 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 100.00
138 INT283053 Gene_expression of Ddah1 1 0.77 5.69 0.31 100.00
139 INT224370 Localization of Ager 7 0.65 11.64 0.3 100.00
140 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 100.00
141 INT129106 Negative_regulation of Mstn 102 0.57 30.57 0.49 100.00
142 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 100.00
143 INT255120 Gene_expression of Celf1 29 0.62 10.82 0.59 100.00
144 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 100.00
145 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67 100.00
146 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51 100.00
147 INT118673 Regulation of Camk4 12 0.48 7.92 5.22 100.00
148 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 100.00
149 INT204463 Gene_expression of Fmr1 50 0.78 23.73 0.78 100.00
150 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2 100.00
151 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 100.00
152 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 100.00
153 INT310885 Regulation of Gene_expression of 53T 1 0.29 4.74 0.96 100.00
154 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 100.00
155 INT250114 Gene_expression of Hoxa3 36 0.77 23.04 1.46 100.00
156 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 100.00
157 INT118676 Positive_regulation of Camk4 34 0.70 16.67 10.9 100.00
158 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 100.00
159 INT250113 Gene_expression of Hoxc11 1 0.75 5.11 0.19 100.00
160 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 100.00
161 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 100.00
162 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 100.00
163 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 100.00
164 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 100.00
165 INT189927 Gene_expression of Arid1a 8 0.59 9.03 0.43 100.00
166 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 100.00
167 INT269265 Positive_regulation of Mecr 1 0.70 3.7 0.03 100.00
168 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 100.00
169 INT231987 Gene_expression of Tsp1 66 0.67 62.58 1.78 100.00
170 INT227949 Negative_regulation of Chrm2 8 0.25 4.23 0.73 100.00
171 INT199258 Positive_regulation of Transcription of Vmn1r66 1 0.07 2.98 0.09 100.00
172 INT159989 Positive_regulation of Ctsk 17 0.69 10.51 2.25 100.00
173 INT320739 Positive_regulation of Gene_expression of Dsg2 1 0.63 8.03 0 100.00
174 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 100.00
175 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 100.00
176 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 100.00
177 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 100.00
178 INT211655 Positive_regulation of Gene_expression of Igj 1 0.57 3.79 0.49 100.00
179 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 100.00
180 INT70885 Gene_expression of Pdgfb 48 0.67 42.27 3.19 100.00
181 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 100.00
182 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 100.00
183 INT238786 Positive_regulation of Binding of Ager 1 0.40 6.84 0 100.00
184 INT133744 Gene_expression of Vcan 27 0.74 10.64 2.85 100.00
185 INT191968 Negative_regulation of Gene_expression of Ide 9 0.39 7.14 0.47 100.00
186 INT116398 Gene_expression of Mog 25 0.77 23.11 6.33 100.00
187 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 100.00
188 INT346829 Negative_regulation of Efnb2 1 0.42 5.08 2.94 100.00
189 INT156488 Binding of Bace1 46 0.48 15.64 3.04 100.00
190 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19 100.00
191 INT116605 Binding of Nos2 28 0.37 16.88 8.18 100.00
192 INT170381 Transcription of Gopc 59 0.60 15.96 6.82 100.00
193 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
194 INT218810 Phosphorylation of Ppp1r9a 1 0.38 3.06 1.35 100.00
195 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 100.00
196 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 100.00
197 INT134821 Gene_expression of Gja3 8 0.77 7.45 4.44 100.00
198 INT46206 Positive_regulation of Scn10a 11 0.60 6.57 1.38 100.00
199 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6 100.00
200 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 100.00
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