D:Testosterone Deficiency

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Disease Term
Synonyms None
Documents 27
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Testosterone Deficiency. They are ordered first by their relevance to Testosterone Deficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13 50.00
2 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12 50.00
3 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 36.80
4 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 36.80
5 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 10.88
6 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
7 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
8 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
9 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
10 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
11 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
12 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
13 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
14 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
15 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
16 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
17 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
18 INT182634 Binding of CCR5 and MIP 2 0.39 1.29 0.2 5.00
19 INT246478 Binding of SERPINE1 and ANGPTL5 1 0.01 1.32 0.1 5.00
20 INT182644 Binding of CXCR4 and Cxcr4 1 0.10 0.66 0.09 5.00
21 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Testosterone Deficiency. They are ordered first by their pain relevance and then by number of times they were reported in Testosterone Deficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227666 Negative_regulation of Gene_expression of IDS 1 0.04 0.25 0 97.88
2 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 97.72
3 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 97.32
4 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 97.12
5 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 92.24
6 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29 92.24
7 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 91.60
8 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 91.60
9 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 91.60
10 INT217723 Regulation of IDS 15 0.25 2.12 0.49 90.80
11 INT61753 Binding of HBN1 13 0.09 21.66 1.38 87.60
12 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 83.20
13 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 83.20
14 INT4146 Binding of SHBG 49 0.47 31 4.71 78.36
15 INT545 Binding of GC 15 0.45 10.74 3.47 78.36
16 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 77.72
17 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 77.16
18 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 75.68
19 INT251113 Positive_regulation of Binding of SHBG 1 0.37 0.47 0 75.00
20 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 74.80
21 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 72.72
22 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 72.72
23 INT227663 Localization of IDS 14 0.63 7.64 1.85 69.76
24 INT227669 Positive_regulation of Localization of IDS 1 0.04 0.15 0 69.76
25 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 68.12
26 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 65.56
27 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 65.20
28 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 64.72
29 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 56.48
30 INT25432 Negative_regulation of Gene_expression of GHRH 6 0.37 2.9 1.12 56.48
31 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 54.56
32 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 50.00
33 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 50.00
34 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 50.00
35 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 50.00
36 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 50.00
37 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 50.00
38 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 50.00
39 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07 50.00
40 INT5205 Localization of AR 43 0.80 12.87 4.63 50.00
41 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 50.00
42 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26 50.00
43 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63 50.00
44 INT185669 Positive_regulation of Localization of AR 7 0.33 1.83 0.73 50.00
45 INT134130 Gene_expression of CYP17A1 2 0.65 2.38 0.26 50.00
46 INT106260 Negative_regulation of HSD3B2 2 0.42 0.57 0.17 50.00
47 INT244649 Negative_regulation of CYP17A1 3 0.17 1.48 0.03 50.00
48 INT251112 Negative_regulation of Gene_expression of CYP17A1 2 0.24 2.04 0 50.00
49 INT147607 Binding of TERT 16 0.48 12.36 1.31 49.88
50 INT34586 Positive_regulation of Negative_regulation of HSD11B1 6 0.49 4.39 1.05 43.76
51 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 42.80
52 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 41.12
53 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 40.80
54 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 38.84
55 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 38.72
56 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33 38.72
57 INT912 Localization of FSHR 91 0.79 23.61 15.58 37.20
58 INT920 Localization of PLOD1 223 0.81 42.25 78.7 34.08
59 INT1793 Localization of CGA 379 0.81 67.38 114.69 33.76
60 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 29.04
61 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 28.88
62 INT217719 Positive_regulation of IDS 19 0.40 3.93 0.63 28.88
63 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 28.40
64 INT32962 Positive_regulation of Localization of GNRHR 3 0.41 0.59 0.49 28.40
65 INT158 Localization of Prl 2431 0.81 378.96 952.2 25.00
66 INT171998 Binding of DMD 58 0.47 38.13 3.35 22.56
67 INT182641 Negative_regulation of Binding of DMD 1 0.05 1.07 0.05 22.56
68 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 19.08
69 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 18.36
70 INT546 Binding of ALB 311 0.48 85.98 60.14 9.72
71 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 8.96
72 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 7.04
73 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
74 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
75 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
76 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
77 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
78 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
79 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
80 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
81 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
82 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
83 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
84 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
85 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
86 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
87 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
88 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
89 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
90 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
91 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
92 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
93 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
94 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
95 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
96 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
97 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 5.00
98 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
99 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
100 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
101 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 5.00
102 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
103 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
104 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
105 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 5.00
106 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 5.00
107 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
108 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
109 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
110 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
111 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
112 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 5.00
113 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
114 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
115 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
116 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
117 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
118 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
119 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
120 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
121 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
122 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
123 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
124 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
125 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
126 INT7587 Localization of GAL 27 0.78 4.79 14.29 5.00
127 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
128 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
129 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
130 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
131 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
132 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 5.00
133 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
134 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
135 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
136 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
137 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
138 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
139 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 5.00
140 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
141 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
142 INT99495 Gene_expression of SRD5A1 14 0.77 5 9.21 5.00
143 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
144 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87 5.00
145 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 5.00
146 INT13435 Positive_regulation of RTCA 31 0.60 7.19 8.5 5.00
147 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
148 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
149 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 5.00
150 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
151 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
152 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
153 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
154 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 5.00
155 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
156 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
157 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
158 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
159 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 5.00
160 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
161 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
162 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
163 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
164 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 5.00
165 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 5.00
166 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 5.00
167 INT99091 Regulation of AR 70 0.45 31.68 5.05 5.00
168 INT58750 Binding of GAL 16 0.47 5.48 4.92 5.00
169 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
170 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
171 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
172 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
173 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
174 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 5.00
175 INT78023 Gene_expression of DDX41 13 0.65 23.55 3.84 5.00
176 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
177 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
178 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 5.00
179 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 5.00
180 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 5.00
181 INT91341 Negative_regulation of Gene_expression of BGLAP 17 0.55 4.91 3.02 5.00
182 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65 5.00
183 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 5.00
184 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
185 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
186 INT7971 Regulation of Gene_expression of GNRH1 12 0.58 1.72 2.43 5.00
187 INT34891 Transcription of PRL 4 0.72 0.69 2.36 5.00
188 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
189 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
190 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99 5.00
191 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 5.00
192 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 5.00
193 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 5.00
194 INT4028 Regulation of HYAL1 8 0.54 1.55 1.8 5.00
195 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61 5.00
196 INT227660 Negative_regulation of Localization of IDS 2 0.23 3.81 1.57 5.00
197 INT31047 Localization of HRH2 5 0.75 1.84 1.53 5.00
198 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52 5.00
199 INT182629 Binding of Cxcr4 12 0.36 5.24 1.47 5.00
200 INT79357 Binding of ERVW-1 32 0.43 16.06 1.35 5.00
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