D:Tauopathy

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Disease Term
Synonyms Tauopathies
Documents 37
Hot Single Events 59
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tauopathy. They are ordered first by their relevance to Tauopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11 100.00
2 INT282708 Binding of MAPT and Y301C7L 1 0.00 0.54 0.16 98.56
3 INT340743 Negative_regulation of CSF2 Positive_regulation of ZNF807 1 0.00 1.77 0 89.80
4 INT340745 CSF2 Positive_regulation of ZNF807 1 0.00 1.76 0 89.80
5 INT149281 Binding of MAPT and Dbp 1 0.00 0.4 0.17 80.48
6 INT344878 ENPEP Regulation of Gene_expression of Mapt 1 0.09 0.33 0 56.72
7 INT344881 ENPEP Regulation of Mapt 1 0.05 0.33 0 56.72
8 INT255808 SMN2 Positive_regulation of SMN1 1 0.41 0.89 0.14 54.00
9 INT255809 Binding of SF1 and U2AF2 1 0.21 0.3 0 16.48
10 INT255810 SLU7 Positive_regulation of Binding of SNRPA 1 0.01 0.23 0 11.28
11 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46 5.00
12 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 5.00
13 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4 5.00
14 INT230501 Il1 Positive_regulation of Gene_expression of S100a8 1 0.01 1.82 0.39 5.00
15 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36 5.00
16 INT312546 Ros1 Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.87 0.25 5.00
17 INT312550 DAK Positive_regulation of Rxra 1 0.00 1.48 0.18 5.00
18 INT288349 TNF Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.1 0.18 5.00
19 INT288351 Mcpt1 Positive_regulation of Gene_expression of TNF 1 0.02 1.1 0.18 5.00
20 INT312519 DAK Positive_regulation of PPARA 1 0.00 1.46 0.18 5.00
21 INT340744 CSF2 Regulation of BDNF 1 0.13 1.45 0.14 5.00
22 INT340742 Positive_regulation of CSF2 Regulation of BDNF 1 0.22 1.46 0.14 5.00
23 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 0.01 0.6 0.08 5.00
24 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
25 INT254909 ARSH Regulation of Sumf1 1 0.00 0.9 0.04 5.00
26 INT254908 ARSH Regulation of Eef1a1 1 0.00 0.89 0.04 5.00
27 INT321683 Binding of Aicda and Mapt 1 0.36 1.23 0.04 5.00
28 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
29 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
30 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
31 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 5.00
32 INT344879 Binding of ENPEP and Mapt 1 0.07 0.08 0 5.00
33 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
34 INT306677 Binding of Mapt and Atxn3 1 0.07 0.49 0 5.00
35 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 5.00
36 INT344880 Binding of ANPEP and Mapt 1 0.08 0.15 0 5.00
37 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 5.00
38 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
39 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
40 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 5.00
41 INT254906 Binding of Igfals and Chmp2b 1 0.02 0.85 0 5.00
42 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 5.00
43 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
44 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 5.00
45 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 5.00
46 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 5.00
47 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 5.00
48 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 5.00
49 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tauopathy. They are ordered first by their pain relevance and then by number of times they were reported in Tauopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 100.00
2 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 100.00
3 INT255824 Regulation of Gene_expression of MAPT 2 0.44 2.62 0 100.00
4 INT255827 Positive_regulation of Gene_expression of MAPT 3 0.49 2.63 0.1 100.00
5 INT63923 Binding of Mapt 4 0.47 6.28 1.19 99.56
6 INT8595 Localization of Mapt 26 0.73 6.81 6.41 99.56
7 INT4652 Gene_expression of CB 13 0.32 7.41 5.57 99.28
8 INT19775 Localization of Il1 183 0.78 145.5 50.91 99.12
9 INT65500 Gene_expression of App 605 0.78 429.94 98.31 98.96
10 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 98.96
11 INT282706 Phosphorylation of Imraq1 1 0.01 0.53 0.2 98.88
12 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 98.80
13 INT107173 Phosphorylation of App 20 0.82 12.64 5.3 98.80
14 INT282704 Phosphorylation of Sla 1 0.31 0.53 0.2 98.72
15 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 98.16
16 INT216107 Gene_expression of Imraq1 30 0.08 6.11 0.8 98.04
17 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 97.76
18 INT8594 Negative_regulation of Mapt 5 0.57 4.47 0.98 97.00
19 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 96.92
20 INT344867 Protein_catabolism of Mapt 1 0.86 0.25 0.17 95.68
21 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 93.60
22 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 92.72
23 INT21023 Gene_expression of Sla 2 0.59 0.64 1.08 92.44
24 INT282702 Gene_expression of Y301C7L 1 0.01 2.09 0.18 92.24
25 INT16794 Binding of App 103 0.48 64.87 19.79 92.08
26 INT163544 Binding of Psen1 40 0.36 15.28 2.42 92.08
27 INT282705 Regulation of Mapt 1 0.25 2.64 0 91.80
28 INT331144 Phosphorylation of Ccnd2 1 0.01 0.57 0 91.08
29 INT118955 Phosphorylation of PCNA 4 0.29 1.54 0.33 90.68
30 INT331145 Phosphorylation of Ccnb1 1 0.17 0.58 0 90.68
31 INT141936 Phosphorylation of Mapt 14 0.80 10.59 0.95 90.48
32 INT75627 Gene_expression of Mapt 41 0.75 22.1 4.58 90.16
33 INT249778 Binding of Ccnd2 2 0.33 1.12 0.13 89.88
34 INT121796 Gene_expression of NeuN 92 0.78 23.18 10.53 89.88
35 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 89.68
36 INT282703 Protein_catabolism of Pain1 1 0.01 1.36 0.05 89.44
37 INT255817 Positive_regulation of Positive_regulation of GNAS 1 0.01 0.85 0 89.24
38 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 88.60
39 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 88.60
40 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 87.96
41 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 87.72
42 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 87.36
43 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 87.00
44 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 86.92
45 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 86.08
46 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 85.28
47 INT217300 Regulation of Syn1 3 0.11 1.64 0.3 84.72
48 INT201632 Positive_regulation of Cdk5r1 20 0.40 21.6 2.75 83.68
49 INT282707 Positive_regulation of Phosphorylation of EID1 1 0.01 0.53 0.08 82.28
50 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16 82.20
51 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 82.08
52 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 81.92
53 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 81.92
54 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31 81.92
55 INT116114 Phosphorylation of EID1 8 0.12 3.99 1.75 81.88
56 INT65502 Regulation of App 77 0.62 52.05 19.44 81.08
57 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 81.08
58 INT149276 Positive_regulation of Binding of MAPT 1 0.49 0.41 0.17 80.96
59 INT68297 Binding of MAPT 9 0.47 4.45 0.75 80.48
60 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54 77.88
61 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 77.64
62 INT340749 Positive_regulation of ZNF807 1 0.00 3.79 0 77.48
63 INT331143 Regulation of Binding of Mapt 1 0.26 1.14 0 77.44
64 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26 76.36
65 INT255830 Positive_regulation of Localization of GNAS 1 0.01 0.28 0 75.52
66 INT331146 Phosphorylation of Ttbk2 1 0.03 0.39 0 75.16
67 INT118711 Positive_regulation of Binding of Om 1 0.05 1.12 0.13 75.00
68 INT118710 Negative_regulation of Binding of Om 1 0.05 1.12 0.13 75.00
69 INT73067 Binding of Om 8 0.08 2.35 2.56 75.00
70 INT108902 Localization of GNAS 5 0.13 1.31 0.23 74.44
71 INT331197 Negative_regulation of Atg4a 1 0.02 0.74 0 73.76
72 INT237161 Regulation of Ccnb1 5 0.17 2.71 0.32 73.68
73 INT176246 Regulation of Cdk2 6 0.30 3.31 0.15 73.68
74 INT216106 Positive_regulation of Gene_expression of Imraq1 6 0.05 2 0.19 73.56
75 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 73.28
76 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22 73.20
77 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57 73.20
78 INT98239 Negative_regulation of Htt 13 0.43 7.84 0.6 69.84
79 INT254883 Negative_regulation of Positive_regulation of Htt 1 0.05 1.14 0 69.84
80 INT255821 Binding of RFX1 1 0.03 0.2 0 69.00
81 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96 67.44
82 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 65.92
83 INT90357 Regulation of BCL10 3 0.05 3.23 0.56 65.12
84 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2 64.32
85 INT125397 Binding of Zmat3 2 0.03 2.34 1.19 64.08
86 INT321674 Binding of Tnfrsf21 1 0.20 1.22 0 63.24
87 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 62.76
88 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 62.72
89 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 61.52
90 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 59.84
91 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 59.20
92 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69 57.12
93 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02 56.96
94 INT331148 Positive_regulation of YWHAQ 1 0.45 0.37 0 55.36
95 INT183046 Transcription of INS 25 0.70 11.14 1.13 55.36
96 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 54.24
97 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 52.36
98 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 50.00
99 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 46.96
100 INT282982 Binding of Map1lc3a 4 0.28 1.77 0.03 45.24
101 INT306658 Binding of Map1lc3b 2 0.13 0.2 0 45.24
102 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 45.12
103 INT254873 Regulation of Map1lc3a 5 0.58 1.24 0.03 44.32
104 INT85621 Regulation of PRNP 16 0.60 8.7 1.15 43.84
105 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16 43.84
106 INT254880 Negative_regulation of Impa1 2 0.05 1.58 0.05 43.64
107 INT193493 Negative_regulation of tor 3 0.25 1.77 0.18 43.52
108 INT331200 Regulation of Atg4a 1 0.01 0.39 0 43.36
109 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 43.20
110 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 43.20
111 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 42.88
112 INT325411 Binding of Tm2d1 1 0.01 0.71 0.07 42.08
113 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 38.08
114 INT246641 Gene_expression of YWHAQ 5 0.58 3 0.22 37.12
115 INT284671 Binding of HOOK2 1 0.06 0.16 0 35.72
116 INT216110 Binding of AAVS1 13 0.36 3.24 0.3 35.04
117 INT157302 Positive_regulation of Map1lc3a 27 0.66 11.31 0.79 34.88
118 INT255833 Binding of SF1 1 0.34 1.03 0 32.88
119 INT340750 Phosphorylation of DLEU1 1 0.44 1.28 0 30.40
120 INT208553 Phosphorylation of YWHAQ 4 0.80 3.42 0.36 28.48
121 INT157301 Negative_regulation of Map1lc3a 5 0.28 3.2 0.41 27.92
122 INT254878 Localization of Map1lc3a 5 0.57 3.32 0.2 27.92
123 INT254874 Negative_regulation of Localization of Map1lc3a 1 0.18 1.05 0 27.92
124 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 27.60
125 INT254882 Localization of Lamp1 3 0.43 2.05 0 27.20
126 INT254887 Negative_regulation of Lamp1 2 0.20 3.17 0 27.20
127 INT254876 Negative_regulation of Localization of Lamp1 2 0.20 2.07 0 27.20
128 INT354841 Regulation of HLA-DRB3 1 0.01 1.88 0.04 27.04
129 INT254881 Negative_regulation of Atg7 9 0.34 5.69 0.32 26.68
130 INT306663 Negative_regulation of Atg5 1 0.10 0.28 0 26.68
131 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 26.24
132 INT203640 Regulation of MR1 7 0.34 3.8 1.26 26.24
133 INT296766 Transcription of IKBKG 1 0.04 1.02 0.17 25.84
134 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 25.44
135 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 22.12
136 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 21.24
137 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 20.80
138 INT255829 Binding of SNRPA 1 0.15 0.49 0 20.04
139 INT147796 Gene_expression of Ccndbp1 5 0.05 3.9 0.4 18.32
140 INT236916 Gene_expression of Ccnd2 5 0.46 2.48 0.14 18.32
141 INT196779 Phosphorylation of Ppp2ca 28 0.72 1.86 3.25 18.16
142 INT196753 Negative_regulation of Phosphorylation of Ppp2ca 3 0.37 0.52 0.7 18.16
143 INT325409 Gene_expression of Tauph 1 0.65 1.14 0.14 18.00
144 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 17.48
145 INT234467 Binding of U2AF2 2 0.34 0.82 0 16.48
146 INT258328 Gene_expression of Aicda 76 0.71 58.29 16.86 16.44
147 INT331147 Positive_regulation of Phosphorylation of YWHAQ 1 0.45 0.6 0.18 15.84
148 INT325408 Gene_expression of C330021F23Rik 1 0.19 2.56 0.62 10.84
149 INT325410 Transcription of C330021F23Rik 1 0.21 1.74 0.4 10.84
150 INT157305 Gene_expression of Map1lc3a 47 0.75 18.04 1.93 8.88
151 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38 8.08
152 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 5.00
153 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
154 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
155 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
156 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
157 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
158 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
159 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
160 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
161 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
162 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
163 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
164 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
165 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
166 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
167 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
168 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
169 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
170 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
171 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
172 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
173 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
174 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
175 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 5.00
176 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
177 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
178 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
179 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
180 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
181 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
182 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
183 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
184 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
185 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
186 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
187 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
188 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
189 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
190 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 5.00
191 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
192 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
193 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
194 INT3920 Localization of Ldha 241 0.81 83.08 58.72 5.00
195 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
196 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 5.00
197 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
198 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
199 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
200 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
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