D:Tendon Injuries

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Disease Term
Synonyms Injuries Tendon, INJURY TENDON, Tendon Injury
Documents 202
Hot Single Events 38
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tendon Injuries. They are ordered first by their relevance to Tendon Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0 90.40
2 INT285758 RETNLB Positive_regulation of Gene_expression of TIMP1 1 0.01 1.79 0.55 88.32
3 INT171050 Negative_regulation of F13A1 Regulation of PLG 1 0.02 0.55 0.28 5.00
4 INT171048 F13A1 Regulation of PLG 1 0.02 0.55 0.27 5.00
5 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24 5.00
6 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1 5.00
7 INT313618 Binding of Acly and Pdgfb 1 0.00 0.18 0.03 5.00
8 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tendon Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Tendon Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 99.92
2 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 99.16
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.94
4 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 98.72
5 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 97.32
6 INT48555 Binding of SP1 30 0.46 11.38 6.53 97.12
7 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 94.76
8 INT143841 Positive_regulation of Mtpn 17 0.17 5.46 2.68 94.76
9 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 94.68
10 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 93.96
11 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 93.96
12 INT324957 Phosphorylation of RBFOX3 1 0.05 0.82 0.64 93.60
13 INT324958 Positive_regulation of Phosphorylation of RBFOX3 1 0.03 0.71 0.42 93.60
14 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11 92.44
15 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 92.24
16 INT5586 Binding of Fos 47 0.48 12.7 21.33 91.44
17 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 91.28
18 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 91.04
19 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 91.04
20 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 90.48
21 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 89.96
22 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 89.44
23 INT5838 Negative_regulation of Positive_regulation of Gfap 10 0.58 6.52 4.39 89.08
24 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35 89.00
25 INT16624 Localization of Grin1 38 0.79 8.46 17.15 88.76
26 INT2225 Binding of Gfap 31 0.47 11.78 8.53 88.60
27 INT169822 Negative_regulation of Binding of Gfap 2 0.41 0.69 0.33 88.60
28 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 88.32
29 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 88.32
30 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27 87.84
31 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 85.60
32 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 85.20
33 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 85.20
34 INT253333 Transcription of SP140 1 0.12 0.15 0 84.40
35 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 81.96
36 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 80.92
37 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 80.80
38 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24 80.12
39 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 79.96
40 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 79.88
41 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56 79.88
42 INT149138 Binding of PDX1 27 0.37 32.62 9.33 79.64
43 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 79.24
44 INT188146 Binding of FST 3 0.31 0.55 0.12 79.12
45 INT153854 Positive_regulation of Ubl7 1 0.00 0.33 0.18 78.00
46 INT172066 Binding of Mtpn 3 0.02 1.51 0.52 76.68
47 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 75.12
48 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 75.00
49 INT79168 Binding of TNC 39 0.47 16.51 7.55 75.00
50 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 75.00
51 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 75.00
52 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 75.00
53 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 75.00
54 INT101104 Positive_regulation of Gene_expression of COL1A2 12 0.69 5.87 1.09 75.00
55 INT150606 Binding of Col5a1 1 0.08 0.33 0.07 75.00
56 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 74.08
57 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 73.40
58 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 73.12
59 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 72.60
60 INT155509 Binding of Myo5c 2 0.00 0.85 1.25 70.00
61 INT102989 Regulation of Gene_expression of MMP3 10 0.53 3.29 1.47 69.84
62 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 69.84
63 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 69.84
64 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 69.84
65 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 69.84
66 INT151309 Positive_regulation of Positive_regulation of MMP3 5 0.60 2.62 2.5 69.84
67 INT119089 Regulation of Phosphorylation of Grin1 17 0.61 3.1 12.82 69.68
68 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 69.20
69 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 68.84
70 INT174844 Binding of Fig4 81 0.41 18.03 12.87 66.36
71 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 65.84
72 INT121599 Negative_regulation of Gene_expression of RETNLB 7 0.21 9.28 8.8 65.48
73 INT111199 Gene_expression of Acly 11 0.16 5.65 0.78 65.36
74 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 65.12
75 INT65889 Gene_expression of RETNLB 73 0.34 60.98 38.3 64.88
76 INT140298 Positive_regulation of Myo5c 2 0.03 2.1 2.16 64.52
77 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 64.44
78 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 64.44
79 INT4535 Localization of PROC 106 0.73 76.24 21.1 64.16
80 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 62.52
81 INT278736 Positive_regulation of Phosphorylation of Smad1 1 0.25 0.83 0 62.28
82 INT79141 Regulation of Gene_expression of NPEPPS 3 0.01 2.95 1.61 62.08
83 INT278734 Phosphorylation of Smad1 5 0.34 1.48 0.3 61.20
84 INT278739 Phosphorylation of Smad5 1 0.33 0.84 0 61.20
85 INT278733 Phosphorylation of Smad9 1 0.32 0.42 0 61.20
86 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 59.52
87 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 59.52
88 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 59.04
89 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 59.04
90 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29 59.04
91 INT86149 Localization of Smad1 2 0.56 1.29 0.76 58.20
92 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 50.00
93 INT2649 Regulation of Calca 433 0.62 146.05 330.95 50.00
94 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 50.00
95 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52 50.00
96 INT264999 Localization of Otor 1 0.04 0.31 0.06 50.00
97 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0 50.00
98 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0 50.00
99 INT153853 Positive_regulation of Fus 7 0.42 8.43 1.59 47.64
100 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 46.24
101 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 42.24
102 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 42.04
103 INT105157 Positive_regulation of Phosphorylation of Gfap 8 0.67 6.48 6.38 42.04
104 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4 42.04
105 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82 39.08
106 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 35.20
107 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 34.16
108 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13 9.32
109 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
110 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
111 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
112 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 5.00
113 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
114 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
115 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
116 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
117 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
118 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
119 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
120 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
121 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
122 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
123 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 5.00
124 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
125 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
126 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
127 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
128 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
129 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
130 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
131 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
132 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
133 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
134 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
135 INT5137 Binding of PCa 45 0.47 16.91 18.47 5.00
136 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
137 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
138 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
139 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
140 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
141 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
142 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
143 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
144 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
145 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
146 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31 5.00
147 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
148 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 5.00
149 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
150 INT237329 Gene_expression of PARPBP 5 0.24 6.36 11.01 5.00
151 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 5.00
152 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 5.00
153 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
154 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
155 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 5.00
156 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
157 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 5.00
158 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
159 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
160 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
161 INT195442 Gene_expression of FIG4 23 0.65 5.13 6.92 5.00
162 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
163 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
164 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45 5.00
165 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26 5.00
166 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 5.00
167 INT80033 Binding of FAS 37 0.48 41.19 5.67 5.00
168 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 5.00
169 INT52631 Regulation of M3c 13 0.53 7.39 5.17 5.00
170 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
171 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
172 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
173 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
174 INT30610 Localization of PCa 35 0.65 13.91 4.25 5.00
175 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 5.00
176 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
177 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
178 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 5.00
179 INT22375 Localization of PDGFA 21 0.75 15.46 3.25 5.00
180 INT17750 Localization of MRXS5 15 0.56 6.65 3.1 5.00
181 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 5.00
182 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02 5.00
183 INT24821 Binding of VTN 14 0.47 5.83 3 5.00
184 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 5.00
185 INT133144 Localization of Mtpn 18 0.24 7.88 2.77 5.00
186 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 5.00
187 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
188 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 5.00
189 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
190 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
191 INT95592 Positive_regulation of Gene_expression of CASP1 15 0.48 13.06 2.1 5.00
192 INT64709 Gene_expression of VTN 11 0.67 11.01 1.97 5.00
193 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
194 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 5.00
195 INT167203 Binding of PRNP 25 0.48 20.09 1.84 5.00
196 INT65070 Gene_expression of SHOX 9 0.55 7.72 1.84 5.00
197 INT48720 Transcription of SERPINE1 11 0.68 4.76 1.67 5.00
198 INT115721 Positive_regulation of Gene_expression of PLAU 11 0.67 7.66 1.55 5.00
199 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
200 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4 5.00
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