D:Tension-type Headache

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Disease Term
Synonyms Headache Idiopathic, HEADACHE PSYCHOGENIC, Headache Stress, Headache Tension, HEADACHE TENSION TYPE, Headache Tension Vascular, Headaches Idiopathic, Headaches Psychogenic, Headaches Stress, Headaches Tension, Headaches Tension Type
Documents 492
Hot Single Events 35
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tension-type Headache. They are ordered first by their relevance to Tension-type Headache and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98 87.12
2 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98 87.12
3 INT41657 IL31RA Positive_regulation of CSF2 1 0.22 0.4 0.41 73.60
4 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 70.72
5 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 68.16
6 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 62.24
7 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 5.00
8 INT258456 PYCARD Negative_regulation of Localization of Tms 1 0.02 0.05 0.21 5.00
9 INT258455 Tms Negative_regulation of Localization of PYCARD 1 0.02 0.05 0.21 5.00
10 INT353551 Pck1 Regulation of SLC17A5 1 0.00 0 0 5.00
11 INT353549 Pck1 Regulation of Gene_expression of Gpt 1 0.00 0 0 5.00
12 INT326809 Binding of Ankrd36 and SLC25A22 1 0.10 0.13 0 5.00
13 INT353550 Pck1 Regulation of Gpt 1 0.00 0 0 5.00
14 INT326808 Binding of Ankrd36 and SLC25A18 1 0.12 0.13 0 5.00
15 INT326793 FGFR1 Positive_regulation of Gene_expression of ST8SIA2 1 0.00 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tension-type Headache. They are ordered first by their pain relevance and then by number of times they were reported in Tension-type Headache. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11375 Negative_regulation of Es2 10 0.50 6.52 5.64 99.84
2 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 99.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.68
4 INT27627 Binding of Rac1 41 0.41 22.88 13.68 99.28
5 INT5490 Binding of CA2 52 0.36 9.73 5.53 98.72
6 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 98.64
7 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48 98.64
8 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26 98.24
9 INT41660 Regulation of IL31RA 2 0.45 1.46 1.81 98.20
10 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 97.40
11 INT105698 Binding of KLK4 3 0.32 2.22 0.69 96.92
12 INT41727 Negative_regulation of Localization of Nts 3 0.39 1.48 3.15 94.60
13 INT81765 Gene_expression of Cts 4 0.58 9.49 7.76 94.24
14 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46 94.24
15 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 94.16
16 INT15044 Localization of Nts 30 0.75 4.58 13.72 93.98
17 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43 93.88
18 INT81764 Negative_regulation of Cts 5 0.37 3.47 2.34 93.88
19 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 93.88
20 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 93.68
21 INT12717 Binding of Pck1 85 0.47 12.49 54.81 93.60
22 INT2649 Regulation of Calca 433 0.62 146.05 330.95 92.40
23 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 89.80
24 INT61231 Gene_expression of SULT1A1 14 0.75 3.01 2.76 88.16
25 INT4159 Gene_expression of Hp 33 0.72 12.49 8.39 86.64
26 INT253 Regulation of PRL 184 0.62 47.27 65.79 86.56
27 INT921 Regulation of GH1 172 0.60 52.88 51.04 86.56
28 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 86.12
29 INT2541 Binding of Calca 200 0.48 67.14 134.62 85.80
30 INT11374 Gene_expression of Es2 7 0.67 3.27 2.89 83.92
31 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 83.68
32 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 83.04
33 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 82.84
34 INT10017 Gene_expression of REL 8 0.65 2.01 0.78 81.76
35 INT223678 Gene_expression of KLK4 3 0.75 1.11 0.14 80.40
36 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 79.28
37 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 77.84
38 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 75.00
39 INT137961 Localization of Ppt1 1 0.64 2.89 3.09 75.00
40 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 74.76
41 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 70.72
42 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88 70.72
43 INT6481 Binding of TNF 624 0.48 510.2 214.82 68.40
44 INT5008 Localization of Calca 204 0.81 80.35 125.16 68.16
45 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 66.24
46 INT10070 Negative_regulation of Fshb 13 0.42 3.48 2.5 66.24
47 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 63.60
48 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 63.60
49 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05 63.60
50 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 63.32
51 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 63.12
52 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 63.12
53 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 63.12
54 INT109559 Localization of Napa 16 0.61 1.3 2.42 62.24
55 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 60.48
56 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 60.48
57 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 60.48
58 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 60.48
59 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 59.64
60 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 58.00
61 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 58.00
62 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 58.00
63 INT2872 Positive_regulation of Maoa 10 0.67 3.26 7.47 54.80
64 INT19492 Regulation of B2M 16 0.60 10.97 2.55 52.64
65 INT37517 Negative_regulation of Protein_catabolism of MME 1 0.43 0.1 0.62 52.40
66 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 50.00
67 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 50.00
68 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 50.00
69 INT9660 Regulation of TNF 363 0.62 312.94 139.99 50.00
70 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 50.00
71 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 50.00
72 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 50.00
73 INT9210 Regulation of IL6 166 0.62 125.61 49.95 50.00
74 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61 50.00
75 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41 50.00
76 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54 48.32
77 INT37518 Regulation of Protein_catabolism of MME 1 0.27 0 0.25 48.32
78 INT25193 Negative_regulation of Pck1 20 0.57 5.66 6.05 35.72
79 INT626 Localization of CALCA 289 0.81 125.39 221.15 33.96
80 INT307700 Regulation of HOPX 4 0.53 7.64 3.5 32.80
81 INT51150 Positive_regulation of HTC2 10 0.67 6.8 2.95 25.00
82 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 20.92
83 INT262876 Localization of ST8SIA2 2 0.16 1.41 1.39 17.36
84 INT309303 Positive_regulation of ST8SIA2 2 0.11 0.65 0.91 14.56
85 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 10.68
86 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 10.68
87 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
88 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
89 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
90 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
91 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 5.00
92 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
93 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
94 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
95 INT4776 Localization of TAC1 82 0.78 16.89 45.21 5.00
96 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
97 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
98 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
99 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
100 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
101 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13 5.00
102 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
103 INT8048 Gene_expression of Nts 45 0.74 8.9 21.84 5.00
104 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
105 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
106 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36 5.00
107 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 5.00
108 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
109 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 5.00
110 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
111 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
112 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 5.00
113 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
114 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
115 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
116 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22 5.00
117 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14 5.00
118 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
119 INT34106 Negative_regulation of Htr1a 14 0.57 4.72 8.73 5.00
120 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
121 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07 5.00
122 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75 5.00
123 INT4810 Localization of PTGDS 20 0.81 4.19 6.97 5.00
124 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
125 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
126 INT22187 Localization of HTR1D 6 0.78 5.26 5.97 5.00
127 INT9567 Binding of Nts 10 0.44 2.14 5.89 5.00
128 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87 5.00
129 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 5.00
130 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73 5.00
131 INT166765 Localization of PYCARD 21 0.70 3.89 5.66 5.00
132 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
133 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
134 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 5.00
135 INT89304 Binding of ST8SIA2 12 0.35 0.93 5.23 5.00
136 INT137593 Regulation of Gene_expression of SLC6A4 7 0.60 2.59 5.23 5.00
137 INT96748 Gene_expression of GOLPH3 7 0.58 5.13 4.42 5.00
138 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
139 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 5.00
140 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
141 INT137702 Binding of TTN 7 0.35 4.48 3.62 5.00
142 INT135234 Regulation of ETFDH 13 0.29 10.8 3.4 5.00
143 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
144 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76 5.00
145 INT68444 Gene_expression of CPE 9 0.76 4.6 2.59 5.00
146 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4 5.00
147 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23 5.00
148 INT183675 Negative_regulation of ETFDH 11 0.37 5.62 2.18 5.00
149 INT78429 Positive_regulation of TRGC1 11 0.44 4.6 2.1 5.00
150 INT161432 Negative_regulation of Gene_expression of Tnc 2 0.38 1.44 1.93 5.00
151 INT180907 Positive_regulation of COQ10A 21 0.60 3.26 1.88 5.00
152 INT246298 Localization of RGS1 1 0.02 1.72 1.6 5.00
153 INT46384 Binding of TRGC1 16 0.41 4.87 1.28 5.00
154 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 5.00
155 INT104872 Positive_regulation of GOLPH3 3 0.18 1.34 1.15 5.00
156 INT277196 Gene_expression of CHI3L2 1 0.01 0.22 1.06 5.00
157 INT262878 Gene_expression of ST8SIA2 7 0.39 4.7 1.01 5.00
158 INT262366 Localization of Adh4 1 0.78 1.88 1 5.00
159 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97 5.00
160 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95 5.00
161 INT105697 Negative_regulation of KLK4 7 0.43 2.78 0.93 5.00
162 INT99287 Binding of GOLPH3 6 0.35 2.87 0.85 5.00
163 INT207421 Positive_regulation of Gene_expression of GPT 9 0.49 5.62 0.83 5.00
164 INT246299 Negative_regulation of RGS1 1 0.01 0.85 0.81 5.00
165 INT246297 Positive_regulation of RGS1 1 0.01 0.78 0.78 5.00
166 INT159531 Positive_regulation of Gene_expression of SLC17A5 8 0.49 9.3 0.77 5.00
167 INT28308 Localization of SLC17A5 10 0.73 6.77 0.7 5.00
168 INT212265 Positive_regulation of Gene_expression of CPE 1 0.44 1.26 0.7 5.00
169 INT103015 Positive_regulation of Tms 3 0.34 0.46 0.68 5.00
170 INT336708 Gene_expression of Lynx1 2 0.49 1.72 0.67 5.00
171 INT351321 Binding of Lynx1 1 0.01 0.87 0.63 5.00
172 INT162801 Localization of CALR 7 0.73 8.69 0.6 5.00
173 INT297394 Gene_expression of Pir 1 0.07 0.62 0.48 5.00
174 INT274704 Localization of GPT 5 0.73 3.91 0.29 5.00
175 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27 5.00
176 INT206445 Binding of SULT1A1 2 0.30 0.24 0.23 5.00
177 INT227702 Negative_regulation of PTCRA 4 0.43 1.21 0.22 5.00
178 INT258453 Localization of Tms 1 0.47 0.05 0.21 5.00
179 INT23930 Regulation of ST8SIA2 2 0.44 0.05 0.18 5.00
180 INT244270 Localization of GOLPH3 2 0.68 0.29 0.17 5.00
181 INT244269 Regulation of Localization of GOLPH3 1 0.16 0.3 0.17 5.00
182 INT330397 Positive_regulation of Gene_expression of FGFR3 1 0.14 0.2 0.16 5.00
183 INT326802 Protein_catabolism of SULT1A1 1 0.08 0.38 0.11 5.00
184 INT186522 Localization of ETFDH 2 0.09 0.35 0.11 5.00
185 INT227763 Positive_regulation of KLK4 8 0.47 1.39 0.1 5.00
186 INT342262 Positive_regulation of Localization of SLC17A5 2 0.49 0.95 0.07 5.00
187 INT342261 Positive_regulation of Localization of GPT 2 0.49 0.95 0.07 5.00
188 INT243552 Positive_regulation of NKX6-2 3 0.27 0.95 0.04 5.00
189 INT326805 Localization of KLK4 1 0.17 0.57 0.04 5.00
190 INT262879 Regulation of Gene_expression of ST8SIA2 2 0.10 1.24 0.03 5.00
191 INT353546 Positive_regulation of Localization of CALR 1 0.05 0.49 0.03 5.00
192 INT326800 Protein_catabolism of KLK4 1 0.23 0.31 0 5.00
193 INT262874 Positive_regulation of Gene_expression of ST8SIA2 3 0.11 1.82 0 5.00
194 INT312969 Negative_regulation of HLA-V 2 0.02 1.01 0 5.00
195 INT326803 Positive_regulation of Localization of KLK4 1 0.12 0.16 0 5.00
196 INT326798 Binding of Ankrd36 1 0.35 0.13 0 5.00
197 INT326807 Positive_regulation of SULT1A1 1 0.06 0.1 0 5.00
198 INT326799 Binding of SLC25A18 1 0.10 0.12 0 5.00
199 INT326806 Binding of SLC25A22 1 0.09 0.13 0 5.00
200 INT326801 Regulation of Gene_expression of SULT1A1 1 0.03 0.06 0 5.00
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