D:Thrombotic Microangiopathies

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Disease Term
Synonyms Microangiopathies Thrombotic, Microangiopathy Thrombotic, THROMBOTIC MICROANGIOPATHY
Documents 8
Hot Single Events 14
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Thrombotic Microangiopathies. They are ordered first by their relevance to Thrombotic Microangiopathies and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT281317 Stx2 Regulation of Gene_expression of tf 1 0.11 1.45 0.03 96.72
2 INT281313 Tlr4 Regulation of Gene_expression of tf 1 0.05 1.45 0.03 96.72
3 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0 83.96
4 INT281310 Stx2 Positive_regulation of Gene_expression of tf 1 0.20 0.89 0 80.80
5 INT281300 Tlr4 Positive_regulation of Gene_expression of tf 1 0.12 2.5 0 80.32
6 INT281305 Binding of St8sia2 and Tlr4 1 0.02 0.98 0 53.20
7 INT281319 Binding of F7 and tf 1 0.24 1 0.16 24.56
8 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0 14.24
9 INT281307 Binding of Selp and Selplg 1 0.01 0.76 0.17 5.00
10 INT281318 Binding of Selp and Selplg Positive_regulation of Gene_expression of Selplg 1 0.00 0.76 0.17 5.00
11 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15 5.00
12 INT281315 Binding of Gp1bb and Itgam 1 0.00 0.62 0.15 5.00
13 INT281301 Stx2 Positive_regulation of Localization of F3 1 0.10 0.19 0.11 5.00
14 INT281311 Tlr4 Positive_regulation of Localization of F3 1 0.04 0.19 0.11 5.00
15 INT281309 Tlr4 Positive_regulation of Gene_expression of F3 1 0.04 0.15 0.09 5.00
16 INT281312 Stx2 Positive_regulation of Gene_expression of F3 1 0.10 0.15 0.09 5.00
17 INT281303 Binding of Stx2 and Tlr4 1 0.11 0.09 0.06 5.00
18 INT281304 Binding of St8sia2 and Positive_regulation of Localization of tf 1 0.04 0.32 0 5.00
19 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0 5.00
20 INT281314 Positive_regulation of Stx2 Positive_regulation of Gene_expression of Itgam 1 0.08 0.21 0 5.00
21 INT281297 Binding of Tlr4 and Positive_regulation of Localization of tf 1 0.08 0.32 0 5.00
22 INT281296 Binding of Tlr4 and Positive_regulation of Localization of F3 1 0.03 0.32 0 5.00
23 INT281308 Binding of tf and Tlr4 1 0.06 0 0 5.00
24 INT281316 Binding of St8sia2 and Positive_regulation of Localization of F3 1 0.01 0.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Thrombotic Microangiopathies. They are ordered first by their pain relevance and then by number of times they were reported in Thrombotic Microangiopathies. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT200524 Protein_catabolism of ADAMTS13 1 0.40 1.34 0.05 99.26
2 INT167637 Negative_regulation of Protein_catabolism of Vwf 1 0.08 3.35 0.19 98.28
3 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 98.28
4 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 98.28
5 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 97.60
6 INT167638 Regulation of Protein_catabolism of Vwf 1 0.05 1.61 0.1 96.52
7 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 96.48
8 INT167636 Protein_catabolism of Vwf 5 0.52 5.09 0.41 95.88
9 INT23226 Positive_regulation of tf 23 0.43 15.55 14.37 94.96
10 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 92.96
11 INT77853 Positive_regulation of Gene_expression of tf 20 0.31 22.75 5.94 92.36
12 INT281284 Positive_regulation of Binding of St8sia2 1 0.07 1.56 0.04 92.00
13 INT23669 Binding of St8sia2 24 0.47 11.37 2.69 91.60
14 INT18412 Binding of PLEK 49 0.47 17.82 10.72 89.36
15 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08 77.84
16 INT281290 Positive_regulation of Hus1 1 0.01 0.95 0 77.16
17 INT9842 Binding of F2 36 0.47 22.79 4.42 75.44
18 INT23665 Gene_expression of St8sia2 14 0.58 6.74 1.08 72.48
19 INT112677 Localization of tf 20 0.48 9.66 1.06 71.80
20 INT281275 Positive_regulation of Positive_regulation of tf 1 0.27 1.12 0.31 71.80
21 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 64.40
22 INT78498 Regulation of Gene_expression of tf 9 0.32 7.69 1.79 62.84
23 INT281285 Gene_expression of Stx2 1 0.63 5.14 0.38 61.48
24 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 60.12
25 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71 58.56
26 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 56.16
27 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 56.16
28 INT281277 Positive_regulation of Stx2 1 0.41 0.93 0.27 56.16
29 INT281280 Positive_regulation of Positive_regulation of Stx2 1 0.41 0.52 0.06 56.16
30 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 48.56
31 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 47.52
32 INT281282 Negative_regulation of Stx2 1 0.34 0.34 0 47.52
33 INT196322 Binding of F2 18 0.15 7.74 0.83 33.20
34 INT78499 Binding of tf 8 0.22 2.64 0.55 31.44
35 INT137203 Positive_regulation of Emr1 3 0.45 2.34 0.24 21.28
36 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 14.96
37 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
38 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
39 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
40 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
41 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
42 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
43 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 5.00
44 INT17584 Regulation of tf 12 0.50 4.69 10.39 5.00
45 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
46 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
47 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 5.00
48 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
49 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
50 INT171117 Binding of Itgam 35 0.36 14.87 2.76 5.00
51 INT156579 Localization of Selp 14 0.73 6.53 2.69 5.00
52 INT137616 Gene_expression of Cd38 19 0.67 9.37 2.54 5.00
53 INT17268 Localization of PLG 9 0.78 11.71 2.06 5.00
54 INT92129 Positive_regulation of Gene_expression of F3 13 0.08 12.13 2.02 5.00
55 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 5.00
56 INT210709 Regulation of Itgam 8 0.28 9.21 1.76 5.00
57 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 5.00
58 INT101314 Gene_expression of Selplg 10 0.75 5.63 1.71 5.00
59 INT17905 Binding of Fgg 9 0.05 4.79 1.68 5.00
60 INT81776 Positive_regulation of F3 8 0.07 3.77 1.21 5.00
61 INT76751 Negative_regulation of Protein_catabolism of F13A1 7 0.13 5.16 0.79 5.00
62 INT81775 Localization of F3 10 0.61 9.12 0.73 5.00
63 INT33733 Binding of ITGA2B 12 0.36 3.86 0.71 5.00
64 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 5.00
65 INT112561 Binding of PSMG1 21 0.34 5.89 0.67 5.00
66 INT112676 Positive_regulation of Localization of tf 3 0.31 2.98 0.65 5.00
67 INT92130 Regulation of F3 3 0.44 1.31 0.62 5.00
68 INT281286 Binding of Stx2 1 0.39 2.02 0.55 5.00
69 INT99615 Gene_expression of GP1BA 12 0.75 2.98 0.5 5.00
70 INT98995 Binding of Selplg 3 0.36 2.59 0.38 5.00
71 INT200523 Regulation of F7 2 0.01 1.82 0.38 5.00
72 INT236352 Positive_regulation of Binding of Itgam 4 0.36 2.92 0.29 5.00
73 INT76159 Gene_expression of CEACAM1 5 0.65 5.12 0.24 5.00
74 INT200522 Negative_regulation of Negative_regulation of PLG 2 0.41 1.53 0.24 5.00
75 INT246070 Gene_expression of GPX2 3 0.65 1.79 0.15 5.00
76 INT281279 Positive_regulation of Positive_regulation of F3 1 0.07 0 0.06 5.00
77 INT281293 Regulation of PSMG1 1 0.01 0.18 0.03 5.00
78 INT281278 Localization of Hus1 1 0.02 0.59 0 5.00
79 INT281276 Localization of Stx2 1 0.61 0.06 0 5.00
80 INT112560 Positive_regulation of Binding of PSMG1 5 0.49 1.27 0 5.00
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